Candibiotic ear drops. Price, instructions for use, cheap analogs, reviews

IN otolaryngology ear drops Candibiotic is prescribed for adult patients and children. The price of this drug exceeds many analogues, which is explained by its complex combined action and therapeutic efficacy.

Composition, release form, price

The drug contains several active ingredients with different principles of action.

You can clearly see this in the table:

P / p No.	Substance name	What effect does	Short description	Amount contained in 1 ml of ear drops
1	Lidocaine hydrochloride	Pain reliever	A local anesthetic, also used in pharmacology as a cardiac depressant.	20 mg
2	Chloramphenicol (synthomycin)	Antibacterial	A broad-spectrum antibiotic in the form of colorless crystals that melt at t ° + 150.5 - 151.5 ° C. The substance is practically insoluble in water, therefore it is produced with alcohol solutions.	50 mg
3	Beclomethasone dipropionate	Anti-inflammatory	Glucocorticoid, readily soluble in chloroform, acetone and alcohol, can be addictive with prolonged use.	250 mcg
4	Clotrimazole	Antifungal	Synthetic antimycotic for external and local use, acts against dermatophytes, yeasts and molds.	10 mg

In addition to the main components, the composition contains auxiliary substances: glycerol and propylene glycol.

They have no therapeutic effect. Ear drops have the appearance of a clear liquid of a light yellow hue.

The medication is manufactured by Glenmark Pharmaceuticals Ltd. (India).

The manufacturer dispenses the liquid preparation into 5 ml vials and packs them in cardboard boxes. Each pack also contains a pipette and annotation.

Candibiotic (ear drops), the price of which differs in different retail chains, can be purchased at retail pharmacies or online pharmacies.

The average cost of 1 package is 350-420 rubles. A bottle of ear drops is usually enough for 3-4 days of treatment.

Mechanism of action

The combined effect of Candibiotic is due to the presence in the composition of the drug of substances from several pharmacological groups at once.

Each of the active ingredients plays an important role in the treatment of inflammatory and allergic ear diseases:

• Chloramphenicol has a bacteriostatic antibiotic effect, demonstrates activity against a number of aerobic and anaerobic microorganisms. The substance destroys the pathogen from the inside and blocks the synthesis of its protein structures.
• Clotrimazole is an antimicrobial agent that eliminates mycotic infection by destroying ergosterol in the fungal cell and changing its permeability.
• Beclomethasone dipropionate relieves inflammation, swelling, and prevents the development of an allergic reaction.
• Lidocaine hydrochloride relieves pain by blocking receptors in the inner and middle ear and preventing sodium ions from passing through cell membranes.

Clotrimazole as part of this combined agent is also used to prevent the development of dysbiosis due to a decrease in local immunity against the background of the use of beclomethasone dipropionate. Hormonal components often cause the multiplication of fungal flora.

Since all of these components have a local effect on inflamed and infected tissues, studies of their pharmacokinetic functions have not previously been conducted.

Indications for use

Indications for the use of Candibiotic ear drops are pathologies of the hearing organs of various etiologies.

Most often, this drug is prescribed for:

• acute otitis media of the middle ear;
• recurrence of chronic otitis media;
• external diffuse inflammation of the ear canal;
• eczema of the auricles;
• chronic course of fungal infections.

Also, the drug is prescribed to patients who are going to undergo planned surgical treatment for the organs of hearing. Candibiotic can also be used after surgery, throughout the entire rehabilitation period in order to prevent the addition of infection and relieve inflammation, swelling.

The drug must be prescribed by a specialist. Self-medication with Candibiotic is unacceptable. No preliminary examinations are required for treatment with these ear drops, since they are effective against pathogens of different groups and subspecies.

Contraindications and side effects

And although Candibiotic in most cases is tolerated by patients satisfactorily, the instructions for use indicate a number of restrictions on the use of this agent. The use of this combined drug in the presence of contraindications significantly increases the risk of complications and dangerous consequences.

It is impossible to drip ears with Candibiotic for those who have an individual intolerance to any of the components in the composition. An allergic reaction is a common contraindication to the use of a medication.

In addition to him, it is worth noting other cases in which it is forbidden to use these ear drops:

• trauma to the tympanic membrane;
• sensorineural hearing loss;
• neuroma of the auditory nerve;
• the presence of polyps of an unspecified nature of origin.

If, against the background of these diseases, the patient has developed inflammation in the middle ear, one-component medicinal drops are selected. The combined composition can provoke the progression of the underlying pathology.

All components of Candibiotic are potential allergens, but in practice, the drug rarely causes side effects. In isolated cases, judging by the reviews, patients experience itching, burning, slight redness.

With more severe reactions, a rash may appear on the tissues of the outer ear. Such symptoms do not need to be treated, since they will disappear at the end of the course of therapy. If this does not happen, you should consult a doctor.

Instructions for use

Candibiotic - ear drops (the price of the drug, according to the manufacturer, is fully consistent with its high efficiency), which may be completely useless if used incorrectly. To achieve the desired therapeutic result, it is important to strictly follow the instructions, observe the dosage, frequency of use and other features of the treatment of hearing organs.

Preparation for instillation

Before proceeding with the direct treatment of a sore ear or ears, it is necessary to clear the ear canal of possible accumulation of sulfur and pus.

This is necessary so that medicinal substances can freely penetrate the walls of the ear canals and be absorbed, providing a therapeutic effect.

To clean the ears before applying Candibiotic, you should use special elongated ear sticks with a thin tip and a wide base. They are moistened in hydrogen peroxide, but before injecting into the ear, it is imperative to squeeze out the liquid, which should not get inside.

The stick must be carefully inserted into the auditory canal and turned several times, collecting sulfur and pus deposits from the edge of the auricle with its help.

A bottle with Candibiotic solution follows 10 minutes. hold in a fist so that the medicine heats up and the instillation process does not cause discomfort. Unlike other drugs, these ear drops do not belong to the vasoconstrictor category, therefore they do not cause vasospasm.

Before taking the required amount of the drug into the pipette, you should make sure that its tip is intact, the absence of manufacturing defects in the form of abrasions or protruding pieces of plastic that can injure the skin ear canal.

Terms of use

The patient in need of treatment is placed with his head on a pillow in such a way as to provide free access to the affected ear. With a pipette, you need to collect the required amount of the medicinal solution, and then introduce it into the ear canal by no more than 0.5 cm, so as not to violate the walls and the eardrum.

You should also take into account other rules for burying ears for inflammatory diseases:

• If Candibiotic is instilled in a child under 4 years old, his ear must be slightly raised and pulled back - this will completely open the passage and provide better access to the medicine. For an adult, a sore ear needs to be slightly raised to the top and pressed against the skull.
• After instillation, if there is no strong pain, it is advisable to slightly press on the tragus - the protrusion of the outer ear, located closer to the face. This will help the mortar to penetrate to its maximum depth.
• It is important to avoid touching the tip of the pipette with the ear canal, especially if pus is discharging from the ear. After each procedure, the instrument must be disinfected with alcohol or hydrogen peroxide.
• You can get up after instilling the ear in 10 minutes, but before doing this, you need to plug the ear canal with a small piece of cotton wool to warm and absorb the remnants of the drug.
• Even if the disease has affected only one ear, the manipulation is necessarily carried out with the second organ.

Dosage

The price of a course of treatment with Candibiotic ear drops may be 2-3 times higher than the cost of one bottle, since they must be used for 7-10 days. Based on the reviews, 5 ml of the drug is often not enough for therapy.

• The drug should be instilled into each ear 4-5 drops at least 3-4 times a day.
• For a child over 6 years old, 2-3 drops are dripped into each ear canal. For younger children, the drug is not prescribed.

As a rule, the patients' well-being improves on the 3-4th day of treatment, but, despite this, the course should be completed. The exact duration of treatment is determined by the doctor on an individual basis, based on the severity and characteristics of the course of the disease.

special instructions

Before using the drug, be sure to read the instructions.

The manufacturer noted in it important points, the observance of which will ensure the effectiveness of therapy:

• Candibiotic should not be used after the expiration date.
• This drug must not be instilled into the nose - it is intended solely for exposure to the ear cavity. If you accidentally swallow the drug, you should immediately rinse the stomach.
• If symptoms of allergy appear (burning, redness, swelling, severe itching), the ear drops must be replaced with an analogue and supplemented with an antihistamine drug.
• The combined agent Candibiotic does not in any way affect the speed of psychomotor reactions, therefore it does not has restrictions on the use of patients associated with the management of cars or complex mechanisms.

Chloramphenicol should not be used if there is a risk of perforation or damage to the tympanic membrane due to the great risk of deafness. The same substance, with uncontrolled use, can cause the development of aplastic anemia, bone marrow hypoplasia. Chloramphenicol preparations are prohibited in patients with acute porphyria.

You should also pay attention to the hormonal component of Candibiotic ear drops. According to doctors, when using the drug for more than two weeks in patients of any age, the risk of systemic absorption of the glucocorticosteroid beclomethasone dipropionate increases.

Against the background of this violation, the functionality of the endocrine organs decreases and, as a result, hyperglycemia, glucosuria, and Cushing's syndrome may occur. As a result of the termination of the use of Candibiotic ear drops after a prolonged course of treatment, the likelihood of symptoms of drug withdrawal is not excluded.

Application during pregnancy and lactation

The gestation period is not an absolute contraindication for the use of ear drops, however, it is advisable the use of this combination remedy during pregnancy must be determined privately by a specialist. There is no confirmed information on the effect of Candibiotic on the composition of breast milk.

Childhood use

The official annotation from the manufacturer contains a strict ban on the treatment of ear diseases with Candibiotic drops in patients under 6 years of age.

This limitation is due to the presence of a corticosteroid in the medication. With prolonged or improper use, the drug inhibits the work of the pituitary gland and adrenal cortex, which in turn can lead to developmental delay in children and growth retardation.

In addition, it is important to know that beclomethasone dipropionate is a topical hormonal substance that rapidly accumulates in tissues, contributing to the development of systemic toxicity in the child's body.

Overdose

At the moment, nothing is known about cases of overdose with the combined drug Candibiotic. When used correctly, the drops do not have a systemic effect.

If the drug is accidentally ingested, the patient needs to urgently take detoxification actions (provoke vomiting, rinse the stomach) to prevent the penetration of active components into the bloodstream, and call an ambulance help.

Efficiency

Since the ear drops contain an antibiotic, they cannot be used for less than 5-7 days. Otherwise, the pathogenic microflora in the inner ear will be destroyed only partially, which can cause a relapse of the disease.

If the drops are used for too long, pathogenic bacteria or fungi will develop resistance to active substances and the drug will lose its effectiveness.

In addition, one should not expect positive dynamics in the treatment of deafness using Candibiotic. This medication is not intended for the treatment of hearing problems.

Candibiotic (ear drops), the price of which is due to the complex action of the drug, belongs to the group of ototoxic agents. This is the main disadvantage of such medicines, since they can cause irreversible hearing loss.

An unfavorable condition for this is the anatomical features of the structure of the organ of hearing: in place the transition of the middle ear to the internal is the auditory nerve, damage to which can provoke ear drops.

Since the outer ear is anatomically separated from the middle by the tympanic membrane, drops do not normally pass outside of it. Therefore, Candibiotic is prescribed mainly for inflammation of the outer ear. In case of perforation of the tympanic membrane or the transferred paracentesis procedure, Candibiotic is not used.

Relief, according to the responses of patients, comes after 2-3 days of instillation and is manifested in a decrease in the severity of pain, elimination of the feeling of stuffiness and lumbago in the ears.

Drug interactions

Ear drops are a local drug, so they do not have a systemic effect on the body. Accordingly, Candibiotic does not interact in any way with other medicines.

It is worth noting that taking systemic antibiotics, anti-inflammatory or hormonal agents simultaneously with the course of treatment with ear drops will improve the patient's well-being faster.

Storage conditions and periods

Solution for ear drops Candibiotic is valid for 2 years from the date of issue. After opening the bottle, use the drug within 1 month. In no case should the medicine be exposed to low temperatures, otherwise it will lose its medicinal properties.

At home, Candibiotic must be stored in a dark place that children do not have access to. The optimum temperature for storing an open bottle is +25 ° C. Before opening the package, the drug should be on the lower shelf of the refrigerator at t ° from + 2 ° C to + 8 ° C.

The list of analogues is cheaper

Candibiotic - ear drops, the price of which makes many people think about looking for more affordable alternative medicines. Since there are no analogues that are completely identical to the composition of Candibiotic, the treatment can be carry out with the help of a drug of combined action or use at the same time 2-3 types of ear drops.

Among the medicines found on the Russian pharmaceutical market, similar medicinal properties have:

• Lorotox. The drug has an anti-inflammatory and analgesic effect due to the content of lidocaine and phenazone. It can be used to treat various otitis media in children from the first days of life in combination with antimicrobial agents. The cost of a 15 ml bottle is 270 rubles.
• Polydexa. This drug is considered the most popular Candibiotic substitute. It is produced not only in the form of ear, but also nasal drops. The active ingredients are neomycin, dexamethasone and polymyxin, which produce antimicrobial and anti-inflammatory effect. Polydexa is about 80-100 rubles cheaper than Candibiotics.
• Otofa. An antibiotic from the rifamycin group, which has a bactericidal effect, is used to relieve inflammation and pain, eliminate the focus of infection. Average price - 190 rubles.

Reviews of Candibiotic ear drops, as well as a comparison of their cost with the prices of analogues, should not be regarded as a recommendation for unauthorized change of the drug. Any adjustments in therapy should be agreed with the attending otolaryngologist.

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