Midrimax (Midrimax) eye drops. Price, instructions for use, where to buy, analogs, reviews

Midrimax - it is a medical ophthalmic agentused for diagnostic purposes. According to patient reviews, the eye drops are well tolerated, but they have a high price.

Forms of release and composition of the drug

This drug is in the form of eye drops, which include 2 active substances - tropicamide and phenylephrine hydrochloride.

Additional ingredients:

• 0.1 mg benzalkonium chloride;
• 1 mg sodium salt of ethylenediaminetetraacetic acid;
• 2 mg sodium metabisulfite;
• sodium hydroxide;
• 5 mg hypromellose;
• hydrochloric acid solution;
• injection water.

The medicine is poured into plastic bottles. The nominal volume of each bottle is 5 ml. All vials are packed in a cardboard box and accompanied by an insert instruction.

Pharmacological properties

The first active ingredient (phenylephrine) belongs to the class of adrenergic drugs. When used topically, this component leads to the formation of mydriasis, promotes the excretion of fluid inside the eye.

The drug has a vasoconstrictor effect aimed at the conjunctival region, and also stimulates the work of alpha-adrenergic receptors. In this case, the component exhibits extremely weak activity in relation to beta-adrenergic receptors.

The ingredient has a high vasoconstrictor capacity. However, it does not affect the frequency and strength of heart contractions. In comparison with norepinephrine, this substance has a lesser effect on vasopressor activity, but has a longer period of exposure.

Upon contact with the surface of the eye, the ingredient leads to an increase in the contractility of the dilating components of the pupil, affects the smooth muscle structures of the arterioles, which ultimately leads to dilated pupil.

This action with a single use of the drug occurs from 10 minutes to 1 hour. In this case, the effect lasts for 4-6 hours. The use of the product does not lead to the development of paralysis of the eyelash muscles.

The main ingredient enhances and complements the action of another active substance, since their pharmacological properties differ. In this case, phenylephrine blocks the ability of the second component to increase pressure in the eye.

The second main substance (tropicamide) is an anticholinergic component that leads to pupil dilation and paralysis of the ciliary muscle. In this case, there is a slight increase in intraocular pressure.

Pupil dilation occurs within 5-10 minutes. after applying the solution. The maximum manifestation of mydriasis is noted by 25-45 minutes. This action lasts for 1 hour. The effect persists for the next 6 hours.

Pharmacodynamics and pharmacokinetics

The first component (phenylephrine) quickly penetrates into the eye tissues. After topical use, the maximum level of the substance is observed after 20 minutes. The ingredient is excreted by the renal system in unchanged form or in the form of inactive metabolites.

The second substance quickly enters the tissues and is absorbed into the local bloodstream. The level of the component in the blood after 5 minutes. after administration of the solution, it varies in the range of 2-3 ng / ml. After 1 hour. The level of the component in the blood was 0.5 ng / ml. After 2 hours. The concentration of the component in the blood reached a value of 240 mg / ml.

Indications for use

Midrimax - eye drops (the price of a medicine is not the main criterion for its effectiveness), which are used for diagnostic measures, leading to a temporary dilation of the pupil.

Indications:

• eye research and diagnostics;
• surgical interventions or laser procedures.

The tool should be used strictly according to the indications of a specialist.

Contraindications

The drug has some restrictions on its use.

Contraindications:

• development of intolerance to components - hypersensitivity;
• narrow-angle or closed-angle form of glaucoma;
• minor age;
• pathologies occurring in the field of the cardiovascular system;
• increased content of thyroid hormones in the body;
• carrying or feeding a child;
• joint use of drugs belonging to the class of MAO inhibitors;
• the presence of type 1 diabetes mellitus.

With great care, the solution is prescribed in the presence of type 2 diabetes mellitus, as well as in old age (in persons suffering from various pathologies of the cardiovascular system) due to the development of arrhythmic conditions or heart attack.

At what age can the drug be used?

This medication is approved for prescription from the age of 18.

Instructions for use, dosage

The drug is intended for topical use.

The solution is instilled into each conjunctival sac, 1-2 drops. Apply the product in 20 minutes. before the start of diagnostic procedures.

Side effects

Midrimax can lead to the development of undesirable manifestations of both systemic and local nature, despite the high price of eye drops.

Local side effects:

• hypersensitivity reactions;
• increased pressure in the eye;
• short-term pain in the eye area;
• burning sensation, fear of light;
• episodes of blurred vision;
• narrowing of the anterior chambers of the eye;
• signs of allergies;
• soreness in the region of the eyebrows;
• inflammatory processes in the conjunctiva;
• increased lacrimation;
• development of keratitis;
• drug-induced constriction of the pupil.

Repeated use of the solution may lead to a less pronounced dilated pupil effect. This feature is observed in elderly patients.

Systemic side reactions:

• feeling of dry mouth;
• blanching of the skin;
• excessive dryness of the skin;
• the development of hyperemia;
• contact form of dermatitis;
• migraine;
• development of bradycardia;
• disruptions in the heart rate;
• heart rate abnormalities;
• increased pressure;
• ventricular forms of occlusions in the area of ​​coronary arteries;
• muscle weakness;
• disorders in the central nervous system;
• arresting processes in the pulmonary artery;
• increased or difficult urination;
• deterioration of the stomach and decreased peristalsis;
• dyspeptic disorders - constipation, vomiting, nausea.

In elderly people with cardiovascular pathologies, the use of drops can lead to a heart attack or the development of ventricular arrhythmias. In the event of adverse reactions, including cases not described in the official instructions. It is necessary to stop using the medication and consult with the attending specialist.

Overdose

If the solution is accidentally swallowed, negative symptoms may develop.

Overdose signs:

• excessive dryness in the area of ​​mucous membranes or skin;
• development of hyperthermia;
• increased heart rate;
• dilated pupils;
• emotional excitement;
• convulsive state;
• coma;
• violation or depression of respiratory functions.

  

The principles of intoxication treatment:

• Carrying out gastric lavage.
• Purpose and use of sorbents - activated carbon.
• Antidote use is benzodiazepines.
• Treatment of a hyperthermic state is the application of cold compresses.
• Therapy for systemic effects is the use of alpha-blockers.

With the development of signs of an overdose, it is necessary to urgently seek help from a medical institution.

special instructions

Midrimax - eye drops (the price of the solution is usually not taken into account when prescribing a similar group of drugs), which it is necessary to apply strictly according to the prescription of the attending specialist and observe all the prescribed rules of admission funds.

The use of the product can lead to the penetration of pigment substances into the fluid of the anterior chamber of the eye. In some cases, particles of suspension or blood cells may be observed in the anterior chamber section.

The use of the drug while wearing contact lenses may lead to the dissolution of some parts of the ophthalmic devices. In this connection, the lenses must be removed before using the solution. It is not recommended to put on the lenses earlier than 20 minutes. after applying the drops.

To prevent the occurrence of systemic adverse reactions when applying the drug, it is necessary to press on the lacrimal sacs for several minutes after the solution is dispensed.

Drops can lead to mydriasis and reduce visual acuity. In this connection, for the entire period of use of the drug, it is recommended to refuse to drive or carry out work that requires increased concentration of attention.

Drug interactions

With the simultaneous use of beta-blockers, an increase in the vasoconstrictor effect of the drug is noted.

The simultaneous use of the solution and guanethidine can lead to a hypertensive crisis. This effect is also noted with the appointment of any adrenergic blocking drugs.

Combined intake of medication and MAO inhibitors (as well as a period within 1 month after cancellation of this group of drugs) lead to an increase in the risks of developing adrenergic reactions of systemic character.

The effect of the drug can increase with the combined use of the solution and the tetracyclic group of antidepressants, methyldopa and m-anticholinergic drugs.

The use of local anesthetic drugs before application of the solution can lead to an increase in the absorbent properties of the drops and cause dilation of the pupils.

Analogs

Midrimax are eye drops, the price of which may differ significantly from similar drugs. In case of intolerance to the components, substitutes are selected based on the indications for the appointment and the pharmacological group of drugs.

Analogs:

• Tropicamide. This medicinal product is a pharmaceutical development of a Polish manufacturer. The drug is produced in the form of eye drops, the main substance of which is the ingredient of the same name - tropicamide. The solution belongs to the class of mydriatic drugs and is used as an agent prescribed before diagnostic or research medical procedures. The medication is also used before surgery or laser exposure in ophthalmology. The solution can be used to prevent the development of inflammation in the postoperative period. The dosage is calculated according to the indications, the area of ​​application, and also based on the dispensed dosage form (concentration). Drops are used in 20-30 minutes. before the start of the procedures. The solution is contraindicated in the presence of various types of glaucoma, as well as in the presence of intolerance to the components that make up the drug. The method of dispensing from pharmacies is prescription. Prices for the drug in pharmacies start at 300 rubles.
• Cycloptic. Romania is engaged in the production of this drug. The drug is made in the form of eye drops, the main ingredient of which is cyclopentolate hydrochloride. Active substances block m-cholinergic receptors and lead to a temporary dilation of the pupil. This drug is used before various ophthalmic (diagnostic) procedures, as well as before using laser exposure. The medicine can be used as a prophylactic agent during the rehabilitation period. Before the research, 1-2 drops of the solution are prescribed for 20-30 minutes. before the start of the procedure. The medication has some restrictions on its use: various types of glaucoma, the presence of injuries in the area sphincter of the pupil, carrying and feeding a child, children under 3 years of age and the presence of allergies to the composition solution. With high caution, the agent can be used in old age, in the presence of intestinal obstruction, as well as in the defeat of the prostate gland by hyperplasia. The drug is dispensed from pharmacies on a prescription. The cost of a bottle in pharmacies is from 380 rubles.
• Midriacil. This pharmacological agent is being developed by a Belgian pharmaceutical company. The drug is produced in the form of an eye instillation solution. Its active ingredient is tropicamide, which belongs to the class of mydriatic substances. The medicine is used before carrying out various diagnostic measures in ophthalmic practice, including fundus examinations. Also, drops are used as part of a comprehensive treatment for the development of inflammatory processes. Often, the agent is prescribed as a prophylaxis after the use of surgical methods of surgery or laser exposure. The dosage regimen depends on the dosage form of the drug and the concentration of the solution. Contraindications to taking the drug: various types of glaucoma, pressure inside the eye, the presence of intolerance to the main component. The method of dispensing drops is according to the prescription of the attending physician. The cost of the solution in pharmacies in Moscow and St. Petersburg starts from 370 rubles. per bottle.

Midrimax are eye drops (the price of the product is not the main factor in choosing an analogue), which are allowed to be replaced with similar drugs only after prior consultation with an ophthalmologist. Self-replacement and use of the medication can lead to the development of hypersensitivity reactions and other complications.

Terms, conditions of sale and storage

• The medicine must be stored in a dry, dark place at temperatures up to 25 ⁰C.
• The shelf life of the solution is 2 years from the date of manufacture.
• Do not use the product after the expiration date indicated on the package.
• Drops are dispensed with a doctor's prescription.

Price

The prices for the solution may differ slightly from each other depending on the trade pharmacy network and the area of ​​the drug dispensing.

Region / region	Dosage form	Price
Moscow, Moscow region	Drops, 5 ml	RUB 587-1418
St. Petersburg	Drops, 5 ml	RUB 655-1097
Saint Petersburg (suburbs)	Drops, 5 ml	RUB 672-851
Novgorod region	Drops, 5 ml	RUB 622-780
Leningrad region	Drops, 5 ml	RUB 652-810

Before using Midrimax, it is recommended to consult with a specialist or pharmacist and carefully study the instructions for use. It is also recommended to read the reviews of patients who have used eye drops. You can find out the exact price of the solution at any commercial or state pharmacy located in your place of residence.

Video about eye drops

How to properly instill eye drops: