Highly active tranquilizer Phenazepam it is used in the complex therapy of neurological disorders, mental disorders and somatic pathologies. The drug belongs to the category of potent drugs. It is impossible to buy it in a pharmacy without a prescription, like most analogues.
Record content:
- 1 Form of release, composition and properties of the drug
- 2 Indications for use
- 3 Contraindications
- 4 Instructions for use, dosage
- 5 Side effects and overdose
-
6 Analogs of the remedy
- 6.1 Adaptol
- 6.2 Bellataminal
- 6.3 Amitriptyline
- 6.4 Diazepam
- 6.5 Ketilept
- 6.6 Phenibut
- 7 Comparison of the cost of the drug and its analogues
- 8 Video about Phenazepam
Form of release, composition and properties of the drug
Phenazepam is produced in the form of orodispersible tablets and an injection solution for intramuscular or intravenous administration. The latter goes on sale in 1 ml clear glass ampoules.
In a box - 10 pcs., A scarifier and an insert with instructions for use. Round white orodispersible tablets dissolve in the mouth and do not require swallowing.
Such a drug is supplied to pharmacy chains in a sealed contour-cellular package made of aluminum foil and a hypoallergenic transparent medical polymer. Each blister contains 7 or 14 tablets.
This dosage form is convenient for patients with dysphygia - a violation of the swallowing reflex. In hospitals, orally dispersible tablets are used if the patient refuses to take the medication, which is often found in mental disorders.
An analogue of Phenazepam without prescriptions, which is more expensive, is inferior to it in efficiency and spectrum of therapeutic coverage, but superior in safety of use. The list of such tranquilizers is small, but you can purchase a remedy suitable for home therapy.
Each tablet, depending on the dosage, contains 0.5, 1 or 2.5 mg of the active ingredient - phenazepam (hydrochlorinated phenylbenzodiazepine bromide).
Auxiliary components of the tranquilizing and anti-anxiety medication:
- betadex - a cyclic carbohydrate with strong stabilizing physicochemical characteristics;
- mannitol - an osmotic diuretic with decongestant properties and stimulating urinary function;
- modified corn starch - a binder that ensures the disintegration of tablets in the dental cavity upon contact with the mucous membrane;
- magnesium stearate - a lubricant for solid dosage forms that maintains the structural structure of the tablets.
Phenazepam has pronounced anxiolytic, sedative and central muscle relaxant properties. The active component of the drug has a pronounced angioneurotic and psychotropic effect.
Indications for use
The drug has a wide range of medical prescriptions. It is used for neurotic and psychopathic conditions.
Phenazepam is used to treat patients with:
- reactive psychoses;
- senesto-hypochondriac syndrome;
- neuropathies caused by alcohol dependence or drug withdrawal;
- substance abuse;
- various types of schizophrenia;
- neurasthenia;
- epilepsy of the temporal and myoclonic types;
- increased anxiety;
- depression;
- autonomic dysfunctions.
A highly active tranquilizer with muscle relaxant properties, it is effective for convulsive conditions and uncontrolled muscle reflexes - athetosis and hyperkinesis. It is often prescribed for patients with emotional lability.
The drug is used to treat insomnia, suppress panic attacks and causeless fears, and other severe mental conditions. Phenazepam is used in the complex therapy of muscle rigidity.
Tranquilizers stop agitation and pathological irritability, suppress excessive emotional stress and phobic states. In surgical practice, the drug is used for drug preparation of drug addicted patients for general anesthesia.
Contraindications
Phenazepam has a large number of clinical restrictions on its use. Taking pills or making intramuscular injections is prohibited in case of myasthenic syndrome - a severe autoimmune pathology.
It is characterized by rapid fatigability of striated muscle fibers and poor patency of nerve impulses. Phenazepam is not prescribed for patients with angle-closure glaucoma, an ophthalmic disease accompanied by impaired drainage function in the optic organ.
You can not take tranquilizers against the background of drug and alcohol intoxication. In case of poisoning with analgesics, the use of Phenazepam is especially dangerous. Do not prescribe a complex anxiolytic drug for exacerbation of bronchial asthma and other respiratory diseases, accompanied by respiratory failure.
You can not take Phenazepam in the 1st trimester of pregnancy and breastfeeding. The drug has teratogenic properties, can affect intrauterine development. A potent psychotropic and muscle relaxant drug is not used to treat minor patients.
It is advisable to choose an analogue of Phenazepam without prescriptions for home use and with individual hypersensitivity to psychoactive substances of the benzodiazepine class. It is forbidden to take tranquilizers for depressed vital functions and multiple organ failure.
Patients with severe depression may develop suicidal tendencies. They are advised to refrain from using Phenazepam.
Do not prescribe the drug for:
- a history of drug dependence;
- organic lesions of the brain;
- sleep apnea syndrome;
- hypoproteinemia - an abnormally low content of protein compounds in the plasma fraction of blood.
Tranquilizers are practically not used to treat elderly patients (age 65+) due to the increased risk of life-threatening complications and unforeseen body reactions.
Instructions for use, dosage
Intramuscular and intravenous injections of Phenazepam are prescribed for the rapid suppression of psychomotor agitation, with exacerbations of neurological disorders and autonomic paroxysms.
The dosage and frequency of use are calculated by the doctor individually, taking into account the patient's history, the severity of the pathological condition, and the general clinical picture. The initial daily volume of the tranquilizer is 500-1000 mg (0.5-1 ampoule).
The average daily volume in intensive care reaches 1500-5000 mg, and the maximum allowable is set at 10,000 mg for infusion.
Dosage regimen and method of administration of ampoule Phenazepam for typical pathologies:
| Disease | Medication volume and delivery method |
| Panic attacks, psychotic and neurotic exacerbations, unmotivated fears and phobias, increased anxiety | The average daily dose in the initial phase of treatment is 3-5 ml of an injection solution with an active ingredient concentration of 1%. With a severe course of the disease, it is permissible to increase it to 7-9 ml. |
| Temporal and myoclonic status epilepticus | The drug is administered intramuscularly or intravenously in a daily dosage of 2.5-5.0 ml, which are divided into 2 injections - in the morning and in the evening. |
| Alcohol withdrawal | The recommended daily allowance is 3 ml. The route of administration is intravenous. |
| Neurological disorders accompanied by increased muscle tone | Phenazepam is installed in the gluteus muscle, 5 ml. Frequency rate of application - 1-2 times a day. |
| Premedication to prepare for operational anesthesia | The medicine is slowly injected into the central artery at the bend of the elbow. The standard dosage is 3-4 ml. |
An analogue of Phenazepam without a prescription (Glycine or Melaxen) is recommended to be taken as a remedy maintenance therapy after the end of the course of treatment with the injectable drug and the achievement of a positive speakers.
Such medicines are suitable for the elimination of insomnia, convulsive readiness and movement disorders. Tablet Phenazepam and its over-the-counter analogs are taken in a dosage of 250-500 mg.
Course treatment of neuroses and psychopathies begins with a daily volume of 1500-3000 mcg. It is divided into 2-3 doses. After 2-4 days, the dose can be doubled, provided that the active substance is well-responsive.
To eliminate the addictive effect, Phenazepam is taken for 2-4 weeks. In some cases, by the decision of the doctor, the treatment can be prolonged up to 60 days. The therapeutic course is completed with a gradual dose reduction.
Side effects and overdose
Taking Phenazepam is associated with the risk of a large number of undesirable consequences. Many of them are explained by the sharp effect of the drug on the nervous system and brain activity.
In the initial stage of the course of treatment, drowsiness, chronic fatigue, and a lethargic state may be observed. After taking Phenazepam, depression of consciousness is felt, dizziness appears, the ability to concentrate is lost.
The most common side effects in terms of frequency of manifestation were distributed as follows:
- Difficulty with spatial orientation. This side effect is reported by the majority of patients who took the tranquilizer in a course manner.
- Ataxic symptoms. The inhibition of nervous activity by benzodiazepine leads to a violation of the coordination of contractions of various muscle groups.
- Confusion of consciousness. It is explained by the effect of the drug on the processes occurring in the brain.
- Cephalalgia. It is caused by an increase in intracranial pressure.
- Feeling of euphoria. Increased secretion of endorphins leads to it.
- Dystonic disorders of an extrapyramidal nature.
In patients prone to epileptic seizures, tremors are recorded. Some side effects are manifested by auditory and visual hallucinations, uncontrollable outbursts of aggressive behavior, spastic state of muscle structures.
The hemostatic system reacts to the benzodiazepine compound by reducing leukocytes and postcellular fragments. From the side of digestion, stool disorders, heartburn, transaminases - an increase in the activity of liver enzymes were recorded.
The side effects of Phenazepam include drying out of the mucous membrane of the dental cavity. In some patients, an increase in the concentration of alkaline phosphatase in the plasma fraction of blood was recorded.
Phenazepam and its analogues, including those sold without a prescription, are capable of suppressing male libido and causing menstrual irregularities in women.
Side effects of potent tranquilizers are:
- development of drug addiction;
- arterial hypotension;
- visual disturbances;
- drastic weight loss;
- cardiac arrhythmia and tachycardia.
An overdose of Phenazepam is fraught with serious problems with the functional state of the body, and in especially severe cases it is a direct threat to life.
Typical symptoms of intoxication with benzodiazepine derivatives:
- a sharp increase in side effects;
- partial suppression of natural biological reflexes;
- pathological drowsiness;
- nausea and vomiting;
- severe dizziness;
- speech disorders;
- violation of respiratory activity;
- bradycardia;
- coma;
- a sudden drop in blood pressure.
If such symptoms are found at home, it is recommended to immediately take an increased dose of enterosorbent and seek medical help. In medical hospitals, gastric lavage is performed and Flumazenil is injected, a detoxifying drug, the only known benzodiazepine antagonist.
Analogs of the remedy
Pharmaceutical companies produce a wide range of complex tranquilizers that have a mechanism of action similar to Phenazepam. Most are prescription drugs.
However, there are several effective and inexpensive medications that can be purchased from a pharmacy without a doctor's prescription. Below are the most popular analogues of Phenazepam.
Adaptol
Mild Latvian tranquilizer used for neurological disorders. The drug does not have a hypnotic effect, therefore it can be used during the daytime. The active ingredient is mebikar, which is a nitrogenous compound.
Auxiliary components of Adaptol are methylcellulose and calcium stearate. The sparing drug has no contraindications, with the exception of individual intolerance, pregnancy and lactation.
Available in oral tablet form. They are taken in a standard dosage of 0.3-0.5 g. Frequency rate of application - 2-3 tablets per day at regular intervals. The maximum permissible daily rate of Adaptol is 3 g. The duration of the course of treatment is up to 3 months.
Bellataminal
Domestic sedative medicine used in the complex therapy of depressive conditions, vegetative-vascular dystonia, neurotic disorders. Bellataminal restores the menstrual cycle, the failure of which is caused by pathological reasons.
The chemical formula of the tranquilizer is based on ergomitan tartrate, phenobarbital and belladonna alkaloids.
The following ingredients were used as additional ingredients in the complex preparation:
- saccharinate;
- corn starch;
- povidone;
- silica;
- magnesium stearate.
It is impossible to buy an analogue of Phenazepam without a prescription in a pharmacy, despite the minimum number of contraindications and side effects. Bellatominal is not prescribed for patients with angle-closure glaucoma, angina pectoris and severe atherosclerosis.
The medicine should not be taken during pregnancy and prenatal preparation. Tablets are taken with meals, 1 pc. 2-3 times a day. The indicative course of treatment is 2-4 weeks.
Amitriptyline
An inexpensive antidepressant with sedative, anti-bulimic (eating disorder), anti-ulcer properties. Non-selectively inhibits the mechanism of neuronal uptake of monoamine compounds.
Composition of the preparation:
- milk sugar monohydrate;
- calcium stearate;
- modified corn starch;
- colloidal silicon dioxide;
- natural gelatin;
- purified talc.
Amitriptyline is not prescribed to patients with impaired myocardial conduction, arterial hypertension, inflammatory diseases of the kidneys and urinary tract.
The medication should not be taken for liver dysfunctions, paralytic intestinal obstruction, hypersensitivity. The tablets are taken without chewing or resorption.
The initial dosage for adults is 25-50 mg. It is advisable to take the medicine before bedtime. The daily rate is increased gradually over 5-6 days until a favorable therapeutic dynamics is achieved. The maximum daily volume is 300-500 mg of active ingredient.
Diazepam
A potent anxiolytic tranquilizer of the benzodiazepine group. It has anticonvulsant, central muscle relaxant and sedative effects. Available in the form of oral tablets and injection solution.
In addition to the active ingredient, it contains lactose monohydrate, calcium stearate and povidone-25. Benzyl alcohol is added to the injection solution as a stabilizer.
The drug should not be taken when:
- intoxication of blood with carbon dioxide;
- severe myasthenic syndrome;
- alcohol, drug and drug addiction;
- pregnancy and lactation.
Depending on the form of release, the tranquilizer is administered orally, intramuscularly or intravenously. The daily dosage is calculated individually. It ranges from 0.5-60 mg.
Ketilept
An expensive synthetic antidepressant used to treat neuroses, schizophrenia, manic and bipolar disorders. It is produced in the form of tablets with an active ingredient content of 100, 150, 200, 300 mg.
You can not use this potent medicine for cardiac diseases, cerebrovascular disorders, acute liver dysfunctions. The pharmacologically active ingredient is quetialin fumarate.
Auxiliary Ingredients:
- microcrystalline cellulose;
- lactose monohydrate;
- dehydrated silicon dioxide;
- potato starch.
Patients with schizophrenic manifestations and acute psychoses are prescribed Ketilept at a dosage of 50-300 mg, depending on the severity of the symptoms. The maximum allowable daily amount of an antidepressant is 750 mg.
The daily dose is divided into 3 doses with equal time intervals. The course of treatment is not established and is determined by the psychiatrist individually. Patients with severe manic-depressive disorders are prescribed a daily dose of 850 mg, provided that the drug is well tolerated.
Phenibut
Nootropic drug with high anxiolytic activity, used to treat anxiety-neurotic and obsessive states, asthenic syndrome. Phenibut has been shown to be very effective in eliminating stuttering in children.
Urologists use the drug in the complex therapy of urinary dysfunction caused by progressive myelodysplasia. The main active ingredient is beta-phenylbutyric acid hydrochloride.
The drug should not be taken in case of acute renal failure and inflammatory diseases of the genitourinary system, which impede the systemic excretion of a pharmacologically active component and can lead to its accumulation in tissues organs.
Care should be taken to prescribe a medicine for chronic digestive pathologies and impaired intestinal motility. Phenibut has an irritating effect on mucous membranes.
Do not treat children under 8 years of age with nootropic tablets, pregnant women or nursing mothers. The drug is taken orally in the course of 1-1.5 months.
The standard daily dosage for adults is 750-1000 mg of active ingredient. In case of extreme clinical need, it can be increased to 2500 mg, but under strict medical supervision.
Elderly patients are advised to limit the daily dose to 500 mg. Children 8-14 years old are usually prescribed 3 tablets per day (total volume 0.75 g). Patients with renal dysfunction and inflammation of the urinary tract are allowed to take no more than 0.25 g of Phenibut per day.
Comparison of the cost of the drug and its analogues
In pharmacies, Phenazepam costs about 100 rubles. for a pack of 7 tablets. For 10 ampoules of solution for injection in the capital, you will have to pay about 140 rubles. It is one of the cheapest and most potent tranquilizers.
Adaptol's price is 764 rubles. Bellataminal is much cheaper (only 134 rubles), but does not have as many therapeutic effects. The cheapest analogue of Phenazepam is Amitriptyline, which is sold in pharmacies for 45 rubles. The most expensive drug presented is Ketilept. Its cost is 1350 rubles.
The relatively low price of Phenazepam is explained by its severe effects on the body and a large number of side effects. Many analogues are more expensive, but they are safer to use. Only Phenibut tablets can be purchased without a prescription at a price of about 90 rubles.
Video about Phenazepam
Doctor about Phenazepam:
