Akatinol Memantine for children. Reviews of doctors, instructions for use, dosage, price

Akatinol Memantine is a drug intended for the correction of disorders in the functioning of brain structures in children and for treating various forms of dementia. Despite the current restrictions on the age of patients, the remedy is often prescribed to young children. Reviews after using it confirm the exceptional effectiveness of the course of treatment.

Forms of release and composition of the drug

The active ingredient is memantine hydrochloride. The drug is available in cell blisters of 14 pieces with an arrow indicating the days of the week for more convenient administration. Blisters are packed in soft cardboard boxes that provide sufficient protection from sunlight.

Number of tablets in individual packages:

• 30 pieces, 10 mg each;
• 90 pieces, 10 mg each;
• 28 pieces, 20 mg each;
• 56 pieces, 20 mg each;
• 98 pieces, 20 mg each.

A special form of release is a set of 4 blisters of 7 pieces with tablets of 5 mg, 10 mg, 15 mg and 20 mg. This option is recommended for the initial stage of the course of therapy. It allows you to smoothly achieve therapeutic efficacy and determine the optimal dosage with a minimum likelihood of side effects.

The kit is also suitable for completing the course use without the development of a drug withdrawal syndrome.

The composition of the tablets, in addition to the active substance, includes the following components:

• micronized cellulose;
• colloidal silicon dioxide;
• magnesium stearate;
• lactose;
• talc.

The tablets are film-coated to facilitate swallowing. After entering the digestive tract, they reach the cavity of the small intestine, where, under the influence alkaline reaction of the surrounding liquids dissolve quickly enough and immediately begin to be absorbed into its walls.

Pharmacological properties

Memantine is an NDMA antagonist mainly used in the treatment of Alzheimer's disease. If necessary, but can be used for many other conditions that require activation of thought processes and improvement of brain function.

Based on the results of the studies carried out, the ability of memantine to stimulate and bring to normal levels has been proven. the development of cognitive abilities, daily activity and compensate for behavioral deviations in patients with the disease Alzheimer's.

A separate ability to improve thought processes was also noted in all forms of vascular dementia. At an easy stage of the development of the disease, therapy using only Akatinol is possible.

In more severe cases, the effectiveness will be higher when combined with drugs-inhibitors. cholinesterases, which, when taken for a long time, effectively restore damaged areas of nerve fibers.

Pharmacodynamics and pharmacokinetics

Memantine hydrochloride is chemically derived from adamantane. The active ingredient selectively blocks N-methyl-D-aspartate (NMDA) - glutamate receptors.

The drug normalizes the transfer of ionic particles, blocks specific channels, and stabilizes membrane functions. The mechanism of pharmacological activity is associated with the launch of a glutamatergic impulse, which determines the interaction of brain regions in the head region.

After internal use, the substance is rapidly absorbed in full. The highest plasma concentration is reached after 2-6 hours. With a healthy function of the renal tissues, accumulation in the body does not occur.

Removal is performed in 2 phases. In phase 1, the half-life is 4-9 hours, in phase 2 - up to 65 hours. Approximately 80% of the dose taken does not undergo biochemical transformation. The rest is some metabolites that do not have a pharmacological effect on the body.

The drug is excreted in the urine. With its alkaline reaction, the process slows down somewhat.

Indications for use

Akatinol Memantine for children, reviews of which are most often positive, intended to correct the symptoms of congenital or acquired dementia:

• disorientation in space and time;
• decreased cognitive abilities;
• lack of self-service skills;
• speech and writing violations;
• loss of acquired skills;
• decreased memorization.

  

The drug can be used in a wide range of severity of these pathologies.

Contraindications

Akatinol Memantine for children, reviews of which are also negative, is prohibited for use in the following conditions:

• severe liver or kidney failure;
• individual intolerance to the components;
• During pregnancy and breastfeeding.

With extreme caution, the drug should be prescribed to patients with thyrotoxicosis, epileptic seizures, and convulsive activity. In the presence of factors that are accompanied by a decrease in the acidity of urine to an alkaline level, caution must also be exercised.

At what age can the drug be used in children?

Age under 18 is also included in the list of contraindications due to the lack of data on the use in this group of patients. Therefore, only a professional specialist should make a decision on the admissibility of using the drug, taking into account the indications, age, body weight of the child and the severity of the existing symptoms.

In the future, regular monitoring will be required to assess the effectiveness and possible adjustments to the prescribed dose.

Instructions for use, dosage

The basic rule throughout the course of treatment is to be taken at the same time of day, regardless of the diet.

Recommendations:

• within 1 week - 5 mg per day;
• from 2 weeks - 10 mg per day;
• from 3 weeks - 15 mg per day;
• from 4 weeks - 20 mg per day.

The highest dose for one day should not exceed 20 mg. In patients with creatinine clearance of 50-80 ml / min, dose changes are usually not required. In patients with CC less than 50 ml / min, the highest daily dose should not exceed 10 mg. In the future, with normal tolerance, the dosage of the drug can be increased no earlier than 7 weeks later to 20 mg per day and continue taking the drug as usual.

Side effects

Actinol Memantine is a serious drug for treatment. Reviews on it often contain information about the development of unwanted side effects.

These include:

• > 1/100 to <1/10 - headaches, drowsiness, digestive disturbances, shortness of breath;
• > 1/1000 to <1/100 - fatigue, infections, surges in blood pressure;
• > 1/10000 to <1/1000 - fungal infections, mental and coordination disorders, hallucinations;
• <1/10000 - convulsive phenomena.

The following side effects have been reported with an unspecified frequency:

• dizziness;
• excitability;
• hypertonicity;
• depression.

In addition to the listed effects, there are many other reactions with an unknown frequency. To reduce the risk of their occurrence, treatment should be carried out under the strict supervision of a specialist.

Overdose

In the event of a significant excess of the recommended dose, the listed side effects will manifest themselves in a pronounced form. In such a situation, it is necessary to rinse the stomach several times with warm water. After that, it is recommended to take sorbents to remove excess drug from the body.

special instructions

In people with severe to moderate Alzheimer's disease, Akatinol may cause abnormal reaction rates. Because of this, throughout the entire course of therapy, it is necessary to avoid potentially dangerous activities that require special care and accuracy of the actions performed.

Drug interactions

Akatinol Memantine enhances the activity of anticholinergic drugs and levodopa. When interacting with antipsychotics or barbiturates, it reduces their effectiveness. The drug should not be prescribed for combination therapy with ketamine, hydrochlorothiazide and cimetidine.

Analogs

The drug is notable for its high cost due to the fact that it is manufactured by Rottendorf Pharma GmbH / Merz in Germany and is original. In addition to him, the market of modern pharmacology offers many budget analogue options.

In the absence of the financial ability to purchase Akatinol Memantine, it can be replaced with more affordable generics. In most cases, this practically does not affect the result of the completed course of treatment.

Memantine Akrikhin

The drug produced by the Polish pharmaceutical joint-stock company POLFARMA has a much more affordable cost. The drug is available in the form of tablets under a film shell.

Each of them contains 10 mg of memantine hydrochloride in combination with additional components:

• silica;
• titanium dioxide;
• milk sugar;
• magnesium stearate;
• crospovidone;
• hypromellose;
• cellulose;
• macrogol ..

Being an adamantane derivative and a specific antagonist of N-methyl-D-aspartate (NMDA) receptors, reduces the increased stimulating effect of cortical neurons on a part of the striatum of the hemispheres brain.

Additionally, the drug regulates the exchange of ions, blocks calcium channels, normalizes the potential of the membranes and improves the processes of conducting nerve signals. The result of the treatment will be an improvement in cognitive abilities and an increase in daily activity.

The bioavailability of the drug reaches 100%. The highest concentration in the body after taking the recommended dosages is observed 3-8 hours after each pill taken.

Reception mode:

• 1 week - 5 mg once a day;
• 2 week - 10 mg per day;
• 3 week - 15 mg per day;
• then 20 mg daily.

The recommended highest maintenance dose is 20 mg per day. The duration of therapy is determined by the patient's responsiveness to the course of treatment and the response to the drug.

Memantinol

A remedy for the treatment of dementia and the correction of mental disabilities is produced by the manufacturer GEROPHARM LLC in Russia. Each pack contains 9 cell blisters of 10 oblong biconvex tablets with "g" and "Ph" engraved on each side.

The pharmacokinetics of the drug is linear in the range of dosages used from 10 to 40 mg. With daily use in a daily dose of 20 mg, the maintenance concentration remains at the level of 70-150 ng / ml (0.5-1 μmol) with significant individual differences.

About half of the dose taken binds to plasma blood proteins. With normal renal function, the accumulation of the drug in the body is not observed.

The drug is taken 1 time per day, regardless of the diet. Throughout the course of treatment, it is recommended to do this at the same time of day. In this case, it is not allowed to interrupt the treatment. Timely administration of the drug should always be monitored. Dosages for therapeutic use are similar to those listed above.

Cortexin

Akatinol Memantine has several analogues for children, which, according to mothers, significantly accelerate the development of the child. The drug is quite popular and is often prescribed to children with developmental defects of almost any type.

As an active ingredient, Cortexin contains cattle cerebral cortex polypeptides. According to its pharmacological properties, the drug stimulates mental activity, neutralizes free radicals, stabilizes neural connections and affects metabolism in tissues.

Indications for use:

• compensation for disorders of blood circulation in the brain;
• recovery period after injury;
• encephalopathy of various pathogenesis;
• cerebral palsy;
• cognitive impairment;
• developmental delays in children;
• decreased learning ability;
• asthenic conditions;
• epilepsy.

Cortexin is produced in vials with a lyophilisate for preparation of a solution for injection into muscle tissue. 1 package contains 10 pieces together with instructions for medical use.

Compound:

• peptide complex with a molecular mass of not more than 10,000 Daltons - 5 mg;
• glycine as a stabilizer - 6 mg.

The peptides that make up the drug activate neural connections and recovery processes in brain tissues, optimize the ratio of excitatory and inhibitory amino acids, dopamine, serotonin. As a result, the convulsive readiness of the brain decreases along with an improvement in its biological and electrical activity.

Special conditions:

• it is not recommended to use it without consulting a specialist;
• the solution ready for administration is not subject to long-term storage;
• it is not allowed to mix it with other medicinal products;
• no symptoms after the initial administration and withdrawal syndrome are observed;
• in the case of a missed dose, the volume should not be doubled in the future.

The drug has no effect on the patient's response and attentiveness. To date, no information has been received about an overdose.

Recommendations for use:

• the contents of the vial should be dissolved in 1-2 ml of 0.5% procaine or novocaine, water for injection or 0.9% sodium chloride;
• then the finished suspension should be drawn into a syringe and treated with an alcohol napkin;
• for children up to 20 kg, the drug is used in an amount of 0.5 mg / kg of body weight;
• with a child weighing from 20 kg, it is recommended to increase the dosage to 10 mg;
• the course of treatment should last at least 10 days.

If necessary, it is allowed to repeat the course of treatment after 10 days.

Terms, conditions of sale and storage

Akatinol Memantine for children, reviews of which should be studied before starting therapy, helps to get rid of developmental problems.

The drug should not be used if the storage conditions established by the manufacturer are violated:

• the storage area should be inaccessible to small children;
• the air temperature should not exceed 25 ° С;
• shelf life - 4 years.

After the expiration date indicated on the package, the drug should be disposed of with household waste.

Price in pharmacies in Moscow, St. Petersburg, regions

Akatinol Memantine for children, reviews of which criticize its cost, does not apply to budget drugs. Average prices depend on the distribution method and the direct location of the pharmacy, the pricing policy of the pharmacy chain.

Average prices:

• 30 tablets of 10 mg each - 1900 rubles;
• 90 tablets 10 mg each - 5300 rubles;
• 28 tablets of 20 mg - 3100 rubles;
• 56 tablets of 20 mg each - 6,000 rubles;
• 98 tablets of 20 mg - 8900 rubles

In some cases, it is possible to receive drugs with memantine free of charge, but they must be confirmed by the relevant documents and verdicts of medical commissions.

Akatinol Memantine is a functional and effective drug for treating children from a large number of pathologies. Strict adherence to the medication regimen and concomitant therapy, according to reviews, give a quick and good result. In most cases, with not too serious brain damage, it is possible to fully compensate for the disorders and accelerate the development of the child.

Video about the drug Akatinol Memantine

Memantine in the treatment of dementia: