Domperidone. Indications, instructions for use, price, reviews

Domperidone - Pharmaceutical antiemetic drug, assigned to patients with the development of pathologies of the digestive system. Indications for the use of the medication suggest the appointment only when certain symptoms appear against the background of pathologies of the stomach and intestines. Therapy should be agreed with the doctor to avoid the development of complications.

Composition and form of release

The drug is available for purchase by patients in the form of standard tablets, which are taken orally. They are placed in standard plastic plates, they are small and round.

The tablets can be white or off-white and are film-coated to prevent disintegration. A plate can contain 10 pieces, and a small box made of cardboard can hold from 1 to 5 plates. A description is attached to them, which indicates the features of therapy, possible indications and contraindications, negative reactions.

In the composition of the tablet medication there is a substance called domperidone, which has the main therapeutic effect.

Like other medicines, tablets contain excipients:

• Talc.
• Magnesium stearate.
• Starch.
• Macrogol.
• Titanium dioxide.
• Cellulose in microcrystalline form.

These ingredients have no medicinal properties. The amount of the main substance per 1 tablet is 10 mg.

Terms of sale, prices

Domperidone (indications for the use of the drug are described in the official instructions) is dispensed in different pharmacies after presenting a certified prescription form from a doctor. This somewhat reduces the likelihood of complications developing on the background of independent use without preliminary examination.

The cost of the medicine differs depending on the number of plates in the package. On average, the price ranges from 150-300 rubles.

Action

Tableted medication has pronounced anti-nausea and antiemetic properties, provided for due to the presence in the composition of a component that affects the motility and functioning of the muscle layer of the digestive system. The pharmaceutical drug quickly eliminates the manifestations of nausea, which makes it possible, if necessary, to use it in the form of an emergency method.

The drug helps to accelerate the peristalsis of the stomach and esophagus, which leads to rapid evacuation of food and prevents food stagnation. The presence of concomitant abnormalities in the internal organs in patients can aggravate symptoms, so the medication has a positive effect on the state of the digestive system and reduces this probability.

When using it, patients note different positive properties:

• The drug belongs to the central antagonists of dopamine receptors, which has a positive effect on the functioning of the digestive tract. The medicine helps prevent the development of complications arising from digestive disorders, as well as the progression of pathologies.
• According to the principle of action, the medication resembles metoclopramide, but less often provokes negative reactions from the nervous system. Tremors and other abnormalities may occur with other antiemetic drugs. Domperidone rarely causes these disorders.
• When using the drug, patients talk not only about eliminating nausea and vomiting, but also about the disappearance of pain in the stomach. Many patients talk about severe discomfort, which appears simultaneously with nausea.
• If the patient suffers from chronic diseases of the digestive system, taking the drug helps to normalize the stool and prevent frequent exacerbation of manifestations within a short period of time.

  

Domperidone, the indications for the use of which should be studied by patients before the start of use, is well absorbed in the body. After oral administration of the tablet, dissolution of its film shell occurs quickly. The main ingredient of the composition penetrates the systemic circulation and has a therapeutic effect on organs and tissues. The drug does not penetrate the blood-brain barrier, which minimizes the risk of developing severe complications from the nervous system.

The component of the composition binds well to plasma proteins, and its bioavailability reaches 80%, which is considered a high indicator. The maximum concentration of ingredients in the blood is reached 1 hour after taking a single therapeutic dosage. For several hours, the effect of the drug remains, after which it gradually disappears.

The processing of the drug is carried out with the help of the liver; during the day, not only processing occurs, but also the excretion of metabolic products. The main amount of metabolites is evacuated by the kidneys, a small part is excreted with feces. In case of violations of the urinary system, the cleansing of the body from decay products slows down. This does not lead to the accumulation of substances in the blood, does not provoke serious complications in the form of an overdose, if the patient does not consume a large number of pills at the same time.

The withdrawal period can be extended with prolonged use of the drug, which also does not affect the therapeutic effect and does not lead to the accumulation of ingredients in the blood. Pharmacokinetic features can change in the presence of severe pathologies of the digestive system.

Indications and contraindications for use

The medicine is used when diagnosing certain symptoms, as well as in combination with other agents as part of a comprehensive treatment.

The main indications for the appointment:

• Nausea while eating poor-quality food, the onset of a symptom as a result of the use of certain medications.
• Repeated vomiting throughout the day. The symptom may occur against the background of gastritis, peptic ulcer disease, but the drug helps to eliminate the manifestations.
• Exacerbation of the chronic form of pancreatitis, in which the patient is worried about nausea, regardless of food intake, after eating many foods.
• Nausea from chemotherapy and radiation therapy. The medication helps to significantly alleviate the condition, even with the severity of the symptom.
• Organic and functional diseases of the gastrointestinal tract, accompanied by frequent nausea and repeated bouts of vomiting.
• Infectious pathologies in which the patient has a disruption of the digestive tract.
• Hiccups. The medication is used for such a violation if the condition is associated with disorders of the stomach and esophagus.
• Belching and heartburn, frequent development of indigestion.
• Bloating and severe flatulence. The drug does not help to reduce the amount of gases formed in the intestines, but improves their removal by stimulating and improving intestinal motility.
• Intestinal atony, which develops against the background of disorders or after operations on the digestive and pelvic organs.

The medicine can be prescribed to prepare the patient for an X-ray examination of the intestines and stomach.

Domperidone is not used in case of intolerance to any ingredient of the composition or a tendency to such reactions. Indications for the use of the drug require a preliminary examination to determine possible obstacles to therapy.

Additional contraindications:

• Gastrointestinal acute bleeding that occurs against the background of damage to the mucous membranes of the gastrointestinal tract. If necessary, agents for parenteral administration may be prescribed.
• Liver pathologies of viral origin. The drug is not prescribed in the acute stage, but can be used after elimination of acute manifestations.
• Severe hepatic failure, in which the functioning of the organ is significantly impaired. Pathology leads to a violation of the processing of ingredients, which can affect the general condition.
• Severe renal pathologies, in which there is a deterioration in the excretion of metabolites from the body.
• The patient's age is up to 5 years. Children are prescribed other medications that are considered less aggressive.
• Acute inflammation of the appendix and the need for immediate surgery.
• Acute mental disorders.
• Pathologies accompanied by a violation of the swallowing reflex.
• Intestinal obstruction, adhesions against the background of inflammatory pathologies. The condition can develop after undergoing surgery.

During pregnancy, the drug is not used, since there is not enough data on its effect on the body of the mother and child. Lactation is a contraindication for therapy, which is associated with the possibility of complications. If it is necessary to use antiemetic drugs during pregnancy and breastfeeding, safer drugs are selected.

With caution, the drug is used in the treatment of patients suffering from acute cardiovascular diseases. If the patient has a history of cerebrovascular accidents, the doctor decides on the appointment on an individual basis.

Like many medicines, tablets can provoke negative reactions from internal organs and systems. Most often, patients talk about stool disorder and the appearance of intestinal cramps. The condition is accompanied by pain, lack of appetite and intense thirst. In patients with a tendency to allergic reactions, symptoms may appear on the skin. It manifests itself in the form of itching and severe burning, peeling of the skin, irritation and rash. In the absence of therapy, the symptoms are aggravated, which leads to the spread of the rash to large areas.

Adverse reactions are considered a reason for refusing therapy and visiting a doctor. You should not take any measures on your own. A specialist individually selects an effective treatment. Overdose during therapy does not develop so often. It manifests itself in the form of severe weakness and constant drowsiness, headache, disorientation.

Overdose should be treated by a specialist in a hospital setting. Usually 3-5 days are enough to normalize the condition. The drug does not have a specific antidote, therefore, therapy with the development of complications is symptomatic.

Method of administration and dosage

Domperidone (indications for the use of the drug suggest an individual prescription) is taken orally after an accurate diagnosis has been established. Depending on the violation and the degree of its severity, the daily rate of the drug is determined.

The standard regimen involves taking 10 mg of the drug 3 times a day for 3-7 days. When taking, you must consume a sufficient amount of liquid. Experts recommend taking it before meals to reduce the likelihood of symptoms after eating.

For nausea and vomiting

Symptoms arise not only as a result of pathologies of the digestive tract, but also in case of poisoning, the use of poor-quality food or potent medications. Medication is started when symptoms appear, and can be combined with the use of other drugs.

A single dosage for such a violation is 10 mg, the drug is taken no more than 3 times per day, but in case of severe symptoms, it is allowed to take it 4 times a day. It is recommended to take approximately equal intervals of time between uses, which will maintain a constant level of the main component in the body.

In the absence of a therapeutic effect, an extension of the course is allowed, but according to individual indications.

With bloating

The medicine when diagnosing bloating is prescribed in combination with medicines, the action of which is aimed directly at reducing the amount of gas in the intestine.

The daily dosage for a patient ranges from 20-30 mg. It must be divided into 2-3 doses during the day. The duration of therapeutic use depends on the severity of the manifestations. Usually 5 days are enough to get the treated result.

With hiccups and indigestion

Domperidone (indications for the use of the medication suggest refusal of treatment after elimination of the manifestations) with hiccups and indigestion is prescribed as part of a comprehensive treatment if the symptoms are provoked by diseases stomach.

A one-time rate for mild symptoms is 5 mg, but if necessary, it can be increased to 10 mg. The reception is repeated 2 times per day, sometimes it is necessary to take it 4 times a day.

Treatment should be comprehensive, and the duration of the course is 5-7 days. On an individual basis, the duration of use and dosage may vary.

Some analogues

The tablet formulation has analogs with similar properties. Many of them contain the same active ingredient.

Product name	Peculiarities
Passages	The drug is based on domperidone, the main difference of which is that it is available in the form of chewable tablets. They are easy to use. The drug has the ability to suppress nausea, helps to stimulate the peristalsis of the intestines, esophagus, which helps to get rid of discomfort. Like the original, the drug is prescribed mainly for adults in short and long courses. Depending on the symptomatology, the duration of the therapeutic course may vary, as well as the dosage of the active component.
Cerucal	A drug with pronounced anti-nausea properties, which contains metoclopramide as an active ingredient. The medicine has a different principle of action, since it blocks not only dopamine, but also serotonin receptors. As a result, heartburn and nausea are eliminated, the process of emptying the stomach from food is accelerated, as it quickly moves into the intestines. The medicine is used according to different schemes, depending on the symptoms. Unlike the original, it is available in the form of tablets and a solution for parenteral administration. This is considered an advantage, since the solution can be used in case of indomitable vomiting, which excludes the possibility of taking oral dosage forms.
Motilak	An analogue of a drug based on domperidone, which is available in tablet form for resorption and oral administration. Each patient can choose the most convenient form for himself. The substitute is indicated as a stand-alone treatment or in combination with other medications to increase its effectiveness. Typically, therapy lasts 7 days, as with Domperidone.
Domrid	A popular substitute that acts due to the presence of domperidone in the composition. Like the original, it is available in tablet form, but the difference is the presence of a dosage form of a suspension. It can be used for children as needed. The duration of treatment with the drug ranges from 5-10 days, and the daily dosage does not exceed 40 mg. It is not worth taking it once, it is better to divide the norm into several doses during the day, making approximately equal intervals.

When choosing an analogue, the doctor takes into account the clinical manifestations in a particular patient. He examines his medical history, notes the presence of possible complications. Despite the similar composition of the preparations, it is not recommended to use any substitutes on their own.

Domperidone is a popular antiemetic drug that is relatively safe and can quickly resolve negative symptoms. Indications for its use necessarily imply a preliminary examination, which determines the appropriateness of the appointment. When taking it, it is important to follow all the doctor's recommendations, as well as listen to your own well-being.

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