Caffeine-benzoate sodium (Coffein-benzoate sodium). Price, instructions for use, what ampoules, tablets are used for, reviews

Caffeine-sodium benzoate - this drug, which belongs to the pharmacological group of psychostimulants. The drug has a nootropic effect on brain tissue, excites and stimulates the central nervous system.

By its nature, Caffeine-Sodium Benzoate is a medicine that is produced by the chemical xanthine. The drug is indicated for admission to patients who suffer from attention disorder.

The average price of the drug is 50 rubles. for a plate of 10 tablets, as well as 33 rubles. for an injection solution of 20% concentration, consisting of 10 ampoules of 1 ml each.

Forms of release and composition

Caffeine-sodium benzoate is a powerful psychostimulant that comes in the form of white and round tablets with oblique edges. A dividing risk passes through the center of the drug. The medication is packaged in plastic blisters covered with foil.

Each drug cassette contains 10 tablets. The main package of sodium caffeine benzoate is a cardboard box complete with detailed instructions for the use of the tablets. The cost of the medication in this form of release may vary depending on the pricing policy of the pharmacy management.

Caffeine sodium benzoate is also available in the form of a liquid solution for injection in 1 and 2 ml ampoules. The concentration of this medication is 10 or 20%, depending on the therapeutic dosage. The drug is packaged in cardboard packages, inside of which there are 10 ampoules with this drug.

Injection solution Caffeine-sodium benzoate is completely transparent, should not show signs of turbidity and sediment, and also does not differ in the specific smell of a chemical compound.

The table below shows the main composition of the tablet preparation Caffeine-sodium benzoate, as well as the dosage of its medicinal component.

The composition of the medication	Dosage of chemicals
Caffeine-sodium benzoate	Caffeine sodium benzoate is the active component of this drug, which has a direct effect on the functions of the human central nervous system. The dosage of this substance is 200 mg in 1 tablet coated with a protective film.

The auxiliary function of the drug Caffeine-sodium benzoate is performed by biochemical substances that are an integral part of the structure medicinal product, and also form its protective shell:

• lactose monohydrate - a natural preservative that is obtained from whole cow's milk;
• corn starch - is part of the protective film of this medication;
• calcium stearate - is an anti-caking agent that improves the structure of the tablets, making it more dense;
• microcrystalline cellulose - improves the therapeutic properties of the main component;
• Povidone is a versatile polymer thickener that is added during the caffeine-sodium benzoate tablet production phase to make them as dense as possible.

Caffeine-sodium benzoate (the price of a medication in the form of tablets is in the range of 50-60 rubles. per plate) is a psychostimulant that differs in the most simple, but at the same time very effective pharmacological formula. In the composition of this medication there are no dyes, harmful additives, carcinogens and preservatives of chemical etiology.

Pharmacological properties

The main effect of sodium caffeine-benzoate tablets is directed at the centers of the brain responsible for the function of psychoemotional arousal, the implementation of the act of breathing and the efficiency of the cardiovascular systems.

This drug has the following pharmacological properties:

• helps to reduce the tone of smooth muscles of internal organs and the musculoskeletal system, which provides an antispasmodic and at the same time relaxing effect;
• expands blood vessels regardless of their physiological type, purpose and location in the human body;
• increases the efficiency of the central nervous system, which makes it possible to achieve the effect of increasing the level of attention and concentration of thought;
• allows you to completely restore reduced psychomotor reactions in patients who need additional stimulation;
• improves blood circulation in the tissues of the brain, internal organs, great vessels, upper and lower extremities;
• is directly involved in improving mental and physical performance;
• reduces the toxic effect after poisoning the body with narcotic substances (Caffeine-sodium benzoate supports the performance of brain tissues, preventing the development of negative changes in their cellular structure);
• restores the impaired functions of the autonomic system (for example, improves the conduction of neural impulses from peripheral nerve endings to the corresponding centers of the brain).

Caffeine-sodium benzoate (the price of the drug is affordable for most consumers) is a drug with a pronounced stimulating effect. The implementation of the therapeutic properties of this agent is possible only in the case of strict adherence to the dosage and instructions for the use of tablets, or a solution for injection.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics of the drug Caffeine-sodium benzoate is realized due to the psychostimulating effect of its main component. After a given drug enters the patient's body in the form of a tablet or injection solution, absorption of caffeine occurs with its further distribution throughout the body along with the flow bloodstream.

The main mechanism for the implementation of the therapeutic properties of this medication is achieved due to the fact that the chemical compound of caffeine-sodium benzoate inhibits the synthesis of the enzyme phosphodiesterase, which is directly involved in the process of intracellular accumulation of cyclic adenosine monophosphate type.

Cyclic adenosine monophosphate stimulates glycogenolysis, promotes a more active metabolism in the cells of the brain, internal organs and tissues of the muscular system of the musculoskeletal apparatus. The main pharmacodynamic feature of the drug Caffeine-sodium benzoate is the binding of its active substance to the purine receptors of the central nervous system.

After caffeine enters the brain tissue, the body's mental and physical arousal effect is realized. There is an increase in motor activity and positive reflexes of muscle tissue. Caffeine sodium benzoate reduces fatigue, drowsiness and the desire to rest.

Pharmacodynamics of the drug Caffeine-sodium benzoate depends on the dose that was taken by a particular patient. As the concentration of the constituent substances of this drug increases, additional stimulation of the cerebral cortex, but at the same time the risk of critical exhaustion of nerves increases cells.

The latter effect is dangerous by the development of concomitant diseases of neurological origin, and the risk of drug dependence increases.

The drug Caffeine-sodium benzoate weakens the effect of narcotic substances and drugs with sleeping pills properties, stimulates the centers of the brain responsible for the motor activity of the walls of blood vessels and organs that perform the act of breathing.

Under the influence of the active component of the drug Caffeine-sodium benzoate, the frequency of heart contractions increases, the general blood circulation in the vessels of the brain and tissues of internal organs increases. An indirect pharmacodynamic property of this medication is an increase in the average daily urine output.

The latter effect of the drug is achieved by suppressing the physiological process of reabsorption of electrolytes in the cavity of the renal tubules. This property of sodium caffeine benzoate should be taken into account by patients who have chronic diseases of the kidneys and other organs of the excretory system.

Pharmacokinetics of the drug Caffeine-sodium benzoate is characterized by good absorption of its active substance and uniform distribution throughout the body. The main component of this drug easily overcomes the blood-brain, placental barrier, and also saturates the composition of breast milk in women who are lactating.

In the process of biological transformation, caffeine-sodium benzoate undergoes oxidation and intense demethylation. The main metabolism of the active substance occurs in the liver tissues.

About 92% of the resulting biochemical decomposition products are disposed of from the body along with urine. The rest of the metabolites are excreted in the feces. The average elimination half-life of this drug is 3 to 7 hours.

Indications for use

Caffeine-sodium benzoate (the price of the drug does not exceed 60 rubles. for 1 blister) is a medication that is prescribed for admission by a general practitioner, psychiatrist or neurologist.

This drug is indicated for use in patients who have the following symptoms or diagnosed diseases:

• asthenic syndrome;
• constant drowsiness, accompanied by a general decline in strength, the nature of the origin of which has not been established;
• hard physical labor, requiring activation of the body's energy resources, additional stimulation of the muscular system of the musculoskeletal system;
• spasms of the blood vessels of the brain (in this case, the drug Caffeine-sodium benzoate is used in complex with other medicines, the action of which is aimed at eliminating the causes of pathology);
• arterial hypotension, manifested by the preservation of low blood pressure values ​​for a long period of time;
• severe infectious diseases, as well as other diseases, one of the symptoms of which is suppression of the functions of the cardiovascular, central nervous system and respiratory organs;
• daily mental work, which requires additional stimulation of the centers of the brain, increasing cognitive abilities.

Depending on the type of disease that was diagnosed in a particular patient, in combination with the drug Caffeine-sodium benzoate, other medicines with stimulating properties. The use of this medicinal product is possible only after a preliminary examination by the attending physician.

Contraindications

Caffeine-sodium benzoate (the price of the drug is much lower than that of other medicines belonging to the category of psychostimulants) is a drug that which is contraindicated for use in the following cases:

• individual sensitivity of the body in relation to the constituent components of this drug, as well as other substances that are industrial substances xanthine (theobromine, theophylline);
• glaucoma and other types of ophthalmic diseases associated with increased intraocular pressure;
• previously suffered acute myocardial infarction;
• atherosclerosis of the great vessels, regardless of the location of the pathology;
• insomnia and violation of the process of falling asleep;
• increased psychoemotional excitability caused by an individual characteristic of the body or side effects of other drugs;
• arterial hypertension or a tendency to frequent and sudden high blood pressure;
• tachycardia of the paroxysmal type;
• all types of diseases of the cardiovascular system associated with a violation of the rhythmic activity of the heart, or the pathological state of the veins and arteries.

The drug Caffeine-sodium benzoate is contraindicated in patients over 60 years of age, in women who are pregnant and breastfeeding. This restriction on the use of the drug is justified by the high risk of side effects and complications from the cardiovascular system.

The attending physician who examines the patient may detect other latent diseases of the body that exclude therapy with this medication.

At what age can the drug be used?

The drug Caffeine-sodium benzoate is approved for use in patients who are 12 years of age or older.

Instructions for use, dosage

The procedure for therapy with tablets and injections of the drug Caffeine-sodium benzoate is regulated by the instructions for its use.

Ampoules

Caffeine-sodium benzoate injection solution is injected subcutaneously. Adults are shown a dosage of 1 ml of the drug, the injection is carried out into the fatty tissue from 2 to 3 times a day.

Children are shown the use of an injection solution of 10% concentration in a dose of 0.25-1 ml 2-3 times a day, depending on the age, weight of the child and the type of disease.

Pills

Children over the age of 12 should take 100 mg of the medication 2 to 3 times a day. The maximum daily dose of this drug for a child is no more than 500 mg. Patients of the adult age group undergo therapy with the psychostimulant agent Caffeine-sodium benzoate at a dose of 100-200 mg 2-3 times a day.

The drug is taken orally at the same time of day. The tablets must be taken with a sufficient amount of water. The duration of the therapeutic course is set individually by the attending physician.

Side effects

Caffeine sodium benzoate is well tolerated by most patients who do not have chronic diseases of the cardiovascular system and central nervous system.

During therapy with this medication, the following side effects may develop:

• sense of anxiety;
• tremor of the upper limbs;
• nausea;
• vomit;
• a feeling of squeezing in the chest;
• muscle cramps of the lower extremities;
• inhibition of the functions of the central nervous system;
• insomnia;
• dizziness;
• violation of the rhythmic activity of the heart;
• increased blood pressure;
• a state of deep depression;
• frequent urination;
• drowsiness;
• various kinds of allergic reactions.

Laboratory studies of the drug Caffeine-sodium benzoate have shown that its constituent components can lead to an increase in urinary acid, cause drug dependence and promote the formation of new receptors of the adenosive type, which are formed in the cells of the head brain.

Overdose

Violation of the rules for dosing with a psychostimulant agent Caffeine-sodium benzoate can provoke the onset of the following overdose symptoms with this medication:

• confusion of consciousness;
• headache;
• increased blood pressure;
• tachycardia;
• convulsions;
• increased urination;
• bronchial spasm;
• urticaria, swelling of epithelial tissues and rashes;
• lowering the threshold of pain sensitivity;
• twitching of individual muscles;
• sense of anxiety;
• nausea and vomiting;
• ringing sensation in the ears.

  

In case of an overdose of Caffeine-sodium benzoate, it is necessary to perform gastric lavage, take sorbent preparations. Severe patients are injected intravenously with Diazepam, Phenytoin, and Phenobarbital, maintain the water-salt balance.

special instructions

It is recommended to refrain from driving and performing work with increased danger until an individual reaction to the constituent components of this drug.

Drug interactions

Caffeine-sodium benzoate enters into drug interaction with the following types of medicines:

• Furazolidone - the risk of arrhythmia increases;
• Primidone - enhancement of metabolic processes;
• Cimetidine - the pharmacological properties of caffeine are more active;
• Mexiletin - the half-life of the active substance of this medication slows down;
• drugs from the group of beta-blockers - there is a mutual suppression of medicinal properties;
• medications with an analgesic effect - enhancing the action of these drugs.

Before starting therapy with a psychostimulant agent Caffeine-sodium benzoate, you must inform your doctor about other medications that are currently being taken.

Analogs

The only analogue of the drug Caffeine-sodium benzoate is the drug Caffeine, which is available in the form of a sterile solution for subcutaneous administration in 1 or 2 ml ampoules with a set of 10 pieces in each pack. The average cost of this analogue in pharmacies is 55 rubles.

Terms, conditions of sale and storage

To buy the drug Caffeine-sodium benzoate, you will need to present a prescription from your doctor. Storage of this medication should be carried out at room temperature, but not higher than +25 degrees. This psychostimulant must be kept away from children and away from direct sunlight. The shelf life of the drug is 6 years.

Price

In retail pharmacy chains, the average cost of the medication Caffeine-sodium benzoate is from 50 rubles. for 1 package of tablets and 33 rubles. for 10 ampoules of injection solution.

Caffeine sodium benzoate is a psychostimulant drug that has a direct effect on the central nervous system. This drug affects the centers of the brain responsible for the functions of the respiratory system, heart, blood vessels, the activity of the muscular system of the musculoskeletal system.

Regular intake of tablets or subcutaneous injection of an injection solution of 10 or 20% concentration provides an increase in mental and physical endurance, improves overall blood circulation, stimulates the cognitive function of the cerebral cortex brain.

The price of this drug is affordable for most consumers with an average income level, and the course of caffeine therapy is determined individually by the attending physician.

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