Miscellaneous

Unidox Solutab. How to take pills, reviews

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Content

  1. Composition and form of release
  2. Terms of sale, prices
  3. Pharmacological properties
  4. Pharmacodynamics and pharmacokinetics
  5. Indications for use
  6. Contraindications
  7. Method of administration and dosage
  8. Uncomplicated gonorrhea
  9. Syphilis
  10. Uncomplicated urogenital infections, non-gonococcal urethritis, cervicitis
  11. Acne
  12. Prevention of malaria
  13. Prevention of diarrhea
  14. Leptospirosis
  15. Prevention of infections during abortion
  16. Severe gonococcal infection
  17. Renal or hepatic impairment
  18. Side effects
  19. Overdose
  20. special instructions
  21. Drug interactions
  22. Analogs
  23. Storage conditions
  24. Video about the drug Unidox Solutab

Unidox Solutab is an antibiotic with a wide range of influence. Belongs to the tetracyclines group. The tablets are required to be taken according to the instructions, not exceeding the indicated dosage. Otherwise, side effects with complications may occur. In this case, you should first consult with your doctor, because there are contraindications for use.

Composition and form of release

The antibiotic is presented in the form of biconvex, round tablets, the color of which can be yellowish-gray, yellowish or brownish interspersed. On one side there is an inscription "173", on the other - risk. The tablets are dispersible 100 mg.

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Unidox Solutab tablets. Instructions, how to take, reviews

The active ingredient of the drug is doxycycline 100 mg.

Additional components:

  • anhydrous colloidal silicon dioxide with saccharin;
  • hypromellose with magnesium stearate;
  • microcrystalline cellulose with lactose monohydrate.

Terms of sale, prices

10 tablets are contained in a blister contour package, which is made of aluminum foil and polyvinyl chloride film. A cardboard container contains 1 contour package with tablets, as well as instructions. The antibiotic is sold by prescription at the pharmacy. The cost of the drug is approximately 300 rubles.

Pharmacological properties

The antibiotic has antibacterial and bacteriostatic effects. It helps to suppress protein synthesis in the microbial cell, which provokes the destruction of the transport link of the RNA of the ribosomal membrane.

Pharmacodynamics and pharmacokinetics

It is an antibiotic with a wide range of effects and is in the tetracycline group. Affects bacteriostatically, inhibiting protein synthesis in microbial cells. It is active against most gram-negative and gram-positive microorganisms.Unidox Solutab tablets. Instructions, how to take, reviews

Some pathogens may develop resistance to doxycycline, as well as to other substances from the tetracycline group.

Antibiotic pharmacokinetics:

Processes Peculiarities
Absorption Absorption is increased and accelerated, while food consumption has practically no effect on this process. The maximum volume of doxycycline in the blood will be after 120 minutes. from the moment of consumption 200 mg. After a day, the indicator of the active ingredient will decrease to 1.5 μg / ml. With the consumption of 200 mg in the first 24 hours and 100 mg on the next day, the indicator will reach 1.5-3 μg / ml.
Accommodation After 45 minutes. from the moment the pill is drunk, the active ingredient will be found in the prostate gland, furrows gums, lungs, frontal sinuses, spleen, bile, kidneys, eye tissues, teeth with bones and liver. If the latter functions well, the concentration of the compound in the bile will be higher, in contrast to the blood. Doxycycline is able to be absorbed through the barrier of the placenta, while a small amount is found in breast milk.
Metabolism A small amount of the active ingredient is subjected to this process.
Withdrawal With a single consumption, excretion will occur within 18 hours. With repeated doses, the process will take 23 hours. 40% of the drug is excreted by the kidneys, 40% through the intestines.

If patients have a malfunction of the kidneys, the half-life of the composition will not change, since its excretion through the intestines increases.

Peritoneal dialysis with hemodialysis will not affect the concentration of the active ingredient in the blood plasma.

Indications for use

Unidox Solutab is required to be taken in the presence of infectious and inflammatory pathologies that were provoked by sensitive microorganisms:

  • Lyme disease with malaria, eye infectious diseases, anthrax, plague, psittacosis, actinomycosis, leptospirosis, tularemia, typhus;Unidox Solutab tablets. Instructions, how to take, reviews
  • as a prevention of purulent consequences after surgery;
  • diseases of soft tissues and skin, as well as severe acne;
  • pathology of the biliary tract and gastrointestinal tract in the form of cholangitis with diarrhea, dysentery, gastroenterocolitis, cholecystitis and cholera;
  • problems with the genitourinary system in the form of endocervicitis, urethrocystitis, cystitis and pyelonephritis;
  • respiratory infections in the form of pleural empyema, pulmonary abscess, community-acquired and lobar pneumonia, bronchopneumonia, tracheitis, acute bronchitis and pharyngitis;
  • sexually transmitted infections (lymphogranuloma venereum with inguinal granuloma, uncomplicated gonorrhea, syphilis and urogenital chlamydia);
  • whooping cough with sepsis, peritonitis;
  • prevention of malaria;
  • tonsillitis with sinusitis and otitis media.

It is undesirable to use an antibiotic during pregnancy. Breastfeeding must be suspended until the completion of the treatment course.

Contraindications

Unidox Solutab is contraindicated in the presence of the following conditions and pathologies:

  • pregnancy;
  • breast-feeding;
  • children under 8 years old;Unidox Solutab tablets. Instructions, how to take, reviews
  • hypersensitivity to the tetracycline group;
  • porphyria;
  • severe dysfunction of the kidneys or liver.

Method of administration and dosage

Unidox Solutab is required to be taken orally when eating. It is permissible to drink the tablet completely, divide it into parts or chew it. You can drink it with a glass of water or stir it in 20 ml of liquid.

The treatment course lasts about 5-10 days.

Adults and children over 8 years old with a weight of 50 kg or more in the first 24 hours of therapy need to take 200 mg for 1 or 2 doses. From day 2 - 100 mg every day. For complicated pathologies, the dose should reach 200 mg within 24 hours throughout the entire treatment therapy.Unidox Solutab tablets. Instructions, how to take, reviews

Children 8-12 years old with a weight less than 50 kg in the first 24 hours of treatment should take 4 mg / kg, then 2 mg / kg per day for 1 or 2 doses. In complicated pathologies, the daily dosage should reach 4 mg / kg at the stage of the entire therapy.

Uncomplicated gonorrhea

In this case, adults need to take 100 mg in 2 divided doses for 24 hours for 7 days. Also prescribed 600 mg for 1 day, dividing the amount into 2 doses of 300 mg. The second consumption of tablets should pass after 60 minutes. after the first.

Syphilis

If the pathology is primary, for 2 weeks it is required to use 100 mg twice a day. If the disease is secondary, for 4 weeks you need to drink 100 mg twice a day.

Uncomplicated urogenital infections, non-gonococcal urethritis, cervicitis

The recommended dose is 100 mg twice a day. The treatment course lasts a week.

Acne

For the treatment of the disease, 100 mg is prescribed for 24 hours. The treatment course lasts from 6 to 12 weeks.

Prevention of malaria

48 hours before the trip, you need to drink 100 mg every 24 hours. After every day at the stage of the trip and for 28 days upon arrival home.Unidox Solutab tablets. Instructions, how to take, reviews

For children over 8 years old, the dosage should be 2 mg / kg every 24 hours.

Prevention of diarrhea

People who are traveling are required to consume 200 mg in 1 or 2 doses during the first 24 hours of the trip. Then 100 mg once a day throughout the journey. The treatment course should be no more than 21 days.

Leptospirosis

For treatment, it is required to take orally 100 mg 2 times for 24 hours. The course lasts a week. For preventive purposes, it is necessary to consume 200 mg every 7 days at the time of being in a disadvantaged region, as well as 200 mg at the end of the trip.

Prevention of infections during abortion

In 60 minutes before the procedure, you need to consume 100 mg. After medical intervention, 200 mg should be drunk.

Severe gonococcal infection

For adults, the total daily volume should reach 300 mg or 600 mg for 5 days.Unidox Solutab tablets. Instructions, how to take, reviews

For children over 8 years old with a weight of 50 kg or more, 200 mg is enough. Children from 8 to 12 years old weighing less than 50 kg need to take 4 mg / kg every day.

Renal or hepatic impairment

It is necessary to lower the daily dosage of doxycycline, because it is gradually accumulating in the body.

Side effects

Unidox Solutab is capable of provoking the development of side effects.

When taking an antibiotic, the following symptoms may appear:

  • asthma with dermatitis, generalized exanthema, anaphylactic reactions, erythema, pericarditis, rash, angioedema, urticaria and exacerbation of systemic lupus erythematosus;
  • hematuria;
  • lymphopenia with leukopenia, leukocytosis, blood clotting failure, toxic granulocyte granulocyte, decreased prothrombin activity, neutropenia, thrombocytopenia and hemolytic anemia;
  • candidiasis may develop;
  • the nail may separate from the nail bed or the nail plate will change color;Unidox Solutab tablets. Instructions, how to take, reviews
  • acute renal failure with anuria, nephrotic lesion, as well as an increase in the urea nitrogen balance, which is caused by the anti-anabolic effect of the agent;
  • pancreatitis, as well as liver damage, if a patient with hepatic or renal failure takes the medicine for a long time;
  • with prolonged use, thyroid tissue may turn dark brown;
  • pseudomembranous colitis with enterocolitis, nausea, dysphagia, vomiting, diarrhea and anorexia;
  • fear with anxiety, arthralgia, myalgia, tachycardia, instability and dizziness, myopia, puffiness of the optic nerve, pain in the head, vomiting and anorexia;
  • children may experience a failure in the normal formation of teeth, and osteogenesis slows down.

Overdose

Unidox Solutab should be taken according to the instructions that are displayed on the package with the tablets. Otherwise, overdose may occur.

With excessive consumption of the antibiotic, the liver is damaged, and the accompanying symptoms also occur:

  • azotemia;
  • high concentration of transaminase;
  • hematoma;
  • jaundice;
  • melena;
  • periodic increase in body temperature;
  • vomit;
  • increase in prothrombin time.Unidox Solutab tablets. Instructions, how to take, reviews

In case of an overdose, irritation and expression of the esophagus are possible, which are complemented by pain behind the sternum, esophagitis and dysphagia. This is because the tablets can stick to the walls of the esophagus. To prevent such a situation, it is necessary to take up to 200 ml of liquid for adults and 125 ml for children.

In order not to provoke further irritation of the esophagus, it is undesirable to independently induce a gag reflex. To reduce absorption, it is allowed to take activated charcoal with a laxative. Hemodialysis will not affect the withdrawal of the active component of the antibiotic.

The treatment course should be symptomatic with constant monitoring of the water and electrolyte balance.

special instructions

With long-term use of the product, it is sometimes necessary to examine laboratory tests of the kidneys, liver and blood.

Since photodermatitis may appear, it is required to limit insolation during the treatment course, as well as for 5 days after the end of therapy.

The consumption of antibiotics can provoke a high growth of insensitive organisms. In this case, you will need to refuse to take the drug by proceeding with corrective therapy.

To avoid dyspeptic symptoms, it is advisable to use the remedy when eating.Unidox Solutab tablets. Instructions, how to take, reviews

To prevent the formation of an esophageal ulcer or esophagitis, tablets must be taken with a large volume of liquid. However, they cannot be taken immediately before bedtime.

Since side effects such as dizziness can occur when taking the pills, it is required adhere to precautions when working with moving machinery and when operating by road.

Drug interactions

The absorption of the active ingredient can decrease when biologically inactive chelate complexes with metal ions appear. The latter are present in the salts of bismuth, iron and antacids. The antibiotic should not be taken immediately with antacids, which contain magnesium with calcium or aluminum, as well as with iron or bismuth. Ion exchange formulations with activated carbon provoke a decrease in the absorption of doxycycline. Therefore, such drugs are required to be used 3 hours after taking Unidox Solutab.

Quinapril helps to reduce the absorption of the active ingredient due to the increased volume of magnesium in Quinapril tablets.

Drugs that increase the acidity of the stomach have a detrimental effect on the absorption of tetracyclines, which dissolve better in an acidic than an alkaline medium.

Doxycycline is able to increase the time of clot development after the penetration of tissue factor into the plasma. At the same time, it contributes to the appearance of anticoagulants in combined treatment. In this regard, it is necessary to reduce the dosage of the anticoagulant.

It is undesirable to use Unidox Solutab simultaneously with beta-lactam antibiotics, since the first drug has a detrimental effect on penicillin.

When alcohol is consumed, the metabolism of the active substance in the liver is accelerated, therefore the half-life stage is reduced.Unidox Solutab tablets. Instructions, how to take, reviews

There are deaths due to the appearance of renal toxicity while taking methoxyflurane with tetracyclines.

The active component of the antibiotic increases the plasma cyclosporine level. Therefore, it is required to carry out regular research with simultaneous use.

The active ingredient of the drug increases the hypoglycemic effect of sulfonylurea derivatives. In this regard, with the simultaneous use of drugs, it is necessary to control the concentration of sugar in the blood. The sulfonylurea dosage can be reduced as needed.

If doxycycline is used initially, during or after retinoid treatment, reversible intracranial hypertension may occur. This occurs with the mutual enhancement of the effect of the compositions. In this regard, co-administration of retinoids with doxycycline is undesirable.

Tetracyclines can affect urinary glucose concentrations. As a result, this is reflected in the results of laboratory examinations: there may be a false increase in the level of catecholamines in the urine, due to the effect on the results of the test with fluorescein.

Analogs

The following antibiotics are considered analogs of the drug "Unidox Solutab":

  • Azithromycin;
  • Amoxiclav;
  • Wilprafen;
  • Doxycycline;
  • Sumamed;
  • Supraks Solutab;
  • Flemoxin Solutab.

Storage conditions

The antibiotic must be kept out of the reach of small children. In this case, the temperature in the room should not be higher than +25 ℃.

The shelf life of the product is 5 years. At the end of the storage period, the drug must not be used.

Unidox Solutab tablets. Instructions, how to take, reviews
Unidox Solutab tablets.

The antibiotic "Unidox Solutab" has a wide range of effects. It can be taken by both adults and children over 8 years old. Before use, you must consult with a specialist, as there are contraindications. Otherwise, complications with irreversible consequences may arise.

Video about the drug Unidox Solutab

Unidox Solutab. efficiency, complications:

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