Gramicidin C (Gramicidin S) tablets for resorption. Reviews

Gramicidin C is a lozenge tablet, which are produced by the Russian pharmaceutical company PFK AO Obnovlenie. This medication belongs to the pharmacological group of polypeptide antibiotics of the local spectrum of action. The scope of application of the drug Gramicidin C is ENT practice, surgical and therapeutic dentistry.

Release form

Gramicidin C is available in the form of rounded tablets for intraoral absorption. The medication is packaged in cell blisters and polymer cans. The complete set of the drug Gramicidin C comes in 10 and 20 tablets, respectively. The main packaging of this antibiotic is a cardboard box, inside which there is a detailed instruction for the use of the drug.

The drug Gramicidin C is also available in the following dosage forms:

• fatty and aqueous solutions;
• thick paste;
• alcohol solution.

Each of the above dosage forms of the drug Gramicidin C has its own indication for use for the treatment of infectious and inflammatory processes in the oral cavity and on the surface of the skin cover.

Composition of the preparation

The active component of this antibiotic is the substance gramicidin C with a concentration of 1.5 mg in 1 tablet, which corresponds to a mass fraction of 1500 units.

The auxiliary function of the drug is performed by the following biochemical compounds:

• calcium stearate at a dosage of 0.006 g;
• flavoring (fruit smell) no more than 0.00198 g;
• sucrose at a concentration of 0.1482 g;
• milk sugar (aka lactose) in the amount of 0.44169 g;
• sodium saccharinate, which is a soluble sugar substitute, does not exceed the norm of 0.00063 g.

The antibacterial agent Gramicidin C is distinguished by a simple, but at the same time effective composition. This drug does not contain sugar, therefore it is approved for absorption by patients with diabetes. People with individual lactose intolerance may develop side effects associated with disorders of the gastrointestinal tract.

Pharmacological properties

Gramicidin C - tablets for resorption, the effect of which is limited locally in the area of ​​their application.

This drug has the following pharmacological properties:

• helps to relieve the inflammatory process in epithelial and soft tissues;
• reduces swelling of the mucous membrane;
• accelerates the process of regeneration of tissues damaged as a result of an infectious, inflammatory or traumatic process;
• exhibits bacteriostatic and bactericidal action;
• normalizes the microflora of the oral cavity and ENT organs in case of infection with infectious microorganisms.

The pharmacological properties of the antibacterial agent Gramicidin C are enhanced in the case of its combined administration with other antimicrobial, as well as anti-inflammatory drugs injectable and tablet form of release.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics of Gramicidin C tablets consists in the bacteriostatic action of their active substance against pathogenic microorganisms of the following strains:

• streptococcal infection, which causes bacterial pneumonia;
• gonococci;
• meningococcal infection;
• representatives of anaerobic microflora.

The use of high doses of the drug Gramicidin C enhances its pharmacodynamic effect. With an increase in the concentration of the active substance gramicidin C to the maximum permissible values, the bactericidal properties of the drug appear, which make it possible to suppress the development of Staphylococcus aureus. This microorganism provokes infectious and inflammatory processes in the oral cavity, larynx and nasopharynx.

A distinctive feature of the pharmacodynamic action of this drug is that Gramicidin C has the ability to increase the permeability of the cell membrane of pathogens. The active component of this antibiotic penetrates the lipid substances of the bacterial infection cell, perforates it, creating a network of many small channels. This process leads to the development of a microorganism with an osmotically unstable cell. The population of bacterial infection is gradually decreasing, which contributes to the rapid extinction of tissue inflammation and the patient's recovery.

The pharmacokinetics of the drug Gramicidin C is not fully understood. The reason for the lack of information data on the distribution of the constituent components of the antibiotic is its low absorption in the tissues of the oral cavity and other ENT organs. The chemical compound gramicidin C acts locally, without saturating the general composition of the bloodstream.

Indications for use

Gramicidin C - tablets for resorption, which are prescribed as an independent means of therapy, as well as in combination with other antibacterial medicines.

This form of release of the drug is indicated for use in the following diseases of the body:

• stomatitis of bacterial etiology;
• chronic tonsillitis;
• purulent tonsillitis;
• acute and chronic periodontal disease;
• inflammation of the gums;
• acute form of pharyngitis.

The antibacterial agent Gramicidin C has proven effective in treating glossitis, which is caused by Staphylococcus aureus and streptococcal infections. If necessary, this drug can be used to treat other infectious and inflammatory diseases of the oral cavity.

The table below shows indications for the use of the antibiotic Gramicidin C in other forms of release.

Release form of the drug Gramicidin C	Indications for prescribing the drug
Fat and water solutions	This form of release of the antibiotic Gramicidin C is indicated for use in the following cases: ulcerative formations on the surface of the skin; festering wounds; traumatic damage to the joints, accompanied by inflammation of their tissues; carbuncles; thermal, chemical, electrical burns of the body; empyema; furunculosis; bacterial osteomyelitis of bone tissue; bedsores in severely bedridden patients; phlegmon. A fatty or aqueous solution of the drug Gramicidin C is intended for washing open wounds, antiseptic irrigation of tampons and gauze dressings before applying them to open areas of the patient's body.
Alcohol solution	This form of release of an antibacterial agent is used to treat pyoderma, and is also used as an auxiliary drug in the complex therapy of the following diseases: blepharitis; otitis externa; infectious infection of the eyelids, accompanied by eczema; scleritis; barley on the upper or lower eyelid (meibomite); iritis. In the treatment of ophthalmic diseases of an infectious and inflammatory nature of origin, Gramicidin C can only be used as part of a combined course.
Paste	Gramicidin C in the form of a paste is prescribed for external use as a main or auxiliary agent. This drug is used to treat burns and open wounds with signs of an infectious and inflammatory process.

The dosage regimen of the drug Gramicidin C in the form of tablets for resorption or in other forms of release is determined by the doctor. This antibiotic is indicated for course use during the period of time established by the doctor. Early termination of therapy with Gramicidin C can lead to a decrease in the therapeutic effect or relapse of inflammatory pathology.

Contraindications

Gramicidin C - tablets for resorption, which have a minimum number of contraindications. This tool is prohibited for use in relation to patients with individual intolerance to its constituent substances. Gramicidin C in the form of a paste, alcohol, fat or water solution is not prescribed to patients with signs of dermatosis. An antibacterial drug based on gramicidin C is contraindicated in women who are breastfeeding a newborn baby.

In case of emergency, this remedy can be prescribed to pregnant women. The attending physician individually assesses the potential benefits of using the tablets, as well as the risk of negative effects of the drug on the fetal tissue. The composition of Gramicidin C contains milk sugar, which should be taken into account by patients with lactose intolerance. The ingestion of this substance into the digestive tract can provoke a short-term or long-term upset of the digestive system.

At what age can the drug be used?

The antibiotic Gramicidin C is prescribed for children from 4 years old. For patients of a younger age group, this medication is contraindicated. Tablets based on gramicidin C should be administered with extreme caution to children aged 4 to 12 years. Patients in this category undergoing antibiotic treatment should be under constant supervision by medical personnel. These precautions are aimed at timely prevention of the possible occurrence of allergic reactions to the constituent substances of the drug.

Instructions for use, dosage

The antibacterial agent Gramicidin C in the form of tablets is taken sublingually after a meal. The medication is slowly absorbed in the oral cavity until it is completely dissolved. Chewing or swallowing tablets will not bring a positive therapeutic effect, and may also cause discomfort in the organs of the digestive system.

Over the next 60 minutes. after resorption of the drug, it is necessary to refrain from drinking various kinds of drinks. During the specified period of time, food should also not be eaten. The introduction of these restrictions is due to the fact that profuse salivation will accelerate the process of flushing the active substance of the antibiotic from the oral mucosa.

The table below shows the dosage regimen of the drug Gramicidin C, taking into account the age category of the patient:

Patient age	Therapeutic dosage
Children aged 4 to 6 years	Take 1 tablet of Gramicidin C up to 4 times a day.
Child of the age category from 6 to 12 years old	Dissolves 1-2 tablets 4 times a day. The maximum allowable dosage is 7 tablets. per day.
Adult patients and children over the age of 12	Take 2 tablets (with an interval of 20-30 minutes. between each table) up to 4 times a day.

The average duration of a therapeutic course with the antibiotic Gramicidin C in tablet form is 5 days. Therapy with this drug for more than 6 days is possible only by agreement with the attending physician, since there is a risk of side effects.

The drug Gramicidin C in the form of a thick paste, water, alcohol and fat solution is applied to the surface of ulcers, wounds and other painful areas of the skin. If necessary, this medication is used as an antiseptic for disinfection of gauze tampons and dressings, which are used in purulent surgery as dressing material.

Gramicidin C in the form of a paste and solutions is applied to diseased skin areas 2-3 times a day. The dressings treated with this antibiotic are changed every 2-4 days, depending on the nature of the wound. Antibacterial paste Gramicidin C can be used as a female contraceptive. To do this, 5-6 g of this medication is injected into the vaginal cavity using a special syringe.

Side effects

The main or auxiliary therapy with Gramicidin C can cause side effects, which are manifested by the following symptoms:

• dryness of the oral mucosa;
• contact dermatitis, which indicates an allergic reaction of the body to the constituent substances of the drug;
• itching of the tongue, gums, parts of the mouth and larynx.

In the case of parenteral administration of the antibiotic Gramicidin C in the form of a solution, there is a high probability of damage to the vascular system of the patient's body in the form of phlebitis or hemolysis. The appearance of side effects is the basis for the immediate termination of further therapy with this drug, regardless of its form of release. The most dangerous symptom of individual intolerance to the constituent substances of Gramicidin C is the occurrence of an allergic reaction in the form of swelling, redness and itching of the laryngeal mucosa.

After detecting side effects, you must contact your doctor for an examination, as well as for additional advice.

In case of an allergic reaction to Gramicidin C, the doctor may prescribe the following types of antihistamines:

• Aleron;
• Loratadine;
• Ketotifen;
• Suprastin.

Patients with signs of adverse reactions to this antibiotic undergo inpatient or outpatient treatment, depending on the nature and severity of the symptoms. In most cases, the course of treatment is 7-10 days.

Overdose

Gramicidin C - tablets for absorption in the oral cavity, which must be taken in a strictly established dosage.

Consuming too much of this medication causes the following overdose symptoms:

• intestinal dysbiosis;
• diarrhea or constipation;
• nausea;
• complete or partial loss of appetite;
• discharge of vomit;
• rumbling in the stomach;
• increased gas formation;
• development of superinfection;
• allergic reactions to the constituent components of the drug.

Patients who have experienced an overdose of the antibiotic Gramicidin C should stop further taking these tablets, and then consult their doctor. Patients with the above manifestations receive symptomatic therapy depending on their general condition.

special instructions

During treatment with the drug Gramicidin C in the form of tablets, the following instructions should be taken into account:

1. This medication does not affect the functions of the central nervous system and does not violate the speed of mental reactions.
2. Patients undergoing therapy with Gramicidin C can drive vehicles, machines, mechanisms and perform work of increased danger.
3. The tablets should not be swallowed whole or chewed. The drug should dissolve only under the action of saliva, evenly distributed over the mucous membrane and all tissues of the oral cavity.
4. Patients with diabetes mellitus should remember that 1 table. Gramicidin C contains about 0.05 XE. (numerical amount of carbohydrate units).
5. Gramicidin C in the form of an aqueous solution is allowed to be taken orally, but only within 3 days after its preparation.

Intravenous administration of solutions based on the active substance gramicidin C is prohibited. Violation of this rule can lead to the development of acute phlebitis and hemolysis.

Drug interactions

The antibacterial agent Gramicidin C is able to enhance the therapeutic effect of other drugs with antimicrobial properties. This form of drug interaction applies to all forms of drug release, including drugs of the systemic and exclusively local spectrum of action. There are no pharmacological restrictions on the use of other drugs from the antibiotic group. The main thing is that they do not contain an active substance in the form of gramicidin C. Otherwise, there is a risk of signs of overdose.

Analogs

The table below lists drugs with antibacterial properties that are analogs of the drug Gramicidin C.

Name of the medication	Characteristics of the medicinal product
Grammidin neo	The active ingredients of this drug are gramicidin C and cetylpyridinium chloride. The release form of this drug is tablets for absorption in the oral cavity. Grammidin neo is used in 1 table. from 1 to 4 times a day. The cost of the drug is from 243 rubles. for 18 tab.
Lizobact	A drug based on the active substances pyridoxine and lysozyme. Lizobact is prescribed to take 1-2 tablets for absorption in the oral cavity 3-4 times a day. The duration of the therapeutic course is 8 days, and the average cost of the medication is from 228 rubles. for 30 tab.
Imudon	A medication that is used in dentistry and for the treatment of ENT organs. The active substance of Imudon is a mixture consisting of bacterial lysates at a concentration of 2.7 g per 1 table. This drug is taken orally in a dosage that is determined individually by the attending otolaryngologist or dentist. The therapeutic effect of Imudon is achieved by repeatedly enhancing the protective functions of local immunity. The average cost of this drug is from 322 rubles. for 24 tab.

Medicines analogs of Gramicidin C tablets should be prescribed only by the attending physician. The use of the above medicines is possible as the main medicine or in the form of auxiliary drugs during complex therapy.

Terms, conditions of sale and storage

The drug Gramicidin C is dispensed without a doctor's prescription. Storage of these tablets should be carried out in a cool dry place at an air temperature not higher than +25 degrees Celsius. The medication should be left out of the reach of children and in its original packaging. The shelf life of the antibacterial agent Gramicidin C is 3 years, after which the tablets must be disposed of.

Price

The average cost of the drug Gramicidin C ranges from 95 to 155 rubles. per pack of 20 tablets for sucking in the mouth.

Gramicidin C is an effective antibacterial agent that comes in the form of lozenges, water, alcohol, fatty solution and external paste. The constituent substance of this medication has a bacteriostatic and bactericidal effect against gonococcus, streptococcal infection, Staphylococcus aureus and meningococcus.

Gramicidin C in the form of tablets is approved for use in children aged 4 years and older. The duration of the therapeutic course is determined by the attending physician, but on average it is 5 days. The antibiotic is prescribed for periodontal disease, gingivitis, chronic tonsillitis, stomatitis of bacterial etiology.

Video about the drug Gramicidin C

Instructions for the use of tablets Gramicidin C: