Miscellaneous

Mexidol ampoules 2-5 ml (injections). Dosage, indications for use, reviews

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Content

  1. Release form
  2. Chemical composition
  3. Pharmacological properties
  4. Pharmacodynamics and pharmacokinetics
  5. Indications for use
  6. Contraindications
  7. At what age can the drug be used?
  8. Instructions for use, dosage
  9. Side effects
  10. Overdose
  11. special instructions
  12. Drug interactions
  13. Analogs
  14. Terms, conditions of sale and storage
  15. Price
  16. Video about the drug Mexidol

Mexidol is a drug with antioxidant properties that are often prescribed to patients with vascular diseases. Ampoules are produced with different dosages of the active ingredient in the composition. The solution is administered parenterally. Depending on the condition, the patient can be infused with 2 or 5 ml, but the doctor makes a decision after examining the patient and determining the stage of the disease.

Release form

The medication can be purchased as a solution for parenteral administration in small glass ampoules of 2 or 5 ml. The solution is transparent and colorless, sometimes a slight precipitate is possible.

In a cardboard box, plastic contour cells are placed, the number of which differs depending on the volume of the ampoule. With a volume of 2 ml, the box contains 10 ampoules. If the ampoule contains 5 ml, then there are only 5 pieces in the box. A description is attached to the product in any volume, indicating all the features of the application, possible contraindications for therapy.

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Pharmaceutical companies also produce a tablet dosage form that can be used at home.

Chemical composition

Mexidol - ampoules (dosage of 2 ml is considered the most popular) containing a solution based on ethylmethylhydroxypyridine succinate. This ingredient has the main therapeutic effect.Mexidol ampoules 2-5 ml (injections). Dosage, indications for use

The composition of the solution includes sodium metabisulfite and water for injection. These components do not have medicinal properties. The dosage of the main ingredient in the composition of the drug is 50 mg per 1 ml, which is important to consider when choosing the volume of the ampoule.

Pharmacological properties

The drug has antioxidant properties, which makes it effective in many systemic diseases. Additionally, the drug has an antihypoxic and membrane-protective effect.

The nootropic properties of the drug make it universal for many deviations of neurological origin. Improving tissue metabolism has a positive effect on the general condition of the patient, prevents the progression of diseases, especially in their chronic course.

The complex effect of the drug on the body improves the general condition of the patient, stimulates cell regeneration.

Pharmacodynamics and pharmacokinetics

After parenteral administration of the drug, the component rapidly spreads through the blood and provides a therapeutic effect. The main substance has nootropic properties, promotes the restoration of brain cells, as well as the peripheral nervous system. As a result, the progression of diseases slows down, partial or complete recovery of damaged areas gradually occurs.

The antihypoxic effect of the drug reduces the likelihood of developing oxygen starvation of tissues, against the background of which neurological and other diseases develop.

The drug also has another effect on the body:

  • Improves cerebral circulation, even if the patient has a history of ischemic stroke.
  • Helps control blood pressure readings, especially in hypertensive patients.
  • It has antioxidant properties, that is, it promotes the renewal of cells damaged as a result of the progression of diseases.
  • Reduces the manifestations of intoxication of endogenous origin, that is, with the progression of any necrotic processes in the body. For example, pancreatitis and pancreatic necrosis are often accompanied by poisoning of the body.
  • It affects the level of bad cholesterol, helps to reduce it, and prevents the progression of atherosclerosis. These conditions are often associated with complications, but using medication can help reduce the likelihood of developing them.
  • It has a positive effect on the muscle layer of the heart, improves blood circulation in the myocardium, which somewhat reduces the risk of developing a heart attack.
    Mexidol ampoules 2-5 ml (injections). Dosage, indications for use
    Mexidol ampoules 2-5 ml

The spread of components in the body occurs rather quickly. The ingredients are concentrated in the affected area, providing a curative effect. The maximum concentration of the substance is observed 20-40 minutes after the administration of the primary therapeutic dose.

Within 4-6 hours, the concentration of the substance gradually decreases. The processing of the component is carried out in the patient's liver, and the products of its decay are evacuated with the help of the kidneys. Within 12-14 hours, the body is completely cleansed of the ingredient's metabolites.

Different patients may have differences in the pharmacokinetic characteristics of the drug. For example, kidney disease can cause a delay in the elimination of metabolites, which in most cases does not affect the therapeutic effect.

Indications for use

Mexidol is used for various diseases. The volume of the ampoule is selected individually, since a dosage of 2 ml is not always enough to obtain a therapeutic result.

The main indications for the use of the medicinal solution:

  • Acute disorders of cerebral circulation, recovery period after suffering a similar disease. The drug shortens the rehabilitation time.
  • Vegeto-vascular dystonia at different stages.
  • Chronic heart pathologies.
  • Arterial hypertension.
  • Acute period of myocardial infarction. The solution is prescribed as part of a complex therapeutic course, it is especially important to use it on the first day after an attack.
  • Intoxication of the body after using drugs from different groups. Usually, the use is necessary in case of poisoning with medications that affect mental processes.
  • Open-angle glaucoma with primary onset of symptoms. The tool is included in complex treatment.
  • Traumatic brain injury.
  • Withdrawal symptoms in severe form. The solution can be prescribed not only to patients with chronic alcoholism, but also to patients who do not suffer from such deviations, but have abused alcoholic beverages.
  • Neurological diseases accompanied by pain and tissue malnutrition.
  • Neurotic and anxiety disorders of various origins. It is allowed to use the drug in the acute stage of the disease or in the chronic course.
  • Dyscirculatory form of encephalopathy.
  • Transient ischemic attacks, which are not always accompanied by disorders of the musculoskeletal system.
  • Mild cognitive disorders associated with atherosclerotic vascular changes.
  • Acute and chronic purulent-inflammatory diseases of the abdominal organs. The drug can be prescribed for pancreatitis, pancreatic necrosis or even peritonitis as part of a comprehensive treatment.Mexidol ampoules 2-5 ml (injections). Dosage, indications for use

Often the drug is used for acute and chronic vascular abnormalities.

Contraindications

The main obstacle to the treatment of the drug is considered intolerance to the components of the composition and the tendency to such reactions in the patient's history.

In the description, you can see other contraindications:

  • Acute viral hepatitis, acute liver failure.
  • Kidney infections, renal failure. With a mild course of diseases, the use of a solution is allowed, but a severe form requires the appointment of other means.
  • The period of childbearing and breastfeeding is considered an obstacle to the use of the solution, since complications may develop in the mother and child.
  • Acute diseases of the stomach and intestines. The drug, when administered, does not enter the digestive tract, but course use can lead to an aggravation of symptoms.
  • Internal bleeding against the background of perforation of the wall of the stomach or intestines. The drug can be used for purulent-inflammatory pathologies of the abdominal cavity, but in the case of bleeding, it often leads to a worsening of the condition.

Other contraindications that are absent in the official instructions can be determined on an individual basis.

At what age can the drug be used?

Mexidol - ampoules (a dosage of 2 ml is suitable for patients with a mild form of a pathological condition), not used for children and adolescents under 18 years of age.

This is due to the lack of data on the effect of the component of the composition on the body of such patients.

Instructions for use, dosage

The drug is administered only parenterally after specifying the symptoms and stage of the disease. Depending on the pathology, it can be administered intravenously or intramuscularly, while the intravenous infusion is drip or jet.Mexidol ampoules 2-5 ml (injections). Dosage, indications for use

The dosage is determined depending on the disease. When prescribing, the doctor takes into account that 1 ml contains 50 mg of the active substance. For jet infusion, the solution must be combined in one syringe with 10-20 ml of sodium chloride 0.9%. With dropwise infusion, the required amount of the agent is added to 200 ml of sodium chloride.

When administered intramuscularly, dilution of the solution is not required. The drug is injected in a jet and drip mode slowly, which somewhat reduces the likelihood of negative reactions during manipulation.

Disease Dosage and duration of use
Cerebral circulation disorders For 2 weeks, the patient is injected drip of 200 mg of the drug 2 times a day. After that, for the next 2 weeks, the patient receives 150-250 mg intramuscularly 1-2 times a day. The total duration of treatment is 4 weeks, but sometimes therapy can be carried out for 5-6 weeks.
Acute myocardial infarction A single dosage for the acute course of the disease is 300 mg, it is administered 2 times a day for 2 weeks. After that, the dose can be reduced by 2 times and administered intramuscularly 2 times a day. The total duration of the course does not exceed 4 weeks.
Traumatic brain injury The dosage for patients with such disorders is 200-500 mg per day. It is administered with a dropper in the morning or evening, the duration of use in most cases is 2 weeks.
Cognitive impairment In case of cognitive disorders against the background of atherosclerotic changes, the agent is used in courses of 14-30 days. In this case, the solution is usually administered intramuscularly at a dosage of 100-300 mg per day.
Encephalopathy In the case of such violations, the drug is administered by drip at a dose of 500 mg per day for 2 weeks. After elimination of acute manifestations, the dose can be reduced to 100-200 mg per day, the solution is administered intramuscularly.

According to individual indications, the features of treatment may change, but patients on their own should not stop using. When administered by means of a dropper, the patient is usually in a hospital or visits a hospital every day for treatment. In the acute course of any disease, a hospital stay is mandatory.

Side effects

Mexidol - ampoules (dosage of 5 ml in the acute stage of many diseases does not help), often used due to the low likelihood of complications. Despite this, doctors note that improper use and violation of recommendations will certainly lead to the appearance of negative symptoms.Mexidol ampoules 2-5 ml (injections). Dosage, indications for use

The most common ones are:

  • Headache, drowsiness, and dizziness are rare. Sometimes patients talk about insomnia, psychoemotional disorders, irritability and decreased performance.
  • On the part of the skin, complications appear in the form of urticaria or Quincke's edema. These reactions are considered rare but can worsen the condition significantly.
  • The lack of effect on the mucous membranes of the stomach cannot exclude the likelihood of complications. During treatment, some patients report nausea, an unpleasant taste in the mouth, dryness of the mucous membranes in the mouth, and intense thirst.
  • Dry cough and sore throat is observed on the part of the respiratory system. Such symptoms are also considered rare, but can worsen the condition of patients with chronic respiratory diseases.
  • Fluctuations in blood pressure indicators are observed if the patient has a history of chronic vascular disease.

Complications can aggravate the general condition, often lead to the progression of diseases. When they appear, it is recommended to consult a doctor who will determine the appropriateness of prescribing additional drugs.

Overdose

The likelihood of developing an overdose is minimal, according to statistics. But experts do not exclude such a risk. In case of an overdose, all symptoms are aggravated, nausea and repeated vomiting during the day are observed.

Patients report abdominal pain, severe weakness and headache. Many people talk about impaired coordination of movements and pain in muscles and joints. Allergic manifestations in case of overdose are expressed in an acute form. A rash spreads quickly on the body, there is severe itching, burning.Mexidol ampoules 2-5 ml (injections). Dosage, indications for use

Overdose requires immediate refusal to use the solution and referral to a specialist. It may be necessary to admit the patient to a hospital and prescribe drugs from different groups to eliminate symptoms.

special instructions

Mexidol - ampoules (a dosage of 2 ml is suitable when the patient has already completed the main therapeutic course), which should be used only as directed. Doctors note that prophylactic use is indicated only when the patient has certain pathologies of neurological origin in a mild form.

With intramuscular injection, it is worth performing the manipulation slowly, since patients often report severe pain in the infusion area.

Drug interactions

The drug enhances the effect of antiparkinsonian drugs, drugs with anticonvulsant properties. When combined with alcohol, it reduces its toxic effect on the body.Mexidol ampoules 2-5 ml (injections). Dosage, indications for use

The drug does not affect the action of other drugs, therefore, if necessary, various drugs can be used, if combined treatment is necessary.

Analogs

The solution for parenteral administration has analogs prescribed as needed. Many of them have a different composition, they can be produced in different dosage forms.

Most popular substitutes:

  • Cortexin available as a lyophilisate for solution preparation, which is administered parenterally when certain indications appear. The remedy is prescribed for neurological, some mental, cardiac pathologies. It has an effect due to the presence in the composition of polypeptides from the cerebral cortex of cattle. Despite the different composition, the drug also has nootropic and antihypoxic properties.
  • Mexicor has a similar composition, is available in the form of a solution for parenteral administration. The product can be used when the patient is allergic to the auxiliary components of the original medicine.
  • Cytoflavin has a combined composition, but has similar therapeutic properties. Unlike the original, the agent is injected only with a dropper. The drug is used in short courses of 10 days, usually long-term use is not required.

When choosing an analogue, the doctor takes into account the peculiarities of the course of the pathological condition and the individual reaction of the body to the component of the composition.

Terms, conditions of sale and storage

The drug can be purchased at pharmacies after presenting a prescription form from a doctor. Its storage period is 3 years. After the expiration date, use is not recommended.

When storing, it is important to limit access to sunlight and moisture, keep out of the reach of children.

Price

You can buy a package of the product for about 420-490 rubles. The price is different in different pharmacies.

Mexidol is a popular medication that is often used to treat pathologies of neurological and other origin. Ampoules are most often used in a hospital, dosages of 2 or 5 ml are selected individually after examination.

Video about the drug Mexidol

Mexidol instructions and doctor's review:

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