Onglyza. Instructions for use, price, analogs

Onglisa is a hypoglycemic a highly effective drug that is often prescribed to patients with type 2 diabetes mellitus in order to improve the condition. Instructions for the use of the medication involves a preliminary diagnostic examination, which allows you to determine the appropriateness of the appointment and possible complications during admission.

Release form

The medication is available in the form of tablets intended for oral administration. They have a round biconvex shape, and the film shell can be pink or yellow, depending on the dosage of the active substance in the composition.

The tablets are placed in small plates of 10, made of plastic. In a small cardboard package there can be 3 plates, a description indicating the nuances of using a tablet medication.

Composition of the preparation

The tablets contain the main ingredient and additional substances. Saxagliptin acts as an active component in the composition, which has a pronounced therapeutic effect on the body with regular use.

As excipients, the drug contains several ingredients:

• Croscarmellose sodium.
• Magnesium stearate.
• Lactose monohydrate.
• Talc.
• Dyes.

Additional substances have no therapeutic properties. 1 tablet contains 2.5 or 5 mg of the active substance, which allows you to choose the appropriate dosage, if necessary.

Pharmacological properties

Ongliza (instructions for the use of the drug allows you to study its features before taking it) has hypoglycemic properties, that is, it reduces blood glucose levels with a sharp increase in patients with diabetes mellitus.

The mechanism of action of the drug is based on the ability to block the activity of enzymes responsible for increasing blood glucose levels when eating food. The tool stimulates the production of insulin and some other components, which has a beneficial effect on the patient's condition, significantly reduces the likelihood of the progression of pathologies.

In combination with other medications, the drug can reduce the number of complications, improve the quality of life of patients.

Pharmacodynamics and pharmacokinetics

The drug begins to act rather quickly after taking it inside in the dosage prescribed by the doctor. The active substance stimulates the production of certain enzymes, but blocks substances that provoke a critical increase in blood glucose levels. In patients with diabetes mellitus, abrupt changes in glucose levels only exacerbate the symptoms of the disease.

The drug has a pronounced effect on the body:

• Improves the work of the endocrine system, the functioning of which is disrupted in severe diabetes mellitus.
• Helps to increase the level of insulin required for the normal processing of food components.
• Prevents the development of hypoglycemic and hyperglycemic states. Such complications occur frequently and can threaten the patient's life.
• Prevents the development of complications from blood vessels, internal organs. Frequent fluctuations in glucose levels lead to many negative reactions.

The drug has a positive effect on the body of patients who suffer from type 2 diabetes mellitus. When diagnosing type 1 of the disease, the medication does not help improve the condition.

After taking the tablet inside, the dissolution of the film shell occurs in the patient's intestines. The ingredients are absorbed through the walls of the organ into the bloodstream and have a therapeutic effect that lasts up to 24 hours, which allows you to take the product only once a day and maintain the work of the pancreas glands. The substance binds well to plasma proteins, which provides high efficiency.

The accumulation of the component in the body does not occur, and after stopping its intake, a repeated critical increase in the level of glucose in the blood is possible. After providing a therapeutic effect, the main substance is evacuated from the body with the help of the kidneys. A small amount of metabolites is excreted in the bile.

The withdrawal period takes no more than 2 days, but the pharmacokinetic features may differ in different patients. Sometimes the withdrawal period is extended, often it takes longer. If the patient has deviations from the digestive and urinary systems, the evacuation of the ingredients is slowed down.

Indications for use

Onglisa is prescribed to patients when diagnosed with type 2 diabetes mellitus. The instructions for use allow taking the medicine only after carrying out a diagnostic examination to determine the glucose level and the presence of concomitant abnormalities other organs.

The medicine is intended for the monotherapy of type 2 diabetes mellitus. Usually this method is used in case of a mild form of the disease. The drug is often included in the complex treatment of the disease, when the patient has concomitant disorders, and the general condition is worsened as a result of the progression of the disease.

In other diseases, the drug is not used, which is due to its specific effect on the patient's body.

Contraindications

The medication has contraindications for use, which should be considered before prescribing.

Major barriers to therapy:

• Identification in the patient of intolerance to the components of the composition or a tendency to such disorders in the anamnesis.
• A severe course of diabetes mellitus, requiring the appointment of injectable insulin preparations.
• Identification of type 1 diabetes mellitus. The pill does not help to improve the patient's condition in this case.
• The appearance of signs of lactase deficiency.
• Galactose intolerance.
• Internal bleeding of varying severity. In the acute stage, other medications are prescribed to the patient, since the absorption of drugs in the digestive tract is impaired.
• Diagnosing hyperglycemic coma. The patient in this case is usually unconscious, and the use of drugs for oral administration does not bring a quick result, like parenteral administration.
• Lactation and pregnancy period. Patients of reproductive age rarely have type 2 diabetes, but if diagnosed, safer medications are prescribed.

With extreme caution, the drug is used in the treatment of patients suffering from acute and severe kidney pathologies. The identification of a deficiency in the work of the paired organ is considered a reason for the careful use of the medication and frequent visits to the doctor in order to control the condition.

At what age can the drug be used?

Onglisa (instructions for the use of tablets should be studied by the patient before starting treatment) is prescribed only to patients over 18 years of age. This is because type 2 diabetes does not develop in children and adolescents. In most cases, pathology occurs in middle-aged and elderly patients.

Instructions for use, dosage

Depending on the purpose of use and the condition of the patient, the dosage of the agent may differ, as well as the duration of therapeutic use.

Treatment type	Drug dosage
Monotherapy for type 2 diabetes	If the medicine is used as the only method of treating diabetes mellitus, take 1 pill every day at the same time. The dosage of 1 tablet is 5 mg. Such a dose is considered effective for most patients, and its change is possible according to individual indications.
In combination with other medicines	If it is necessary to combine the drug with other medicines, the daily dosage is also 5 mg. The time of taking the medicine is determined by the doctor individually. You should not use several drugs at the same time, it is better to take breaks, the duration of which is determined during a consultation with an endocrinologist.
Therapy for patients with kidney pathologies	With a mild form of kidney pathologies, the dosage for the patient does not change and is 5 mg. If the patient is diagnosed with severe renal failure, it is possible to reduce the daily dose of the drug to 2.5 mg. Reception is carried out at approximately the same time every day.

On an individual basis, the treatment regimen may change, but the drug is always taken once a day, preferably at the same time every day, which will maintain the therapeutic effect. The duration of taking the medication in most cases is long, that is, patients use pills for many months. Sometimes the remedy is used in courses of 3-6 weeks, after which another medication is prescribed due to the low effectiveness of the first one.

Taking pills on an ongoing basis requires regular visits to a specialized specialist who determines the effectiveness of therapy and prescribes a study to determine glucose levels.

Side effects

Onglisa (instructions for use describe possible contraindications) often provoke negative reactions, even if all the doctor's recommendations are followed.

The most common disorders occur:

• From the side of the respiratory system, disorders occur quite often. Patients talk about rhinitis, signs of sinusitis, and some other abnormalities. The increased production of mucus and its release from the nasal passages worsens the condition. The lack of normal nasal breathing provokes disorders on the part of the patient's nervous system.
• The digestive system suffers during therapy in patients who have chronic pathologies of the digestive system. Patients talk about severe nausea, heartburn, pain in the stomach, poor appetite. Often, taking pills provokes an aggravation of the symptoms of the disease, which leads to a worsening of the condition. Flatulence and bloating are not so common, some people note upset stools.
• The cardiovascular system does not suffer so often during therapy. Only sometimes patients have arrhythmia and tachycardia, especially if they have a history of chronic heart disease.
• Nervous system disorders are considered the most common. They manifest as dizziness and headache, sleep disturbances and increased irritability. After stopping treatment, symptoms may disappear on their own.
• Allergic disorders appear as classic symptoms. A rash appears on the body, areas of peeling and irritation, and severe itching is observed. Symptoms can spread to the mucous membranes of the mouth, nasal passages, eyes, which leads to lacrimation, itching and other unpleasant reactions.

Atypical complications include urinary tract infections, the course of which can be aggravated by the use of the medication. Respiratory tract infections can also develop as a result of the use of tablets over an extended period of time. If negative reactions appear, it is worth refusing to use the medication and visiting a doctor who will determine the need to use medications to improve the condition.

Overdose

The drug can provoke an overdose, despite the lack of a cumulative effect. Such cases have not been recorded by specialists, but they cannot exclude the likelihood of developing such a complication. When taking the drug in an increased dosage for a long period of time, negative reactions appear from the side of internal organs and systems.

Patients report repeated vomiting during the day, pain in the stomach, and upset stools. For several hours, the general condition worsens if the patient continues to take the drug. It is possible to aggravate allergic manifestations, which, in case of an overdose, turn into Quincke's edema or acute urticaria.

A severe course of allergy threatens not only health, but also the patient's life. If such symptoms appear, the patient should immediately stop taking the pills and consult a doctor. Help can be provided in a hospital if the doctor considers it necessary. Signs of overdose do not go away on their own, so do not self-medicate and ignore them.

special instructions

Ongliza (instructions for the use of the medication describe not only the features of the reception, but also possible complications) is prescribed for specific indications. Prophylactic pills are not allowed. Self-administration of the medication is also prohibited.

Changing the duration of the course and the dosage prescribed by the doctor is not allowed. This can provoke complications, including death, in the absence of timely assistance.

After taking the medication, many patients note the appearance of short-term dizziness. The symptom is not considered a reason to discontinue use if concomitant disorders do not appear. But drivers and patients performing manipulations that require increased concentration of attention should take this into account when using the medication.

Drug interactions

The drug is combined with caution with other medicines with hypoglycemic properties. This is not always necessary, but in the case of an appointment, it is worth following all the doctor's recommendations.

The use in combination with barbiturates and glucocorticosteroids can slightly reduce the concentration of the main substance in the blood, which weakens the therapeutic effect. If you need to prescribe such drugs, you should regularly visit a doctor.

If you need to use any medication, you must first consult with a doctor, who determines the appropriateness of using the medication.

Analogs

Sometimes a drug cannot be prescribed to a patient for various reasons. Then the doctor selects substitutes with similar properties.

Effective counterparts of the remedy:

• Trajenta in tablet form contains the substance linagliptin and has hypoglycemic properties. A medication is prescribed when diagnosing type 2 diabetes mellitus, both as monotherapy and in combination with other drugs. Despite the presence of another active substance in the composition, the mechanism of action of the analogue does not differ from the original.
• Januvia - a tablet medication with hypoglycemic properties, which acts due to the presence of sitagliptin in the composition. The effect of the component on the body does not differ from the action of the original, the medication is considered effective, it is used mainly in type 2 diabetes mellitus.

The dosage and duration of drug use is determined individually for the patient. The drugs are often used on an ongoing basis.

Terms, conditions of sale and storage

The medication is dispensed in different pharmacies after presenting a prescription form from a doctor. The maximum storage time is 3 years.

After the expiration of this period, use is not allowed, and information about the manufacture is on the package. During storage, avoid direct sunlight on the tablets for a long period.

Price

The price of the drug is quite high, fluctuating between 1700-1900 rubles. per packing. It may differ from pharmacy to pharmacy.

Onglisa is an effective hypoglycemic agent for patients with type 2 diabetes, which is often prescribed to correct and maintain glucose levels at the desired level. Instructions for the use of the medication assumes taking only according to indications and after a preliminary examination.

Video about the drug Onglisa

Onglisa for the treatment of diabetes mellitus: