Ivabradine 5-7.5 mg. Price, instructions for use, reviews

Ivabradine - medication for the treatment of pathologies of the cardiovascular system, prescribed to patients in order to alleviate the condition and relieve acute symptoms. The dosage of the drug can be 5 or 7.5 mg, which allows you to choose the optimal dose for the patient. The price of the product differs depending on the manufacturer and the region of its distribution.

Release form

The drug is produced in tablet form, which allows you to use it at home if necessary. The tablets are small, depending on the manufacturer, their color and shape may vary.

The tablets are packaged in small plates of 10 or 14 pieces. In a cardboard box you can find one or more plates, as well as a description indicating the nuances of use, possible complications during treatment.

Chemical composition

The medicine contains the substance ivabradine, which has the main therapeutic effect on the body.

The tablet formulation includes auxiliary ingredients:

• Starch.
• Talc.
• Magnesium stearate.
• Iron oxide.
• Titanium dioxide.
• Hypromellose.

These ingredients have no medicinal properties. The dosage of the active substance per 1 tablet is 5 or 7.5 mg.

Pharmacological properties

Ivabradine 5 mg (the price of the drug depends on the manufacturer) and the medicine in a different dosage has anti-ischemic properties, which makes it an important element in the treatment of chronic heart pathologies forms.

The antianginal effect of the drug is noted, which has a beneficial effect on the condition of patients suffering from acute and chronic angina pectoris. The drug has a positive effect on the state of the vascular wall, prevents the development of complications against the background of the rapid progression of the disease.

Pharmacodynamics and pharmacokinetics

After the drug enters the body, the film membrane dissolves, the ingredients enter the bloodstream, spread through large and small vessels. Ivabradine blocks the work of certain channels that affect the heart rate and other processes. As a result, it is possible to prevent the development of tachycardia, an attack of angina pectoris.

There is no effect on atrial and ventricular contractility, heart rate.

The drug is considered quite effective and has other properties:

• It does not affect the patient's blood pressure, which makes it possible to use it in the treatment of angina pectoris and arrhythmias in patients with hypotension and hypertension.
• Reduces the frequency of angina attacks in patients with a chronic course of the disease. When using the drug, the likelihood of developing myocardial infarction and other complications decreases.
• The drug reduces the amount of oxygen required for the normal functioning of the myocardium, but the decrease in heart rate is insignificant. The risk of developing bradycardia is minimal, even with prolonged use.
• During treatment, patients may develop photopsia, that is, the retina's sensitivity to bright light increases.
• The medication does not affect peripheral vascular resistance, metabolism of fats and carbohydrates in tissues.

After the drug penetrates inside, it is rapidly absorbed in the digestive tract. Binding to plasma proteins occurs by 70%, and the maximum concentration of components in the blood is reached 1 hour after taking a single therapeutic dosage. This period can be extended if the tablets are consumed at the same time as food.

The processing of the ingredients of the composition takes place in the liver. The duration of the elimination period can be 12 hours, but individually varies depending on the patient's body. The evacuation of ingredients is carried out mainly with the help of the kidneys, a small amount is excreted with the help of the intestines.

Violation of the functioning of organs leads to a slowdown in the cleansing of the body from metabolites. Despite this, the healing effect is not weakened. Experts draw the attention of patients to the dose-dependent effect of the drug, as well as the insignificant accumulation of the ingredient of the composition in the body. After stopping taking the pills, the effect persists for several more days.

Indications for use

Ivabradine is prescribed to patients for various disorders, since its price is affordable, and the presence of a dosage of 5 and 7.5 mg allows it to be used for patients with varying degrees of disease.

The main indications for the use of the drug:

• Diagnosing angina pectoris in patients with unchanged sinus rhythm. Sometimes such patients develop an allergy to beta-blockers, but the doctor can replace them with a similar medicine.
• A chronic form of heart failure, in which mild bradycardia is observed. Many medications for such a violation are contraindicated, since they affect the heart rate, can reduce it excessively, which provokes complications.
• Some forms of coronary heart disease, when the patient is additionally diagnosed with hypertension.
• Mild atrial fibrillation.
• Atrial fibrillation and tachycardia. The drug is included in the course of the main treatment to prevent complications.

The medicine can be used simultaneously with other systemic medicines, which increases the effectiveness of therapy.

Contraindications

Do not prescribe a remedy in case of diagnosing an allergy to any of its components, both main and auxiliary.

Other obstacles include the following conditions:

• Acute stage of myocardial infarction. Sometimes the drug is used after elimination of acute manifestations of the disease, if there are appropriate indications.
• Severe bradycardia and hypotension. Despite the lack of influence of the ingredient of the composition on the indicators of heart rate and blood pressure, the use may aggravate the manifestations somewhat.
• Severe liver failure. The medicine can disrupt the functioning of the organ, and its processing is difficult in the presence of such diseases.
• Identification of sick sinus syndrome in patients.
• Cardiogenic shock of varying severity. Pills can only worsen the patient's condition.
• Sinoatrial block in middle-aged and elderly patients.
• The period of gestation and breastfeeding. Studies on the effect of the ingredients of the composition on the body of a woman and a child have not been conducted.
• An unstable form of angina pectoris. The drug is often used for angina pectoris, but in the case of an unstable form, it can provoke complications.
• The presence of artificial stimulants in the patient's heart.
• Severe atrioventricular block.
• A neglected form of heart failure. With such a violation, patients often experience persistent hypotension and bradycardia, which is considered the reason for refusing to use the pills.

The medicine is used with caution for patients who suffer from chronic kidney disease. In each case, there may be individual contraindications, determined during the diagnostic examination.

At what age can the drug be used?

Ivabradine 5 mg (the price of the drug depends on the amount in the package) and the drug with a higher dosage of the main ingredient is prescribed to patients over 18 years of age.

There is no data on the safety of treatment for children and adolescents, therefore, if necessary, other medicines are selected for them.

Instructions for use, dosage of Ivabradine

The medicine can be taken according to the general and individual scheme, depending on the disease and the severity of its symptoms. The standard method involves the appointment of 10 mg of the drug in the initial stages of therapy.

The patient should take 5 mg of the drug in the morning and in the evening, drinking the tablets with sufficient water to accelerate the dissolution of the film shell. The duration of therapy can reach 3-6 weeks, it is determined taking into account the manifestations of the disease.

On an individual basis, it is possible to change the dose and duration of the course, since the body of each patient reacts differently to the main ingredient of the tablets.

With tachycardia

Since the drug does not significantly affect the heart rate and only slightly reduces it, its use as an independent method of therapy is not so efficiently.

But pills are often included in the course of the main treatment to increase its effectiveness. The initial dosage for such a violation does not exceed 10 mg per day, but if necessary and there is no effect, it can be increased by a specialist.

Depending on the disease that provokes tachycardia, the duration of the course application ranges from 3-8 weeks.

With atrial fibrillation

Atrial fibrillation is most often a symptom of another heart disease, so the medication is included in the course of the main treatment. The daily dosage for mild pathology is 10 mg. It must be divided by 2 times and taken during the day at regular intervals.

Lack of effect is not always considered a reason to refuse therapy. It may be necessary to increase the daily allowance to 15 mg with its obligatory division into 2 doses during the day. The duration of the therapeutic course is 2-4 weeks.

With atrial fibrillation

The medicine for such a violation is used in combination with other medicines to increase the effectiveness of therapy. Usually, the drug is used according to the standard scheme, that is, they take 10 mg per day.

If this is not enough, the maximum daily allowance for such patients does not exceed 15 mg. It is not recommended to use such a dose once, it is better to divide it into 2-3 times and take it during the day at regular intervals. Treatment lasts an average of 3 weeks.

With angina

Angina pectoris in patients can occur with various complications that aggravate the course. The prescription of the medicine is done after the examination. It is used alone or in combination with other medicines.

The initial dose may be 7.5 mg 2 times a day. If improvement is observed within 2 weeks, the dose is reduced to 10 mg per day. The total duration of use of the tablets is 6 weeks.

With ischemic heart disease

Ivabradine 7.5 mg (the price of tablets is not always affordable for patients) is prescribed to patients with severe coronary heart disease and the development of complications in patients against the background of this disorder.

The patient takes the drug in this dose 2 times per day. If complications appear during the period of therapy, it is possible to continue taking the medication at a lower dosage. Sometimes doctors only prescribe 5 mg per day. After the disappearance of negative reactions, the daily rate may increase.

Side effects

During treatment, patients often experience complications, even if taken in the minimum dose and all recommendations are followed. Violations affect the work of the heart of other organs.

Damage area	Frequent negative reactions
Nervous system	Headache and dizziness often appear in patients during treatment. Especially often, such symptoms occur in patients who have a tendency to hypotension and bradycardia. After refusal to use the drug, the manifestations disappear, but they can persist for some time, which leads to sleep disturbances, irritability and anxiety.
Heart and blood vessels	In patients with prolonged use, it is possible to reduce the heart rate, the appearance of pain in the region of the heart, and the development of atrioventricular blockade. Refusal of treatment does not always help to eliminate manifestations, therefore, patients are prescribed medications to normalize the condition. Only sometimes the use provokes a change in blood pressure indicators in one direction or another, which leads to a deterioration in the work of the entire cardiovascular system.
Digestive tract	With pill therapy, disorders of the digestive system occur frequently, especially if there is a history of chronic pathologies. Patients often report nausea, which leads to poor appetite. As a result, the patient becomes weak, thirst increases, heartburn and upset stools are possible. If the patient continues to use pills, the symptoms are aggravated, which aggravates the general condition of the patient, and can lead to other disorders.
Musculoskeletal system	Pain in muscles and joints occurs in patients with the use of tablets for a long period of time. Sometimes patients have seizures, especially if there are concomitant neurological abnormalities.
Blood system	The drug often leads to a change in the number of the most important blood cells. When it is taken, the production of leukocytes, erythrocytes is disrupted, which can provoke other complications from the blood system.

Allergy during treatment often develops, even if all the rules of treatment are followed. It manifests itself with classic signs in the form of rash and itching of the skin, irritation and peeling. Sometimes there is swelling of the mucous membranes of the mouth, nasal passages and eyes. If complications arise, experts recommend that patients visit a hospital.

Overdose

Ivabradine 7.5 mg (the price of the product is lower when purchasing a small package of tablets), like the medicine in a lower dosage, with prolonged use, it can provoke disorders in the form overdose.

In this case, all negative reactions are aggravated, but severe bradycardia is considered the most frequent manifestation. The patient speaks of severe weakness and headache, impaired coordination of movements. The physical and mental performance of the patient is reduced, and fainting is often observed.

In severe cases, patients are prescribed beta-adrenostimulants, treatment is carried out in a hospital.

Basic instructions

The appearance of negative reactions is not always a reason to refuse treatment. Sometimes patients are simply reduced in dosage and monitored for several days. When the manifestations worsen, therapy can be canceled, and remedies can be prescribed to eliminate the manifestations.

It is strongly not recommended to exceed the daily dosage or prolong the course on your own.

Drug interactions

The drug is not prescribed simultaneously with drugs that contain the same active ingredient. This can provoke complications. With caution, the agent is used in combination with thiazide and loop diuretics.

Some antibiotics can lead to a decrease in the effectiveness of the drug or an increase in its concentration in the blood, therefore it is important to visit a doctor beforehand if it is necessary to combine them. The combination of drugs is always determined by a specialist in each case individually.

Analogs

If it is impossible to prescribe a medication, an analogue with similar properties is selected.

Often the following substitutes are selected for patients:

• Vasonat has an anti-ischemic effect due to the content of meldonium. Possesses pronounced properties and is available in the form of capsules for oral administration and solution for parenteral administration.
• Koraksan is available in tablet form and contains ivabradine as its main ingredient. The tool can be used if it is impossible to assign the original due to the intolerance of the auxiliary components of its composition.

Substitutes with a different composition can only be prescribed by a doctor.

Terms, conditions of sale and storage

The drug does not require special storage conditions. The maximum shelf life is 3 years. The medicine can be purchased with a prescription from a specialist.

Price

The cost of packaging the medicine ranges from 500-1200 rubles. depending on the number of tablets.

Ivabradine at a dosage of 5 or 7.5 mg is often prescribed to patients when diagnosing pathologies of the cardiovascular system. The cost of the product can be high, but the effectiveness fully justifies it. The prescription of the medicine is done only by the doctor.

Video about Ivabradine

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