Suppositories with Prednisolone rectal. Instruction, price

Rectal suppositories can be prescribed to eliminate hemorrhoids, constipation, or to treat dysbiosis. Of the listed options, suppositories for hemorrhoids are more popular, since other pathologies can be eliminated with oral agents, which are most convenient to use. Moreover, the most effective in the fight against hemorrhoids are candles with Prednisolone in the composition.

Chemical composition

The only variant of rectal suppositories with Heparin is presented in the form of domestic suppositories Hepazolon. The drug is produced in a torpedo-shaped head with a smooth surface. The candle has a white color, possibly a yellow or cream shade. Suppositories are placed in contour plastic blisters in the amount of 5 pcs. and 2 blisters per pack.

The medicinal properties of the drug, as well as the desired appearance, are provided by the following components:

List of elements	Description of the components
Basic substances
Prednisone	It is a hormonal component that has pronounced anti-inflammatory and anti-allergic properties. In addition, the component eliminates pain, itching and reduces the amount of exudate secreted.
Heparin	The substance thins the blood, preventing the development of blood clots. Also, the element eliminates swelling, inflammation and accelerates wound healing, due to the acceleration of tissue regeneration.
Lidocaine	The component has a strong local anesthetic effect.
Secondary components
Witepsol N15	The substance gives the suppositories the desired texture.

The mass of one suppository is 1 g. Additionally, the package contains instructions for using the drug.

Pharmacological properties

Rectal suppositories with prednisolone "Hepazolone" are a combined topical drug, possessing antithrombotic, analgesic, anti-inflammatory, as well as decongestant and anti-allergic effect.

Pharmacodynamics and pharmacokinetics

Suppositories with Prednisolone rectal after administration into the rectum have the following therapeutic actions:

• reduce the activity of mediators responsible for the development of inflammation, as a result, the inflammation process is rapidly supervised and does not spread to nearby tissues;
• restore the state of blood vessels;
• eliminate itching and burning;
• activate the process of tissue regeneration, as a result, the affected areas of the rectal mucosa recover faster;
• prevent blood stagnation in hemorrhoids;
• do not allow blood clots to form;
• eliminate tissue swelling;
• reduce the production of exudate (fluid released from blood vessels during inflammation);
• suppress the production of substances responsible for the development of an allergic reaction;
• quickly eliminate the pain symptom by acting on the transmission channels of nerve impulses;
• contribute to the narrowing of the lumen in the vessels, as a result, the bleeding stops faster;
• reduce vascular permeability, which increases with the development of inflammation;
• accelerate the healing process of small cracks and wounds;
• after undergoing a course of therapy with suppositories with Hepazolone, the likelihood of re-development of hemorrhoids decreases.

The described therapeutic effect of the suppository is noted in the first hours and lasts up to 1.5 days. The components of the drug are excreted in the urine and feces.

Restoration of tissues in the rectum is observed approximately 3-4 days of the course of treatment and is manifested by the following changes:

• the bowel movement becomes painless;
• bleeding from the anus stops;
• hemorrhoids decrease in size or completely dissolve;
• discomfort in the anal area is eliminated.

Positive dynamics is observed in about 99% of patients.

Indications for the use of rectal suppositories with prednisone

Rectal suppositories containing prednisone are prescribed by doctors in the following cases:

• the presence of a fistula (a narrow channel of a natural or pathological nature that connects hollow organs or body cavities) in the rectum;
• inflammation of the anal veins due to the development of thrombosis;
• identification of anal fissures in the patient, including bleeding;
• itching in the anal area caused by irritation or an allergic reaction;
• inflammation of the rectal tissue;
• hemorrhoids (external or internal) in mild and moderate severity, as well as during an exacerbation of pathology;
• tissue restoration after surgery in the rectum.

Suppositories are also prescribed before surgery in the rectal area, in order to prevent the development of these pathologies.

Contraindications

Suppositories with Prednisolone rectal are contraindicated for use if the patient has the following contraindications:

• intolerance to the elements that make up the suppository;
• diagnosis in the anal area of ​​a viral, tuberculous or fungal infection;
• profuse anal bleeding;
• carrying a child;
• increased intraocular pressure in severe form;
• violation of blood coagulation;
• severe disruption of the heart and adrenal glands;
• the presence of malignant tumors in the rectum;
• period of breastfeeding.

Suppositories with prednisone are not prescribed for patients under 12 years of age.

Methods for using rectal suppositories with prednisone

Rectal suppositories containing prednisone should be used according to the instructions that come with the drug, since depending on the purpose of the application of the dosage rule of the drug and the duration of the course change.

Features of using the drug depending on the type of pathology:

Purpose of use	Daily dosage	Course and features of treatment
External hemorrhoids	The suppository should be injected in the morning and evening or only in the evening. In this case, it is not required to inject the suppository deeply, the composition of the drug must be in the affected area.	7-10 days.
Internal hemorrhoids	The drug is used in the morning and evening. The medication should be injected as deeply as possible so that the components of the agent fall into the zone of hemorrhoids development.	1-2 weeks.
Hemorrhoids in the acute stage	The candle is used 2-3 times every 24 hours. The depth of administration of the suppository depends on which area (external or internal) hemorrhoids appear.	5-7 days. Further, the dosage is reduced to normal. The total duration of therapy is about 14 days.
Fistula	The medication is used in the morning and evening. The depth of the suppository depends on the location of the fistula.	The tool is used in complex therapy for no more than 2 weeks.
Inflammation of the anal veins	Candles are injected in the evening at a medium depth.	Duration of treatment is 10-14 days.
Anal fissures	Suppositories are used in the morning and evening. If the pathology is running, then the drug can be used even in the daytime.	The course of using the medication is 2 weeks.
Itching in the anal region	The remedy is used mainly in the evening, but it is also possible in the morning. Depends on the severity of the itching.	Use a suppository as needed, but not more than 2 weeks if the product is used daily.
Inflammation of tissues in the rectum	Insert the suppository into the rectum at a medium depth in the morning and evening. With a mild form of pathology, it is enough to use the drug only in the evening.	The duration of therapy is 10-14 days. It is advisable to use complex therapy.
After rectal surgery	The drug is used 1-2 times every 24 hours. The exact dosage is set individually.	Use the medication for no more than 2 weeks.
Preparation for rectal surgery	Candles are used 1 time in the evening. The depth of insertion depends on the location of the surgical site.	Suppositories are prescribed approximately 3 days before the operation.

In severe forms of the listed pathologies, as well as if the patient has chronic diseases, then the dosage and course of treatment should be established by a specialist on an individual basis.

The course of treatment will have a greater therapeutic effect if, before starting its passage, you familiarize yourself with the main nuances of using rectal suppositories:

1. Before using the suppository, it is recommended to clear the rectum from feces. To do this, you can use enemas or oral laxatives.
2. After the defecation process, hygiene procedures must be performed. If the anal area is not thoroughly washed with soap, then along with the suppository, an infection can be introduced into the rectum.
3. Wash and dry hands thoroughly.
4. Separate one suppository from the blister, print it. To do this, pull on the edges of the package (the place where they are pointed).
5. Place the suppository on a clean saucer.
6. The patient should take a horizontal position, it is better to lie on the side.
7. To make the anus as relaxed as possible, it is advisable to bend the "upper" leg at the knees and pull it a little to the stomach.
8. Take the suppository in your hand and hold it in your closed palm for about 15 seconds. Thanks to the heat, the candle will melt a little and it will be easier to insert it into the anus.
9. Insert the suppository to the desired depth with the pointed edge forward. Usually it is inserted up to the middle of the index finger. In this case, push the buttocks with your free hand.

Advice, if the suppository is difficult to inject, then the anal area can be pre-lubricated with petroleum jelly. After the injection of the drug, it is enough to wipe the anus with a dry napkin.

1. Remove the finger from the rectum and make sure the suppository does not come out of the anus.
2. Straighten the "upper" leg and roll over onto your stomach. Remain in a supine position for approximately 15-20 minutes. If the drug is used to treat external hemorrhoids, it is recommended to stay in the supine position for about 40 minutes.
3. After the allotted time, wash your hands with soap and water.

If you ignore the listed rules, then most of the drug will quickly flow out without providing the desired therapeutic effect.

Side effects

Rectal suppositories are recommended to be selected and used as prescribed by a specialist, and to strictly observe the dosage.

If these conditions are ignored, suppositories with Prednisolone can cause the following negative reaction:

• prednisolone is a synthetic hormonal substance, so suppositories can cause an increase in the production of hormones by the adrenal glands;
• oppression of the adrenal glands;
• the development of hormone-dependent diabetes;
• decreased sensitivity to glucose;
• changes in the functioning of the heart;
• a decrease in the amount of potassium in the body;
• violation of the rhythm of heart contractions;
• an increase in the value of blood pressure;
• decrease in the number of heartbeats;
• dizziness;
• sleep disturbance and the process of falling asleep, or vice versa, increased drowsiness;
• increased sweating;
• a decrease in the number of platelets in the blood, it is dangerous to develop bleeding, including internal;
• muscle weakness and fatigue;
• increased intraocular pressure;
• deterioration of bone fusion in fractures, therefore, in case of a fracture, it is advisable to discontinue the use of the suppository;
• increased urge to urinate;
• hearing impairment;
• cramps or tremors of the limbs;
• formation of sand in the kidneys;
• breathing disorder;
• increased itching, burning or redness in the anal area as a result of the development of an allergy to the composition.

The severity of the development of side effects is due to the absorption of the components of the drug into the blood in the rectum. The listed side effects appear in patients usually on the 5-6th day of the course.

Overdose

An overdose with suppositories can develop if the suppositories are used more often than indicated in the instructions, as well as if the drug is accidentally taken orally.

In case of drug poisoning, the following symptoms appear:

• severe disruption of the adrenal glands;
• development or exacerbation of diabetes;
• pain in the region of the heart;
• in extremely rare cases, cardiac arrest;
• a sharp increase or decrease in the pressure indicator;
• stomach ache;
• severe diarrhea and vomiting;
• faster or slower heart rate;
• violation of the composition of the blood;
• a sharp decrease in the quality of hearing and vision;
• impaired coordination of movement due to severe dizziness;
• loss of consciousness;
• severe lethargy drowsiness;
• severe muscle pain;
• profuse sweating;
• the development of bleeding, which is difficult to stop due to a strong decrease in the number of platelets;
• urinary incontinence;
• severe cramps;
• the appearance of kidney stones;
• increased fragility of bones and a violation of the condition of the teeth;
• suffocation, respiratory arrest is not excluded.

When the patient is allergic to the composition, anaphylactic shock may develop. If an overdose has occurred as a result of an increase in the dose of the drug, then the drug is canceled and symptomatic treatment is performed. When the poisoning has occurred as a result of oral administration of a suppository, it is necessary to perform a gastric lavage (in within 30 minutes after poisoning), then sorbents are used for faster withdrawal of the drug components from organism. After this, symptomatic therapy is prescribed.

In the case when the victim's symptoms are expressed in a vivid form, you should immediately call emergency help.

special instructions

Suppositories with Prednisolone rectal must be used in accordance with the following rules:

• for the period of use of the suppository, you need to use sanitary pads, since part of the candle flows out onto your underwear and stains your clothes;
• inject the suppository to the depth indicated in the instructions, depending on the purpose of use;
• if the suppository was installed incorrectly and leaked out, or if an act of defecation occurred immediately after the manipulations, then hygiene procedures should be performed and the candle should be re-inserted into the rectum. If the leakage of the drug or the process of defecation is repeated again, then the candle is already injected into the next "reception";
• open the suppository before use, do not print the drug in advance;
• it is advisable to enter the first suppository in the morning to check for an allergic reaction and a tendency to side effects;
• if a negative reaction is detected in a patient, after using the medication, or if the patient has contraindications, then suppositories with prednisolone are not used;
• candles Hepazolon cannot be combined with alcohol, as it will provoke an increase in adverse reactions;
• for the period of use of the suppository, it is recommended to abandon driving vehicles and performing hazardous work.

To accelerate recovery, and to exclude a repetition of the development of pathology, combine the use of a suppository (and also after the end of the course of therapy) is necessary with dietary nutrition and an increase mobility.

Drug interactions

Rectal suppositories with Prednisolone should be used with caution with other hormonal agents, as they will increase the severity of side effects. Also, the medication cannot be used simultaneously with other rectal drugs. If necessary, the interval between the introduction of funds should be at least 1 hour.

Since suppositories have a fairly large list of contraindications and side effects, it should be used in complex treatment only with the permission of a specialist.

Analogs

Suppositories with Prednisolone rectal can be replaced with analogues. Replacement is carried out by a doctor in cases where the drug did not fit in composition, its use caused the development of side effects, or when the desired result is not observed on the 4th day of therapy.

List of possible analogs with a short description:

Name of analogues and price	Active element and its action	Instructions
Proctosed. The average cost is 500 rubles. Available with a prescription.	Suppositories with a hormonal composition (including hydrocortisone) provide analgesic, anti-inflammatory and antipruritic effects. Additionally, the product has an antibacterial effect.	Indications, contraindications for the remedy are identical to the original. But in addition, the medication helps to destroy the infection in the rectum, unlike Hepazolone. The drug is used 1-2 times a day for no more than 7 days. The use of the drug can cause the development of allergies and the addition of an infection, other side effects have not been recorded.
Betiol. The average price is 100 rubles. You don't need a prescription to buy.	Suppositories have a natural composition and provide analgesic, antispasmodic and anti-inflammatory effects.	Used to eliminate hemorrhoids and anal fissures. The drug is not prescribed until the patient reaches 18 years of age, as well as for glaucoma and adenoma. The agent is injected into the rectum 3 times every 24 hours for 7-10 days. The course of treatment may be accompanied by nervous overexcitation, blurred vision and increased dry mouth.
Olestezin. The cost is about 200 rubles. Leave without a prescription.	Suppositories are presented in a combined composition with benzocaine. The drug has analgesic, antimicrobial and anti-inflammatory effects. Additionally, the components of the drug accelerate the process of tissue regeneration.	The indications for the use of the medication are identical. Mediums of contraindications to suppositories are only allergic to the composition and age of the patient up to 18 years. The agent is administered in 1-2 suppositories 2 times a day. The course is 7-10 days. The use of Olestezin can only provoke a thinning of the stool and an allergic reaction. No other data available.

In addition to the drugs considered, rectal suppositories Hepazolon can be replaced with drugs:

• Ultraproject. The drug is dispensed with a prescription. Estimated price 600 rubles;
• Relief. Suppositories are sold freely. The approximate cost of 450 rubles.;
• Anusole. The drug is dispensed without a prescription, the approximate price is 100 rubles;
• Posterized. You don't need a prescription to buy, the estimated cost is 500 rubles;
• Proctosan. Candles are sold freely, the approximate price is 300 rubles;
• Nigepan. Suppositories are dispensed by prescription, the approximate cost is 300 rubles.

The replacement of the suppository should be carried out by the doctor, since it is important to choose a suitable analogue, taking into account the indications, contraindications and the reason for replacement.

Terms of sale and storage, prices

Since suppositories are hormonal, a prescription from a doctor is required to purchase them. At home, it is required to store the medication in a dark place at a temperature of 2-15 degrees above zero.

In a whole package, the shelf life of candles is up to 24 months from the date of production. It is required to store the medicinal product in a place protected from children.

The cost of the Hepazolone suppository depends on the point of purchase, manufacturer and pharmacy margins. Average price range 350-450 rubles. for 10 suppositories.

Rectal suppositories, despite the hormonal composition, subject to the rules of use, rarely cause the development of adverse reactions, while the effectiveness of the agent is high. The drug not only fights the signs of hemorrhoids, but quickly and permanently eliminates the pain symptom, thanks to its inclusion in Prednisolone.

Author: Kotlyachkova Svetlana

Video about suppositories with prednisone

Prednisolone is a multifunctional hormonal drug: