Eylea aflibercept eye injection. Reviews, price

Eilea is an effective medicine to improve visual acuity and prevention of complications against the background of any diseases. An injection in the eye is prescribed in case of progression of pathologies; it is considered one of the most effective methods of quickly relieving symptoms.

Patient reviews about the action of the medication are mostly positive, but use without preliminary examination is prohibited.

Terms of dispensing from pharmacies, drug price

The drug is dispensed in different pharmacies only with a prescription from a doctor, which excludes independent use without a preliminary examination.

The cost of 1 bottle with a solution starts from 41,700 rubles.

Such a high price is due to the difficulties in obtaining the active component, as well as high efficiency. Sometimes promotions are held on different sites and in pharmacies. For 1 package with a bottle, you will need to pay about 27,000 rubles.

Composition, release form

Eilea - an injection in the eye (reviews of the medicine are mostly positive), which contains the aflibercept component, which has the main therapeutic effect on tissues.

As an auxiliary component, sodium chloride 0.9% and some other ingredients are present in the composition:

• Sucrose.
• Polysorbate.
• Sodium hydrogen phosphate heptahydrate.
• Water for injections.

The auxiliary components do not have therapeutic properties. The drug is available in the form of a solution, which is intended for intraocular and intravenous administration. The solution is transparent, placed in a transparent glass bottle, a special syringe is attached to it, which facilitates administration.

The vial and syringe are placed in a small cardboard box, in which you can also find a description indicating all the features of therapy and possible contraindications for its implementation.

Principle of operation and efficiency

The main component in the composition of the solution has the ability to improve the vision of patients with various deviations from the visual apparatus. The ingredient is obtained in a complex way, it is a recombinant hybrid protein produced by a special technology of recombinant DNA by Chinese hamster cells.

The principle of action of the drug is based on the ability of the main ingredient to increase vascular permeability, as well as reduce the amount of blood flowing to various neoplasms in the eye.

This helps not only to stop the progression of the pathological condition, but also somewhat reduces the risk of complications against the background of rapid tumor growth. Violation of nutrition in it leads to an improvement in the patient's condition. In some cases, the solution completely stops the growth of the neoplasm.

For different violations, the effect of the medication may differ:

• With the wet form of age-related macular degeneration (AMD), fluid seeps into the central zone of the retina, followed by its thickening. The medicine helps prevent such complications, somewhat improves vision and prevents its rapid deterioration against the background of the progression of the disease.
• Diagnosis of macular edema that develops against the background of occlusion of the central retinal vein is also successfully treated with medication. The drug relieves symptoms and reduces the risk of a significant decrease in visual acuity.
• With macular edema against the background of the progression of diabetes mellitus, the drug normalizes the condition, stops the progression of the disorder. With this disease, retinal vessels are often affected, but the solution reduces the risk of complications.

Eilea - an injection in the eye (patient reviews after manipulation help other patients evaluate the effectiveness), which is considered effective. When administered directly into the vitreous body (intravitreal), the absorption of the solution into the systemic circulation is not so fast.

The maximum plasma concentration is noted no earlier than 4 hours after administration. In this case, the drug does not accumulate in the blood of patients if it is used according to the standard scheme and is administered in a single therapeutic dose no more than 1 time in 4 weeks.

When used in higher doses, a slight accumulation of the ingredient in the tissues is possible, which somewhat enhances the therapeutic effect. The main substance slowly spreads through the systemic circulation, its processing is carried out in the liver. In the presence of organ disorders in patients, a deterioration in the metabolism of the substance is noted, which does not reduce the effectiveness of therapy.

The period of elimination of the drug from the body takes up to 2 weeks, but in each case, the pharmacokinetic features may differ. Sometimes traces of the drug are found 3 weeks after the last dosage has been administered.

After 4 weeks, in a laboratory blood test, traces of the drug are not found. The excretion of ingredients occurs with the help of the kidneys, but if their functioning is disrupted, the process may deteriorate.

Indications and contraindications for use

Eilea is prescribed for various diseases of the visual apparatus. An injection into the eye helps not only to eliminate the symptoms of pathologies, but also prevents their progression.

Patient reviews confirm the effectiveness of the appointment in the presence of the following deviations:

• Diagnosing the wet form of age-related macular degeneration, accompanied by a decrease in visual acuity.
• Deterioration of vision against the background of damage to the vessels of the retina of the eye in diabetes mellitus. The remedy can be used as the main treatment or in combination with other medicines.
• Retinal vein occlusion and deterioration of the functioning of the visual apparatus against the background of this disorder.
• The presence of tumors in the visual apparatus, the progression of which is accelerated in the absence of therapy.
• Deterioration of vision of other origin, which reduces the patient's quality of life.

The drug is not used for prophylactic purposes, but can be prescribed to patients with a mild form of any disease to prevent its progression.

The medicinal solution has contraindications, the most important of which is considered intolerance to the components of the composition and a tendency to such manifestations in the patient's history.

But the remedy is not used when a severe form of arterial hypertension, advanced liver failure, coronary heart disease is detected. In heart failure and in the treatment of elderly patients, the drug is used with caution and after a preliminary examination.

Contraindications include severe infectious eye pathologies, accompanied by signs of inflammation and other acute disorders. The medicine is not used if severe damage to the eyeball is detected. It is contraindicated in children under 18 years of age.

During the period of breastfeeding and carrying a child, the medicine is not prescribed, but in some cases it can be used when the intended benefit is higher than the possible harm. Usually, experts categorically prohibit use in the 1st trimester, but in the 2nd and 3rd periods of gestation, use is allowed for individual indications.

The tool often provokes complications if the instructions are violated. With intraocular administration, severe pain in the eye area, as well as burning, temporary deterioration in the quality of vision, is possible. For several days after the introduction, discomfort in the eye area is possible, which manifests itself when blinking.

Increased tearing and sourness of the eyes is often observed during therapy with the agent. Usually, experts recommend that you stop using the medication and note an improvement or worsening of the condition. But it is possible to continue therapy if the symptoms do not worsen or gradually disappear without special treatment.

Instructions for use

Eilea - an injection in the eye (reviews of the remedy can be negative when complications arise in the course of treatment), prescribed only by a specialist after undergoing an examination. For different diseases, the scheme and dose may differ, sometimes a standard method is used to treat various disorders.

In most cases, the standard therapeutic dose for 1 time is 2 mg of the drug, that is, 0.05 ml of solution. The medicine is injected only into the vitreous body, which allows you to achieve the maximum therapeutic effect. The procedure is carried out only on an outpatient basis or in a hospital if the patient is simultaneously undergoing treatment for any chronic disease.

Disease	Features of the use of the drug
Age-related macular degeneration	With such a violation, the agent is also injected at 0.05 ml at a time. For 3 months, the injection is given once a month. After that, the interval between injections is increased to 2 months. The patient receives such treatment for 1 year. After that, the doctor evaluates its effectiveness and, if necessary, prolongs it. With this treatment regimen, constant monitoring is not required between injections of the agent, which is considered an advantage. In each case, the number of injections is determined individually, depending on the severity of symptoms and the presence of concomitant deviations.
Macular edema of various origins	A single dosage for this disease is also 0.05 ml. Enter it once a month. The interval between injections should not be less than 1 month. There is no standard duration of treatment for such a disorder, since therapy lasts up to until the maximum visual acuity is achieved against the background of the absence of the main diseases. For some patients, 10 injections are enough, others receive the solution for 12-18 months.
Diabetic macular edema	In the case of diagnosing such a violation, the initial course consists of 5 injections, which are given at intervals of 1 month. Thereafter, the intervals between injections are 2 months. For 1 year, the remedy is used according to this scheme, after which the doctor evaluates the result, prolongs the course or cancels the therapy if the maximum possible effect has been achieved. During the first 12 months of therapy, constant monitoring of the state of the visual apparatus is not required, but after completion of the primary course, the patient regularly visits the doctor, who determines the need for further use.

Only a specialist who has experience in the intraocular administration of the drug should carry out the manipulation. This will avoid complications and improve the effectiveness of treatment.

For 2-3 hours after manipulation, the patient is advised to avoid mental and physical stress, manipulations that can affect intraocular pressure. The patient receives individual recommendations in the ophthalmologist's office, if such a need arises.

If complications appear during the period of therapy, a decision is made on an individual basis to cancel or continue the course. The drug does not provoke an overdose, even with prolonged use, which is associated with the minimum dosages used during the therapy period.

Despite this, careful monitoring of the state of the patient's visual apparatus is required.

With intravenous infusion of a medicinal solution, an overdose may develop, in which there is a deterioration in the general condition and an increase in intraocular pressure. In this case, an immediate cancellation of therapy is required and the appointment of special means to eliminate the symptoms.

Storage duration

The storage time of the drug solution is 2 years, but the temperature should not exceed +8⁰WITH. If the product is stored at room temperature, an unopened vial of medicinal solution can be stored for no more than 24 hours.

After the expiration date, the use of the medicine in any way is not allowed. It is important to study the information on the package before use. If any sediment, discoloration or consistency is visible in the solution before opening, use is not allowed.

Some analogues

Eilea is an eye injection, reviews of which differ from patient to patient, used only for patients with severe visual impairment. The drug has analogues that can be used in the absence or impossibility of prescribing for various reasons.

Most popular substitutes:

• Lucentis - solution for intraocular administration, which affects the growth of blood vessels in the visual apparatus, prevents the progression and growth of neoplasms. The medicine helps to improve vision, which worsens against the background of edema, degeneration of various origins and the formation of neoplasms. The cost of the solution starts from 47,000 rubles. Despite such a high price, it is used frequently. The solution contains another active ingredient, ranibizumab, but it has the same therapeutic effect as the ingredient in the original drug.

• Vizudin - solution for intravenous administration, which contains another active ingredient, but has pronounced properties. With degeneration of the corpus luteum and some age-related changes in the visual apparatus, the solution helps to significantly improve the patient's condition. The medicine is used only as directed and after a preliminary examination. Its cost starts at 85,000 rubles, but it is justified by its high efficiency.

• Makugen - a solution for the treatment of ophthalmic pathologies with pronounced properties. The tool helps to improve the condition of the visual apparatus with age and other changes, accompanied by a decrease in visual acuity. The drug is expensive, its price starts at 50,000 rubles. Despite this, the solution is often used because of its high efficiency. The solution is injected only into the vitreous body, and the dosage is usually standard for all patients. Only the scheme of administration of the solution differs, which is determined depending on the disease.

The selection of an analogue is carried out by a specialist depending on the specific manifestations of the disease, as well as the presence of concomitant complications. Despite the other components in the composition of the funds, they have similar medicinal properties.

Eilea is a popular injection that is given to the eye in the presence of age-related or other changes in the visual apparatus. Reviews about the action of the medication are mostly positive, but there are also negative responses from patients.

Usually they are associated with the development of negative reactions from the internal organs or the visual apparatus. The choice of the correct treatment regimen and the implementation of all recommendations can reduce the risk of negative reactions.

Eilea drug video

The principle of action of the drug Eilea: