Insulin Toujeo Solostar. Price, instructions for use, where to buy, manufacturer, reviews

For effective insulin is used for diabetes therapy Tujeo SoloStar. This drug is manufactured by Sanofi. The drug is a concentrated insulin with a long-term principle of action. The drug for 35 hours. continues to monitor blood glucose levels.

The active components of the drug are slowly absorbed, gradually distributed throughout the body and rapidly metabolized. The slightly inflated price of the drug is justified by its effectiveness and good tolerance. By following the recommended dosage, the risk of nocturnal hypoglycemia can be significantly reduced.

Form of release and composition of the drug, manufacturer

Insulin Tudgeo SoloStar (price, reviews and instructions for use of the drug should be studied by the patient before taking) is a solution that is injected subcutaneously. Insulin glargine is used as an active ingredient.

Additional substances include:

• Zinc chloride.
• Metacresol.
• Sodium hydroxide.
• Hydrochloric acid.
• Purified water.
• Glycerol.

  

The solution of the drug is transparent, colorless. The drug has a hypoglycemic pharmacological property, and the hormonal component present in the composition is a long-acting insulin.

The drug is available in the form of a solution contained in small cartridges, the volume of which is 1.5 ml. You can buy 5 insulin pens in a cardboard box.

Pharmacological properties

Insulin Tudgeo SoloStar (the price of the drug is justified by its effectiveness, as well as long-term hypoglycemic action) is intended for the treatment of type 1 and 2 diabetes mellitus.

The medication contains glargine, which is the latest generation of insulin. The drug helps to normalize the patient's condition without sharp fluctuations in glucose indicators. The medicine has an improved form that makes the therapy safer.

The period of drug activity is from 24 to 34 hours. The active ingredient of the drug is similar to insulin, which is produced by the human body.

Subject to the recommended dosage, the agent has a positive therapeutic effect, improving glucose metabolism. The drug helps to increase protein synthesis and also suppresses the formation of sugar in the liver. The components included in the composition normalize the absorption of glucose by the tissues of the body.

The drug dissolves well in an acidic environment, is gradually absorbed and evenly distributed throughout the body. The maximum activity is 36 hours. the half-life is 19 hours.

Pharmacodynamics and pharmacokinetics

Insulin Tudgeo SoloStar is slightly overpriced, but the components included in the composition have a prolonged hypoglycemic effect, and are also well tolerated by the patient's body. 1 ml of the drug contains 300 units of insulin.

When compared with the common drug Lantus, the dose of the active ingredient in Toujeo Solostar is 3 times more. Increased protein production has a depressing effect on glucose synthesis by liver cells. In this case, the process of glucose absorption by tissues is stimulated.

Indications for use

The described tool is intended for the treatment of those patients who have been diagnosed with diabetes mellitus. The drug can be used by the elderly over 65 years of age, as well as in the presence of renal or hepatic insufficiency.

In people of retirement age, kidney function may deteriorate in the presence of concomitant diseases, due to which the need for insulin decreases. With renal failure, the patient less often needs to use insulin, since the body's metabolism slows down.

Due to the prolonged action of the medication, it is possible to change the timing of injections, as well as increase the interval between procedures. When using the described drug, the concentration of glucose in the blood decreases gradually. Thanks to this, you can choose the optimal dose of insulin therapy, minimizing the likelihood of sudden surges in blood sugar levels.

The manufacturer claims that the drug is equally effective regardless of the patient's gender and age. The medicine can be injected under the skin at the same time or on a special flexible schedule. The components included in the composition are safe for patients over 65 years of age. The drug maintains the normal physiological state of the patient, reduces the likelihood of complications.

Contraindications

Insulin Tudgeo SoloStar (price, contraindications and side effects are described later in the article) can not be used for all categories of patients.

The main contraindications include:

• Children's age (the patient is less than 18 years old).
• Hypersensitivity of the body to the components of the drug.
• Diagnosed endocrine pathologies.
• Chronic liver and kidney disease in the acute stage.

Endocrinologists note that when using insulin, it is necessary to keep the condition of patients over 65 under control, since in this category of people the metabolism gradually slows down. You need to check your glucose readings periodically.

Patients need to learn how to administer a medication and stop hypoglycemia or hyperglycemia. For a person with kidney disease, the dosage of the drug must be selected individually, since his ability to gluconeogenesis is significantly reduced.

At what age can the drug be used?

In laboratory conditions, the necessary research has not been carried out on how the components of the drug Toujeo Solostar affect the child's body. In pediatrics, the use of the described drug is prohibited. In the annotation to the medicinal product, the manufacturer indicated that the medicinal product is intended exclusively for adult patients.

Instructions for use, dosage

Insulin Tudgeo SoloStar (the price of the drug depends on the markup of the selected pharmacy network) is available in the form of injections. The drug is injected subcutaneously at the same time.

The maximum difference in time of drug administration should be 3 hours. If the patient did not enter the medication in a timely manner, then he needs to check the blood for glucose concentration, and then return to the previous treatment schedule. It is forbidden to inject a double dose of insulin, as this will negatively affect the work of the whole body.

For diagnosed type 1 diabetes, the medication must be administered with fast-acting insulin with meals.

For a person with type 2 diabetes, Toujeo Solostar is recommended to be combined with other hypoglycemic medications. At the first stage, 0.2 U / kg should be administered over several days. It is forbidden to inject insulin intravenously, as there is a risk of severe hypoglycemia.

To achieve the maximum therapeutic effect, it is recommended to adhere to the following scheme of actions:

1. You need to get the syringe pen out of the refrigerator in 60-75 minutes. before use. Cold medicine can also be injected under the skin, but this procedure will be accompanied by painful symptoms. It is necessary to double-check the expiration date of the drug. It is forbidden to use insulin that has lost its transparency.
2. It is necessary to remove the protective coating applied by the manufacturer from the needle, screw it all the way to the syringe (no force is needed). The outer cap must be removed from the needle, but not discarded. The inner cap, however, cannot be reused.
3. There is a special dose counter window on the syringe. Thanks to this innovation, there is no need to calculate the dosage yourself. The syringe must be filled up to 3 units by rotating the dose sector until the pointer stops at the desired number. Press the dosage control button. If a drop of liquid appears on the surface, then you can use a syringe pen. Otherwise, the patient will have to repeat all the steps from the beginning. If the result does not change, then the needle is faulty.
4. Only after attaching the needle, you can draw insulin and press the dosing button. With an insufficient amount of units, you can enter the drug in 2 injections, but with a new needle.
5. The drug can be injected into the shoulder, thigh, or abdomen. After pressing the dosing button, you need to wait until the number "0" appears in the window. The patient should count to 5, after which the button can be released and the needle removed (this is the only way to get the full dose of insulin). The sites for the injection of the drug must be constantly alternated.
6. It remains to take the outer cap and insert the needle into it, the product must be disposed of. The syringe must be closed with a cap and left out of the reach of UV radiation.

For the treatment of type 1 diabetes mellitus, Toujeo Solostar is administered no more than 1 time per day together with short-acting insulin. Periodically adjusting the dosage, which depends on the age, weight and condition of the patient. In type 2 diabetes mellitus, the dosage of the drug should be within 0.2 U / kg body weight.

Side effects

The risk of adverse reactions was studied using special clinical studies using insulin at a dosage of 100 U / ml.

Experts were able to determine that the most common negative reaction is hypoglycemia, which develops as a result of a significant excess of the permissible dosage. This side effect is accompanied by a strong feeling of hunger, nervous overexcitation, anxiety, tremors of the upper limbs, tachycardia.

Against the background of the development of neuroglycopenia, the patient may be disturbed by the following symptoms:

• Migraine.
• Increased fatigue.
• Deterioration of vision.
• Loss of consciousness.
• Drowsiness.
• Nausea.
• Convulsions.

Constant glucose monitoring can result in short-term vision problems. This is due to a short-term violation of the refraction of the lens. In a few days, the work of the visual system will be restored, and the risk of developing retinopathy will decrease. In severe cases, hypoglycemia can cause temporary loss of vision.

Lipodystrophy may occur at the injection site, which can slow down the absorption of insulin. But when using glargine, such an adverse reaction worries patients only in 2% of all cases. Changing the injection sites will help reduce the likelihood of developing lipodystrophy.

Local reactions include:

• Development of the inflammatory process.
• Itching, burning of the skin.
• Puffiness.

Allergic reactions occur in isolated cases. Most often, hypersensitivity to the components of the drug is manifested by Quincke's response, a sharp decrease in pressure. In isolated cases, side effects can threaten the patient's life, which will require urgent medical attention.

Overdose

A significant deterioration in the patient's well-being can occur if the dosage of the injected drug is several times higher than the norm established by the endocrinologist. Overdose can be severe or mild. In the latter case, hypoglycemia is corrected by taking glucose or carbohydrates.

In case of a severe overdose, loss of consciousness, coma is not excluded, which will require qualified medical assistance. To improve the patient's condition, glucagon or glucose is administered. After that, the endocrinologist monitors the patient's condition in order to avoid repeated episodes.

special instructions

During the period of bearing a child, insulin can be used only after prior consultation with a gynecologist. The need to use this drug may be reduced in the 1st trimester of pregnancy and gradually increased during the 2nd and 3rd trimesters.

After the baby is born, the likelihood of developing hypoglycemia increases. Endocrinologists attach great importance to the constant monitoring of the ratio of glucose in a woman's blood.

Additionally, patients should take into account the following nuances of using the drug:

• Even when changing the needle, the syringe can only be used by one patient.
• Change the needle before each injection. Otherwise, blockage of the product is not excluded, due to which the dosage will be erroneous.
• You should always keep extra sterile needles in stock, as well as an alcohol wipe and container for collecting used material.
• A safety test must be done before each injection.

You can not dilute and mix the described drug with other drugs. You can use a pen-syringe only after reading the attached instructions.

The described drug has the following positive characteristics:

• Adverse reactions develop in rare cases.
• The drug lasts 34 hours.
• With regular use of the product, you can avoid gaining excess weight.
• The likelihood of hypoglycemia at night is significantly reduced.
• To achieve the desired therapeutic effect, a small dosage of the agent is needed, due to which insulin is consumed much more economically.
• High compensating properties.
• The drug acts smoothly, eliminating the risk of a sudden increase in blood glucose levels.

Among the disadvantages of the drug, one can single out the fact that Tudgeo SoloStar is not used for the treatment of diabetic ketoacidosis. The drug should not be used in pediatrics.

Drug interactions

Some medications can interfere with glucose metabolism. MAO and ACE inhibitors, salicylates, sulfonamides can increase the final hypoglycemic effect of insulin.

When these drugs are combined, the risk of hypoglycemia increases. The effectiveness of insulin can be weakened by diuretics, corticosteroids, sympathomimetics, as well as protease inhibitors and phenothiazine derivatives.

Clonidine, as well as ethanol and lithium salts, can significantly enhance or weaken the final therapeutic effect. If you combine insulin with pentamidine, then in the end you can increase the likelihood of developing hypoglycemia, which can develop into hyperglycemia.

The most dangerous is the combination of guanethidine, beta-blockers and clonidine with the described insulin, since there may be no symptoms of the central nervous system response to hypoglycemia. When used together with pioglitazone, pathologies of the cardiovascular system may occur.

Analogs

In the presence of individual intolerance to the components of the described drug, it can be replaced by basal insulins, which belong to a new generation of drugs. But it is better to entrust the choice of a suitable analogue to an endocrinologist, who will draw up a drug treatment regimen and select the optimal dosage of the drug.

Drug name	Description
Tresiba	Effective insulin with a long-term principle of action. Each injection has a positive effect on the patient's body for 42 hours. It is easy to control blood glucose levels with this drug. The drug can be used to treat adults and children over 1 year old. The optimal dosage of insulin is selected individually, since it all depends on the age, weight and condition of the patient. The manufacturer recommends administering the medicine once a day.
Tujeo	A hypoglycemic drug used in the treatment of type 1 and type 2 diabetes mellitus. Injections must be administered once a day. For the treatment of type 2 diabetes mellitus, the standard daily dose should not exceed 200 units. If the patient lacks this dose of insulin, then additional drugs with hypoglycemic properties can be selected.
Lantus	It is one of the first analogs of human insulin. The drug is indicated for adults and children from 2 years of age with type 1 or type 2 diabetes mellitus (in case of ineffectiveness of tablet medicines). It is forbidden to use the product for the treatment of diabetic ketoacidosis, as well as for hypoglycemia.
Levemir	The drug is intended for the treatment of type 1 and type 2 diabetes mellitus in adults and children from 2 years of age. The dosage for each patient is selected individually. The starting dose is 10 units. Most often, the injection is injected into the area of ​​the front of the abdomen or thigh, shoulder, deltoid or gluteal region.
Aylar	This drug belongs to the category of antidiabetic immunobiological drugs, analogs of human insulin. The dosage of the drug is individual, since it all depends on the blood sugar level, the amount of carbohydrates consumed, and physical activity. The standard daily dose is in the range of 0.3-1 IU / kg. With obesity, as well as during the period of bearing a child, the patient's need for insulin increases significantly.
Basaglar	This insulin is a medium-acting insulin. The drug was obtained using a special technology of recombinant DNA. The drug begins to act in 90 minutes. Before using the medication, you need to consult with an endocrinologist to eliminate the likelihood of adverse reactions.
RinGlar	The drug can be used for the treatment of diabetes mellitus in children from 2 years of age. The medicine should be administered subcutaneously once a day. RinGlar can be prescribed for monotherapy, as well as in combination with other hypoglycemic medications.

A qualified endocrinologist should select a quality analogue, who will conduct a comprehensive examination of the patient's health status and eliminate the likelihood of adverse reactions.

Terms, conditions of sale and storage

You can buy the drug only with a doctor's prescription. Insulin should be stored in a cool place, at temperatures from +3 to +8 C. It is forbidden to freeze the medicinal product. After the first use, the syringe pen is allowed to be used for 28 days. You need to store the syringe out of the reach of children, in a well-ventilated place. The air temperature in the room should be between +18 and +25 C.

The syringe must be isolated from dust and dirt, and the outside can be wiped with a dry, clean cloth. It is forbidden to throw or hit the product.

Price

The cost of insulin Tudgeo SoloStar 300 U / ml depends on which pharmacy the drug is purchased from, as well as on the region. For a package of 5 syringe pens, you will have to pay from 2500 to 2860 rubles. Numerous patient reviews confirm that the overestimated price of the drug is justified by its effectiveness and long-term principle of action.

Video about Tudgeo SoloStar

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