Tavegil in ampoules. Price, instructions for use, reviews

Tavegil is Swiss first generation antihistamine. The tool is produced in the form of tablets and solution in ampoules, for intravenous and intramuscular administration. The latter form of release is used mainly for the rapid relief of signs of allergy, in cases where the disease is life-threatening. Additionally, the price of the solution is higher than that of the tablets.

Composition and form of release

Tavegil in ampoules is released in the form of an injection solution, which is represented by a transparent liquid with a light yellow or light green tint. The medication is placed in transparent glass ampoules in an amount of 2 ml. Ampoules are in a protective plastic container in the amount of 5 pcs. The carton contains 1 container and instructions.

The components of the solution in ampoules are:

List of components	Component characteristics
The main component
Clemastine	The substance is a histamine blocker, it also has a sedative, mild hypnotic and antipruritic action, reduces vascular permeability, prevents the formation of puffiness and reduces the production of exudate.
Additional components
Sodium citrate	The element stabilizes the composition of the blood, and also reduces its clotting.
Ethanol	The component has a disinfectant and local irritant effect. Also, the element is necessary to extend the shelf life of the solution.
Sorbitol	The substance stimulates bile formation, activates the excretion of bile, eliminates spasms, also has a laxative effect, accelerates the elimination of toxins and is a sugar substitute.
Propylene glycol	The component is necessary to combine the components used and has a slight bactericidal effect.
Water for injections	The element is necessary to combine the substances used and to give the solution the required concentration.

The main element in 1 ml of solution contains 1 mg.

Terms of sale, prices

Tavegil in ampoules, the price of which varies depending on the manufacturer and the place of purchase, can only be purchased with a prescription from a doctor. It is required to store the product at home in a package and in a place protected from the sun, as well as at temperatures from 15 to 30 degrees above zero. The shelf life of a closed ampoule is 5 years.

Important. Ampoules should be used immediately after opening. Do not store open ampoules. It is also unacceptable for the drug to be available to children.

The price for 5 ampoules in Russia can vary from 250 to 300 rubles. At the same time, you can buy a medication not only in a regular pharmacy, but also order online (delivered by courier). It is recommended to first verify the authenticity of the site. To do this, you should pay attention to the date of its creation, the availability of reviews (there should not be only positive ones).

Pharmacological properties

Tavegil in the form of a solution for injection belongs to the group of antihistamines with antipruritic action.

Pharmacodynamics and pharmacokinetics

Tavegil in ampoules (the price of the product is considered budgetary) after intravenous or intramuscular administration, has the following effect on the body:

• helps to stop allergies;
• block the transmission of nerve impulses;
• relieves nervous and mental stress;
• reduces vascular permeability;
• eliminates muscle spasms;
• relaxes the walls of blood vessels, normalizing blood flow;
• reduces pain symptom;
• eliminates itching;
• normalizes the production and outflow of bile;
• accelerates the withdrawal of feces, providing a laxative effect;
• prevents the penetration and development of infection;
• reduces blood clotting;
• accelerates the removal of harmful substances, including toxins;
• prevents the development of puffiness;
• does not cause drowsiness;
• reduces the production of exudate.

The use of tavegil does not cause the development of mutations in cells, does not affect conception and does not contribute to the formation of tumors.

After the injection is made, the effect of the medication is noted immediately and can last up to 12 hours. Sometimes the therapeutic effect of Tavegil lasts for a day.

Indications for use

Tavegil in the form of a solution for injection is prescribed by doctors for the following allergic reactions:

• symptoms of pathology that manifested themselves after taking or injecting the medication;
• allergy after blood transfusion;
• anaphylactic shock. Pathology is manifested by a violation of the vital functions of all vital organs;
• severe swelling and redness of the skin, in addition, severe itching may be present;
• Quincke's edema. There is swelling of the mucous membranes, subcutaneous tissue of the muscles. Quincke's edema can cause severe suffocation and even cardiac arrest;
• severe allergic conjunctivitis;
• allergy damage to the digestive tract (manifested by vomiting, diarrhea, severe abdominal pain);
• a severe allergy arising from an insect bite;
• exacerbation of dermatological diseases of an allergenic nature;
• a febrile condition provoked by an allergic reaction;
• vascular inflammation after vaccination. Pathology manifests itself approximately 7-14 days after the procedure and is manifested by an increase in lymph nodes, fever, and joint pain.

Tavegil in the form of a solution for injection can be used for prophylactic purposes, in cases where the possible onset of an allergic reaction is life-threatening.

Contraindications

Tavegil in ampoules can not be used categorically until all contraindications are excluded. Since the plus and minus of the drug is its rapid penetration into the blood, in the end it can be difficult to eliminate the complication that has arisen (which appeared due to ignoring the contraindications). Also, doctors do not recommend using an injection solution with a low price, since most likely the drug is expired or it is a fake.

The list of contraindications to the use of Tavegil for injection:

• high susceptibility to the composition or the possible development of an allergy to the composition of the solution;
• carrying a child, all trimesters;
• the patient's age up to 1 year;
• breastfeeding the baby;
• bronchial asthma, especially during an exacerbation;
• the presence of pathologies (infectious or chronic) of the lower respiratory tract;
• narrowing of the opening between the stomach and duodenum;
• obstruction of the urinary tract;
• a stomach ulcer in the form of an exacerbation;
• increased intraocular pressure, including angle-closure glaucoma;
• an increase in the size of the prostate gland;
• disruption of work and heart condition in moderate and severe form;
• excessive production of thyroid hormones;
• high blood pressure;
• liver pathology in moderate and severe form;
• epilepsy or seizure tendency;
• violation of pigment metabolism;
• alcoholism, since the medication further increases the load on the liver.

Despite the contraindication to use Tavegil for children under 1 year old, in stationary conditions it is allowed to use the solution for injection from birth.

Method of administration and dosage

Tavegil in the form of a solution for injection is used for intramuscular and intravenous administration. The agent is not injected subcutaneously. Manipulations should be performed only in a hospital or in a polyclinic in a treatment room.

The standard dosage of the drug for patients over 12 years old is 1 ampoule 2 times every 24 hours. Children from 1 to 12 years old are administered 12.5 mcg 2 times a day.

The following are the rules for dosing the medication, taking into account the pathology:

Purpose of application	Age	Dosage and frequency of procedures	Notes (edit)
Allergy to a medication injected	1 to 12 years old	12.5 mcg 2 times a day.	The need to repeat the injections the next day is determined by the doctor. The course is determined individually.
Over 12 years old	2 mg 2 times every 24 hours
Allergy to a medicine used by mouth	1 to 12 years old	12.5 mcg once a day.	After the injection is given, the patient is advised to rinse the stomach, take sorbents and a laxative.
Over 12 years old	2 mg once a day.
Allergy after blood transfusion	1 to 12 years old	12.5 mcg 1-2 times every 24 hours.	If the allergic reaction is not very pronounced, then you can preliminarily perform hardware purification of the blood.
Over 12 years old	2 mg 1-2 times a day.
Anaphylactic shock or Quincke's edema	1 to 12 years old	12.5 mcg 2 times throughout the day.	If the drug does not work, then you may need to use another antihistamine.
Over 12 years old	2 mg 2 times within 24 hours.
Vascular inflammation after vaccination	1 to 12 years old	12.5 mcg once a day.	Tavegil is recommended for use in combination therapy.
Over 12 years old	2 mg once every 24 hours.
Allergy Fever	1 to 12 years old	12.5 mcg 1-2 times throughout the day.	The use of Tavegil is recommended to be combined with antipyretic drugs.
Over 12 years old	2 mg 1-2 times a day.
Allergy symptoms of moderate severity	1 to 12 years old	12.5 mcg 1 time in 24 hours.	Tavegil in ampoules is used in cases where the oral form does not work.
Over 12 years old	2 mg once a day.
Allergy prevention	1 to 12 years old	12.5 mcg 1 time in the morning.	Before use, Tavegil should be diluted with 0.9% sodium chloride solution. The proportions of the medication and solution are set individually according to age.
Over 12 years old	2 mg is administered once a day.

The table shows the approximate dosage and frequency of procedures. The exact course of therapy can be tweaked by a strictly treating specialist, taking into account the patient's age and condition.

If it is necessary to carry out manipulations at home (only on condition that the person who will inject has a medical education), when setting injections, a sequence must be followed, which depends on the type of injection (intravenous or intramuscularly).

Rules for the introduction of Tavegil intravenously

Features of the introduction of the drug intravenously consist of the following stages:

1. Initially, you need to lay the patient on a flat surface, face up. If the patient is able to sit, then he is seated in a chair next to the table.
2. After that, you need to prepare an ampoule, syringe, cotton swab, as well as a disinfectant (it is recommended to use medical alcohol).
3. Whoever will make the injection must disinfect their hands well.
4. Determine on which hand the veins are better visible and well palpable. If the veins are hard to see, a warm compress can be used.
5. Apply a tourniquet above the elbow and ask the patient to start clenching his hand into a fist. Manipulation will allow blood to flow into the vein, and the vessel will be easier to find.
6. Determine the vein into which the medicine will be injected. After that, the patient must put his hand on a special pad. Even if the patient is lying down.
7. Disinfect the puncture site with a needle.
8. Treat the "neck" of the ampoule with a disinfectant solution, then open the ampoule (open carefully so that glass particles do not get into the ampoule or on the floor) and draw the required amount of Tavegil into the syringe. If necessary, dilute the medication with saline. Important. Before opening, be sure to check the expiration date of the solution. It is indicated on the ampoule.
9. Release air from the syringe. This point is important. Since the ingress of air into a vein can cause death. To get all the air out, tap the syringe with the nail of your index finger.
10. Re-disinfect the puncture site and insert the needle up into the vein. It is required to insert the needle no more than half the length. The angle of the needle in relation to the vein is approximately 45 degrees.
11. Check that the needle is in the vein, for this you need to slightly pull the plunger of the syringe "towards you", blood should get into the syringe.
12. Gently remove the tourniquet to restore blood flow and inject the drug very slowly. The time of drug administration can last up to 3 minutes.
13. Apply a cotton swab with alcohol to the injection site, then remove the needle from the vein and clamp the puncture site well together with the cotton swab. Otherwise, blood will flow from the vein or a large hematoma will form. To do this, you need to bend your arm at the elbow or apply a bandage over the fleece for about 20 minutes.
14. Throw away the ampoule and syringe with a needle. The syringe cannot be reused.

Let the patient lie down until the condition stabilizes.

Rules for the introduction of Tavegil intramuscularly

The stages of drug administration intramuscularly are arranged in the following sequence:

1. Lay the patient on a flat surface on his stomach.
2. Prepare a syringe, ampoule, cotton wool, and disinfectant.
3. Whoever performs the manipulations must disinfect their hands.
4. Draw the medication into the syringe and release the air from it.
5. Divide the buttock into 4 squares. The injection should be placed in the outer upper square.
6. Treat the injection site of Tavegil with a disinfectant.
7. Ask the patient to relax the buttocks.
8. Insert the needle about 3/4 of the length (it should be perpendicular to the buttock) and slowly inject the drug into the buttock. When inserting the needle, it is important not to get into the nerve. And also make sure that the needle does not break.
9. Remove the needle and immediately apply a cotton swab dipped in alcohol to the puncture site.
10. The patient should be in a supine position until the condition is stabilized.

After completing the manipulations, you need to throw out the ampoule and syringe.

Important. If the Tavegil injection is done for the first time, then the procedure should be performed only in the hospital. Since the doctor must monitor the patient's response to the drug.

Side effects

Tavegil in ampoules, the price of which may fluctuate by region, may cause the development of a negative reactions in the body, even if all the rules are followed (dosage, subtleties of staging injection).

Side effects of the drug can manifest with the following symptoms:

• hand tremor;
• dizziness;
• increased fatigue and a feeling of fatigue;
• lethargy;
• deterioration in movement coordination;
• cramps in the limbs;
• short-term euphoria;
• nervous overexcitement and anxiety;
• tingling and creeping sensation on the skin;
• changes in the quality of sleep (drowsiness or insomnia);
• noise in ears;
• double vision;
• photophobia;
• stomach ache;
• bowel disruption in the form of diarrhea or constipation;
• dry mouth;
• violation of sputum discharge from the lungs;
• loss of appetite;
• a decrease in the number of platelets and red blood cells in the blood;
• increased heart rate;
• development of bronchospasm;
• decrease in blood pressure;
• violation of the outflow of urine or frequent urge to go to the toilet;
• respiratory failure, rhinitis, skin itching and other signs of the onset of the development of an allergy to the composition;
• the appearance of a hematoma at the injection site.

Any side effect should be reported immediately to the doctor.

Overdose

An overdose of Tavegil is possible if the dose prescribed by the doctor is exceeded.

In this case, the patient may complain of the following symptoms:

• nervous overexcitement or, on the contrary, complete apathy towards the outside world;
• the appearance of hallucinations accompanied by euphoria;
• severe abdominal pain with subsequent disruption of the digestive tract;
• diarrhea, constipation, or lack of urine;
• blood flow to the face (more often occurs if the drug is injected into a vein quickly);
• dilated pupils;
• a sharp deterioration in vision;
• congestion in the ears;
• a sharp and strong increase in the number of heart contractions;
• severe cramps or tremors;
• severe breathing disorder;
• drop in blood pressure;
• violation of gait as a result of impaired coordination of movement;
• severe dryness in the mouth.

In case of an overdose of Tavegil, it is recommended to give the victim saline laxatives to accelerate the withdrawal of the drug from the body. Additionally, symptomatic therapy can be prescribed.

special instructions

Tavegil in ampoules (the price of a solution can be checked with a doctor) should be used after becoming familiar with the following subtleties of use:

• when using Tavegil solution, it is strictly forbidden to consume alcoholic beverages. The prohibition is due to the presence of ethanol in the drug, as a result (in the case of taking alcoholic beverages), the load on the liver increases;
• the solution cannot be injected into the artery and subcutaneously;
• when injecting children and patients over 65 years of age, special monitoring of the patient's well-being is required;
• after using Tavegil, allergo tests should not be carried out for 5-7 days;
• Tavegil is strictly forbidden to use until all contraindications are excluded;
• injections with the drug should be carried out only by a specialist, especially if the medication is chosen to be administered intravenously;
• it takes a long time to inject the solution into the vein. Approximately 2-3 minutes. Faster administration of the medication increases the manifestation of side effects

The drug affects the nervous system and the quality of vision, therefore, driving vehicles and performing hazardous work is prohibited during the period of using the medication.

Drug interactions

Tavegil in the form of a solution for injection is allowed to be used in combination therapy only after the permission of the attending specialist.

Limitations are justified by the interaction of the drug with the following drugs:

• Tavegil increases the effect of antipsychotics (drugs used in psychiatric treatment);
• do not use Tavegil and blood thinners, as there is a high likelihood of internal bleeding;
• the simultaneous use of Tavegil and drugs to reduce pressure leads to an increase in the action of the latter;
• Tavegil also enhances the effect of sleeping pills and sedatives.

In addition, Tavegil cannot be used in conjunction with antidepressants from the group of MAO inhibitors. You can use the drug only a week after the end of the admission.

Analogs

Tavegil solution for injection is distinguished by a large list of side effects, so if a negative reaction has arisen to taking the drug or the medication is not suitable due to the presence of contraindications, then it can be replaced with the following analogs:

• Donormil. Tablets, the average price for which is 150 rubles. The active substance doxylamine succinate has a sedative, hypnotic and antihistamine effect. The drug is allowed to be taken from the age of 16. Additionally, the analogue has a minimal list of contraindications and side effects.
• Benadryl. Tablets and syrup, with an average cost of about 500 rubles. The main element of diphenhydramine hydrochloride has an antihistamine and sedative effect. The substitute can be used from birth. In addition, the drug has a small list of contraindications and side effects.
• Clemastine. Tablets, the average price of which is 250 rubles. The main component of clemastine, furamate, has only an antihistamine effect. The product can be taken from the age of 6. The analogue has a moderate list of contraindications and negative reactions.
• Sonmil. Tablets with an average cost of 250 rubles. The main element of doxylamine, succinate, has an antihistamine, sedative and hypnotic effect. A substitute is allowed for admission from the age of 15. The list of contraindications and side effects is small.
• Suprastin. Solution for injection and tablets, with an average price of 250 rubles. The active substance chloropyramine hydrochloride has an antihistamine effect. There are no age restrictions for use. The analogue has a moderate list of contraindications and negative reactions.

The choice of an analogue is carried out taking into account the reason for the replacement, as well as the general condition of the patient.

Tavegil in ampoules has become popular among patients due to its rapid effect. But in addition, users note a fairly frequent manifestation of a negative reaction, which often manifests itself in the form of dizziness and an increase in the number of heartbeats. Not a small plus of the medication is its budget price.

Author: Kotlyachkova Svetlana

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