Analogs of NO-SHPA in tablets are cheap. Price

Violations of the gastrointestinal, urinary tract, blood vessels are accompanied by involuntary muscle contractions or spasms. To relieve pain and normalize the work of internal organs, antispasmodics are used. 30% of patients with digestive dyskinesia choose No-shpu in tablets or similar analogues of the drug.

Drotaverin, the active ingredient of the drug, was synthesized at the Hungarian plant "Hinoin" in 1961 and patented under the trade name "No-shpa".

The medication is 4 times more active than papaverine and has a number of other advantages:

• bioavailability 100%;
• used for renal diseases, prostatitis;
• relieves vascular spasm without lowering pressure;
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• does not show serious side effects;
• thins the blood, which is important for intestinal ischemia;
• does not mask the symptoms of the disease when making a diagnosis.

A universal antispasmodic reduces the painful tone of smooth muscles, regardless of the location of the pathology, thanks to which it is used by doctors in 50 countries. In clinical trials, the drug has shown efficacy in 60-70% of patients. No-shpa is available in 40 mg tablets, an increased dosage of 80 mg, injections.

Compositional analogs

Well-known pharmaceutical factories have established the production of generics No-shpy. The basis of these drugs is drotaverin, but differences in production technology, purification of raw materials, auxiliary fillers affect the effectiveness. The main advantage of analogs is the low price compared to the original, since a percentage of the cost of a patent is included in the brand value.

A cheap drug is less likely to be tampered with than an expensive one.

The mechanism of action of drotaverine: relaxation of the tone of the organs as a result of a decrease in the intracellular intake of calcium. The drug inhibits an enzyme responsible for the biochemical process.

Indications:

1. Relief of spastic pains:

• biliary tract with cholecystitis, stones in the gallbladder;
• urinary tract with cystitis, pyelitis, urolithiasis;
• Gastrointestinal tract with ulcers of mucous tissues, colitis, irritable bowel syndrome.

1. In gynecology and obstetrics:

• for the complex treatment of dysmenorrhea;
• for opening the cervix during planned childbirth.

1. Adjunctive therapy:

• during FGS, colonoscopy;
• in preparation for the operation.

The medicine relieves headaches associated with prolonged tension of the cervical muscles, uncomfortable posture.

Contraindications:

• AV block II – III degree;
• allergy;
• renal, liver failure.

Drotaverine is not recommended for pregnant and lactating women due to insufficient statistics. Children are assigned from 6 years old, special notes are indicated in the instructions.

Side effects: tachycardia, sweating, dermatitis.

Analogs of No-shpy in tablets are used according to a single scheme. The maximum daily amount of medication is 120-240 mg, divided into 3 doses. Individual doses, the duration of the course are determined by the attending physician. Russian generics do not undergo clinical trials, but are tested for bioequivalence to the original: solubility, optimal dosage.

Comparison of prices of direct analogs:

A drug	Manufacturer	Price in rub.
Doverin 40mg No. 48	Avexima, Russia	130
Drotaverin 40mg No. 50	Organic, Russia	40
Drotaverin-TEVA 40mg No. 20	Bulgaria	79
Spazoverin No. 30	India	130
Drotaverin 40mg No. 20	Biosynthesis, Russia	18

Judging by the reviews of patients, analogues help no less than the Hungarian drug No-shpa. Exceptions are explained by the increased sensitivity of the body.

Action analogs

The ability to relax muscle tone is possessed by substances of different composition and chemical structure.

The class of antispasmodics is divided into subgroups, united by the mechanism of action:

• neurotropic drugs, pain relievers due to impaired conduction of nerve impulses;
• myotropic medicines that work at the level of intracellular biochemical processes;
• complex drugs of general action;

Neurotropic antispasmodics

Atropine sulfate, platifillin, scopolamine quickly relieve pain, are included in the ambulance range. Used by injection, prescription. The mechanism of action affects the receptors in the brain, so complications from the cardiovascular and other systems are possible.

Analogs of No-shpy in tablets are also presented by "Buscopan", which acts on the muscles of the gastrointestinal tract, without affecting the brain. Contains hyoscine, which helps with kidney, intestinal colic, treatment of stomach ulcers. Disadvantages - high cost and side effects. Shows atropine-like properties, dispensed by prescription.

Myotropic antispasmodics

Among this category there are drugs that act on the entire fine muscles, and there are drugs that affect only the muscles of certain organs.

Antispastic drugs Papaverine and later invented Drotaverin are popular among Russian patients due to their effectiveness and low price. However, the lack of selectivity of action narrowed the range of application of these drugs in clinical medicine. In chronic pathologies, such as irritable bowel syndrome, disorders of the sphincter of Oddi, it is necessary to increase the dose. At the same time, there are adverse vascular side effects.

Galidor 100 mg No. 50

This myotropic drug is used in neurology, cardiology, gastroenterology. Halidor exhibits both vasodilating and antispasmodic effects, therefore it is used for multipurpose therapy:

• circulatory disorders of the brain;
• obliterating arteritis;
• hypermotor states of the gastrointestinal tract;
• spasms of the urinary tract.

The advantages of Halidor are a decrease in blood viscosity, local anesthetic activity. The disadvantages are side effects on the central nervous system, restrictions and contraindications, high price. A potent drug is dispensed from pharmacies as prescribed by a doctor.

Mebeverin

The invention of selective antispasmodics made it possible to select therapy with a predominant effect on the stomach, small or large intestine, and other organs. Spasm of muscle fibers of the gastrointestinal tract is eliminated due to the double action of mebeverine: blockade of sodium intake and depletion of calcium intracellular stores.

The advantage of the drug is a normalizing effect on the intestinal wall. The substance removes hypermotility, little suppressing peristalsis. Thanks to this feature, long-term treatment of irritable bowel syndrome does not lead to muscle weakening. Release form: sustained-release capsules containing 200 mg of active substance. Indications: spastic conditions of the gastrointestinal tract, mainly the intestines.

Contraindications:

• pregnancy;
• lactation;
• age under 18;
• hypersensitivity.

The regimen is prescribed by the attending physician.

In addition to Mebeverin-Vertex, pharmacies sell its direct analogs under the names:

• Duspatalin;
• Niaspam;
• Sparex;
• Dutan.

Comparison of Duspatalin and Niaspam

Analogs of No-shpy, identical in composition, are produced using different technologies, therefore there are differences in the effect on the gastrointestinal tract. Duspatalin capsules are covered with 2 protective layers that dissolve in the bile ducts, small intestine. Niaspam tablets gradually lose their membrane, affecting the entire intestine, including the lower section.

Properties	Duspatalin	Niaspam
Pain relief	80%	60%
Elimination of dyspepsia	32%	58%
Effect on bile secretion	Oppression	Does not suppress
Preferential indications	Duodenal motility, sphincter of Oddi	Whole intestinal motility, lower spasms

A contraindication for the use of Duspatalin is hypotension of the gallbladder.

Sparex

The selectivity of mebeverine analogs is an advantage over No-shpa, which cannot be said when comparing their cost. Sparex produced by ZAO Kanonfarma has the most competitive price: 30 capsules cost 275 rubles. The price of 50 tablets of Duspatalin is 650 rubles, and 30 capsules of Niaspam are 400 rubles. Research on the basis of the State Institution Scientific Center of the Russian Academy of Medical Sciences confirmed the bioequivalence of Sparex to the imported drug Duspatalin.

Gastroenterologists respond positively to the drug and are prescribed for the following violations:

• irritable bowel syndrome;
• gastrointestinal colic;
• pain in the abdomen associated with a disorder of the gastrointestinal tract.

The drug does not show serious side effects. Therapeutic intake: a tablet 3 times a day half an hour before meals. Not recommended for use under 18 years of age, during pregnancy and breastfeeding. Available without a prescription.

Trimebutin

The substance, discovered in 1969 in France, has become especially demanded by gastroenterologists. Like all analogues of No-shpa in tablets, the drug relieves gastrointestinal spasms.

Numerous clinical studies have revealed additional properties:

• "Balancing" effect on the motility of the gastrointestinal tract;
• anesthesia exceeding the effect of lidocaine;
• positive impact on the patient's psychosomatics;
• no adverse side effects.

  

The ability to normalize intestinal motility allows prescribing the drug for both constipation and dyspepsia, and can be used to treat children from 3 years of age. The Universal Medical Portal site calls the antispasmodic unique in terms of effectiveness - safety.

In Russia, there are two trade marks of trimebutin in tablets: Neobutin and Trimedat. The drugs are available in 200 and 300 mg for adults, 100 mg for children. Indications: gastrointestinal tract motor disorders, irritable bowel syndrome, reflux disease, flatulence. Patients respond positively about the effect of drugs, about the possibility of choosing a regimen.

Analogues of No-shpa in tablets Neobutin Retard and Trimedat Forte, containing 300 mg, are recommended to be used 2 times, 200 mg each - 3 times a day, before meals. Children from 3 to 5 years old with problems with the gastrointestinal tract are prescribed 25 mg, from 5 to 12 years old - 50 mg up to three times a day.

When comparing prices, Neobutin wins: the cost of 30 tablets is 470 rubles. The same package of Trimedat is 1.5 times more expensive - 650 rubles.

Dicetel

This myotropic selective antispasmodic is successfully used in the treatment of irritable bowel syndrome (IBS) as monotherapy and in complex regimens. Patients note after taking the rapid relief of pain, restoration of intestinal motility without laxatives. Dicetel reduces the production of gastric hydrochloric acid, eliminating additional antacids.

Standard packing - 20 tablets of 10 mg of active substance, pinaverium bromide. In the acute period, take one tablet with meals. After relieving the condition, 50 mg is enough three times a day, 2-4 weeks. Benefits: fast pain relief; selective effect on the muscles of the gastrointestinal tract, which makes it possible to use it for glaucoma and prostatitis. Disadvantage: high price.

Spasmomen 40mg No. 30

The active substance is otylonium bromide, which belongs to myotropic antispasmodics.

Indications:

• irritable bowel syndrome;
• biliary dyskinesia;
• mucous colitis, enteritis;
• preparation for studies of the gastrointestinal tract.

It is forbidden to pregnant and breastfeeding women, with glaucoma, hypersensitivity to the components. Price from the manufacturer Berlin-Chemie, Germany - 800 rubles.

Combined drugs

Analogs of No-shpy in tablets, combining several components, differ in efficiency and cost.

Papaverine with Platyphylline No. 10

The antispasmodic acts not only on the gastrointestinal tract, but also on the muscles of the uterus, bronchi, and blood vessels. Overdose is dangerous, therefore it is available with a prescription. The cost is 130 rubles.

Unispaz N No. 12, India

Ingredients: drotaverine 40 mg, paracetamol 500 mg. The drug combines antispasmodic, analgesic, anti-inflammatory effects.

Indications:

• spasms of the muscles of the gastrointestinal tract, urinary tract;
• dysmenorrhea;
• neuralgia;
• spasmodic headache.

Possible side effects: allergies, tachycardia, changes in the blood picture. Cannot be used for severe heart, kidney, liver, hypertension. Continuation of the course after three days of admission requires the consultation of the attending physician. Price RUB 87

Maxigan 500 mg No. 20

Components: analgesic metamizole, antispasmodic pitofenone, anticholinergic blocker fenpiverinium. Quickly relaxes muscles, relieves pain, fever, inflammation. When used for more than 7 days, monitoring of the condition of the blood and liver is required. Price 160 rubles. The advantages of combinations of antispasmodics with analgesics are a quick effect and a low price.

Flaws:

• summation of side effects of incoming substances;
• insecurity of long-term use;
• erasure of signs of the underlying disease, which complicates the diagnosis.

This group includes Spazgan, Spazmalgon, Trigan.

Herbal antispasmodics

Traditional medicine uses the ability of herbs to influence the muscle walls of the internal organs of a person. Decoctions and tinctures relieve spasms, pain, have no side effects. The pharmaceutical industry produces a phytopreparation based on tinctures of mint, wormwood, valerian and belladonna - Gastroguttal. Stomach drops eliminate spasms and pain in the gastrointestinal tract, soothe the central nervous system. Assign for hypoacid gastritis, colitis, cholecystitis, 20-30 drops per water up to 3 times a day.

The cost of 25 ml is 170 rubles.

Avisan

The tablets contain dry extract of dental ammonia. The plant relieves renal colic, removes salts in case of urolithiasis.

Indications: urinary tract spasms, cystitis, catheterization. It is used after meals, one tablet three times a day. The course is from 1 to 3 weeks.

Precaution: reception requires plenty of fluids to facilitate the movement of calculi through the ureters.

Cost - 70 rubles.

Odeston 0.2 No. 20

Modern technologies make it possible to create analogs of natural components. Odeston's active principle, gimecromon, is an example of such an invention. The composition of the drug includes a complex of extracts of lovage, fennel, chamomile and an active synthetic component that gives Odeston the quality of a selective antispasmodic. The action of the medication extends only to the biliary tract, without disturbing the contractions of the muscles of the gastrointestinal tract, without affecting blood pressure.

Appointments:

• non-calculous cholecystitis and cholangitis;
• disorders of the sphincter of Oddi by hypertype;
• nausea, constipation as a result of hypersecretion, stagnation of bile;
• postoperative condition associated with cholecystectomy.

Contraindications: ulcerative colitis, Crohn's disease, hemophilia. Not recommended for children under 18. Odeston is prescribed before meals, 200 mg, 15-30 days. The price of 20 tablets is 360 rubles.

Relief of spasmodic pain, reduction of smooth muscle tone is an important component of clinical medicine. No-shpa in tablets and its numerous analogues remain in demand among doctors of various specialties. Medicines are included in the Essential Medicines List. A range of different directions of action, composition options and prices allow you to choose the right medicine for each patient.

Video about the analogue of No-shpy

No-shpa or Drotverin - which is better: