Cerebrolysin (Cerebrolysin) injections. Indications, instructions for use, price, reviews

Manufacturing company solution for injections Cerebrolysin positions it as a neuropsychotropic drug that increases the efficiency of cellular respiration in the mitochondria of the brain. Among the indications for use, one can also see an improvement in psychomotor reactions, previously disturbed as a result of pathological processes occurring in the central nervous system.

The benefits of a protease drug derived from the brain of a cloven-hoofed domestic pig include the ability to improve the multi-step process of protein synthesis and maturation in the developing and aging brain brain. But the uncontrolled intake of Cerebrolysin is strictly prohibited.

Composition and form of release

The neuroprotective drug Cerebrolysin is produced by the German pharmaceutical company EVER Neuro Pharma. It is released in the form of an injection liquid, colored in a light yellow color, which is packed in dark glass ampoules, and sealed in cardboard packages with separate cells.

The number of ampoules in a pack depends on the volume of the drug in them:

• 1 ml - 10 hermetically sealed containers in a box:
• 2 ml - 10 ampoules;
• 5 ml - 5 ampoules;
• 10 ml - 5 ampoules;
• 20 ml - 5 ampoules.

1 ml of solution contains 215 mg of active ingredient, which is represented by a complex peptides - ultra-short "chains" consisting of 3-4 amino acids obtained from the brain pigs. In addition, the composition includes caustic alkali and water for injection, which has gone through several stages of cleaning at once.

Terms of sale, prices

Cerebrolysin is included in the prescription drug category, which means that in order to buy it at the pharmacy, you will need to provide a prescription from your doctor. In it, the pharmacist has the right to indicate when the medicine was sold, in what dosage and for how long it will last. Also, a prescription can be taken at a pharmacy so that a person does not have the opportunity to buy a drug again, and this will not violate consumer rights.

Since Cerebrolysin, or rather, its low molecular weight biologically active neuropeptides, are capable of overcome the blood-brain barrier on the way to nerve cells, self-medication can turn into sad the outcome. People take it uncontrollably at their own risk, which further undermines their health. And that is why the decision was made to dispense the drug strictly according to the prescription.

Cerebrolysin injections, the indications for the use of which will be discussed below, can be called an expensive medication. The average cost of a 2 ml package is 1,090 rubles, 10 ml - 1,540 rubles, 20 ml - 3,000 rubles. You can store the nootropic substance in ampoules for no more than 5 years (but after opening the container cannot be stored) at a temperature not exceeding 25 ° C. It is strictly forbidden to put the solution in the refrigerator.

Action

The pharmacological properties of the psychostimulant and nootropic solution for injection are to stimulate cell differentiation, activate defense mechanisms and regenerate neurons. As a result of laboratory tests, it was found that peptide hydrolases that cleave peptide bonds between amino acids in proteins and peptides, are able to influence the adaptation mechanism in the central nervous system (neuronal plastic).

And also on the ability of synapses to functional and morphological rearrangements in the process of activity. In order to clearly demonstrate this, scientists injected the drug into young, adult and old animals that are practically not amenable to education and training.

In the course of experiments, models with a history of a disease that develops due to a lack of oxygen necessary for the functioning of the brain (cerebral ischemia), the size of the affected muscle tissue decreased during a heart attack, as well as:

• the appearance of puffiness was minimized;
• blood circulation in the smallest blood vessels has stabilized;
• Cognitive and neurological impairments normalized, and survival rates doubled.

With Alzheimer's disease, the symptoms of which are personality changes, impaired memory and progressive decline in intelligence, Cerebrolysin increases the concentration of molecules responsible for the transport of glucose across the barrier between capillary blood and neurons of the central nervous system. This allows you to compensate for the critical energy deficit that is characteristic of this diagnosis.

Cerebrolysin injections improves cognitive function and the patient's ability to self-care. Regardless of what the indications for use are, the first improvements in health are noted after 14 days. Neurodegenerative processes first slow down their progression, and then stop altogether.

Indications and contraindications for use in injections

Doctors design a treatment regimen with Cerebrolysin and give the patient a prescription for the drug for the neuropsychiatric syndrome of acquired dementia, which is medically called dementia. With this diagnosis, due to brain damage or diseases, the psyche is partially destroyed (only after the age of three).

Other indications include the following diagnoses:

• discirculatory encephalopathy or chronic cerebrovascular pathologies;
• ischemic stroke;
• Alzheimer's disease;
• mental retardation in children, when toddlers start talking late and have impaired motor / cognitive abilities;
• intracranial injury, spinal cord injury;
• neurological-behavioral developmental disorder characterized by problems with concentration and poorly controlled impulsivity, attention deficit;
• endogenous depression with resistance to psychotropic drugs (antidepressants).

It is strictly forbidden to inject Cerebrolysin in the acute form of the syndrome of impaired renal function. And also when the patient is prone to epileptic seizures, which follow one after another and last at least half an hour. Another contraindication is hypersensitivity or intolerance to the active components of the neuroprotective drug.

Exclusively under the strict supervision of Dr. Cerebrolysin is used in the first 3 months of pregnancy and during lactation. In most cases, during lactation and while carrying a child, the doctor prescribes the drug only when the possible risks for the newborn are fully compensated for by the benefits for the future mother. In the course of clinical studies, it was found that Cerebrolysin does not have a negative effect on embryonic development, but it is still not worth the risk.

Method of administration and dosage

This neuroprotector is characterized by a parenteral route of administration, in which its active substances bypass the digestive tract. The dosage regimen and the duration of the therapeutic course depends on the symptomatic picture, the severity of the diagnosis, and also on how old the patient was at the time of treatment.

Some diseases involve a single administration of Cerebrolysin (the volume of the injected drug should not exceed 50 ml), but in order to increase the chances of recovery and relief of symptoms, it is recommended to give preference to a full course. The duration of this treatment is 10 to 25 days. Information on the recommended doses of medication in accordance with a particular diagnosis is collected in the table below.

Diagnosis	Method of treatment
Complications after a stroke, manifested in the form of paralysis of the muscles of the limbs and face, complete loss of motor activity of the muscles of the arm or leg, as well as acute impairment of cerebral circulation.	15 ml of solution intravenously, or dilute 50 ml of the drug in a solution of sodium chloride, glucose and Ringer for setting a dropper.
Damage to the bones of the skull and / or soft tissues (meninges, brain tissues, nerves, blood vessels), the consequences of neurosurgical operations.	10 to 50 ml intravenously.
Alzheimer's disease, dementia, endogenous depression.	5 to 35 ml IV.
In neurological pediatrics.	No more than 1-2 ml intravenously every 24 hours.

Cerebrolysin injections, the indications for the use of which were indicated earlier, must be administered slowly. Haste when giving an injection is fraught with hyperhidrosis, dizziness, nausea and a feeling of heat. Some patients complain of a rapid heartbeat or a condition where the heart rhythm is not sinus at a frequency of 60-100 beats per minute.

As for side effects as a result of a violation of the dosage regimen or individual intolerance to the active components, then from the internal organs that perform the function of mechanical and chemical processing of food, vomiting, constipation, dullness or complete loss of hunger, frequent liquid chair.

On the part of the nervous system, the following side conditions are encountered:

• aggressiveness;
• confusion of consciousness, expressed in personality disorientation and inability to navigate in the area / time;
• insomnia;
• epileptic seizures and involuntary contractions of certain muscle groups (these symptoms are extremely rare).

On the part of the immune system during the treatment with Cerebrolysin, hypersensitivity and allergies with severe migraines are manifested. Numbness of the limbs or lower back is possible, as well as recurrent pain in the neck. Some patients experience chills, a change in the frequency, rhythm and depth of breathing due to a feeling of lack of air, and circulatory collapse.

Local reactions are represented by rare symptoms in the form of redness on the skin, itching and burning at the injection site. In elderly patients, after injections of Cerebrolysin, it is rare, but involuntary oscillatory movements of body parts, hyperventilation, intense breathing that exceeds the body's needs for oxygen. Depression and detachment to everything that happens around is not excluded from the list. The perception of the surrounding reality (impaired consciousness), colds and coughs may also be impaired.

Particular attention should be paid to the point about drug interactions of Cerebrolysin with other medicines. Co-administration with antidepressants or monoamine oxidase inhibitors requires a reduction in the dose of drugs with thymoanaleptic effect and aimed at combating depression. It is strongly not recommended to mix a solution of Cerebrolysin and a substance that contains lipids or components that can change the pH of the medium for one injection.

The neuroprotective agent in complex therapy can be used together with vitamins and medications, the action of which is aimed at improving the coronary circulation. But the injections, again, must be done alternately, in no case mixing the drugs in one syringe.

Cerebrolysin (injections), the indications for the use of which are indicated above, does not have a negative effect on the ability to drive a vehicle or perform work that requires maximum concentration attention. But some patients may still experience undesirable side effects from the central nervous system, so during treatment it is better to refrain from driving.

Some analogues

Only the attending physician is able to choose a generic Cerebrolysin, which is based on the results of the tests and studies, the individual characteristics of the patient. The dosage regimen and the duration of the course of treatment are also determined on an individual basis. The most popular analogs of the neuroprotector include the following names.

Mexidol

Available in the form of tablets and solution for intravenous / intramuscular administration. It contains ethylmethylhydroxypyridine succinate (active ingredient), lactose, magnesium stearate and sodium carboxymethylcellulose.

Mexidol, as a heteroaromatic antioxidant, performs the following functions in the body:

• increases stress resistance indicators;
• prevents memory impairments that often occur in the elderly;
• stimulates microcirculation and reduces the concentration of platelets;
• has an anticonvulsant effect;
• improves the metabolism of brain tissue and the process of blood flow to them.

Mexidol is prescribed for cardiovascular / respiratory disorders, poor stress tolerance and physical exertion. Other indications for use are craniocerebral trauma, withdrawal symptoms for alcoholism, encephalopathy, and ischemic heart disease.

The drug is contraindicated in people with an acute form of hepatic or renal failure, susceptibility to the substances that make up the composition. The average cost of Mexidol is 513 rubles.

Gliatilin

Cerebrolysin injections (indications for use are discussed in the article) because of its considerable cost, not everyone can afford. Therefore, it can be replaced with Gliatilin, a centrally acting cholinomimetic with a predominant effect on the central nervous system.

Due to the content of choline alfoscerate, this drug optimizes the transmission of nerve impulses in cholinergic neurons. Has a positive effect on the movement of blood through the network of cerebral arteries and veins that supply the brain, enhances metabolic processes. During the research, it was also found that Gliatilin reduces cholinergic activity, improves elasticity of membranes, helps to restore consciousness in situations where the brain was affected in as a result of injury.

During pregnancy and lactation, injections of choline alfoscerate are strictly prohibited. The substance can negatively affect the development of the embryo or enter the child's body with mother's milk. Otherwise, the indications for this analogue of Cerebrolysin are the same as for the original drug. The cost of one pack of ampoules is 615 rubles.

Cerebrolysate

Solution for intramuscular administration, which is distinguished by its yellow color and specific aroma. It, like Cerebrolysin, contains organic compounds and biologically active peptides that can penetrate to nerve cells, thereby improving metabolic processes. A nootropic drug by stimulating the bioelectrical activity of the brain increases the reserve compensatory capabilities of hemodynamics and minimizes neurological deficits.

It is advisable to use Cerebrolysate in the complex treatment of encephalopathy, movement disorders that occur in children due to damage to various brain structures in the perinatal period. The indications also include the consequences of ischemic stroke, compression of the spinal roots, traumatic brain injury. If the patient is prone to seizures, hypersensitivity to the components of the medication and during pregnancy, Cerebrolysate should not be used

Exceeding the daily dosage (1-5 ml per muscle every day) for 3 weeks leads to manifestations of symptoms of an allergic reaction, increased blood pressure, pain and itching at the injection site. One package of Cerebrolysate will cost 1000 rubles.

Cerebrolysin in injections (and many of its analogues) is used not only in psychiatry, but also in narcology. Among the indications for use can be found alcohol dependence, memory improvement with excessive psychoemotional stress. But, in order not to harm yourself even more, it is imperative to consult a doctor. Moreover, you cannot buy Cerebrolysin without a prescription.

Video about the drug Cerebrolysin

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