Ophthalmic drug Midriacil It is used to dilate the pupil during diagnostic examinations and operations. With the help of eye drops, refraction is determined. The affordable price of the drug allows it to be widely used in the complex therapy of synechiae of the iris and for the treatment of conjunctival inflammation.
Record content:
- 1 Release form and composition of the drug
- 2 Pharmacological properties
- 3 Pharmacodynamics and pharmacokinetics
- 4 Indications for use
- 5 Contraindications
- 6 At what age can the drug be used?
- 7 Instructions for use, dosage
- 8 Side effects
- 9 Overdose
- 10 special instructions
- 11 Drug interactions
- 12 Analogs
- 13 Terms, conditions of sale and storage
- 14 Price
- 15 Video about the active substance Midriacil
Release form and composition of the drug
Midriacil is a clear solution designed for drip delivery into the eyeball area. The drug composition based on tropicamide is delivered to pharmacies in vials from a purified and hypoallergenic medical polymer.
Each container is equipped with a tapered drip tip for accurate injection. The bottle contains 15 ml of ophthalmic medicinal composition. Drops are released in a concentration of 0.5% and 1% of the pharmacologically active component.
Midriacil is produced by the Belgian concern Alcon-Couvreur. 1 ml of medicinal solution contains 5 or 10 mg of tropicamide. The biochemically active component is an effective blocker of M-choline receptors. It acts on the sphincter of the iris covering of the ciliary muscle. Tropicamide briefly dilates the pupil and paralyzes accommodation.
Auxiliary components of eye drops:
| Pharmacologically active substance | Properties |
| Edetate disodium | Anticoagulant with a stabilizing effect. Possesses emollient properties. Forms stable complexes with heavy metals: cadmium, lead, mercury, others. Facilitates their removal from the body. |
| Sodium chloride | Maintains osmotic pressure, moisturizes the mucous membrane of the eyes and increases the volume of blood circulating in the capillaries. Easily penetrates the cell membrane, participating in electrophysiological processes. |
| Benzalkonium chloride | Antiseptic with antifungal and antiprotozoal action. Inactivates common viral strains. |
| Hydrochloric acid | Normalizes the pH of the visual organ. Improves motor skills, has antimicrobial effect. |
Midriacil - eye drops, the price of which is affordable, which allows the drug to be widely used in ophthalmological practice, including in diagnostics and surgical interventions. The drug has a large number of contraindications and side effects.
Pharmacological properties
The ciliary muscles cause an accommodative effect - the ability to refract light entering the retina in such a way that the contours of objects are equally clearly distinguished at any distance.
Crystals and Zinn's ligament are involved in this important physiological mechanism. This visual function is achieved by the elasticity of the ciliary muscle, its ability to constantly contract and relax. Tropicamide temporarily blocks the accommodative mechanism.
It paralyzes the ciliary muscle for 1.5-2 hours, allowing for an ophthalmological examination, the necessary diagnostic measures, and surgical procedures. Paralysis of the ciliary muscle opens the fundus for viewing. The action of tropicamide affects the receptors of the muscular layer of the iris - the sphincter.
The effect occurs in 5-7 minutes. after conjunctival installation. The pharmacological properties of Midriacil are based on the ability of its main active ingredient to block the work of m-cholinergic receptors of the ciliary muscle and to suspend the secretion of connective proteins of the zinc ligament.
Pharmacodynamics and pharmacokinetics
Tropicamide inhibits the accommodative function, which causes mydriasis. The drug acts quickly, but for a short time. Midriacil increases intraocular pressure. This effect is less pronounced than with the use of atropine.
Along the way, ophthalmic medication has a therapeutic effect. Due to the content of sodium edetate in its composition, which reacts with strong oxidants, Midriacil reduces the toxic effect of harmful environmental factors on the visual organ.
Benzalkonium chloride reduces the risk of infection during surgery. The pharmacodynamic properties of a chemical compound are based on the ability to integrate into the cell membrane and destroy the protective lipid coating of pathogenic microorganisms.
Tropicamide is able to be absorbed into the systemic circulation to affect the entire body. The eye drops are metabolized in the kidneys and eliminated through the urinary system. The bioavailability of the active substance is 96% after 8-10 minutes. after conjunctival delivery.
Indications for use
Midriacil is intended to artificially dilate the pupil for diagnostic and surgical purposes. For the treatment of ophthalmic diseases, it is practically not used.
Sometimes Midriacil is added as an adjuvant to the complex drug therapy of acute inflammation of the optic organ and synechia of the iris.
It is required to cause mydriasis when performing ophthalmoscopy - a diagnostic examination of the fundus. A typical indication for the use of Midriacil is the clinical need to determine the parameters of refraction - the refractive power of the optical mechanism.
With the help of such a survey, the degree and characteristics of myopia are determined. Disorder of refractive function is often the leading etiological factor in a sharp deterioration in vision. The drug is used for laser correction, surgical removal of pathologies of the retina or vitreous fibers of the organ.
Midriacil - eye drops (the price of the medicinal solution is available, which ensures it prevalence) of specific pharmacological action and influence on biochemical processes optical system. The drug is actively used for extra- and intracapsular cataract removal.
Contraindications
Eye drops are potent ophthalmic medications with the ability to enter the systemic circulation. There are absolute contraindications to their use and relative (situational) restrictions.
It is necessary to refrain from using Midriacil in case of biological insensitivity of the components of the medicinal composition, so as not to provoke the development of acute anaphylactic reactions.
The drug is not prescribed for:
- angle-closure or mixed glaucoma;
- increased intraocular pressure;
- chronic pathologies of the respiratory system;
- active inflammatory processes localized in the injection zone;
- dysfunction of the kidneys;
- heart failure;
- infection of the urinary tract.
Midriacil is used with caution in prostatitis, a shallow depth of the conjunctival sac and the anterior chamber of the orbit. During pregnancy and breastfeeding, the medicinal solution can be used only if absolutely necessary and with the permission of a doctor.
Clinical studies of the effect of the pharmacologically active components of the drug on the processes of intrauterine development have not been carried out. The effect of the medication on fertility has not been proven.
There is no reliable scientific data on the ability of tropicamide to be absorbed into breast milk. The effect of Midriacil on reproductive function and labor is unknown. During pregnancy and lactation, ophthalmologists do not prescribe Midriacil.
At what age can the drug be used?
Eye drops in an active substance concentration of 1% are prescribed for children from 6 years of age. A medicinal solution with a tropicamide content of 0.5% can be used for patients from 2 years old.
Midriacil is used in pediatric ophthalmology as actively as in adults. Eye drops are used to prevent the development of myopia. The low price allows it to be used for prophylaxis with a hereditary predisposition to poor vision.
Deterioration of the biological optical system begins in most cases to manifest itself in middle school age. The main etiological factor is the increasing load on the optic nerve fibers.
Midriacil successfully and quickly eliminates their spasmodic state, exerting a relaxing effect on the tissues perceiving visual information. This is an effective prevention of the flow of false myopia into true one.
The latter is congenital or genetic in nature. False myopia is characterized by a disruption in the work of neuromuscular fibers due to their spasm as a result of excessive stress. Midriacil copes with such a negative effect.
They begin to take it for preventive purposes from early school age in combination with physiotherapy procedures (special gymnastics for the eyes and others) to achieve the maximum possible clinical result.
Instructions for use, dosage
The drug is used exclusively for conjunctival injection into the cavity between the eyeball and the retracted lower eyelid. To induce the state of mydriasis, prophylaxis and in relation to children under 6 years of age, a medicinal solution is used at a concentration of 0.5%.
In the complex therapy of visual inflammatory processes and in the treatment of other ophthalmic pathologies in adult patients, eye drops with a tropicamide content of 1% are used.
The drug has a specific purpose. It is imperative that you adhere to the dosage indicated by your doctor. When performing diagnostic procedures to provoke paralysis of the ciliary muscles, the dose is increased by 1 drop of 1% of the drug.
This does not allow focusing the gaze and opens access to the fundus. When studying the refractive parameters of the biological optical mechanism, 2 drops are injected into each eye. After 5-7 minutes. the procedure is repeated.
If the study lasts more than 1 hour, the effect of tropicamide begins to weaken, the installation is repeated. Patients with highly pigmented irises are allowed to increase the dose by 1-2 drops by the doctor's decision.
This improves the view of the posterior surface of the orbit. In case of therapeutic use, in case of missing the next instillation session, it is forbidden to use an increased dose.
Contact lenses must be removed immediately before conjunctival administration of the drug and reinserted after 20 minutes. after the procedure.
Self-instillation at home is performed as follows:
- First you need to wash your hands thoroughly.
- Then the bottle is opened without touching the dispenser tip with your fingers.
- During the procedure, contact of the container with the drug and the skin of the eyelids or periorbital zone should be avoided.
- The dose prescribed by the doctor (usually 1-2 drops in each eye) is given after the lower eyelid is pulled back with a finger.
At the end of the procedure, it is recommended to perform several light massaging movements in the area of the corners of the eye sockets and lower eyelids to evenly distribute the medicine. This will help prevent medication from entering the nasopharyngeal cavity.
Side effects
Midriacil - eye drops (the price of a solution in a concentration of 0.5% and 1% is almost identical), which can cause negative effects of local and systemic manifestations. The latter often occur in children and elderly patients.
Typical local side effects that appear immediately after instillation:
- a short burning sensation in the area of drug delivery;
- impaired visual acuity;
- an increase in intraocular pressure;
- hyperemia;
- edema of the conjunctival membrane;
The systemic side effects due to the penetration of tropicamide into the bloodstream are more numerous and varied.
These include:
- drying out of the mucous membrane of the oral cavity;
- violation of heart rhythms;
- vertigo syndrome;
- headaches;
- decreased muscle tone;
- deterioration of gastrointestinal motility;
- dysuria - a disorder of urinary function;
- psychotic reactions;
- allergic rash on the skin of the hands and face;
If such symptoms occur, you should stop taking the drug.
Overdose
If the recommended norm of Midriacil is regularly exceeded, typical signs of drug intoxication are possible.
In severe cases, the following are observed:
- disorder of neuromuscular coordination;
- auditory and visual hallucinations;
- fast or irregular heart rate;
- convulsive conditions;
- blurred vision;
- convulsions;
- a sharp increase in body temperature;
- pulmonary cardiac collapse.
In the last 3 cases, resuscitation procedures are urgently required. Such acute conditions occur extremely rarely and only in the presence of concomitant pathologies. With conjunctival administration of the drug, temporary symptoms of local toxicity are more often manifested.
If they are found, rinse the eye sockets with warm water. In case of systemic overdose after resuscitation, symptomatic and supportive therapy is prescribed.
Tropicamide is neutralized by intramuscular injection of physiological salicylate, which is common in clinical practice. Medicines of the category of benzodiazepines are used - psychoactive compounds of sedative, hypnotic and anxiolytic (anti-anxiety) action.
special instructions
With regular prophylactic use of the drug, it is advisable to abandon the use of contact lenses, especially if they are made of a soft polymer composition based on benzalkonium chloride.
Midriacil - eye drops, the price of which is low, belonging to the category of potent ophthalmic drugs. It is important to observe the dosage and rules for the administration of the conjunctival solution.
To prevent the development of systemic side effects, it is recommended to squeeze the lacrimal sacs at the inner corner of the visual organs for 1-2 minutes after installing the medication.
The medicine is intended for temporary disturbance of accommodation. After the instillation session, you cannot drive vehicles, perform work that requires maximum concentration of attention and eye strain.
Drug interactions
The effectiveness of Midriacil is enhanced by dofimin receptor blockers used to treat neuroses and other mental disorders. These include Butyrophenone. Amantadine, a medicine prescribed for Parkinson's disease, has a similar effect.
You can not combine Midriacil with phenothiazines, antihistamines, tricyclic antidepressants. All drugs with antimuscarinic properties enhance the pharmacological effects of eye drops. Their combined use can cause side effects.
The combination with nitrate-containing medications and glucorticosteroid medicinal formulations increases intraocular pressure. When combined with tricyclic antidepressants, mutual potentiation is observed. M-cholinomimetics weaken the effect of tropicamide.
Analogs
The therapeutic and diagnostic drugs used by ophthalmologists include a number of drugs with pharmacological properties identical to Midriacil. It is easy to replace it if there are contraindications.
The most popular analogues:
- Unitropic - eye drops with high parasympatholytic activity;
- Atropine sulfate - an effective blocker of choline receptors of the visual organ, acting similarly to Midriacil.
- Cyclomed - a solution for conjunctival use, which suspends the biochemical functions of acetylcholine, a mediator of cholinergic synapses of the pupillary sphincter and ciliary muscle;
-
Irifrin - an ophthalmic drug based on phenylephrine hydrochloride, used to induce mydriasis and treat iridocyclitis, disruption of the lacrimal glands, and other pathologies.
All of these drugs are comparable to Midriacil in terms of price, safety and clinical efficacy.
Terms, conditions of sale and storage
Potent eye drops of specific use are dispensed in pharmacies only if there is a correct prescription filled out by a doctor. The drug is suitable for use within 36 months from the date of production.
After breaking the tightness of the bottle, the eye drops must be used as directed for 30 days. The optimum storage temperature for the medicinal solution is + 8... + 25 ° C. Children should be excluded from access to the medication and direct sunlight should be avoided on the surface of the bottle.
Price
The ophthalmic drug Midriacil in a concentration of 1% of the active ingredient costs about 380 rubles. The price of a medicinal solution containing 0.5% tropicamide is slightly less - about 360 rubles. The cost of eye drops varies slightly depending on the pharmacy and the region.
Video about the active substance Midriacil
Tropicamide - pharmacy drug or eye drops:
