Corvalation analogs in Russia in terms of composition. Price

Corvalment is a drug that belongs to the pharmacological group of sedatives and vasodilators that have a calming effect on the centers of the brain. This medication is produced by the Kiev Vitamin Plant in the form of spherical gelatin capsules. Inside the drug contains a yellowish oily liquid with a characteristic smell of menthol.

During the interaction of the active substance of Corvalment with the receptors of the oral cavity, the process of local irritation of the mucous membrane is triggered. This medication is indicated for symptomatic use in the treatment of neuroses, increased irritability, and angina attacks. Drugs with similar properties are sold in Russia.

Domestic analogues of Corvalment

In Russia, there is a wide selection of medicines that are analogues of the drug Corvalation. These are medicines of domestic and foreign production with an identical composition of active substances.

Validol

Validol is a domestic analogue of Corvalment, which is produced on the territory of the Russian Federation by the pharmaceutical company Marbiopharm.

These medicines have the following similarities in pharmacological characteristics:

• both drugs are available in the form of gelatinous capsules with a spherical shape and a yellowish tint;
• Validol and Corvalment have the same reflex action in terms of expanding the lumen of blood vessels;
• the active components of these drugs act as coronary dilators with a pronounced sedative effect and effect on the central nervous system;
• due to the vasodilating properties of Validol and Corvalment, they cause a decrease in blood pressure indicators, which is especially strongly felt by patients prone to hypotension;
• in the process of reflex expansion of blood vessels, the active component of these drugs causes irritation of the receptors of the mucous membrane of nerve endings that interact with muscle tissue of cardio-vascular system;
• Validol and Corvalment have the same level of pharmacological activity in terms of regulation of capillary permeability processes;
• these medicines are applied sublingually by resorption of the capsule inside the oral cavity until complete dissolution of its mucous membrane with further absorption of the active ingredient into the mucous membrane shell;
• both drugs are actively involved in the synthesis and release of endorphins and other hormonal substances of the peptide group;
• the active ingredient of Validol and Corvalment provides the onset of the therapeutic effect within 5 minutes. after sublingual administration of 1 tablet of these drugs;
• these medicines act on peripheral nerve endings, which are responsible for the body's susceptibility to pain;
• the release of the active substance from the capsule shell of the Validol and Corvalment preparations occurs within 3 minutes;
• the mechanism of distribution of the main component of these medicines throughout the patient's body is carried out by penetration into the mucous membrane and tissues of the oral cavity with further saturation of the bloodstream and metabolic decay in the liver;
• the excretion of the active substance of Validol and Corvalment is performed by the kidneys along with urine (the final product of the biochemical breakdown of vasodilators is glucuronide).

The distinctive features of the medicines Validol and Corvalment include their following characteristics:

• inside the Corvalment gelatin capsule there is a menthol solution in the composition of isovaleric acid menthyl ester with a concentration of 25%, and in Validol a solution of liquid levomenthol in menthyl isovalerate (in fact, this is the same active substance, which has slight differences in molecular structures);
• Corvalment capsules contain no sugar and any other carbohydrate-based components from which glucose can be converted, and the drug Validol contains dextrose (in this case Corvalment is approved for admission to diabetics, and Validol affects the blood sugar level patient);
• packaging of the drug Corvalment is carried out only in polymer blisters, and Validol capsules are also packed in plastic jars;
• Corvalment is contraindicated in patients with signs of coronary syndrome, and Validol does not have such restrictions on use.

Corvalment, analogues (in Russia this product is presented under other trade names) which are sold without a prescription, characterized by rapid elimination of blood vessel spasm, improvement of general circulation and reduction of pain sensitivity.

Preduct

Preductal is a drug, the therapeutic properties of which are similar to those of Corvalment. Despite this, these medicines contain different active substances.

Preparations Preductal and Corvalment have the following similarities:

• both drugs improve the functional state of the cardiovascular system;
• Preductal and Corvalment are indicated for use for the prevention of mild angina attacks;
• by increasing blood circulation in the coronary vessels, these medicines increase the efficiency of the heart muscle, prevent the development of ischemic disease;
• these drugs are equally contraindicated for use in patients under the age of 18;
• Preductal and Corvalment can be used as a monotherapeutic agent and as part of a complex treatment of cardiovascular diseases;
• both medications have a similar effect on the central nervous system, slowing down the speed of a person's psychomotor reactions, reducing the level of his attention.

  

Medicines Preductal and Corvalment have not only similarities in therapeutic action, but also a number of the following differences:

• the active substance of the drug Preductal is a synthetic substance of trimetazidine dihydrochloride at a concentration of 20 mg per 1 tablet;
• Corvalment is produced in the form of transparent gelatin capsules intended for sublingual administration, and Preductal - these are tablets covered with a layer of a protective film (the last medication is taken orally to dissolve in the cavity Gastrointestinal tract);
• the main therapeutic focus of Preductal is aimed not only at expanding blood vessels, improving blood circulation in the coronary vessels, but also the improvement of metabolic processes in myocardial tissues (Corvalment with these does not possess properties);
• Preductal tablets prevent the development of energy starvation of the cells of the cardiovascular system, maintaining they have a stable number of ATP molecules, and Corvalment capsules are not able to have a similar effect on the body human;
• the drug Preductal can be used only for the prevention of angina pectoris, but is not used for the purpose of its course treatment (in this case, Corvalment is considered more effective, since it allows you to stop the already happened cardiac attack);
• the active substance of the drug Preductal slows down the physiological processes of fatty acid oxidation in the intracellular space, and in the pharmacodynamics of the drug Corvalment similar properties absent;
• the drug Preductal is categorically contraindicated for use in relation to women who are in a state of pregnancy, and Corvalment can be used to treat patients with this categories;
• during the treatment of patients over the age of 75 years, the drug Preductal is used with caution, and in the case of using Corvalment capsules, there are no such warnings.

By analyzing the pharmacological similarities and differences of the above drugs, you can come to the conclusion that Preductal is more suitable for the prevention of angina pectoris and coronary heart disease muscles. If there is a need to stop an attack that has already arisen, then in this case it is better to use Corvalment.

Corvalment, analogs (in Russia, most vasodilators are dispensed with a prescription) of which are accepted therapeutic courses, shows a positive therapeutic effect in the first minutes after its resorption in the oral cavity. Trimetazidine is a Russian-made drug.

This medication is produced by the pharmaceutical company Kanonpharma Production CJSC. Corvalment and Trimetazidine have the following pharmacological similarities:

• both have a positive effect on the function of the heart muscle and blood vessels;
• Trimetazidine and Corvalment are used to prevent attacks of mild angina pectoris;
• these medicines improve blood circulation in the coronary vessels, which automatically minimizes the risk of coronary artery disease;
• Trimetazidine and Corvalment are equally contraindicated for use in patients under the age of 18;
• both drugs can be used as a monotherapeutic agent, and are also included in the complex treatment of cardiovascular diseases;
• Trimetazidine and Corvalment have an identical effect on the centers of the brain in terms of slowing down the speed of psychomotor reactions and reducing attention.

Despite the fact that these drugs have a similar effect on the human cardiovascular system, their pharmacokinetics and pharmacodynamics have a number of significant differences.

They are as follows:

• the therapeutic properties of Trimetazidine are best manifested during maintenance and prophylactic therapy of pathological changes in myocardial tissues;
• the active component of the drug Trimetazidine is a chemical substance of a synthetic nature of origin - trimetazidine dihydrochloride at a dosage of 20 mg per 1 tablet;
• the drug Trimetazidine is intended for oral administration, and the active substance of the drug is absorbed into the intestinal walls (Corvalment is taken sublingually);
• Trimetazidine is not used for symptomatic relief of an attack of angina pectoris, but only for prevention this disease of the heart and blood vessels, Corvalment can be used for the timely prevention of the disease, as well as its treatment;
• the drug Trimetazidine has a pronounced antihypoxic effect on the muscle tissue of the heart and neurons of the head the brain, and the active substance of Corvalment is only able to expand the lumen of the walls of blood vessels, improving microcirculation blood.

The drug Trimetazidine is contraindicated for use in patients with severe renal impairment. Corvalment capsules do not have these restrictions, and the metabolism of their active substance does not create a critical load on this organ.

Cordinic

Cordinic is a peripheral vasodilator that activates potassium channels dependent on the functional state of ATP molecules.

This medication has the following pharmacological similarities with Corvalment:

• both drugs have a relaxing effect on the smooth muscles of the cardiovascular system;
• Kordinik and Corvalment dilate the walls of blood vessels, increasing the total blood flow;
• the active substances of these medicines improve the oxygenation of the coronary arteries;
• Cordinic and Corvalment have no effect on glucose metabolism, which makes these drugs safe for diabetics;
• both medicines are intended for the symptomatic treatment of angina attacks without signs of complications;
• drugs Kordinik and Corvalment are relatively safe for elderly patients, as well as patients suffering from renal and hepatic insufficiency.

Pharmacological differences between the medicines Kordinik and Corvalment are in their following characteristics:

• the medication Kordinik is produced in the form of yellowish tablets, coated with a layer of an enteric coating;
• the active substance of the drug Kordinik is the chemical compound nicorandil in a dosage of 10 and 20 mg;
• the drug Corvalment is intended for sublingual administration by absorption in the oral cavity, and Kordinik tablets must be taken with water;
• the active ingredient of the drug Cordinic has the therapeutic property of opening potassium channels that interact with intracellular ATP molecules, and Corvalment does not have a similar action;
• the maximum concentration of the active substance of the Kordinik tablets is reached after 30-60 minutes. after taking a standard therapeutic dose, and Corvalment begins to act in the first 5 minutes. after resorption of 1 capsule;
• Corvalment can be used to treat women in a state of pregnancy, and Kordinik is categorically contraindicated for admission to patients of this category;
• course or symptomatic therapy with Cordinic tablets can cause severe side effects in the form of rectal opening bleeding, ulcerative lesions of the gastrointestinal mucosa, the development of angioedema, and Corvalment's intake is more safe.

Corvalment, analogs (in Russia, most drugs with identical therapeutic properties are intended for oral administration, which slows down the period of their absorption) which expands blood vessels and improves the functions of the heart muscle, has a key pharmacological advantage. This is the minimum number of side effects and the provision of rapid therapeutic efficacy when it is necessary to relieve an attack of angina pectoris within 3-5 minutes.

Antisten MV

Antisten MV is a drug produced by the Russian pharmaceutical company Ozone LLC. This medication is characterized by a prolonged action.

Antisten MV and Corvalment have the following similarities:

• both medicines help to improve blood circulation in the coronary arteries;
• therapy with Antisten MV and Corvalment tablets reduces the incidence of angina attacks in people who periodically experience symptoms of this disease;
• these drugs improve the functions of the cardiovascular system;
• active substances Antistena MB and Corvalment have a therapeutic effect on the centers of the brain and cardiomyocytes;
• both drugs have the property of reducing the speed of psychomotor reactions, impairing attentiveness, can cause distraction of thoughts (a similar effect of Antisten MV and Corvalment tablets is manifested in the first 30 min. - 2 hours after a single dose of a therapeutic dose).

  

The antihypoxic agent Antisten MV and Corvalment have the following differences, which lie in their pharmacodynamic and pharmacokinetic properties:

• the active substance of the drug Antisten MV is a synthetic compound of trimetazidine dihydrochloride at a concentration of 35 mg per 1 tablet;
• taking the course of the drug Antisten MV allows you to achieve a cytoprotective effect in terms of protecting the cells of the heart muscle from the negative effects of external and internal factors;
• Antisten MV tablets increase the energy potential of the intracellular space, maintaining ATP molecules at a consistently high level;
• in patients with signs of acidosis, Antisten MV normalizes the work of ion channels, which prevents the pathological accumulation of calcium and sodium compounds in the composition of cardiomyocytes;
• Antisten MV eliminates the symptoms of ischemic disease, which are expressed in attacks of dizziness, tinnitus;
• Corvalment drug can be used not only for the prevention of angina pectoris, but also for therapeutic purposes, and Antisten MV is used only to prevent this disease;
• the drug Corvalment is taken sublingually by resorption of the capsule in the oral cavity, and Antisten MV tablets must be taken with a sufficient amount of water so that they dissolve in the digestive tract.

The active substance of the drug Corvalment does not create a critical load on the patient's body elderly, and Antisten MV is indicated for use with extreme caution in patients older 65 years old.

Corvalment, analogs (in Russia, drugs are produced with exactly the same therapeutic effect, but with a different chemical composition) which have a tablet form of release, is taken in short courses of 5-7 days. This period of time is enough to completely stop the attacks of angina pectoris, as well as minimize the risk of recurrence of this disease.

Prices

The average cost of the drug Corvalment is 1,490 rubles. for 80 tab. The table below lists the main drugs analogs of this medication, as well as their prices.

Drug name	Pharmacy price range
Validol	from 31 to 35 rubles for 20 tab. with a dosage of 100 mg
Preduct	from 718 to 825 rubles. for 30 tab. 80 mg
Trimetazidine	from 93 to 127 rubles. for 60 tab. with an active substance concentration of 20 mg
Cordinic	from 325 to 467 rubles. for 60 tab. with a dosage of 10 mg
Antisten	from 250 to 368 rubles. for 60 tab. with a share of the main component 35 mg

Corvalment is a coronary dilating drug, which is distinguished by a reflex mechanism of therapeutic action. This medication has vasodilating and sedative properties. Sublingual administration of the drug ensures the achievement of a rapid therapeutic effect with the ingestion of the active substance of the drug into the general blood flow.

Corvalment is taken with extreme caution by patients who drive vehicles and perform work with increased danger. This medication, as well as its Russian counterparts, can cause slight dizziness, a decrease in blood pressure and increased drowsiness.

Video about analogues of Corvalment

Instructions on how to take Validol: