Tabex (Tabex). Reviews of pills for smokers, price

Official phytopreparation Tabex used for the treatment of chronic tobacco addiction (dependence on nicatin). There is no nicotine in its composition, despite this, according to reviews on pills, it is not inferior in effectiveness medicines containing this substance, intended to relieve symptoms provoked by therapy dependencies.

The active ingredient is cytisine, which affects the human body in the same way as nicotine. The medication makes it easier to quit a bad habit, eliminating the unpleasant symptoms that accompany this period.

Composition and form of release

Round tablets of a light brown shade, film-coated, biconvex. The shade of the inner contents when cracked can vary from white to creamy.

Blister in the form of foil and PVC film cells contains 20 pieces. In a cardboard box there are 5 blisters and an insert-instruction in Russian and state languages.

The composition of each tablet:

Active substance:

• Cytisine. Content - 1.5 mg.

Supporting components	Content, mg
talc	2
microcrystalline cellulose	67,5
lactose monohydrate	28
magnesium stearate	1

Film coating composition:

Substances	Content, mg
opadry II brown	3
partially hydrolyzed polyvinyl alcohol	1,2
polyethylene glycol 3350	0,606
titanium dioxide	0,654
talc	0,444
iron dioxide: Red yellow black	0,018 0,062 0,016

Terms of sale

The drug is dispensed without a prescription. The cost in different pharmacy chains in which it is sold can vary up or down. The price starts at 1030 rubles.

Composition and action

The active ingredient, cytisine, does not undergo significant enzymatic changes when taken orally, it is easily absorbed in the digestive system. Cytisine is an alkaloid synthesized from the plant Cytisus laburnum. In terms of chemical composition, it is identical to lobeline and nicotine.

Prevents the latter from connecting to certain receptors, thus exerting an antagonist effect.

Under the action of the active component, the ability to start the mechanism that is the cause of the formation of dependence on tobacco is lost. As a result, negative manifestations gradually decrease and disappear.

Other pharmacodynamic properties of the active substance:

• excitement of the autonomic nervous system;
• involuntary activation of breathing;
• activation of the release of adrenaline;
• increased blood pressure.

Tabex (reviews of tablets can be found on the websites of pharmacy chains) contains the main component - the alkaloid cytisine, which has an n-cholinomimetic effect. Despite the fact that the mechanism of action is identical to that of nicotine, the active substance has a reduced level of toxicity and a high therapeutic index. Cytisine is much more effective in inhibiting the coordination of nicotine with certain receptors, which stimulates the gradual reduction and complete elimination of tobacco dependence.

Pharmacokinetic criteria for the active substance were studied after taking Tabex by 36 healthy volunteers inside 1 tablet (single dose of 1.5 mg).

The active ingredient is not synthesized in the human body. After ingestion, cytisine is rapidly synthesized from the intestines. The maximum plasma content is reached within 0.92 hours and is approximately 15.55 ng / ml. The kidneys excrete 64% of the dose taken during the day. The reabsorption time is approximately 4 hours. On average, the retention period of the active substance is 6 hours.

Clinical studies on the distribution of the drug in humans have not been carried out, therefore this information is not available. When tested on mice, after oral administration or intravenous administration, a high content of the active component in the plasma is established in the kidneys, liver, and adrenal glands. During studies on rabbits after oral administration or intravenous administration, the volume of distribution is 1.02 and 6.21 l / kg.

Indications for use

Tabex (reviews of pills can be studied on the Internet) is used to alleviate the negative manifestations caused by the refusal of cigarettes (nicotine addiction therapy). Physiological and psycho-emotional dependence - a condition characterized by the presence of constant desire smoking when a person is not able to abstain from cigarettes, even while realizing what harm nicotine does to the body.

Contraindications

Tabex has certain limitations in which its use for treatment is not recommended.

Tabax is categorically contraindicated in case of a history of the following pathologies and disorders:

• hypersensitivity to the active or auxiliary components of the drug;
• arrhythmia, angina pectoris;
• atherosclerosis;
• period of bearing the child;
• acute course of myocardial infarction;
• less than a month ago suffered a stroke;
• severe hypertension;
• hereditary disorders of the conversion of galactose into glucose (lactose is present in the medication);
• lactation;
• patients under the age of majority and elderly people over the age of 65.

Before you start taking Tabex, it is recommended to seek advice from a pharmacy employee where the drug is purchased, or a doctor, if the following pathologies are present in the history:

• ischemia: disorders of the blood supply to the muscle of the heart;
• weak heart muscle;
• diabetes;
• hypertension;
• cerebrovascular disorders;
• arterial disease obliterating;
• chronic and acute liver and kidney pathologies;
• increased functioning of the endocrine gland;
• adrenal neoplasms;
• stomach ulcer;
• regular reflux of stomach contents into the esophagus;
• certain forms of schizophrenia (mental disorders).

Mode of application

Tabex is recommended to be taken, strictly adhering to the instructions. If you have any pathologies and disorders, you need to consult a pharmacist or doctor.

Reception is carried out orally, swallowing the tablet and drinking it with a large volume of clean water.

Treatment regimen and recommended dosage:

1-3 days	Take 1 tablet every 2 hours (6 in total)
4-12 days	Frequency of admission - 2.5 hours for 1 tablet (total 5 pcs.)
13-16 days	Take 1 tablet every 3 hours (4 pcs. per day)
17-20 days	Reception every 5 hours (total 3 pcs.)
21-25 days	Take 1-2 tablets per day.

No later than 5 days from the day Tabex is started, it is recommended to stop smoking. The number of cigarettes smoked during therapy will decrease. If taking the drug did not give the desired effect, the treatment is stopped. You can renew it after 2 months. At the end of therapy, the patient should make every effort not to allow himself to return to the bad habit.

Side effects

Studies have proven excellent patient tolerance of the drug. The unpleasant sensations that arise are not pronounced. As a rule, it is observed on the first day of taking the medication and after a certain time they pass on their own.

This is more related to giving up cigarettes, and not a consequence of taking Tabex. Dizziness, sleep disturbances, migraines are observed. If you adhere to the dosage recommended by the instructions, no serious negative manifestations are observed.

Tabex tablets, according to reviews, after use, can provoke the following unpleasant symptoms:

The cardiovascular system	Rapid contraction of the heart muscle, an insignificant increase in blood pressure.
central nervous system	Sleep disturbances, irritability and migraines.
Respiratory system	Shortness of breath on exertion and at rest
Digestive tract	A feeling of dry mouth, taste changes, decreased or increased appetite, nausea, diarrhea, regular constipation, painful sensations of a different nature in the abdomen.
Muscle and connective tissue	Pain syndrome in the muscles.
Metabolism and diet	Intense sweating, dramatic weight loss.
Other	Pain in the sternum

If you experience any unpleasant symptoms that are not even described in the table, you need to get advice from a pharmacist or doctor. If the condition worsens, it is recommended to stop taking the pills and consult a doctor.

Overdose

If the dosage indicated by the instructions is exceeded, pupil dilation, heavy breathing, increased heart rate, vomiting may occur. First aid means gastric lavage by drinking large amounts of fluids, taking absorbent medications. It is necessary to monitor breathing, blood pressure and pulse.

special instructions

Tabex (reviews of pills are evidence of effectiveness if you want to get rid of a bad habit) are recommended to be taken only if a person is serious about quitting smoking. Continued smoking during drug therapy can provoke nicotine intoxication.

There have not been enough clinical studies of the effect of the active component of Tabex on the body of patients with a history of the following pathologies:

• partial or complete cessation of blood supply to the heart muscle;
• hypertension;
• diabetes;
• disorder of the ability to pump blood by the heart;
• pathology of blood vessels and brain;
• diseases of the arteries obliterating;
• excessive production of thyroid hormones by the endocrine gland;
• ulcers of the stomach and duodenum;
• liver and kidney pathology.

Taking the drug by patients suffering from any of the above pathologies is possible only after a comprehensive examination and assessment of the condition by the attending doctor.

Since studies of the safety of taking the drug in patients with mental disorders, chromaffin neoplasms of the adrenal glands and the regularly repeated throwing of gastric juice into the esophagus was not carried out enough, therefore, only a specialist can prescribe the drug, assessing the possible benefits and harm.

Also, there have not been sufficient clinical studies on the safe use of pills in patients under the age of majority and in the elderly over 65 years of age. Therefore, taking Tabex in people of this age is not recommended.

The medication contains an auxiliary component - lactose. Therefore, the reception is categorically contraindicated in patients with rare hereditary galactose intolerance.

The reception of Tabex does not affect the ability to control vehicles and work with potentially dangerous devices. Therefore, they can be taken by patients whose professional activities are related to driving.

Drug interactions

With an absolute cessation of tobacco smoking, negative manifestations may increase.

When taking drugs together, the active ingredient of which is pyridostigmine, acetylcholine, revastigmine, carbachol, galantamine, dystigmine with Tabex, often there is an increase in the following negative manifestations:

• increased salivation;
• tearing;
• cough with bronchial secretion;
• high rice developing an asthma attack;
• nausea;
• constriction of the pupils;
• increased muscle tone;
• colic;
• increased urination;
• unexpected muscle contraction.

Co-administration with HMG-CoA reductase inhibitors increases the likelihood of muscle pain.

Joint intake of tablets with antihypertensive medications weakens the effectiveness of the latter.

Analogs

Tabex (reviews of pills note the effectiveness of the medication) helps to facilitate the process of quitting smoking. He is able to relieve discomfort and negative symptoms.

There are several analogues of medicines with an identical effect:

• Brizantine. Available in tablet form. Thanks to domestic production, the cost is much lower than its foreign counterpart. Despite the fact that the analog has a different active substance, it is effective in the treatment of nicotine addiction.
• Nicorette. A medication from an American pharmaceutical manufacturer to relieve symptoms in the treatment of tobacco dependence. Release form - tablets for resorption. Released in a package of 30 tablets.
• Lobelin. Tablet form of release. It has an active component of the same name, which is synthesized from the leaves of some types of tobacco. In terms of effectiveness, the compound is not inferior to cytisine, but it has a milder effect. Gradually increases the tone of the autonomic nervous system, does not provoke sudden surges in blood pressure. Therefore, it is safe for patients with vascular and heart problems, especially those who have a long history of smoking.
• Nikvitin. It is a nicotine-based transdermal therapeutic system. The dosage is 7-21 mg. It is used to relieve the symptoms of smoking cessation. Contraindicated for the treatment of patients under the age of majority.
• Champix. The cost of the tablets is much higher than that of Tabex. The active ingredient is varenicline at a dosage of 0.5 and 1 mg. It has an identical effect, reducing the negative manifestations provoked by smoking cessation.

Store Tabex in its original cardboard packaging in a place protected from moisture, and also where there is no access for small children. The room temperature should not be higher than 25 degrees. According to numerous reviews of pills, they effectively help to facilitate the process of getting rid of tobacco dependence, smoothing out the negative consequences provoked by treatment.

It is categorically contraindicated to use an expired drug. The expiration date is indicated on the carton. Unused drug is not recommended to be thrown into household waste or sewage system. The method of disposal of the medication can be checked with the pharmacist or doctor.

Video about the drug Tabex

How to quit smoking with Tabex: