Telsartan H 40-80 mg. Price, instructions for use, reviews

Telsartan N is a medical product that is used to restore normal blood pressure levels. The drug has an acceptable cost, which depends on the specific dosage (40 or 80 mg).

Release form

The medication is produced in India in the form of tablets for oral use. Description: 2-ply, oval white or pink. The capsules may contain various pink inclusions. The product is packaged in blisters and packed in cardboard boxes.

Composition of the preparation

The drug contains 2 active ingredients: telmisartan and hydrochlorothiazide.

Additional composition:

• caustic soda;
• meglumine;
• twin-80;
• PVP K30;
• milk sugar;
• a solution of hexahedral alcohol;
• a mixture of magnesium salts and stearic acid;
• coloring matter (food additive E172).

Pharmacological properties

The drug belongs to the group of combined drugs that have an antihypertensive effect. The combination of active ingredients allows you to achieve a more pronounced therapeutic effect than their use alone. The first main ingredient (telmisartan) is an angiotensin-2 receptor antagonist. At the same time, it does not suppress the activity of these receptors and has no structural similarity with other binding receptors.

Taking the drug leads to a decrease in the level of aldosterone, does not suppress the effect of renin and does not cause blocking of ion channels. The component does not reduce the activity and action of the angiotensin-converting enzyme. The drug promotes the destruction of bradykinin and leads to a decrease in all risks of developing side effects caused by the substance.

When the 80 mg tablets are taken, there is a decrease in blood pressure caused by angiotensin-2. The therapeutic effect is noted after 3 hours after taking the medicine. In this case, the effect lasts for a day. A pronounced therapeutic effect occurs 1 month after the systematic use of the drug.

The active substance helps to lower blood pressure, but does not affect the heart rate (HR). After discontinuation of therapy, the pressure gradually returned to baseline values. In this case, the pseudosyndrome does not develop. The second main ingredient (hydrochlorothiazide) is a representative thiazide diuretic. Its action is aimed at expanding arterioles, thereby reducing pressure. Under normal pressure, the substance does not affect.

The ingredient is able to remove electrolytes and fluids. However, it begins to act 2 hours after application. The maximum efficiency is noted after 3-6 hours. The result lasts for 6-12 hours. After discontinuation of the drug, the effect lasts for about 1 week. To achieve a hypotensive effect, lower dosages are required than for the development of a diuretic effect.

When using high single dosages, there is a rapid development of the antihypertensive properties of the drug. When using small doses, blood functions remain little changed. The active ingredient can lead to disturbances in the production of breast milk. The maximum effect of the drug is achieved with its systematic intake for 1-2 months.

Pharmacodynamics and pharmacokinetics

Telsartan N 40 mg (the price of the drug has nothing to do with its pharmacological properties) and 80 mg have identical mechanisms of action. The first active ingredient is well absorbed from the gastrointestinal tract. The bioavailability level is about 50%. The maximum concentration is reached after 0.5-1.5 hours. Food intake can reduce this indicator, but after 3 hours. concentration is balanced.

The level of protein binding is above 99.5%. The ingredient lends itself to metabolic transformation and breaks down into inactive forms. The half-life of the main substance is over 20 hours. It leaves the body in an unchanged form through the intestines. In this case, only about 2% is excreted by the renal system. In patients with renal insufficiency, bioavailability reaches 100%. In this case, the half-life remains unchanged.

The second active component interacts with proteins. At the same time, the level of interaction varies from 40 to 70%. Bioavailability is about 60%. The maximum concentration of the ingredient occurs within 1-3 hours after application.

The main substance does not lend itself to metabolic transformation and leaves the body in an unchanged form along with urine. Approximately 60% of the taken dosage is excreted after 2 days. The half-life is from 12 to 15 hours. With functional impairment of the kidneys, the elimination time may be reduced.

Indications for use

Tablets are prescribed for arterial hypertension.

Contraindications

The remedy has some restrictions on admission, which are associated with the special conditions of the patient and the effect of active ingredients on the body.

Contraindications:

• functional disorders of the kidneys and liver;
• obstruction in the area of ​​the bile ducts;
• potassium deficiency;
• excess calcium;
• minor age;
• pregnancy;
• lactation period;
• intolerance to the components.

With extreme caution, the medicine can be used in the following cases:

• the development of stenosis in the region of the renal arteries;
• decreased volume of circulating blood caused by various factors;
• increased potassium in the blood;
• rehabilitation after kidney transplant;
• functional disorders of the liver;
• hepatic pathologies at the stage of progression;
• narrowing of the lumen in the area of ​​the mitral and aortic valves;
• heart failure (chronic disorder);
• diabetes;
• arrhythmia and / or heart failure (hypertrophic obstructive type of the disease);
• angle-closure glaucoma;
• gout;
• Connes syndrome.

Before using the medication, it is recommended to undergo additional studies for the presence / absence of contraindications.

At what age can Telsartan N be used?

Telsartan 80 mg (the price of the medicine in the regions is much lower than in the capital's pharmacies) and 40 mg are prohibited for use in pediatric practice. Age restrictions - for patients over 18 years old.

Instructions for use, dosage

The medication is intended for oral administration.

Dosage regimen: 1 tablet 1 time per day. In severe violations, the daily rate can be increased to 160 mg.

For functional disorders of the liver, the maximum dosage should be no more than 40 mg. The duration of the course is individual, according to the doctor's recommendations.

Side effects

Adverse reactions depend on the degree of tolerance of the components, as well as on the presence of various additional disorders in the patient.

Side effects:

• Respiratory system: RDS, development of shortness of breath.
• Cardiovascular disorders: irregularities in the heart rhythm (various types and types), decreased blood pressure.
• Central nervous system: sleep disorders, fainting, dizziness, anxiety or depression, impaired sensitivity, migraines, irritability.
• Digestive organs: excessive dryness in the mouth, diarrhea, flatulence, epigastric pain, vomiting, nausea, lack of appetite. In some cases, there were signs of gastritis, excessive weight loss, an increase in potassium and cholesterol levels. Also, the drug led to the development of pancreatitis, liver functional disorders, dyspeptic disorders, and jaundice.
• Skin reactions: hyperhidrosis.
• Musculoskeletal disorders: soreness, spasms, convulsive conditions, arthrosis, symptoms of arthralgia, myalgia.
• Hematopoietic function: various forms of anemia, increased levels of eosinophils, lack of platelets and leukocytes.
• Signs from the urinary system: kidney failure, the presence of glucose in the urine, nephritis (tubulointerstitial form).
• Disorders in the sense organs: visual dysfunction (fuzziness), angle-closure glaucoma, myopia, distortion of color perception.
• Reproductive disorders: decreased potency, up to its complete absence.
• Infectious processes: septic lesions, pathologies of the upper respiratory tract and urinary system, sialoadenitis.
• Metabolic disorders: there was an increase in the level of substances such as creatinine, liver enzymes, uric acid (in plasma), triglycerides, potassium and creatine kinase. At the same time, there was a decrease in the following elements: potassium, glucose, sodium, hemoglobin, and the volume of circulating blood decreased. Glucose intolerance reactions have also occurred.
• Allergic manifestations: development of vasculitis, exacerbation of systemic lupus erythematosus, local reactions, eczema lesions, anaphylaxis, angioedema.
• Other: general malaise, fever and flu-like conditions.

With the development of these signs, it is recommended to stop further use of the drug and consult a doctor.

Overdose

Telsartan N in dosages of 40 or 80 mg (the cost of various forms of the drug may differ from each other) did not lead to the development of undesirable manifestations. At the moment, no cases of drug overdose have been registered.

However, if the established norms are exceeded, the following reactions and conditions may develop:

• changes in water and electrolyte balance;
• a decrease in the volume of circulating blood;
• various forms of arrhythmia;
• cramping;
• lowering blood pressure.

Treatment is symptomatic.

special instructions

Since the drug affects the renin-angiotensin-aldosterone system, and also leads to an increase in the concentration of nitrogenous substances in the blood, treatment should be carried out with strict control of functions kidneys. Patients with stenosis are at increased risk of developing kidney failure and a significant decrease in blood pressure. Use the drug with extreme caution in patients with liver disorders, as it can lead to hepatic coma.

With diabetes mellitus, an adjustment of the dosage of insulin and hypoglycemic agents is required. Taking the drug in some cases led to the formation of uric acid in the blood, which can aggravate the symptoms of gout. Pills in patients with diabetes mellitus in combination with cardiovascular diseases can lead to heart attack myocardium or sudden cardiovascular death, therefore, before taking them, it is necessary to undergo additional research.

The medication can lead to a sharp deterioration in visual functions, up to a complete loss of vision. In this connection, at the first such signs, the drug should be canceled. During the period of using the product, it is necessary to periodically measure the level of electrolytes in the blood.

A decrease in potassium levels can occur in patients with liver cirrhosis. An increase in the concentration of the macronutrient is observed in patients with renal or heart failure. The drug can lead to loss of magnesium. When using the drug in patients with ischemic heart disease (with a sharp decrease in pressure), a heart attack or stroke may occur.

In isolated cases, taking pills led to the development of systemic lupus erythematosus. Hepatic dysfunction in most cases was observed in the Japanese. At the same time, the effectiveness of the drug is less pronounced in patients of the Negroid race. Care must be taken when driving or performing work that requires the speed of psychomotor reactions.

Drug interactions

Telsartan N 40 mg (the price of a drug is not an indicator of its therapeutic effect) or 80 mg can react with other drugs.

Drug groups and effects:

• Drugs that lower blood pressure - enhanced hypotensive effect.
• Lithium preparations - an increase in the level of lithium, accompanied by intoxication.
• NSAIDs - the development of acute kidney failure.
• Digoxin - an increase in the concentration of the drug.
• Alcohol, barbiturates, pain relievers (opioid group) - orthostatic collapse may develop.
• Hypoglycemic agents and insulin-containing drugs - dosage adjustment is necessary.
• Metformin - increases the risk of lactic acidosis.
• Cardiac glycosides - risks of developing arrhythmias, a decrease in magnesium and potassium in the blood.
• Pressor amines - a decrease in the therapeutic effect of this group of drugs.
• Receptor and membrane channel blockers - an increase in the effect is possible.
• Medicines for gout - an increase in the concentration of uric acid in the blood, the development of allergies.
• Calcium supplements - an increase in the level of a macronutrient. Possible dosage reduction.
• Β-blockers and diazoxide - an increase in the concentration of glucose in the blood.
• M-anticholinergic drugs - a decrease in the motor function of the stomach, an increase in the bioavailability of the main drug.
• Amantadine - an increased risk of side effects of this drug.
• Cytotoxins - a decrease in the volume of excretion of the components of the funds.
• Hypokalemic drugs - an increase in the excreted amount of potassium.
• Medicines that increase the level of potassium - an increase in the concentration of a macronutrient in the blood.

Before using drugs of different groups together, you must first consult with your doctor.

Analogs

Telsartan 80 mg (the price of similar drugs can be significantly higher) can lead to the development of undesirable effects to a greater extent than in a dosage of 40 mg.

If such reactions occur, the medicine should be replaced with another drug that is similar in action and indications.

Telpres Plus

• Generic is available in Cyprus as an oral tablet.
• The active ingredients are hydrochlorothiazide and telmisartan.
• The drug is prescribed for chronic high blood pressure.
• Dosage regimen: 1 capsule 1 time per day. The duration of treatment is individual, according to the instructions of a specialist.
• The medicine has an extensive list of contraindications and restrictions, identical to the main remedy.
• Dispensing system - prescription.
• The cost in regional and regional pharmacies in Russia is from 250 rubles.

Telmista N

• This substitute is produced in Slovenia as an oral tablet.
• The main substances are telmisartan and hydrochlorothiazide, which have a pronounced combined hypotensive effect.
• A remedy is used for arterial hypertension.
• Dosing rules: 1 tablet 1 time per day. The duration of the course is individual, according to the doctor's recommendations.
• The medication has numerous restrictions and contraindications, which you should familiarize yourself with in advance.
• Dispensing conditions - prescription.
• The price of a medicine varies from 270 to 415 rubles.

MikardisPlus

• This analogue is manufactured in Germany in the form of tablets based on 2 active ingredients - telmisartan and hydrochlorothiazide.
• The medicine is prescribed in the treatment of arterial hypertension.
• Dosage regimen: orally, 1 tablet 1 time per day. The duration of therapy is individual, according to the recommendations of the attending specialist.
• The drug has identical restrictions and contraindications, as well as the main remedy.
• Pharmacy dispensing - prescription.
• The cost of the medication is from 990 to 1120 rubles.

Terms, conditions of sale and storage

• The medicine should be stored in a dry and dark place at a temperature not exceeding 25⁰C.
• Shelf life is 3 years from the date of issue.
• Do not use tablets after the expiry date stated on the package.
• Terms of sale - prescription.

Price

The cost of an oral solution may differ depending on the region where the drug is sold.

Region / region	Dosage form / dosage	Price
Moscow, Moscow region	Tablets, 40 mg, 28 pcs.	RUB 230-470
St. Petersburg	Tablets, 40 mg, 28 pcs.	RUB 160-400
Saint Petersburg (suburbs)	Tablets, 40 mg, 28 pcs.	RUB 210-420
Novgorod region	Tablets, 80 mg, 28 pcs.	RUB 100-535
Leningrad region	Tablets, 80 mg, 28 pcs.	140-510 rub.

Before using Telsartan N, you must carefully read the instructions for use of the product and study the dosage rules for each form (40 or 80 mg). You can find out the exact price and purchase pills at any pharmacy located in the patient's place of residence.

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