Allopurinol (Allopurinol) analogs and substitutes for gout. Price

Allopurinol - it is an effective anti-gout remedy, which helps to disrupt the synthesis of uric acid. This drug is considered a structural analogue of hypoxatin. It inhibits an enzyme such as xanthine oxidase, which is actively involved in the conversion of hypoxanthine into xanthine, and even the latter into uric acid.

It is thanks to this effect that it is possible to reduce the concentration of uric acid and its salts in liquid media. the body, or rather in the urine, which allows you to dissolve urate deposits and prevent their formation in tissues and kidneys. After taking this drug or its substitutes, the urinary excretion of xanthine and hypoxanthine increases.

The drug is produced in tablet form, the main component is the substance of the same name.

It is thanks to this component that the drug is recommended for patients with the following problems:

• gout therapy;
• kidney stone disease, accompanied by the formation of urates;
• hyperuricemia;
• hemoblastoma;
• therapy of neoplasms, psoriasis, massive therapy with corticosteroids.

A specialist should prescribe and select a dosage in each individual case. Self-medication can lead to serious and irreversible consequences.

Allopurinol, according to those who have already tried its effect on themselves, is an effective remedy, which in a short time not only relieves symptoms, but also eliminates the cause that provoked the development ailment.

But you cannot take it uncontrollably, since the drug has contraindications:

• special intolerance to the active ingredient;
• serious impairment of kidney and liver function;
• intolerance to galactase, lactase, glucose-galactose malabsorption syndrome;
• women during gestation and breastfeeding;
• children under 6 years of age.

Uncontrolled intake of the drug can provoke the appearance of unwanted symptoms, manifested in the form of nausea, vomiting, skin rash, leukopenia, leukocytosis, amnesia, neuritis and other serious problems.

Allopurinol is sold in Russian pharmacies without a doctor's prescription, the average cost of one package of tablets with 100 mg of the active ingredient varies within 100 rubles. the price is low, but analogues and substitutes for the drug may be needed for those who have sensitivity to the components or any other contraindications.

Compositional analogs

Gout or gouty arthritis is an metabolic ailment in the human body that affects metabolic processes derivatives of uric acid, which ultimately provokes increased deposition of uric acid salts in tissues organism. It is because of these deposits that malfunctions of some organs and tissues are formed in a short time.

The joints, kidneys and other organs are most often affected. Serious problems can occur if no action is taken. It will not be possible to completely cure the disease, but you can achieve a stable remission, the main thing is to contact get qualified help and take effective medications such as Allopurinol or its analogs.

Purinol

Allopurinol, whose analogs and substitutes include Purinol, is a drug that is actively used in urology and is often recommended for patients with a diagnosis such as gout. Both drugs have an identical active ingredient, which has a special ability to inhibit the formation of uric acid. After taking both drugs, the concentration of uric acid in the blood is significantly reduced, due to which the active dissolution of urate stones occurs.

Both drugs are indicated for:

• psoriasis;
• gout;
• enzyme disorders;
• other serious pathologies.

Contraindications for both drugs are similar, and the undesirable manifestations of Purinol are much greater. The price of the drugs is identical.

Hello

Allopurinol (analogs and substitutes are described in this article) and Allo's remedy are 2 drugs that have an identical active ingredient. The dosage of the substitute is selected individually in each case, because it all depends on the patient's state of health and the complexity of the course of the disease. So, for example, if the symptoms are mild, then it will be enough to take 200-300 mg of the drug per day, but with pronounced symptoms, the dosage can be doubled.

The undesirable manifestations, contraindications and indications for taking the 2 drugs are identical. The only difference between them is the price: for Allo it is slightly higher.

Allupol

Allopurinol (analogs and substitutes) and Allupol are 2 identical medicines that help in the treatment of gout. Both drugs have the same active ingredient. But before making a replacement, it is better to consult a specialist.

As indicated in the instructions, for both drugs, the minimum dosage is 200 mg per day, and the maximum dosage is no more than 900 mg. In no case should the prescribed dosage be exceeded on your own, even if the symptoms persist. Increasing the dosage can lead to serious complications.

There are differences between the 2 drugs, for example, Allupol cannot be taken by people who have problems with the functioning of the kidneys and liver. While taking Allupol, it is imperative to monitor the work of internal organs. The price of both drugs differs little.

Milurite

When choosing an analogue of Allopurinol, you should pay attention to such a drug as Milurit. Both drugs have an identical active ingredient that helps to inhibit the formation of uric acid. It is in allopurinol and its main metabolite oxypurinol that it has the unique property of disrupting the synthesis of uric acid.

As a result of taking drugs, the concentration of uric acid in the blood decreases and urate stones dissolve. Both drugs have similar indications, contraindications, as well as undesirable manifestations in case of non-compliance with the established rules of admission. Their cost is identical.

Sanfipurol

This is another effective anti-gout agent that is considered the ideal analogue of Allopurinol.

The preparation contains an identical active substance that has the ability to inhibit the formation of lactic acid. Allopurinol and its main metabolite, oxypurinol, have the unique property of disrupting uric acid synthesis.

Both drugs contain 100 or 300 mg of the active ingredient. It is worth taking them twice a day, the dose is selected individually, depending on the severity of the disease. The indications, contraindications and undesirable manifestations of both drugs are identical. The price is also not much different.

Action analogs

While Allopurinol is suitable for some patients in the treatment of gout, others have a special sensitivity to its active component. It is for such people that it is required to select an analogue with an identical effect, but having another substance in its composition as the main component.

Colchicine

Allopurinol (analogs and substitutes can be taken only after agreement with the attending physician) and Colchicine are produced in an identical form - in tablets. Also, 2 drugs are prescribed for gout, but this is where the similarity of their properties ends.

Colchicine contains a substance of the same name, which also has a direct effect on the metabolic processes of uric acid in the human body. The substance belongs to the alkaloids isolated from the corms of the splendid columbus.

It is thanks to this component that the drug has a pronounced analgesic and anti-inflammatory effect. The tablets suppress the mitotic activity of granulocytes. Reduces the migration of leukocytes to the focus of inflammation, inhibits the phagocytosis of uric acid, delaying its deposition in the tissues of internal organs.

Colchicine has a minimum of contraindications: special sensitivity, pregnancy, and kidney and liver failure.

The number of undesirable manifestations is also minimal: vomiting, nausea, impaired renal function, with prolonged use, alopecia can be observed. There is one more difference - this is the price, for Colchicine it is much higher.

Febuxtat

Febukstostat is another effective Allopurinol substitute recommended for the treatment of gout. Comparing the 2 drugs, we can say that they are both available in tablet form and have inhibitory properties on the formation of uric acid. Both drugs have identical contraindications for admission. This is where their similarity ends.

As for the differences, the first is the active substance. In Febukstat, it is a component with the same name. The drug should be taken 1 time per day.

In case of exceeding the dosage or increasing the course, the following undesirable symptoms may be observed:

• gout attack;
• liver dysfunction;
• nausea;
• headache;
• allergic reaction.

The price of the analogue is much higher, almost twice.

Azurix

This is another medication that is prescribed to treat gout. There are a minimum of similarities between 2 drugs - Azurix and Allopurinol. One of them is the release form - tablets.

Azurix, as an active component, contains the substance febukstostat. It is thanks to this component that the drug is a derivative of 2-arylthiazole and is the strongest selective non-purine xanthine oxidase inhibitor. This enzyme catalyzes 2 stages of purine metabolism: the oxidation of hypoxanthine to xanthine, and then xanthine is oxidized to uric acid.

It is due to the inhibition of xanthine oxidase that the concentration of uric acid in the blood decreases. If the drug is taken in a therapeutic dosage, then it does not inhibit other enzymes that are actively involved in the metabolism of purines or pyrimidines.

According to the reviews of patients and specialists who prescribe Azurix, the drug is effective in the treatment of gout, but it has a lot of undesirable manifestations and contraindications. In addition, the price of the drug is significantly higher than that of Allopurinol.

Fullflex

Currently, this drug is very popular. It is he who is prescribed to patients with gout in case Allopurinol is not suitable for any reason. This drug is available in 2 forms: tablets and a cream for external use, which allows you to treat the disease from the inside and outside. The drug is included in the group of short-term drugs, has analgesic and anti-inflammatory effects.

Comparing both drugs, we can say for sure that they have different components. Fulllex contains many natural ingredients and each of them has its own special effect on the human body. The active ingredients and their properties are described in the table below.

Martiniya fragrant	It has many beneficial and healing effects. The components that make up it have a powerful anti-inflammatory effect, have an analgesic effect.
White willow bark extract	Copes with inflammation, quickly relieves pain. This extract is also often referred to as herbal aspirin.
Vitamins PP and E	Vitamins, as well as the correct diet, will help to quickly relieve symptoms and send the disease into long-term remission.

Also included are other components that are no less useful for the musculoskeletal system.

Among them:

1. Juniper extract.
2. Sage.
3. Essential oils:

• eucalyptus,
• willow bark,
• horse chestnut,
• birch bark.

Both drugs have identical indications:

• rheumatism;
• gout;
• arthritis;
• myalgia.

Contraindications and undesirable manifestations are also similar. Here is the price for Fulflex a little more expensive.

Liquidation

This is another effective analogue of Allopurinol, which is no less effective in treating gout, but is very different. If we compare 2 drugs, then they are similar in indications for admission and identical in form of release, but they have much more differences.

Likvestia has a completely different active ingredient - it is febuxostat. There are other equally significant differences, for example, Likvestia has almost no contraindications for admission, and undesirable manifestations observed in very rare cases, and then only when the patient tries to achieve a quick effect and independently increases the daily dosage. Likvestia also has another significant difference - the price is almost 7 times higher than that of Allopurinol.

Blemaren

This is another good and effective analogue for helping to dissolve urinary deposits. The drug additionally increases the pH level of the urinary fluid. The drug is produced in the form of effervescent tablets, which are recommended to be dissolved in a glass of water or a cup of tea before taking. Effervescent pills contain three active components at once: potassium bicarbonate, citric acid and sodium citrate.

It is thanks to this composition that the drug dissolves, and in the future it prevents the formation of uric acid stones and all due to alkalization of urine. Also, the agent reduces the excretion of calcium, improves the solubility of calcium oxalate in the urine, inhibits the formation of crystals, and therefore prevents the appearance of calcium oxalate stones.

The similarities between the 2 drugs are quite few - these are indications for admission, and so everything else is very different. It is for this reason that it is better to consult a specialist before starting to take the drug.

Allopurinol is an effective, inexpensive anti-gout drug that, when taken correctly, can help send gout into permanent and long-term remission. The drug is effective, but some people have a special sensitivity to its main component or to additional components, which is why you have to look for an equally effective analogue or substitute.

Only a specialist should select a drug, because many analogues have their own contraindications and undesirable manifestations and, in order not to provoke the development of complications, you need to know about them even before the start taking the drug.

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