Fevarin. Reviews of patients who took the drug, instructions for use, analogs, where to buy, who is prescribed, price

Antidepressants - a group of drugs, the action of which is aimed at correcting the level of serotonin in the human body. Fevarin belongs to this category. Reviews of patients taking the medication are mostly positive.

Selling features

Fevarin, like most antidepressants, requires a prescription from pharmacies. The cost of the package varies depending on the dosage: 50 mg - 850-900 rubles, 100 mg - 2000-2200 rubles. The buyer must show the pharmacist the prescription on form No. 107 (1 / y).

It contains the following information:

• the age of the patient;
• F. AND. O. the specialist who wrote the prescription;
• the name of the drug and its price;
• F. AND. O. the patient.

The duration of the prescription (number of months) is indicated by the attending physician. After the sale of Fevarin, the pharmacist keeps the form for himself.

Composition and active ingredients

Release form - oval (less often round) white enteric-coated tablets. In a cardboard box - 1-4 blisters. The main component is fluvoxamine. The substance is presented in different concentrations: 50 mg or 100 mg.

Additional elements:

• vegetable starch (corn) - 40/80 mg;
• hexavalent alcohol (mannol) - 152/303 mg;
• silica (silicon oxide) - 0.8 / 1.5 mg;
• sodium fumarate (fumaric acid) - 1.8 / 3.5 mg;
• alpha starch (pregelatinized) 6/12 mg

The composition of the easily soluble shell:

• titanium dioxide (additive E171) - 1.5 / 2.1 mg;
• mineral talc (additive E553b) - 0.3 / 0.4 mg;
• hydropropyl methylcellulose (HPMC) - 4.1 / 5.6 MG;
• ethylene glycol polymer - 1.5 / 2 mg.

The dosage form also contains small amounts of sugar and lactose.

Mechanism of action

Fevarin (reviews of patients who took the drug prove its effectiveness in depressive conditions) are referred to as 3rd generation antidepressants. Third-generation selective serotonin reuptake inhibitor (SSRI) differs from tricyclic medicines with good tolerance and a low probability of side effects, even against the background of prolonged reception.

Fevarin is prescribed for people who have contraindications to most antidepressants (closed-type glaucoma, arrhythmia). The principle of action is based on the ability of the drug to increase the level of "mood hormone" in the brain. With a normal concentration of serotonin, the psycho-emotional background of a person remains flat.

The selective blocking process takes place in the synaptic cleft. Nerve endings continue to function normally, the circulation of impulses is not disturbed. Under the influence of fluvoxamine, cells that are inhibited by serotonin deficiency are activated.

Fevarin does not affect the synthesis of norepinephrine in any way.

Weak interaction is observed with the following receptors:

• serotonergic;
• m-dopaminergic;
• beta and alpha adrenergic;
• cholinergic;
• histaminergic.

Due to the readily dissolving shell, the drug is quickly adsorbed from the intestinal tract. The maximum level of fluvoxamine in the blood is detected 5-7 hours after ingestion. The presence of food in the organs of the digestive tract does not in any way affect the rate of absorption of the drug. Bioavailability is high - at least 60%, the component binds to blood proteins by 78-82%.

The elimination period of fluvoxamine is 15-22 hours (depending on the medication regimen). Metabolized by the liver, the products formed in the process are partially active (2 of 9). The body is left with urine.

Indications for use

Fevarin (reviews of patients who took the drug indicate the normalization of the psycho-emotional background in patients), is prescribed for:

• functional and somatoform disorders (as part of complex therapy);
• anxiety, obsessive thoughts;
• disorders of the psycho-emotional background, developed as a result of diseases of the internal systems (including benign or malignant tumors);
• obsessive-compulsive syndrome combined with anxiety conditions;
• bipolar disorder;
• affective disorder with cognitive impairment (single episodes);
• depressive conditions (moderate and mild).

The drug has an anti-anxiety effect. The drug is taken during agitation.

Contraindications and side effects

Fevarin (reviews of patients taking the drug indicate good tolerance) is prescribed for depression of varying severity.

Despite its high effectiveness, the antidepressant is contraindicated in people:

• Suffering from hypersensitivity. Before starting treatment, you must consult with a specialist. Various ailments that arose while taking the drug may indicate intolerance to the auxiliary components or the main active ingredient.
• Taking an antidepressant at the same time as monoamine oxidase inhibitors. It is strictly forbidden to combine these drugs due to the high likelihood of increased side effects.
• Suffering from bipolar disorder with manic episodes. It is strictly forbidden to treat pathologies of this type with 3rd generation antidepressants.

Relative contraindications include:

• children's age (up to 18 years old);
• the period of bearing the child and breastfeeding;
• hemorrhagic diathesis (including idiopathic thrombocytopenic purpura);
• epileptic seizures;
• cardiovascular pathology (including atherosclerosis, stroke, history of myocardial infarction);
• renal or hepatic impairment (moderate).

Side effects occur against the background of an incorrectly selected dosage regimen or treatment regimens.

They arise from the following systems:

• Genitourinary: menstrual irregularities in women, late or premature ejaculation, spontaneous flow of breast milk, urinary incontinence, enuresis, urinary retention, nocturia.
• Musculoskeletal: fragility of bones, joint and muscle pain.
• Digestive: liver dysfunction, dyspeptic disorders, bouts of nausea, uncontrolled vomiting, fecal congestion.
• Cardiovascular: increased heart rate, lower blood pressure.
• Visual: increased intraocular pressure, dilated pupils.
• Nervous: feeling of pins and needles, serotonin intoxication, convulsions, impaired motor function, oscillatory movements of the limbs, sleep disturbances (insomnia or drowsiness), prolonged migraines, anxiety, aggression.
• Endocrine: deficiency of vasopressin, increased levels of prolactin in the blood.
• Circulatory: high risk of bleeding (gynecological, gastrointestinal).

Side effects can also include:

• suicidal behavior;
• obsessive thoughts;
• persecution mania;
• excitation;
• various allergic reactions (skin rash, anaphylactic shock, Quincke's edema, fear of sunlight).

Ailments may occur with abrupt withdrawal of the drug. The dose should be reduced gradually.

Instructions

Fevarin must be taken according to the instructions. According to reviews of patients taking the drug, the risk of side effects is reduced if the dosage regimen is followed.

The drug treatment regimen is selected individually:

• initial dose - no more than 100 mg once (1 or 2 tablets);
• the daily rate is not more than 300 mg;
• the dose is increased gradually.

You can take no more than 1 tablet at a time. The daily allowance must be divided into several parts.

Detailed instructions:

• remove the pill from the blister;
• put it in your mouth and swallow it whole without chewing;
• drink the medicine with plenty of warm water.

If the individually selected dosage regimen is exceeded on its own, the risk of developing an overdose is quite high.

The patient's well-being sharply worsens, the following symptoms appear:

• lowering blood pressure;
• increased heart rate;
• violation of sinus rhythm;
• severe dizziness;
• convulsions;
• dyspeptic disorders;
• coma (rare).

There is no specific antidote for fluvoxamine intoxication. The patient needs to rinse the stomach as soon as possible: for this he is given a solution of potassium permanganate (at least 1.5 liters) and enterosorbent (black or white activated carbon) to drink. Forced diuresis or hemodialysis is ineffective in overdose.

The drug can be taken after meals. It is impossible to wash down the tablets with milk, tea, freshly squeezed juices.

Application during pregnancy and lactation

Fevarin (reviews of patients who took the drug - positive) are prohibited from taking during pregnancy and during lactation.

The drug in the early stages can provoke the following defects in the fetus:

• violation of pulmonary bleeding;
• embryonic hernia;
• anencephaly;
• abnormal development of the skull (including craniostenosis);
• Congenital heart defect.

A serotonin reuptake inhibitor during pregnancy is prescribed only in extreme cases and only in the 1st trimester. Taking the drug should not harm the health of the woman and the fetus in her womb. If, after conception, the patient was diagnosed with depression, then she should be under the supervision of a specialist until remission occurs.

In the presence of a convulsive syndrome (in history) in a pregnant woman, treatment with Fevarin should be abandoned. Hyponatremia is diagnosed with abrupt withdrawal of the drug. Side effects, manifested in the form of vomiting and nausea, intensify in the 1st trimester, but disappear on their own after 12-14 days of regular intake.

With abrupt withdrawal, pregnant women may complain of anxiety, increased sweating, heart palpitations, irritability, agitation, and dizziness. If the patient was diagnosed with a mild degree of depression (in this case, the daily rate of Fevarin does not exceed 150 mg), then she can continue to drive on her own.

The active substance is able to penetrate into breast milk, therefore, a woman is instructed to temporarily stop lactation while taking Fevarin. It is better to transfer the baby to artificial feeding.

Drug interactions

The drug can be combined with antiviral, decongestant, mucolytic drugs.

Interaction with other groups of medicines:

• an antidepressant is able to reduce clearance and slow down the metabolism of quinidine;
• the drug does not combine well with metoclopramide, increasing the likelihood of developing neurological complications;
• a serotonin reuptake inhibitor is not combined with Buspirone, reducing the effectiveness of the latter;
• the medication enhances the effect of valproic acid;
• while taking an antidepressant and warfarin, the risk of bleeding increases;
• the drug enhances the negative effects of Galantamine;
• with the combined administration of haloperidol and Fevarin, the concentration of lithium in the blood increases.

The drug is able to increase the concentration of the following drugs in the blood:

• Theophylline;
• Propranolol;
• Olanzopin;
• Clozapine;
• Trimipramine;
• Carbamazepine;
• Maprotiline;
• Imipramine;
• Clomipramine;
• Amitriptyline.

Fevarin is not recommended to be combined with Diazepam, Bromazepam, Alprozalam. The complex intake of these medicines is accompanied by severe malaise. Serotonin syndrome develops in the treatment of depression with MAO inhibitors and Fevarin at the same time.

Storage conditions and periods

The shelf life of opened Fevarin packages is 36 months. The medicine should be kept away from pets and children. The place of storage of drugs should be well ventilated and dry: with high humidity, the mechanism of action of the antidepressant may change.

Fevarin is kept in a tightly closed plastic box, away from other medications. The container can be placed on the top shelf of the cabinet. Neighborhood of medicines with spices, strongly smelling spices is unacceptable. Do not keep packages in the refrigerator.

Analogs

In pharmacies, you can buy a number of analogues with a therapeutic effect similar to the original.

Their prices may vary depending on the composition of the medicines:

Name	Composition and form of release	Indications for use	Contraindications	Price
Deprivox	1 tablet contains 50 mg or 100 mg of fluvoxamine. Accessory components may vary depending on the manufacturer.	Mental disorders (obsessive-compulsive states, depression of mild to moderate severity).	Intolerance to the main component or excipients, simultaneous administration of an antidepressant with MAO inhibitors and tizanidine.	The cost varies between 770-800 rubles.
Deprex	Available in capsule or tablet form. The main component is fluoxetine. Additional elements - mannitol, talc, silicon dioxide (depending on the form of release).	Depression of varying severity (neglected, moderate, mild), obsessive compulsions, alcoholism, anorexia, bulimia.	Cachexia, hepatic or renal failure of the compensated type, epilepsy, Parkinson's disease. You can not take the drug during pregnancy, along with MAO inhibitors.	Packing price - 670-700 rubles.
Fluxonil	It is sold in the form of tablets or capsules. The main component is fluoxetine hydrochloride.	Depressive states, obsessive-compulsive syndrome.	Children's age, period of childbearing and breastfeeding, combination with MAO inhibitors, liver and kidney dysfunction, convulsions, intolerance to active and additional components.	Packing cost - from 540 rubles.
Prodep	1 capsule contains fluoxetine hydrochloride. The composition may contain auxiliary elements.	Bulimic neurosis, depression of varying severity, obsessive-compulsive syndrome.	Hypersensitivity, breastfeeding period and pregnancy, convulsions, combination with MAO inhibitors, prostatic hyperplasia, renal failure, urinary outflow disorders, glaucoma.	Price - 335 - 600 rubles.
Fluoxetine (Prozac)	Capsule release form. The active component is the component of the same name. Additional substances - crospovidone, starch, lactose monohydrate.	Bulimia, obsessive-compulsive syndrome, depressive conditions of varying severity.	Pregnancy, childhood, intolerance of the main component, pathology of the kidneys and liver, pathology of the organs of vision.	Cost - from 420 rubles.
Paroxetine (Paxil)	1 tablet contains paroxetine hemihydrate. Auxiliary elements - calcium dihydrate, magnesium stearate, aerosil.	Post-traumatic stress, generalized anxiety, social phobia, depression, bulimia, OCD, panic attacks.	Children's age, combined administration with pimozide and thioridazine, reversible and irreversible MAOIs, hypersensitivity.	Price - from 230 rubles.
Escitalopram (Lexapro)	It is sold in the form of tablets. The active ingredient is the substance of the same name in the form of oxalate. Additional elements may vary depending on the manufacturer.	OCD, generalized anxiety, social phobia, agoraphobia with panic attacks, depression.	Milk sugar intolerance, lactation, pregnancy, childhood, Relative contraindications - hypersensitivity. renal failure, liver pathologies, diabetes mellitus, conditions close to suicide.	Cost - from 340 rubles.
Citalopram (Celexa)	1 tablet contains citalopram hydrobromide. Auxiliary elements - MCC, magnesium stearate, vegetable starch.	Panic disorder, depression of varying severity.	Children's age, combined administration with MAO inhibitors and pimozide. Contraindicated in hypersensitive people.	Price - from 180 rubles.
Flunisan	Release form - capsules or tablets. The active ingredient is fluoxetine. Additional components may vary.	Premenstrual dysphoria, OCD, bulimia, depression (moderate to mild).	Children's age, combined use of an antidepressant with pimozide, thioridazine, MAO inhibitors. Caution is indicated for hypersensitive people.	Cost - from 280 rubles.
Serenata	The tablet form contains sertraline hydrochloride. Additional substances - polysorbate, microcrystalline cellulose, magnesium stearate.	Social phobia, post-traumatic shock, panic attacks (with or without agoraphobia), obsessive-compulsive syndrome, depression.	Intolerance to auxiliary or active substances, combination with tryptophan, MAO inhibitors. Contraindicated in pregnant women, breastfeeding women and children under 18 years of age.	Cost - from 418 rubles.

All the analogs described above, like Fevarin, require a prescription from pharmacies. The drugs must be taken according to an individually selected scheme. According to the reviews of patients taking medications, antidepressants are well tolerated, side effects are rare and go away on their own.

Video about Fevarin

Features of the drug Fevarin: