Selana Reviews of the drug, instructions for use, price

Selana is drug used in tumor therapy. The drug has proven itself well in the fight against malignant neoplasms and has many positive reviews.

Release form

The medicine is manufactured in Russia in the form of tablets for oral use. They are white, round, odorless. Capsules are packed in contour blisters and are contained in cardboard boxes.

Chemical composition

The active ingredient is anastrozole.

Additional composition:

• magnesium aluminometasilicate;
• colloidal form of silicon dioxide;
• croscarmellose sodium;
• magnesium stearic acid salt;
• lactose;
• PVA;
• talc;
• macrogol;
• food additive E171.

Thanks to the complex action of all components, a therapeutic effect is achieved.

Pharmacological properties

The drug belongs to the group of antineoplastic agents, the action of which is aimed at suppressing the production of estrogen. It also inhibits aromatase production.

The drug helps to reduce the production of estradiol and has a therapeutic effect against cancers caused by increased production of this hormone (estradiol). With the systematic intake of tablets, the level of the substance decreases by more than 80%. The drug has no progestogenic, androgenic and estrogenic effects. When using the product, there is no need to carry out additional hormone replacement therapy (HRT).

Pharmacodynamics and pharmacokinetics

After oral administration, the active ingredients of the agent are rapidly absorbed into the bloodstream from the gastrointestinal tract. The maximum level of their content is noted after 2 hours.

At the same time, food intake does not affect the level of absorption, but to some extent slows down its speed. The components interact with plasma proteins. The binding rate is about 40%. When using the product within 1 week, the maximum content of the component reaches 90-95%. There is no information on other pharmacokinetic parameters that depend on time and the dose taken.

The drug undergoes metabolic transformation and breaks down into several metabolites, the main of which is triazole. This substance has no therapeutic effect. The components of the agent leave the body mainly together with urine. About 10% is displayed unchanged. The duration of elimination is about 3 days.

The half-life of the ingredients is approximately 45-50 hours. The clearance values ​​do not change in healthy patients and patients with functional renal disorders or liver cirrhosis. The pharmacokinetic properties of the drug in the period after the onset of menopause remain unchanged.

Indications for use

Selana (reviews of the drug in most cases are positive and declare its high therapeutic action) is used in the treatment of cancers developing in the area of ​​the mammary glands and caused by menopause.

Contraindications

The drug has some limitations, in the presence of which you should refuse to take it, since this can complicate existing diseases or lead to the development of additional disorders.

Contraindications:

• period of onset of menopause;
• kidney failure, proceeding in moderate or severe form;
• pregnancy;
• intolerance to the components;
• lactation period;
• childhood.

In these conditions, it is recommended to choose a different treatment.

With extreme caution, the medicine can be used in the following cases:

• high blood cholesterol;
• osteoporosis;
• lactase deficiency, lactose allergy, glucose-galactose malabsorption syndrome;
• Ischemic heart disease (ischemic heart disease);
• functional disorders of the liver.

Before taking the tablets, you should make sure that you are not allergic to them. To do this, you need to take a single dose and observe the reaction. In the event of the development of any negative signs, it is recommended to abandon the further use of the product.

At what age can the drug be used?

The drug is not intended for use in pediatric practice.

Instructions for use, dosage

The medicine is intended for oral administration

Dosage regimen: 1 capsule 1 time per day with a sufficient amount of liquid. The drug should preferably be taken at the same time of day. The recommended duration of therapy is 5 years. With mild to moderate severity of renal and hepatic insufficiency, dosage adjustment is not required.

Side effects

Adverse reactions occur extremely rarely and are associated with the individual characteristics of the patient's body and the influence of active components.

Side effects:

• Endocrine system: hot flashes, thinning and deterioration of the hair structure, excessive dryness in the area of ​​the vaginal membrane.
• Digestive tract: excessive weight loss (anorexia), signs of dyspepsia (nausea, vomiting, diarrhea). In some patients, an increase in hormone levels was noted.
• Central nervous system: asthenic syndrome, increased drowsiness, migraines.
• Musculoskeletal and connective tissue: arthritis, joint stiffness, pain, myalgia and arthralgia.
• Metabolic processes: an increase in blood cholesterol levels.
• Skin manifestations: rashes on the skin, itchy elements, hyperemia. Erythema multiforme and cutaneous vasculitis may also occur.

Other reactions not associated with taking the drug:

• anemic disorders;
• constipation;
• sense of anxiety;
• dyspeptic symptoms;
• pain in the back;
• abdominal pain;
• increased blood pressure;
• increase in body weight;
• depressive conditions;
• sleep disturbance (insomnia);
• dizziness;
• loss of sensitivity (parasthesia).

In the event of the development of these signs, as well as other reactions not noted in the instructions, it is recommended to stop further taking the drug and seek advice from a specialist.

Overdose

Selana (reviews on the drug report the need for strict adherence to the dosages indicated in the instructions) is well tolerated by all groups of patients and does not cause addiction or withdrawal syndrome.

If the dosages prescribed by a specialist are exceeded, a negative effect may develop. At the moment, several cases of adverse reactions associated with daily excess of doses have been registered. With the development of such symptoms, further use of the medication should be canceled and a doctor should be consulted for symptomatic therapy. It is necessary to artificially induce vomiting on your own. Requires constant monitoring by a specialist to monitor the patient's condition.

The agent does not have a specific antidote. In some cases, dialosis is performed.

special instructions

There is no information on the safety of using tablets during pregnancy and childhood. If necessary, before starting therapy, it is necessary to conduct a number of additional studies that will determine and confirm the hormonal status of a woman.

The drug is not effective against breast tumors caused not by estrodil, but by other factors. The exceptions are cases when a therapeutic effect was observed while taking tamoxifen (previous treatment).

There is no information on the use of the drug in women with moderate functional disorders of the liver, therefore it is not recommended to carry out drug therapy in the presence of these deviations. With the development and persistence of bleeding from the uterus caused by taking the medication, it should be constantly monitored by a specialist.

Patients with a predisposition to the development of osteoporosis or who are at risk require systematic monitoring of bone density. At the moment, there is no information on enhancing the effectiveness of treatment combined with chemotherapy. Data on the safe use of the drug for a long time are not available or not provided.

The drug can lead to various negative reactions from the central nervous system, therefore, for the entire period of treatment, it is necessary be very careful or completely refuse to drive a car or carry out work that requires the speed of psychomotor reactions.

Drug interactions

The medication can react with other drugs and lead to the development of undesirable manifestations. The drug can reduce the therapeutic effect of estrogens. According to clinical trials, the simultaneous use of tablets and antipyrine with cimetidine does not cause negative drug interactions.

There is no information on reactions when taking the drug with other tumor treatments. The combined use of the main drug with tamoxifen should be avoided, as such a combination may reduce the effectiveness of therapy. When using other drugs during the period of prescribing the medication, you should inform the treating person about it in advance. doctor, which will avoid drug incompatibility and, as a result, prevent the development of negative reactions.

Analogs

Selana in some cases can lead to the development of reactions of intolerance. In the event of such manifestations, it is recommended to replace the agent with another drug that is similar in indications and action. When choosing an analogue, you should first familiarize yourself with the reviews of doctors and patients who took it.

The selection of generics should be carried out by the attending physician, taking into account the severity of the course of the disease, the condition and other physiological characteristics of the patient.

It is not recommended to prescribe and use substitutes on your own, since an incorrectly selected drug can worsen the condition and cause the development of additional complications.

Axastrol

This product is manufactured in Latvia in the form of tablets for oral use, the active ingredient of which is anastrozole. The drug belongs to the group of antineoplastic agents and is prescribed in the treatment of malignant lesions (cancer) of the mammary glands. Dosage regimen: 1 capsule 1 time per day. The medicine is intended for long-term use. If the disorder is severe, the agent should be used within 5 years.

Contraindications:

• intolerance to the components;
• premenopause;
• liver failure, proceeding in moderate and severe form;
• pregnancy;
• lactation period;
• childhood.

The medicine is not intended for joint use with other medicinal products similar to the indications (combination therapy). Terms of sale - prescription. The price of a medicine in public and private pharmacies in Russia starts from 670 rubles.

Arimidex

Selana (reviews of the drug and its analogues may differ from each other, so you should familiarize yourself with them in advance) should be replaced by other similar medications, taking into account all the physiological characteristics of the patient, stage and severity diseases. This substitute (Arimidex) is available in the UK as an oral tablet. The active ingredient is anastrozole. The drug belongs to the group of anticancer drugs and is used in the treatment of malignant neoplasms developing in the area of ​​the mammary glands.

Recommendations for the appointment:

• previous surgical interventions for estrogen-dependent tumors;
• common forms of malignant neoplasms in patients after menopause;
• previous surgical interventions for estrogen-dependent neoplasms after tamoxifen therapy.

Dosage regimen: inside 1 tablet 1 time per day. The duration of therapy in severe cases is 5 years.

Restrictions on admission:

• the period before the onset of menopause;
• moderate to severe liver failure;
• intolerance to the components;
• concomitant use of tamoxifen;
• pregnancy;
• lactation period;
• childhood.

The drug should not be used in conjunction with other similar drugs aimed at combating malignant tumors.

Dispensing conditions - prescription. The cost of the drug in regional and regional pharmacies in Russia varies between 1290-1425 rubles.

Brasser

Selana (reviews of the drug report its additional beneficial properties) can be replaced by such a popular and no less effective foreign-made product like Bracer. This generic is produced in India as an oral tablet. The active ingredient is anastrozole.

The drug has antitumor activity and is used in the development of breast cancer that arose in the period after menopause. Dosing rules: inside 1 capsule 1 time per day. The product is intended for long-term use. The recommended duration of therapy is 5 years. The tablets should be taken at the same time.

Contraindications:

• premenopause;
• intolerance to the components;
• childhood;
• kidney failure (severe and moderate pathology);
• pregnancy;
• lactation period.

The drug is prohibited for joint use with other medicines similar in indications. The way of implementation is prescription. The cost of a medicine in commercial and state pharmacies in Russia is 825-840 rubles.

Terms, conditions of sale and storage

• The drug should be stored in a dark and dry place at temperatures up to 25 ⁰C.
• Shelf life is 3 years from the date of issue.
• Do not use after the expiration date stated on the package.
• Dispensing method - over-the-counter.

Price

Prices for pills may vary slightly depending on the region of sale and the pharmacy trade network. You can clarify the cost and purchase the medicine at any commercial or state pharmacy located in your place of residence.

Region / region	Dosage form / dosage	Price
Moscow, Moscow region	Tablets, 1 mg.	RUB 880-1295
St. Petersburg	RUB 940-1200
Saint Petersburg (suburbs)	RUB 900-1245
Leningrad region	RUB 950-1100
Novgorod region	RUB 970-1080

Before using Selana, you should consult with a specialist and carefully study the instructions for using the drug. It is also recommended to read the reviews of patients who have already taken the drug in tumor therapy.

Selana drug video

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