Calming & Relieving Anxiety Neuleptil, together with the potentiation of analgesics and hypnotics, has a sedative effect on the body. It also relieves vomiting and muscle cramps, as evidenced by reviews. But the remedy, even for children, should be carefully taken along with other medicines.
Record content:
- 1 Composition, release form and price
- 2 Mechanism of action
- 3 Indications for use
- 4 Contraindications and side effects
- 5 special instructions
- 6 Symptoms and consequences of an overdose
- 7 Instructions for use
- 8 Drug interactions
- 9 Storage conditions and periods
- 10 Analogs
- 11 Video about antipsychotics for children
Composition, release form and price
The drug Neuleptil, intended for oral administration and produced in the form 4% solution, with a mint flavor and a light brown tint, consists of:
- active pericyazine (40 mg);
- alcohol;
- caramel;
- peppermint oil;
- tartaric and ascorbic acids;
- glycerol;
- purified water and sucrose.
Before implementation, the agent is placed in dark glass vials of 30 ml with a 30 ml dropper dispenser or 125 ml with a measuring syringe made of plastic.
The cost of the corrective drug Neuleptila in drops starts from 300 rubles. for 30 ml and 1300 rubles. for 125 ml.
Mechanism of action
A phenothiazine derivative, the neuroleptic Neuleptil, has a therapeutic effect on psychotic disorders. Its active component, pericyazine, blocks histamine and brain receptors, which has a positive effect on suppressing anger and irritability. Having quickly hit all tissues, the active substance of the drug subsequently comes out with feces or bile.
The main constituent element of Neuleptil, which has an anticholinergic effect, weakens and corrects such behavioral disorders as:
- disinhibition;
- excitability;
- aggressiveness;
- impulsiveness;
- irascibility;
- hostility;
- autism;
- hyperactivity.
Once inside the body, peritsiazine is well absorbed, and then excreted by the liver or intestines. After taking the medicine, there is no lethargy and lethargy. After completing the treatment course with the drug, patients become calmer and more sociable.
After using the soothing drops of Neuleptil, after half an hour, a weakening of aggressiveness and excitability is observed. Depression and depression also disappear.
In terms of its pharmacological effect, Neuleptil is:
- antiemetic;
- antispasmodic;
- sleeping pills;
- antipsychotic;
- antihistamine.
Indications for use
Neuleptil is prescribed for therapy:
- pre- and senile diseases;
- aggressiveness;
- epilepsy;
- schizophrenia;
- paranoia;
- excitability and agitation;
- psychopathic disorders and disorders;
- aggressive symptoms;
- recurrent delusional disorders;
- psychomotor agitation;
- anxiety states.
Contraindications and side effects
Neuleptil for children (reviews about him are completely different), is distinguished by a selective effect that normalizes behavior with hyperactivity and increased aggression. The drug can also be used as a sleeping pill.
Diseases and conditions that are contraindications for the use of the medication:
- cardiovascular diseases;
- renal or hepatic impairment;
- agranulocytosis;
- porphyria;
- Parkinson's syndrome;
- closed glaucoma;
- collapse;
- severe myasthenia gravis;
- age up to 3 years;
- high sensitivity to components;
- deficiency of sucrose.
Side effects from taking the medication can be:
- sensitivity to ultraviolet light;
- a decrease in the level of leukocytes;
- hepatitis A;
- obesity;
- breast augmentation in boys;
- drowsiness;
- paresis;
- delay in urination;
- constipation;
- lowering pressure;
- feeling of dry mouth;
- extrapyramidal disorders;
- depressed mood;
- dyskinesia;
- increased aggression;
- insomnia;
- anxiety;
- apathy;
- akathisia;
- violation of motor activity;
- respiratory depression;
- arrhythmia;
- rash;
- bronchospasm;
- runny nose;
- nausea and vomiting.
Adverse reactions from the use of Neuleptil also include:
- mental disorders;
- disorders of the central nervous system;
- problems with the cardiovascular system;
- metabolic and endocrine system disorders;
- failure of immunity.
special instructions
Neuleptil for children (consumer reviews notify that it must be taken with extreme caution), despite all its danger, is quite effective. The agent in drops almost never causes side effects if its dosage is determined correctly.
If a fever occurs after taking the drug, they urgently turn to doctors for the delivery and check of a blood test. Neuleptil cannot be combined with levodopa. When treating with a drug, if signs of neuroleptic malignant syndrome appear, therapy is completely canceled.
The manifestations of such a disease will be:
- unstable pressure and pulse;
- heavy sweating;
- muscle rigidity;
- disorders of consciousness;
- pallor;
- an incomprehensible rise in temperature.
In case of pain in the stomach and bloating, the patient is checked for intestinal permeability. To exclude withdrawal syndrome, the drug should be stopped gradually.
To avoid cognitive impairment from the use of Neuleptil, children are clinically tested every year for their ability to learn.
The drug Neuleptil is prescribed with caution to patients prone to thromboembolism. Children's doses of the drug are constantly adjusted, monitoring the condition of small patients. Suffering from galactose and fructose intolerance, the use of the drug is strictly prohibited.
Neuleptil drops are not prescribed:
- pregnant women;
- people with brain damage due to medication or injury;
- suffering from epilepsy;
- people with alcohol addiction;
- with a sick liver.
If the patient has agranulocytosis or leukopenia, peripheral blood is constantly monitored. After detection of granulocetopenia or hyperleukocytosis in it, neuroleptic therapy is immediately stopped.
Neuleptile is treated with extreme caution:
- the elderly;
- having problems with blood vessels and heart;
- those who have renal or hepatic impairment;
- suffering from dementia;
- patients at risk of stroke.
During the treatment course with the drug, patients are not recommended to sunbathe and stay in the sun for a long time because of the possibility of developing hypersensitivity to ultraviolet from taking Neuleptil.
Symptoms and consequences of an overdose
An overdose of an antipsychotic agent is determined by the following criteria:
- drowsiness, turning into an areflexive coma;
- delirium;
- excitement;
- mydriasis;
- stupor;
- agitation;
- confused mind;
- anxiety;
- cyanosis;
- depressed breathing;
- heavy swallowing;
- muscle spasms and twitching;
- trembling limbs;
- narrow pupils;
- lowering pressure;
- polyuria and dyskinesia, which are precursors of dehydration;
- anticholinergic syndrome.
Neuleptil for children (parental reviews for the drug are ambiguous) cannot be purchased without medical prescriptions. A potent remedy is first prescribed in very small doses in order to monitor its effect on the child under control. It is not suitable for everyone and has contraindications.
Symptoms of an overdose with Neuleptil, until they disappear completely, are treated in a clinic with mandatory parallel monitoring of cardiac and respiratory functions. While waiting for an ambulance to a poisoned person, if 6 hours have not yet passed after administration, aspiration or gastric lavage is performed. Antiemetic drugs are strictly prohibited.
There is no specific antidote to Neuleptil. But activated charcoal will help alleviate the condition of the poisoned person. In case of hypotension, the victim is placed horizontally, and his legs are raised. In this state, the patient is contraindicated in epinephrine. For long-lasting dangerous disorders, it is also prohibited to use antiarrhythmic drugs and lidocaine.
Overdose seizures with Neuleptil are usually relieved with intravenous diazepam. Extrapyramidal disorders are soothed with special intramuscular drugs. Severe dystonic reactions are treated with intravenous orphenadrine or procyclidine. But all these medicines should be administered only by a doctor.
Instructions for use
The dosage is determined individually for each specific case. It depends on the patient's condition and indications. The effective minimum assignment is gradually increased.
The dose is divided into 2-3 doses per day. A significant part of it is transferred to the evening, almost before bedtime. Children after 3 years of age are prescribed a daily appointment of Neuleptil in an amount of 0.1-0.5 mg per 1 kg of the child's weight.
Drug interactions
The drug must not be combined with:
- ropinirole;
- quinagolide;
- pramipexole;
- piribedil;
- pergolide;
- lisuride;
- entacapone;
- cabergoline;
- bromocriptine;
- apomorphine;
- amantadine;
- levodopom.
The combined use of the listed agonists with Neuleptil will aggravate psychotic disorders.
Neuleptil for children (doctors' reviews characterize it as an effective remedy for solving neurological problems) is a mild neuroleptic. It is considered an effective remedy for emotional arousal.
Non-recommended medications for joint use with Neuleptil include:
- sultopride, since arrhythmia develops from this and the rhythm is disturbed;
- guanethidine;
- clonidine;
- amphetamine;
- ethanol.
Neuleptil should be used with caution with:
- cisapride;
- lithium salts;
- tricyclic and sedative antidepressants;
- sertindole;
- mefloquine;
- methadone;
- erythromycin;
- moxifloxacin;
- diuretic thiazides;
- antihypertensive drugs;
- other antipsychotics and hypnotics;
- anxiolytic agents;
- antitussive;
- analgesics;
- phenothiazines;
- anticholinergics;
- hypoglycemic drugs;
- antacids;
- drugs that suppress appetite.
The simultaneous use of Neuleptil and drugs that increase the qt interval increases the risk of arrhythmia. Simultaneous administration of an antipsychotic drug with diuretics also leads to such a violation. In this case, along with arrhythmias, hypomagnesemia and hypokalemia occur.
Alpha-blockers together with Neuleptil can lead to hypotension with an additive effect, as well as increase the hypotensive effect. Beta-blockers with an antipsychotic develop tardive dyskinesia and arrhythmias. The drugs that depress the central nervous system, together with Neuleptil, worsen breathing.
Antidepressants and antipsychotics increase anticholinergic and sedative effects on the body.
The combination of anticholinergic drugs and antipsychotic drugs leads to:
- weakening the action of the neuroleptic;
- heatstroke;
- dry mouth;
- constipation and urinary retention.
Lithium salts in tandem with Neuleptil will cause:
- drug intoxication, expressed by vomiting or nausea;
- weakening of the absorption capacity of the gastrointestinal tract;
- increasing the rate of saline excretion.
Neuleptil with ephedrine or epinephrine weakens the effect of adrenergic agonists and greatly lowers blood pressure. Antithyroid drugs with an antipsychotic drug develop agranulocytosis. Apomorphine with Neuleptil depress the central nervous system even more. Hypoglycemic drugs with antipsychotics weaken their effectiveness, which entails a mandatory increase in their dosage.
Peritsiazine is worse absorbed by the gastrointestinal tract with oxides and salts:
- calcium;
- aluminum;
- magnesium.
Neuleptil reduces efficiency:
- sultopride;
- blood pressure medications;
- dopamine agonists.
The neuroleptic effect of Neuleptil itself is weakened by agonists from extrapyramidal disorders. Therefore, anticholinergics are used instead. Dopaminergic drugs are gradually withdrawn before antipsychotic medication with a moderate dose reduction.
Storage conditions and periods
Neuleptil in drops is approved for use from the age of three. For adults and children, the dosage of the drug is prescribed exclusively by the attending specialist. You should not rely only on reviews and use the remedy yourself, without the prescription of doctors.
The storage temperature for Neuleptil should not be more than + 25 ° С. The bottle with the medicine must always be kept out of the reach of children, since with uncontrolled, accidental and large use of the drug by a child, even a lethal outcome is possible.
Storage of Neuleptil with intact packaging is 4 years. The medicine from the bottle opened for the first time is available for use no more than 6 months after that.
Analogs
The table presents analogs of Neuleptil, their composition and prices:
Analog name | Active ingredient | Cost, rub. |
Trevikta | paliperidone | 35900 |
Xeplion | paliperidone | 8000 |
Invega | paliperidone | 3800 |
Ariprizol | aripiprazole | 2500 |
Zilaxera | aripiprazole fumarate | 2300 |
Amdoal | aripiprazole | 3100 |
Risperidone | risperidone | 45 |
Torendo | risperidone | 60 |
Rispaxol | risperidone | 100 |
Rispolept quicklet | risperidone | 3500 |
Risset | risperidone | 145 |
Rispolept Konsta | risperidone | 4000 |
Rispolept | risperidone | 220 |
Rileptide | risperidone | 300 |
Limipranil | amisulpride | 1700 |
Solian | amisulpride | 2200 |
Sulpirides | sulpiride | 45 |
Eglonil | sulpiride | 150 |
Betamax | sulpiride | 200 |
Servitor | quetiapine | 900 |
Quetiapine | quetiapine | 280 |
Seroquel prolong | quetiapine | 1800 |
Quentiax | queantin | 480 |
Seroquel xr | queantin | 7200 |
Seroquel | queantin | 840 |
Ketilept | queantin | 1300 |
Olanzopin | olanzopine | 150 |
Olanzopin tl | olanzopine | 970 |
Egolanza | olanzopine | 850 |
Parnasan | olanzopine | 1600 |
Zolafren | olanzopine | 1750 |
Zyprexa zidis | olanzopine | 2100 |
Zalasta | olanzopine | 900 |
Zyprexa | olanzopine | 500 |
Leponex | clozapine | 2300 |
Clopixol akufaz | zuclopenthixol | 1300 |
Klopiksol depot | zuclopenthixol | 300 |
Clopixol | zuclopenthixol | 100 |
Chlorprothixene Zentiva | chlorprothixene | 170 |
Truxal | chlorprothixene | 300 |
Fluanksol depot | flupentixol | 2200 |
Fluanksol | flupentixol | 370 |
Zeldox | ziprasidone | 1600 |
Serdolect | sertindole | 1800 |
Haloperidol Richter | haloperidol | 45 |
Haloperidol ratiopharm | haloperidol | 40 |
Haloperidol Decanoate | haloperidol | 250 |
Haloperidol | haloperidol | 15 |
Tisercin | levomepromazine | 200 |
Triftazin | trifluoperazine | 25 |
Aminazin | chlorpromazine | 100 |
Sonapax | thioridazine | 200 |
All of the listed analogs, except for Sonapax, have properties and actions that differ from Neuleptil. They are similar to him only in the way of application. But, nevertheless, they are still considered analogues of it.
Children who are hyperactive and mentally retarded need treatment. Psychiatrists often prescribe Neuleptil for this. According to their reviews, it is noted that the drug significantly improves sleep and reduces emotional arousal.
Author: tanyda
Video about antipsychotics for children
Why do children need antipsychotics: