Omeprazole during pregnancy 1-2-3 trimester

Omeprazole - antiulcer drug with pronounced properties, which is used in diagnosing pathologies of the digestive tract. The medicine is often prescribed during pregnancy when symptoms of a disease occur. Often, the 1st trimester is accompanied by such disorders. The use of the drug during this period requires a preliminary visit to the doctor, who will determine the appropriateness of the appointment and the duration of admission.

Composition and release form of the drug

The drug is available for purchase by patients in the form of capsules for oral use and a lyophilisate, from which a solution is prepared for parenteral administration. The capsules have a standard size and shape, blue color, and are packaged in plates of 10 pieces. Blisters are placed in cardboard packages of 1-12 pieces, a description is attached to them, which indicates the nuances of use.

The lyophilisate is a compressed white powder that is placed in a small glass bottle. When shaking the bottle, the mass disintegrates into a homogeneous powder. The bottle is placed in an individual cardboard box, a description is also attached to it. Capsules and powder have no specific aroma.

In the composition of the product, the substance omeprazole is present in various forms, which provides the main therapeutic effect.

The capsules contain auxiliary ingredients:

• Sodium hydrogen phosphate.
• Dodecahydrate.
• Cetyl alcohol.
• Hypromellose.
• Sucrose.

The lyophilisate contains additional substances in the form of disodium edetate, sodium hydroxide. 1 capsule contains 20 mg of the main substance, 1 vial of lyophilisate contains 40 mg of omeprazole.

Pharmacological properties

Omeprazole during pregnancy (the 3rd trimester can also be accompanied by disorders of the digestive system) is used due to its antiulcer properties. The drug belongs to the group of proton pump inhibitors, which allows it to be used to reduce the acidity of gastric juice.

As a result, the likelihood of damage to the mucous membranes of the stomach and duodenum is reduced against the background of active production of hydrochloric acid. The drug has a positive effect on the functioning of the patient's entire digestive tract.

Additionally, the drug reduces the likelihood of developing complications from the intestines and other organs of the digestive system.

Pharmacodynamics and pharmacokinetics

The drug acts rather quickly after oral administration or parenteral administration in the form of a solution. The absorption of the ingredient into the systemic circulation occurs quickly, it spreads throughout the body and has a healing effect on the body.

Omeprazole inhibits the last stage of the formation of hydrochloric acid, which reduces the acidity of gastric juice and minimizes the negative effect on the walls of the stomach.

There is also another effect on the body:

• The medicine helps to eliminate stomach pain, heartburn, which often bothers patients with increased acidity of gastric juice.
• Improves the functioning of the digestive tract, prevents the development of indigestion.
• Stimulates the production of digestive enzymes necessary for the normal functioning of the intestines and stomach.
• For several days, it helps to achieve a constant acid concentration at a minimum level.

The agent is well absorbed in the patient's body. Its maximum concentration is reached in the blood 40 minutes after oral administration. When using a parenteral dosage form, this period is somewhat reduced.

The processing of the ingredient is carried out in the liver. Disruption of the functioning of this organ can lead to a slowdown in the process, but does not reduce the therapeutic effect. After processing, excretion occurs with the help of the kidneys. Renal failure in acute or chronic form slows down the evacuation of components, can lead to the accumulation of substances of the composition in the body.

Pharmacokinetic features in pregnant patients do not differ, but a slight deviation is possible when used at a later stage of gestation.

Indications for use

Omeprazole can be prescribed during pregnancy if certain indications appear. Often, the 1st and 3rd trimester requires the use of medication.

The main indications for the use of the medication:

• Peptic ulcer of the stomach and duodenum in the acute stage. The drug relieves acute manifestations, preventing the progression of the disease.
• Gastritis with increased acidity of gastric juice.
• Frequent occurrence of heartburn in the absence of a history of stomach pathologies.
• Diagnosis of gastritis as a result of the multiplication of the bacteria Helicobacter pylori.
• Dyspeptic disorders against the background of increased acidity of gastric juice. The remedy can be used with the appearance of flatulence, nausea and vomiting, and some other symptoms that can lead to the development of complications.
• Reflux esophagitis, in which there is a regular reflux of stomach contents into the esophagus. In the last stages of gestation, women often suffer from such disorders.
• Diseases of the pancreas, in which complications from the stomach appear. In this case, the drug is used as part of a complex treatment to increase its effectiveness.

The medicine is used in short and long courses, depending on the severity of the symptoms of a particular disease.

Can I take the drug during pregnancy?

Official instructions indicate the possibility of using a pharmacological agent during gestation if necessary.

At the same time, the specialist takes into account the potential benefits for the mother and harm to the child. A woman alone cannot use a medication, even if she had previously taken it, but negative reactions did not arise.

Contraindications for use

Omeprazole during pregnancy (1 trimester is the most responsible and difficult for many women, especially when digestive disorders occur) can not always be prescribed to patients.

Contraindications for treatment include the following conditions:

• Intolerance to the components in the composition of the drug, both basic and auxiliary.
• Decrease in gastric acidity.
• Internal bleeding against the background of the progression of pathologies of the mucous membranes of the stomach.
• A severe form of liver failure, accompanied by a violation of the functioning of the organ.
• Kidney pathology of infectious origin in acute form, renal failure at an advanced stage. With a mild course of the violation, it is possible to use the medicine according to indications and under the supervision of a doctor.
• Severe gestation period, accompanied by toxicosis and other disorders. Despite the presence of complications from the digestive tract at this time, the use of the drug is not recommended.

For each patient, individual contraindications can be determined that are not indicated in the official instructions.

How to use Omeprazole during pregnancy?

The drug in the form of capsules is taken orally in a dosage prescribed by a specialist and for a certain time. Depending on the purpose of use and the specific disease, the treatment regimen may differ.

Pathology	Dosage and duration of treatment
With heartburn	When diagnosing heartburn, the drug is taken for 10 days in a minimum effective dosage of 20 mg. Reception is carried out in the morning on an empty stomach, it is important to drink the capsules with a sufficient amount of water. The duration of use may vary depending on the course of the pathological condition.
With gastritis	Gastritis is treated for 2 weeks. The daily dosage for a mild form is 1 capsule, that is, 20 mg. In severe cases of the disease, the dose is increased to 40 mg per day. The drug for gastritis is taken 30 minutes before meals, observing approximately equal time intervals.
With peptic ulcer	Peptic ulcer disease is treated for 2-4 weeks, depending on the severity of its manifestations. The dosage per day is 40-60 mg, it must be divided into 2-3 doses during the day with approximately equal time intervals.

Treatment of pregnant women is usually carried out with the help of capsules, since the solution contains 2 times more active substance, and its administration is carried out intravenously.

Only sometimes, if a woman cannot take capsules for various reasons, a lyophilisate is prescribed. It is administered intravenously using a dropper and a syringe. You must first dissolve the powder in saline. With jet infusion, 20 ml of sodium chloride is sufficient, with drip infusion - 100-200 ml.

Infusions are made once a day, and the course is usually not milked for more than 2 weeks. In each case, the choice of the dosage form is made by the doctor, taking into account the individual characteristics of the patient.

Side effects

Omeprazole during pregnancy (2 trimester may require prescribing medication if acute symptoms of gastritis) often provokes negative reactions, even if all recommendations are followed doctor.

Complications affect not only the work of the digestive system, but also other organs:

• Disorders from the digestive system are manifested in the form of constipation or frequent loose stools, abdominal pain and flatulence. Sometimes women note nausea and vomiting, as well as complications from the mucous membranes of the oral cavity in the form of stomatitis. Symptoms can appear after several days of therapy, sometimes disappear on their own or worsen.
• From the side of the musculoskeletal system, complications manifest themselves in the form of pain in the joints, muscles, weakness of the limbs and a decrease in physical activity.
• Often, the drug in various forms disrupts the functioning of the nervous system, which manifests itself in the form of headache, weakness, irritability and sleep disturbance.
• Hair loss is sometimes noted, as well as deterioration of the skin and nails.
• The drug can lead to visual impairment, loss of taste, and other sensory disorders. Such complications in women during gestation rarely develop, but can significantly worsen the condition.
• Allergy to the drug often manifests itself, accompanied by the appearance of a rash on different parts of the body and severe itching. Rashes can be observed only in certain areas of the skin, but often spread to the limbs and even the face. The condition worsens with an increase in the area of ​​the lesion, as well as scratching the skin.

Complications during pregnancy often appear in an acute form and worsen the woman's condition. Experts draw the attention of patients to the fact that it is important to immediately consult a doctor if negative symptoms appear.

Overdose

When taking the medicine in the prescribed dose, an overdose does not develop. If a woman accidentally takes a large dose of the medicine, such complications are possible. The condition is accompanied by the aggravation of all negative reactions, a general deterioration in well-being.

There is repeated vomiting during the day, upset stools, pain in the abdomen. In the absence of therapy, the condition is aggravated, the appearance of seizures, dizziness is possible. Allergy in case of overdose manifests itself in an acute form, accompanied by swelling of the mucous membranes of the throat. As symptoms progress, the disorder is accompanied by suffocation, which can be fatal.

It is prohibited to ignore the manifestations of an overdose, as well as to use any medications without the appointment of a specialist. Such symptoms are especially dangerous for women during the period of bearing a child. Overdose is treated in a hospital, the patient is constantly monitored, receives parenteral drugs.

special instructions

Omeprazole during pregnancy (the 3rd trimester of gestation is often accompanied by heartburn and indigestion associated with increased pressure on the stomach from the diaphragm) should be used with caution. For the first few days, a woman should monitor her condition, note positive and negative reactions.

If even a minimal positive effect is absent during the week, you need to visit a doctor. Perhaps the medication is not suitable for a particular patient and a change in treatment is necessary.

Drug interactions

The drug is not prescribed simultaneously with other drugs from this group, as well as some antibacterial agents. During pregnancy, several medications are rarely prescribed, but drug interactions are taken into account when prescribing.

If the drug is shown to be taken simultaneously with antacid medicines, it is necessary to take a break for at least 2 hours so that the effectiveness of Omeprazole does not decrease.

Analogues during pregnancy

During gestation, it is especially important to choose an effective substitute that is considered relatively safe for the patient.

The following means are considered the most effective:

• Omez is a popular analogue of Omeprazole based on the same active ingredient. The drug helps to suppress the acidity of gastric juice, improves the condition of gastritis, peptic ulcer and some other deviations. During pregnancy, it is prescribed in short courses of 10-14 days, if necessary. The substitute is available in the form of tablets and lyophilisate, which allows you to choose the most convenient form.

  

• Pantoprazole contains the component of the same name in the composition and has similar properties. Like the original, it reduces the acidity of gastric juice, helps fight heartburn, gastritis symptoms, peptic ulcer disease. During pregnancy, the agent is usually used in the form of capsules, which are taken orally. The dosage for patients usually does not exceed 40 mg per day, but sometimes 60 mg may be prescribed.
• Gastrozole in the form of capsules contains omeprazole as the main active ingredient, can be used as a substitute. The medicine in the form of capsules is used in diagnosing pathologies of the digestive tract, accompanied by increased acidity of gastric juice.

When choosing an analogue, it is worth considering its effect on the body of a particular patient, as well as recommendations from the manufacturer. A woman without an appointment cannot select analogues and take them at home.

Terms of sale, storage and prices

The medicine can be purchased at different pharmacies after presenting a prescription form. Its cost ranges from 60-130 rubles. depending on the dosage form and the amount of the drug in the package.

During storage, do not allow moisture and direct sunlight to come into contact with the product. The storage period of the capsules is 3 years, the lyophilisate is allowed to be stored for 2 years. After the expiration date, use is not allowed. The production date can be seen on the packaging.

Omeprazole is an effective antiulcer drug that is actively used to treat pathologies of the digestive system. The remedy can be used for women during pregnancy, if the intended benefit is higher than the possible harm to the child. Often, the 1st and 3rd trimester of gestation is accompanied by heartburn and concomitant manifestations, so doctors prescribe medications to prevent the progression of diseases.

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