Valdoxan Reviews of patients who took the drug, instructions for use, analogues are cheaper, where to buy, price

Valdoxan is an effective drug that has pronounced antidepressant properties. The drug is prescribed for admission to patients of the adult age group who have neurological disorders and disorders in the functioning of the central nervous system.

According to reviews of people taking this medication, Valdoxan allows you to eliminate feelings of fear, depression, anxiety and attacks of sudden panic attacks. The drug is taken in courses with strict adherence to the dosage regimen.

Indications for use

Valdoxan is a modern and safe antidepressant that is indicated for the complex treatment of episodes of major depression with preservation of a prolonged feeling of psychoemotional oppression, apathy, lack of interest in the surrounding world and what is happening in it events.

This drug can be used to prevent episodes of depression triggered by an exacerbation of bipolar disorder. In the latter case, the medication is used with extreme caution, and the mental state of the patient is also monitored. According to reviews of patients taking the drug, Valdoxan does not impair the functions of the cardiovascular and reproductive system.

Valdoxan has the following pharmacological properties, the presence of which provides the drug with an excellent therapeutic effect:

• eliminates signs of a depressive state;
• normalizes the functions of the central nervous system, which have been impaired by prolonged episodes of depression or bipolar disorder;
• improves mood, returning a positive perception of the world around and daily events;
• increases the resistance of the central nervous system to stressful situations and prolonged psycho-emotional overstrain;
• allows you to successfully fight insomnia of a neurological nature of origin (while Valdoxan does not cause drowsiness in the daytime, and also does not provoke the development of addiction syndrome);
• prevents the occurrence of complications in people who suffer from prolonged and deep depression (the appearance of mental illness, signs of suicidal behavior, accompanied by attempts to commit suicide);
• restores the stable flow of circadian rhythms, which has a positive effect on the general condition of the body, the improvement of the central and peripheral nervous system.

The pharmacological properties of Valdoxan are provided by drug stimulation of melatonin receptors. At the same time, this drug is devoid of the severe side effects that are characteristic of most other antidepressants that have a similar therapeutic effect.

Compound

Valdoxan (reviews of patients who took the drug indicate its high effectiveness) is a drug that affects directly to the centers of the brain responsible for the level of mood, a sense of joy, a positive perception of the world around and what is happening events.

The table below describes in detail the constituent components of this antidepressant, their concentration and pharmacological purpose are indicated.

Compound	Pharmacological characteristics of the constituent components
Agomelatine	Agomelatine is the active substance of this antidepressant, which provides a direct effect on the centers of the brain. The composition of 1 tablet of the drug contains 25 mg of the main chemical component.
Lactose monohydrate	Lactose monohydrate is a milk sugar that acts as a natural and safe preservative. The mass fraction of this substance is 61.84 mg. This is an auxiliary component that is considered completely safe for humans, but only if the patient's digestive system is lactose tolerant. Otherwise, a side effect may develop.
Silica	Silicon dioxide is an excipient of the antidepressant Valdoxan, the concentration of which does not exceed 0.26 mg. This component is used as an anti-caking agent, improving the structural characteristics of the drug under conditions of long-term storage.
Corn starch	This substance performs auxiliary functions. Cornstarch makes the tablet more dense, preventing it from disintegrating into a powder. As part of Valdoxan, it is contained in a dosage of 26 mg.
Povidone K-30	Povidone K-30 is an auxiliary component of an antidepressant, which is a water-soluble polymer. In the production process, Valdoxan is used as a stabilizer for the chemical composition of the drug. The mass fraction of this substance does not exceed 9.1 mg.
Stearic acid	Stearic acid is an additional component that is used as a preservative. It prevents the change in the chemical properties of the basic substance during the long-term storage of the drug. The dosage of stearic acid is 2.6 mg.
Iron oxide dye	Iron oxide is an antidepressant adjunct that acts as a coloring agent. This chemical compound is part of the protective shell of the drug, providing it with a rich yellow color with an orange tint. The concentration of the iron oxide coloring pigment does not exceed 0.196 mg.

The drug Valdoxan has a simple chemical composition, which is considered completely safe for the human body. A distinctive feature of the drug is that, unlike other antidepressants, it is capable of causing a minimum number of side effects.

In what form is it produced

Valdoxan (reviews of patients who took the drug are positive) is a drug that is produced in the form of oblong tablets covered with a protective film. The medication has a rich orange-yellow hue with the image of the manufacturer's corporate logo, which is made in blue.

The antidepressant is packaged in a plastic blister of 14 tablets each. The main packaging of the medication is a rectangular box made of thick cardboard. Included with the drug is detailed instructions for the use of an antidepressant.

Pharmacodynamics

The pharmacodynamics of Valdoxan is due to the pharmacological properties of its active substance in the form of agomelatine. This chemical compound is an agonist of the MT1 and MT2 melatonin receptors. and also acts as an antagonist of the centers of the brain responsible for the identification of serotonin.

Valdoxan is an antidepressant, the mechanism of action of which is based on stimulating the release of two main hormones that affect the psychoemotional state of a person. These are dopamine and norepinephrine, which, under the influence of agomelatine, saturate the prefrontal region of the cerebral cortex.

At the same time, the antidepressant does not cause an increase in the level of extracellular serotonin, the absorption of monoamines, does not have cholinergic, benzodiazepine and histaminergic effects. This pharmacodynamic feature of the drug has been proven based on the results of multiple clinical trials.

At the same time, the drug can successfully fight episodes of severe depression, anxiety attacks, unfounded fears and panic attacks. Agomelatine allows you to restore healthy sleep, circadian rhythms of the body, as well as activate the process of melatonin release.

The pharmacodynamic properties of Valdoxan are realized when the drug is taken by therapeutic courses. Clinical trials of the drug have shown that short-term use of an antidepressant is possible, but only if the daily dosage is from 25 to 50 mg with a duration of treatment 6-8 weeks.

Valdoxan is equally effective for prolonged deep depression and a high level of anxiety, accompanied by periodic attacks of panic, severe fear, anxiety.

Valdoxan is able to provide not only a therapeutic effect on the mental state of patients with severe depression, but also provides prevention of complications caused by dysfunction of the central nervous systems.

Regular intake of an antidepressant at a dosage of 25 mg promotes a more rapid onset of the deep sleep phase with a decrease in heart rate. Already from the first week of therapy, there is a significant improvement in the quality of sleep, during which a full recovery of the body takes place.

Pharmacokinetics

Valdoxan (reviews of patients who took the drug are 95% positive) is a potent antidepressant that is rapidly absorbed into the intestinal wall. After taking the first tablet, the maximum concentration of agomelatine in the blood plasma is reached after 1-2 hours. The bioavailability of the drug is low and is within 5%.

When prescribing therapeutic doses of the drug, the maximum concentration of the active substance in the blood plasma increases in proportion to the dosage. The bioavailability of agomelatine is increased in patients who smoke or take oral contraceptives.

Agomelatine has a high propensity for binding to blood plasma proteins, which is at the level of 95%. In this case, it does not matter the age of the patient, concomitant diseases of the liver and kidneys, as well as the dosage of the medication. Agomelatine metabolism occurs in the liver tissues.

The active substance Valdoxan undergoes a rapid oxidative reaction with the formation of hydroxylated and demethylated chemical compounds. The half-life of agomelatine is 1 to 2 hours, depending on the patient's renal function.

Excretion of about 80% of the formed metabolites is carried out in the urine. The rest of the half-life products are disposed of together with the feces.

Application

Valdoxan (reviews of patients who took the drug indicate its excellent therapeutic effect) is intended for the treatment of patients with severe forms of depressive conditions.

For children under 18

This antidepressant is approved for use in patients of the adult age group. The medication is contraindicated in children, since there are no clinically confirmed data on the effect of agomelatine on the psycho-emotional state of the child. In this case, Valdoxan is not used even in the minimum dosage.

For adults

For patients of the adult age group, the dosage regimen of Valdoxan is established by a psychiatrist on an individual basis. The manufacturer of the medicinal product focuses on the fact that the therapeutic dose of agomelatine should not exceed 25 mg per day.

At the initial stage of treatment, Valdoxan is taken 1 tablet immediately before bedtime. In this case, the medication should not be chewed. Food order does not affect the antidepressant dosing regimen.

In the event that after 2 weeks of treatment, there is no improvement in the patient's psycho-emotional state, then a single dose of Valdoxan can be increased to 2 tablets per day.

The decision to increase the dosage should be made by the attending physician based on the results of the patient's examination, as well as an objective assessment of the therapeutic benefits and the risk of side effects. Throughout the entire period of treatment, it is necessary to monitor the performance of the liver and kidneys. The functional activity of these organs should be checked every 3 weeks.

The minimum duration of therapy with Valdoxan is at least 6 months, or until the symptoms of a depressive state completely disappear. Stopping the medication at an earlier date can lead to a relapse of the disease in the future.

In case of deterioration of the condition of the kidneys and liver, which is caused by a side effect of the active component of the drug, it is necessary to immediately stop further taking Valdoxan.

For pregnant

The antidepressant Valdoxan is not recommended for women who are pregnant or breastfeeding.

For the elderly

Elderly patients take Valdoxan in a standard regimen and a dosage that is intended for all other adults. The drug is prescribed with extreme caution to persons over 65 years of age.

Contraindications

The antidepressant Valdoxan is contraindicated for use in the following cases:

• individual sensitivity to the main or auxiliary component of the drug;
• renal failure;
• severe liver disease;
• lactose intolerance;
• concurrent therapy with inhibitors of the isoenzyme CYP1A2.

Valdoxan is prescribed with caution to patients who abuse alcohol or have functional disorders in the liver.

Overdose

Violation of the rules for taking medication with a single dose of more than 50 mg

Valdoxan can provoke an overdose, which is accompanied by the following symptoms:

• physical ailment;
• nausea;
• cramping pain in the stomach;
• vomit;
• loss of appetite;
• feeling anxious;
• drowsiness;
• psycho-emotional stress;
• cyanosis.

Patients with signs of overdose should receive symptomatic therapy in a hospital toxicology department. The specific antidote to agomelatine has not been established.

Side effects

Most of the side effects that were caused by Valdoxan were unexpressed. In clinical studies, the drug was taken by 7900 people suffering from severe depression.

It was found that Valdoxan can provoke the following side effects:

• headache;
• nausea;
• noise in ears;
• constipation;
• cramping pain in the stomach;
• loss of appetite;
• decrease or gain in body weight;
• short-term visual impairment;
• allergic rash and itching of the skin;
• diarrhea;
• cramps of the lower extremities;
• drowsiness;
• back muscle pain;
• rapid fatigability of the body;
• suicidal thoughts;
• hives;
• swelling of the epithelial tissues of the face;
• nightmares;
• feeling of increased anxiety and anxiety;
• irritability, accompanied by bouts of aggression.

The appearance of signs of side effects of Valdoxan should be the reason for the cancellation of further administration of the drug. You should contact your attending psychiatrist so that the doctor picks up an antidepressant with a different active substance.

Drug interactions

The antidepressant Valdoxan is contraindicated for concomitant use with Fluvoxamine, Ciprofloxacin, and other potent inhibitors of hepatic enzymes.

This limitation is due to the fact that drugs in this group can lead to an increase in the level of agomelatine in the blood plasma. Valdoxan is combined with extreme caution with the medicines Propranolol and Grepafloxacin. During the period of agomelatine therapy, one should refrain from drinking alcoholic beverages.

Storage conditions and periods

Valdoxan should be stored in a dark and cool room, where the air temperature does not exceed +30 degrees Celsius.

The medication must be out of reach of children. Storage of tablets should be carried out in the original packaging of the manufacturer. The shelf life of the antidepressant is 3 years, after which further administration of the drug is prohibited.

Conditions of dispensing from pharmacies

To buy Valdoxan, you need a special prescription from your attending psychiatrist. The average cost of a medicine is 735-750 rubles. per packing.

Analogs

The following drugs are presented on the pharmaceutical market, which have pronounced antidepressant properties, as well as are analogs of Valdoxan:

• Amitriptyline Is a budgetary domestic antidepressant with an active substance concentration of 25 mg, the cost of which is 45 rubles.
• Fevarin - this drug is produced by the Dutch pharmaceutical company Abbott, and the price of the drug is 800 rubles. for 15 tablets with a mass fraction of the active substance of 100 mg;
• Prozac - This is a potent antidepressant, which is produced by the French pharmaceutical concern Eli Lilly (the cost of a drug in pharmacy chains is 450-480 rubles. for 14 capsules with a dosage of 20 mg);
• Trittico Is an Italian-made antidepressant, the price of which starts at 630 rubles. for 20 tablets with a mass fraction of the active ingredient of 20 mg;
• Melipramine Is an effective drug with antidepressant properties, which is produced by the Hungarian pharmaceutical company Egis (the cost of the drug is 340 rubles. for 50 tablets with a dosage of the main substance of 25 mg).

All of the above drugs are dispensed exclusively by prescription from a psychiatrist. Therapy with these antidepressants is possible only after a preliminary examination by a specialist. The duration of admission and the dosage regimen with these medications are determined on an individual basis.

Valdoxan is a potent antidepressant that is indicated for the treatment and prevention of severe depressive conditions. The medication is used only for patients of the adult age group. The minimum duration of therapy with this drug is at least 6 months.

If necessary, Valdoxan can be used for a longer time until the symptoms of depression disappear completely. Reviews of patients taking an antidepressant indicate its high therapeutic efficiency, absence of a large number of side effects and its safety for the central nervous system.

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