Montelukast 4-5-10 mg. Price, instructions for use, reviews

Montelukast at a dosage of 4 mg - a pharmacological agent in demand in allergology. The price of the drug depends on the place of production, but its composition is identical. With its help, it is possible to quickly improve the well-being of patients suffering from bronchial asthma and allergic rhinitis. The drug is usually well tolerated, therefore it is used in pediatric practice.

Release form

Montelukast is produced by many Russian and domestic pharmaceutical companies. The drug is produced in the form of small round light pink biconvex tablets without film shells, heterogeneously colored at the fracture. Cells of soft metallized blisters serve as the primary packaging for the preparation. In addition to them, instructions for use are in a cardboard box.

Chemical composition

The active substance of the drug is montelukast, included in the clinical and pharmacological group of anti-inflammatory anti-bronchoconstrictor drugs.

The auxiliary composition of the tablets is represented by the following components:

• mannitol;
• sorbitol;
• hydroxypropyl cellulose;
• red iron oxide;
• croscarmellose sodium;
• sodium cyclamate;
• microcellulose;
• flavoring;
• magnesium stearate.

Thanks to the additional ingredients, montelukast is fully adsorbed into the bloodstream, in which it quickly accumulates in the maximum therapeutic concentration. Excipients of the medicinal product provide dosed release of the active ingredient from the tablet, indirectly enhancing its therapeutic effects.

Pharmacological properties

The therapeutic effects of the drug are due to the ability of the main component to block receptors that are sensitive to leukotrienes. These potent pro-inflammatory biologically active substances are released into the bloodstream from various cells in the body, including mast cells and eosinophils. The binding of important pro-asthmatic mediators to the nerve endings that are sensitive to them and becomes the cause of the development of an allergic reaction.

The localization of cysteinyl-leukotriene receptors is the respiratory tract. There are many of them in pro-inflammatory elements, for example, in eosinophils. It has been established that the development of pathologies with an allergic component is provoked precisely by cysteinyl-leukotrienes.

In the first case, they start processes that lead to pathological effects:

• the occurrence of bronchospasm;
• an increase in the production of mucous secretions;
• increased vascular permeability;
• an increase in the quantitative content of eosinophils.

Allergic rhinitis develops as a result of the release of pro-inflammatory mediators from the mucous membranes of the nasal passages in response to the introduction of allergens into the upper respiratory tract.

This leads to the appearance of pronounced symptoms of a sensitization reaction:

• itching in the nasal cavity;
• sneezing;
• difficulty in nasal breathing;
• mucous discharge from the nose.

Taking Montelukast helps to improve the well-being of patients with bronchial asthma and allergic rhinitis by stopping the inflammatory process. The results of biochemical and pharmacological analyzes confirm that the active substance of the drug has an affinity for cysteinyl-leukotriene receptors. Moreover, its effect is selective.

Montelukast does not bind to other pharmacologically important sensitive nerve endings of the upper respiratory system:

• prostaglandin;
• cholinergic;
• β-adrenergic.

Under the influence of Montelukast, the physiological properties of receptors sensitive to cysteinyl-leukotrienes are inhibited due to the binding of its active substance to them. But the stimulating effect on them is not observed, as in the case of a process characteristic of an inflammatory reaction. Bronchodilation appears within 2 hours.

Pharmacodynamics and pharmacokinetics

After taking the pill, the active substance is rapidly and fully absorbed into the systemic circulation from the gastrointestinal tract. At the maximum therapeutic concentration, it accumulates after about 2 hours. More than 70% of montelukast is absorbed into the bloodstream, and the presence of food in the stomach does not affect this parameter.

The active substance forms complexes with plasma proteins. According to the results of biochemical studies, if they overcome physiological barriers, then in an amount insufficient for a pronounced effect on the functioning of vital systems. Its biotransformation takes place in the hepatic structures.

Plasma clearance parameters slightly exceed 40 ml / min. Almost completely metabolites and unchanged montelukast are evacuated with feces. Only a small part of them is excreted from the body by the organs of the urinary system.

Indications for use

Montelukast is intended for the complex therapy of a number of diseases with an allergic component.

Doctors include it in the treatment regimens of patients with the following pathological conditions:

• bronchial asthma complicated by individual intolerance to non-steroidal anti-inflammatory drugs, including hypersensitivity to drugs based on acetylsalicylic acid;
• seasonal and / or year-round hay fever;
• bronchial asthma.

The drug is actively used for prophylactic purposes, including for the prevention of bronchospasm as a result of physical exertion. Montelukast is used only to eliminate symptoms, since it has no effect on the causes of the development of diseases.

Contraindications

The drug is not prescribed by doctors to people with individual intolerance to the active or one of the auxiliary ingredients. The drug is not included in the therapeutic regimens of patients with hypersensitivity to fructose.

There is no evidence of the absence of teratogenic and mutagenic properties in it. Therefore, taking pills during pregnancy and breastfeeding is allowed in exceptional cases, for example, when safer means are ineffective, and in consultation with your doctor. He assesses the benefits of Montelukast to the woman and the potential risks to the fetus or baby. During lactation, the patient may be advised to stop breastfeeding. It is allowed to resume it a few days after the end of therapy, during which the active substance is completely removed from the body.

At what age can the drug be used?

In pediatric practice, the drug is used from 2 years old. In the treatment of children, the drug is used in standard (a tablet per day in the evening) or individual doses.

Instructions for use, dosage

The medicinal product is intended for oral administration. The tablet is swallowed whole with plenty of water. Chewing the tablet is allowed. The presence of food in the stomach has no effect on the therapeutic effects of Montelukast.

The dosage regimen depends on the diagnosis:

Disease	Dosage regimen
Bronchial asthma	Pill a day in the evening
Allergic rhinitis	Tablet per day in the evening or in individual doses for relapse
Bronchial asthma and allergic rhinitis	Pill a day in the evening

Montelukast 10 mg exhibits pharmacological effects during the day, their severity is not influenced by the place of production and price. Correction of doses in old age, in the presence of concomitant hepatic or renal pathologies is not required. The duration of the therapeutic or prophylactic course is individual, determined by the doctor.

With bronchitis

Patients with bronchial asthma, seasonal and / or year-round hay fever should use the drug according to the previous dosage regimen. With bronchitis, dose adjustment is not required.

With ARVI

Patients with bronchial asthma, seasonal and / or year-round hay fever take the drug in accordance with the previous dosage regimen. With ARVI, dose adjustment is not required.

With pneumonia

Patients suffering from bronchial asthma, seasonal and (or) year-round hay are treated with the drug in doses recommended by the doctor. With pneumonia, dose adjustment is not required.

Side effects

Montelukast 5 mg, the price of which varies depending on the dosage, enters the bloodstream, so the occurrence of systemic and local negative effects is possible.

Similar reactions from the body are manifested as follows:

• infectious lesions of the upper parts of the bronchopulmonary system;
• disorders of hematopoiesis;
• a decrease in the functional activity of the lymphatic system;
• a predisposition to the opening of bleeding of any localization;
• thrombocytopenia;
• weakening of local and systemic immune defenses;
• symptoms of individual intolerance, including anaphylactic shock;
• eosinophilic hepatic infiltration;
• motor restlessness, often proceeding with strong emotional excitement, anxiety and fears, depressive states;
• nightmares, insomnia;
• psychoemotional instability, irritability, anxiety, trembling of the limbs;
• disinhibition of motor centers in the absence of control over them by consciousness during sleep;
• teak;
• decreased concentration, memory impairment;
• hallucinations, suicidal tendencies;
• headaches, dizziness, drowsiness, paresthesia, convulsions;
• heart palpitations;
• nosebleeds;
• pulmonary eosinophilia;
• diarrhea;
• bouts of nausea, vomiting;
• dyspeptic disorders: pain in the upper abdomen of unclear localization, heartburn, a feeling of fullness in the stomach, fast satiety after eating;
• a feeling of dryness in the mouth;
• pancreatitis;
• increased activity of hepatic parameters;
• hepatitis, hepatic cholestatic, hepatocellular and mixed lesions;
• rashes, itching, urticaria, a predisposition to subcutaneous hemorrhage;
• angioedema;
• erythema nodosum or multiforme;
• joint pain, myalgia, including muscle cramps;
• infantile enuresis;
• febrile condition;
• weakness, fatigue, swelling, thirst.

Seek medical attention if one or more side effects occur. The doctor will prescribe drugs to eliminate them, if necessary, Montelukast will be replaced with an analogue with another active ingredient.

Overdose

Montelukast 4 mg, the price of which differs in different pharmacy chains, causes an overdose. It is possible with too long a dose, or a single accidental use of a large number of pills.

A pathological, health-threatening condition is manifested by the following symptoms:

• feeling of thirst;
• drowsiness;
• bouts of vomiting;
• psychomotor agitation;
• headaches;
• abdominal pain.

In case of an overdose provoked by taking pills in large quantities, you should rinse the stomach as soon as possible before the clear water flows out. Then take one of the enterosorbents, for example, activated carbon, and immediately seek medical attention. The doctor will carry out a set of measures aimed at the forced excretion of the active substance of Montelukast, prescribe drugs to eliminate symptoms.

special instructions

It is forbidden to use the drug without the consent of the doctor. It is not recommended to use Montelukast for acute bronchospasm, since there is no clinical data on its effectiveness during this period. For its immediate relief, it is required to keep the medicines prescribed by the doctor on hand. We combine Montelukast with each of them.

The active substance does not have a negative effect on memory, concentration, and speed of psychomotor reactions. During treatment, it is allowed to drive vehicles, perform technically complex work. It is not recommended to consume alcohol, as its depressing effect on the central nervous system can provoke the development of adverse reactions.

If, after a few days of using the drug, there is no improvement or they are insignificant, the doctor will make changes to the therapeutic scheme, if necessary, replace Montelukast with a more effective one analogue.

Drug interactions

Montelukast 4 mg, the price of which depends on the number of tablets in the package, goes well with other drugs. Medicines used for prophylactic and therapeutic purposes by patients with bronchial asthma, allergic rhinitis simultaneously with it, do not have a significant effect on pharmacokinetic indicators.

It is combined with the following drugs:

• Theophylline;
• Prednisone;
• Prednisolone;
• contraceptives, the composition of which is represented by ethinyl estradiol, norethisterone;
• Terfenadine;
• Digoxin;
• Warfarin.

  

The total concentration of the drug in the blood plasma is almost halved in the presence of Phenobarbital, but dose adjustment in this case is not required.

Despite the fact that its active substance is able to block isozymes from the oxidase system cytochrome P450, a clinically significant interaction with drugs metabolized with their help is not happens.

It is allowed to combine Montelukast with the following drugs:

• Paclitaxel;
• Rosiglitazone;
• Repaglinide;
• Gemfibrozil;
• Trimethoprimo;
• Itraconazole.

In therapeutic regimens for patients with bronchial asthma, allergic rhinitis, Montelukast is often combined with bronchodilators and / or glucocorticosteroids in the form of inhalation. Recommended after improvement of patients' well-being, achievement of a significant therapeutic effect, reduce the dose of these drugs in order to reduce the pharmacological load on the body the patient.

Analogs

Montelukast is an effective and relatively safe remedy. But if the patient is intolerant of one of the components or because of its absence in the pharmacy, the use of analogues is required.

They have similar therapeutic properties:

• Singular.
• Vanseira.
• Glemont.
• Lucasta.
• Milucantha.
• Moncasta.
• Montela.
• Singlon.
• Tevalukasta.

Montelukast 4 mg, the price of which is usually lower than analogs, can only be replaced by a doctor. The drug selected by him should be as effective, well tolerated, and not provoke the development of adverse reactions. Doctors often give preference to substitutes Vanceyr and Tevalukast.

Terms, conditions of sale and storage

The shelf life is three years. The tablets should be stored at room temperature in a place protected from sunlight. It is forbidden to use them when cracking the surface of the tablets, discoloration. It is necessary to store the drug out of the reach of children. To purchase Montelukast, you need to present a prescription form from a doctor to pharmacies.

Price

The average cost of drug No. 10 from domestic manufacturers is 200 rubles, from foreign manufacturers - from 350 rubles. It will be possible to purchase drug No. 28 from Russian pharmaceutical companies for about 450 rubles, from imported ones - from 700 rubles.

The price of the drug Montelukast 4 mg varies depending on the number of tablets in the package and the pharmaceutical company that produces it. Compliance with the recommendations of the instructions allows you to speed up recovery and avoid side effects. The use of Montelukast helps to stop the leading symptoms of an attack of bronchial asthma, to get rid of the clinical manifestations of allergic rhinitis.

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