Naphazoline nasal drops. Instruction, price, reviews

Congestion and impaired nasal breathing occur with swelling of the mucous membrane against the background of infection or allergic reactions. In the presence of these symptoms, it is advisable to use vasoconstrictor nasal drops. One of these drugs is Naphazoline, a potent topical anticongestant.

Release form

Naphazoline - yellow nose drops, less often transparent, colorless. The drug is produced in dropper bottles of 10 ml, 15 ml and 20 ml. Some manufacturers produce Naphazoline in the form of a nasal spray with identical properties and composition. The only difference is the spray method and dosage distribution.

Chemical composition

The main active ingredient is naphazoline nitrate, a light crystalline powder. The concentration of the active ingredient in the composition of the drops varies from 0.5 mg to 1 mg per 1 ml.

Naphazoline nitrate is poorly soluble in water. Boric acid acts as a solvent in these drops. Also, the drug contains benzalkonium chloride, which acts as a preservative, disodium edetate and purified sodium salt.

Pharmacological properties

Naphazoline - anti-decongestant nasal drops. The active substance causes narrowing of the venous and capillary vessels in the nasal mucous tissues. The medicine has a pronounced anti-edematous and anti-inflammatory effect. When applied, Naphazoline restricts blood flow to mucous tissues, eliminates congestion, and improves breathing through the nose.

Pharmacodynamics and pharmacokinetics

Naphazoline drops, when in contact with the nasal mucosa, have an exciting effect on adrenergic receptors. This leads to a sharp narrowing of blood vessels and a decrease in blood flow. Due to this, local edema is eliminated, airway patency is restored. At the same time, the secretion of inflammatory exudate decreases.

The vasoconstrictor effect develops quickly - within 5-10 minutes from the moment the drug is applied. Local action lasts 3-4 hours.

The drug is able to penetrate through mucous tissues into the general bloodstream. The systemic effect of drops is manifested in the form of an increase in blood pressure. The components of Naphazoline do not penetrate the blood-brain barrier, therefore the agent is considered non-toxic to the central nervous system. Residual decay products are excreted from the body along with urine.

Indications for use

Naphazoline - nasal drops, which are prescribed for symptomatic therapy. The tool is used in otolaryngology, in the treatment of diseases accompanied by inflammation and swelling of the nasal mucosa. The tool is used to restore breathing, reduce the severity of other symptoms of inflammation.

Naphazoline nasal drops are indicated for the following diseases:

• infectious and allergic rhinitis;
• sinusitis;
• sinusitis;
• polyps and cysts of the paranasal sinuses;
• injury or deformation of the nasal septum;
• vasomotor ethmoiditis.

Drops can be prescribed before physical therapy or in preparation for surgery. For prophylactic purposes, the described medicine is not used.

Naphazoline is prescribed exclusively for symptomatic purposes and only as an auxiliary medication.

The active components of the drug do not eliminate the causes of mucosal inflammation. Drops are not intended for long-term use, they can be addictive and side reactions.

Contraindications

Naphazoline is safe for the body, but if used incorrectly, it can be harmful. Before taking it, you need to make sure that there are no absolute and relative contraindications, age restrictions.

Absolute contraindications for admission:

• individual hypersensitivity to components;
• hypertensive heart disease;
• suffered heart attacks, strokes, angina attacks;
• atherosclerosis against the background of strong blood thickening;
• coronary heart disease;
• bronchial asthma;
• diabetes;
• pathology of the thyroid gland with impaired secretion of thyroid hormones.

Naphazoline is not recommended for patients with severe renal or hepatic impairment. Among the relative are contraindications in which the admission is allowed, provided that the expected therapeutic effect will outweigh the potential harm.

These contraindications include:

• pregnancy (up to 12 weeks);
• simultaneous administration with monoamine oxidase inhibitors;
• lactation period;
• severe dryness in the nose;
• tumor neoplasms in the adrenal glands;
• closed glaucoma.

Naphazoline is prescribed with caution to elderly people, especially in the presence of regular bouts of hypertension and tachycardia.

At what age can the drug be used?

Naphazoline - nasal drops, which are rarely used in pediatrics due to the increased sensitivity of the child's body. The medicine is prescribed to patients who are 12 years old.

In childhood, short-term use of drops with a minimum concentration of the active ingredient - 0.5 mg per 1 ml is allowed. In this case, you can use Naphazoline from the age of 6.

Instructions for use, dosage

Naphazoline is intended for short-term use. The dosage will vary according to the age of the patient. If necessary, the attending physician adjusts the regimen. Children from 6 years old are prescribed Naphazoline 0.5%. 1-2 drops are injected into the right and left nasal canal. Reception is repeated 2-3 times a day. Duration of treatment is 3 days. If necessary, taking drops can be repeated 4-5 days after cancellation.

Adults and children over 12 years old are prescribed Naphazoline 1%, 1-3 drops. Reception is repeated 2-4 times a day at regular intervals. The maximum duration of use is 1 week.

How to take Naphazoline:

1. Clear the nasal passages from accumulated mucous secretions.
2. If the bottle is stored in the refrigerator, warm it up in your hands beforehand.
3. Remove the cap from the dispenser, tilt the head and insert the vial tip into the nasal canal.
4. Keep your head up with your chin so that the drops reach the mucous membrane.
5. Wipe the pipette tip and close the bottle.

The nasal drop bottle is intended for one patient only, which is associated with the risk of infection transmission. You cannot use nasal drops if you have heavy nosebleeds.

Side effects

The use of drops of Naphazoline may be accompanied by adverse reactions, the frequency of which depends on the duration of treatment and the individual characteristics of the patient. If the dosages are observed, the likelihood of developing negative reactions is minimized.

Possible side effects include:

• moderate cephalalgia
• an increase in blood pressure;
• heart palpitations;
• muscle weakness;
• dryness of the nasal mucosa;
• local hyperemia;
• itching and burning sensation;
• tearing;
• skin rashes.

In some cases, the use of drops of Naphazoline may be accompanied by dizziness, arrhythmia attacks. Also, isolated cases of the development of severe allergic reactions accompanied by angioedema were recorded.

With prolonged use, Naphazoline is addictive. In this case, the effectiveness of the active component of the drops decreases, since the receptors in the vessels gradually adapt to the action of the drug, and the mucous membrane stops responding to the substance.

If the drops are used for more than 7 days, rhinitis medication is possible. It is accompanied by the death of epithelial cells of the mucous membrane with a simultaneous suppression of local immunity. Because of this, the nasal passages become more sensitive to infections and other pathogenic factors, which can lead to aggravation of the primary disease.

Overdose

Poisoning with Naphazoline is possible with a significant excess of the permissible dosage. Also, cases of intoxication have been recorded in children who accidentally swallowed the contents of the bottle.

Overdose is accompanied by the following symptoms:

• decreased heart rate (less often tachycardia);
• high blood pressure;
• increased sweating;
• pallor of the skin;
• nausea, vomiting;
• dizziness;
• dry throat;
• oppression of consciousness.

In severe cases, an overdose leads to respiratory distress, loss of consciousness, drug-induced coma. If signs of intoxication appear, it is necessary to abandon the further use of drops and seek medical help. In case of overdoses with Naphazoline, symptomatic treatment is carried out taking into account the individual clinical picture.

special instructions

Naphazoline is not used in the treatment of chronic atrophic rhinitis. This is due to the fact that the active ingredient constricts the vessels of the mucous membrane, preventing blood flow. In the atrophic form of the disease, this leads to thinning of the tissues of the mucous membrane and aggravates the pathological process.

The presented drug is not intended for long-term use. However, if a long-term intake is required, it must be carried out intermittently for 3-5 days. This will reduce the risk of side effects and pharmacological tolerance.

The drug is taken with caution when:

• simultaneous administration with drugs that increase blood pressure;
• diseases accompanied by metabolic disorders;
• adherence to therapeutic diets;
• heavy menstrual bleeding;
• the presence of any form of drug allergy;
• irritation and skin diseases in the area of ​​the wings of the nose.

Patients using Naphazoline for a long time should have their blood pressure and heart rate checked regularly. If any adverse reactions from the cardiovascular or nervous system appear, further use must be abandoned.

Naphazoline may cause short-term drowsiness. Therefore, drops are not recommended for patients while working with mechanisms, when driving or performing other actions that require increased concentration of attention.

Drug interactions

Naphazoline is used with caution in combination with other decongestants and hypertensive drugs. Simultaneous reception can lead to a significant deviation of blood pressure from the norm. It is allowed to use Naphazoline with antihistamines and corticosteroid agents for topical application.

When used simultaneously with local anesthetic agents, Naphazoline slows down their absorption. Thus, the anesthetic effect is less pronounced. Drops should not be used prior to surgical procedures that require general or spinal anesthesia.

It is not recommended to use the product at the same time as drinking alcohol. Alcoholic beverages enhance the hypertensive effect of the drug and at the same time increase the toxic load on the liver and organs of the excretory system.

The use of nasal drops in combination with certain groups of antidepressants leads to an increase in the decongestant effect. However, Naphazoline cannot be used concurrently with MAO inhibitors, which are often used as antidepressants.

Analogues of Naphazoline

In otolaryngology, both direct analogs and drugs with identical properties but different composition are used. Naphazoline nitrate in the form of drops is available under various trade names.

Among them:

• Sanorin.
• Naphthyzin.
• Naphazol.
• Nazorin.
• Ivelect.

Drops with identical pharmacological properties can be used as analogues of Naphazoline.

Tradename	Short description
Xylometazoline	Nasal drops used for infectious and allergic rhinitis, sinusitis, ethmoiditis. When in contact with the mucous membrane, it provokes vasoconstriction, eliminating edema. The duration of the effect is about 3-4 hours.
Xymelin	Direct analogue of Xylometazoline. Temporarily relieves swelling of the tissues of the nasal cavity, making breathing easier. It is used no longer than 10 days due to possible side effects. Allowed for children from 2 years old. It can be used with caution by women during pregnancy, lactation.
Nazivin	The active ingredient is oxymetazoline. The drug narrows blood vessels at the site of application, eliminates edema and inflammation. Full breathing is restored in 10-15 minutes from the moment of application. The effect lasts about 8 hours.
Nazol	Available in the form of drops, nasal spray. The drug is characterized by a vasoconstrictor effect, suppresses local edema. When applied intranasally, it restores nasal breathing. It is prescribed for colds and viral diseases of the respiratory tract. It is not used in the treatment of allergic diseases.
Lazolvan Reno	Spray used in the treatment of acute rhinitis, sinusitis. The main active ingredient is tramazolin. The drug relieves swelling of the mucous membrane, eliminating congestion. The effect after administration lasts for 8-10 hours.

Before taking analogs, you must read the instructions and make sure there are no contraindications. It is advisable to use drops for nasal congestion only as directed by an otolaryngologist or other attending physician.

Terms, conditions of sale and storage

Naphazoline can be purchased over the counter without a prescription. A closed bottle with drops is allowed to be stored for 3 years from the date of manufacture. It is impossible to use the drug with an expired shelf life. The contents of an open bottle must be used within 1 month.

The medicine should be kept at a temperature of 15 to 25 degrees. It is necessary to exclude exposure to sunlight on the surface of the bottle. It is advisable to keep the drops separate from food, to restrict access to children.

Price

The cost of drops varies depending on the manufacturer, the volume and concentration of the active ingredient. The minimum cost of a 10 ml bottle (0.5 mg) is 8 rubles. and for 20 ml - from 15 rubles. Naphazoline is also available as a nasal spray. Cost - from 65 rubles for a bottle with a capacity of 25 ml.

Naphazoline is an effective nasal drops that relieves swelling of the mucous membrane. The drug quickly restores airway patency, relieving congestion. Despite the relatively safe composition, the agent must be taken with caution, strictly following the instructions in order to eliminate the risk of side effects.

Video about the analogue of Naphazoline

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