Tretinoin cream. Reviews, instructions for use, where to buy, analogues, price

Tretinoin - cream, used to eliminate pathologies of the skin. Reviews about the action of the remedy may be different, depending on the individual characteristics of the application and the condition of the skin before the start of treatment. In each case, a preliminary examination is required, since a potent cream can provoke complications.

Forms of release and composition of the drug

A drug with this name can be produced in different dosage forms.

The cream is considered the most popular, but you can also see on drugstore shelves:

• lotion;
• solution for external use;
• capsules for oral use.

In some pharmacies, you can find a gel for external use. The cream can have an active ingredient concentration of 0.025%, 0.05% or 0.1%.

It has a standard consistency, light aroma. The product is packaged in tubes of 20 g, placed in cardboard boxes. Each tube is accompanied by instructions for the correct use of the product, describing all the features of the treatment and possible complications.

The product contains tretinoin or transretinic acid as an active component. Due to it, the main therapeutic effect is realized. The cream contains auxiliary ingredients in the form of a base for the cream and fragrances, which provide a pleasant aroma and facilitate application. The product has a light consistency and is quickly absorbed.

Pharmacological properties

Tretinoin is a cream (reviews of the therapeutic action of the drug help a person evaluate its effectiveness), which has pronounced regenerating properties. The tool helps to speed up the process of regeneration of skin cells in case of various injuries.

The tool also has anti-seborrheic properties, helps to eliminate the external manifestations of acne, acne and other cosmetic defects.

As a result of course use:

• damaged skin is restored;
• signs of inflammation are eliminated;
• local immunity improves.

The drug also has keratolytic properties, which improves the condition of the outer layer of the skin and prevents the progression of the pathological condition. The complex effect of the drug helps to quickly eliminate acute manifestations of the disease and prevent the recurrence of manifestations.

Pharmacodynamics and pharmacokinetics

After applying the product to the skin, it begins to actively act due to the content of tretinoin as the main substance. The ingredient quickly penetrates into the outer layers of the skin and helps to eliminate acute manifestations of diseases. The substance relieves inflammation, which allows you to get rid of swelling, redness and discomfort.

Depending on the degree of neglect of the condition, the effectiveness after the first application differs. The active substance helps to restore damaged cells in case of burns, frostbite and other injuries of varying severity. Tretinoin helps to increase the activity of local immunity, which is especially important when used to eliminate immunity.

The tool does not destroy beneficial bacteria on the skin, but increases their ability to fight pathogens that provoke the inflammatory process.

The likelihood of infection of wounds is significantly reduced when using an external drug. The active substance of the composition helps to remove dead skin cells that inhibit the regeneration process. Thanks to this, the recovery period is shortened, especially in combination with systemic remedies.

Tretinoin also has other properties:

• Promotes the opening of closed acne and the gradual cleansing of the skin from inflammatory foci.
• Prevents the production of melanin.
• Prevents the appearance of acne.
• Makes the skin even, smooth, significantly improves the condition.
• Possesses antimicrobial properties, which reduces the risk of re-occurrence of inflammation.
• Normalizes the work of the sebaceous glands.

The regenerating properties of the cream appear a few days after the start of application. Strengthening local immunity, combined with a stimulating effect, helps to quickly improve the condition.

The main ingredient in the cream belongs to the group of retinoids, which explains the pharmacological properties. The substance in its action resembles retinol, has the ability to inhibit the division of promyelocytes, but stimulates the restoration of skin cells.

When an external agent is used topically, the active ingredient penetrates well through the cell membranes, forming a cytoplasmic complex. During this process, a hormone-receptor complex is formed, which has the ability to bind to DNA and inhibit reactions that slow down the restoration of damaged layers of the skin.

When applied externally, the active ingredient is absorbed in small quantities into the systemic circulation and spreads throughout the body. Its maximum concentration is found 2 hours after application. The amount of an ingredient in the body depends on the condition of the skin and the duration of use. Tretinoin does not accumulate in blood and tissues, which is considered to be its advantage.

The processing of the active substance of the composition is carried out in the liver. The excretion of the decomposition products of the ingredient occurs with the help of the kidneys. The evacuation period takes no more than 1 day, but with severe kidney damage, this time may increase. Depending on the patient's body, pharmacokinetic features differ, which does not affect the effectiveness of treatment.

Indications for use

Tretinoin is an effective and relatively safe cream that is used for various skin problems.

Patient reviews confirm the effectiveness of the remedy in the following cases:

• Acne of varying degrees of neglect. The tool can be used to treat confluent acne, that is, lesions that form as a result of the fusion of several rashes located close to each other.
• Acne vulgaris, accompanied by the formation of nodules and large foci of inflammation. The remedy is considered effective in the initial and progressive stages.
• Comedones and pustules on the skin of the face, provoking severe discomfort.
• Dermatosis of unspecified origin, accompanied by severe skin problems. The tool can be used when lesions appear on the body or face.
• Hyperpigmentation of the skin of the face, chest and upper back. The tool is not used on a permanent basis, but can be used in short courses to eliminate external cosmetic defects.
• Long-term non-healing wounds and cracks without signs of infection.
• Mild burns and frostbite. The drug helps to shorten the recovery period, prevents the development of complications, but it is used less often, with extreme caution.

The cream can be used as part of the complex treatment of many dermatological diseases, for example, with exacerbation of psoriasis, dermatitis.

Contraindications

The cream is contraindicated if there is an intolerance to its components or a tendency to similar manifestations in the patient's history.

There are other contraindications for external treatment:

• Severe forms of frostbite and burns of the skin. With a mild form of such injuries, the cream helps to improve the condition, but when the condition is neglected, it provokes complications.
• Infected wounds with pus and severe inflammation. With such pathologies, the cream is not considered effective, but improper use can provoke an aggravation of symptoms.
• The period of gestation and breastfeeding. The safety of the external agent has not been proven at this time. If use is required during lactation, you should first consult with a specialist who will determine the advisability of prescribing a cream.
• Eczema in acute and chronic stages. It is especially important not to take the medicine during an exacerbation of the condition.
• Epithelioma of a hereditary type. In this case, the stage of development of the pathology does not matter. The cream is also not used if there is such a diagnosis in the patient's history.
• Diabetes mellitus and advanced pancreatitis.

The drug is used with caution for the treatment of elderly patients suffering from pathologies of the cardiovascular and digestive systems, urinary organs.

At what age can the drug be used?

Tretinoin is a cream (reviews of the remedy do not always help to preliminarily assess the effectiveness of treatment, but it is recommended to study them), prescribed to patients from 12 years old. At an earlier age, use is not recommended, as there is a risk of complications.

Many doctors do not use the drug to treat patients over 50, but short courses are allowed, provided there are no absolute contraindications.

Instructions for use, dosage

The cream is used only externally after a preliminary examination and revealing the degree of neglect of the condition. Depending on the specific disorder, the drug use regimen may differ.

Skin pathology	Rules for the use of funds
Draining eels	When lesions appear, it is worth using the cream for 2-3 weeks, depending on the severity of the manifestations. The patient applies the cream to the affected areas 2 times per day. In this case, the layer should be thin, and the application is carried out pointwise, that is, only on the affected area. It is allowed to use a cotton swab, which will facilitate spot application. After 6 hours after application, it is necessary to remove the remnants of the product under running water.
Acne vulgaris and comedones	With such problems with the skin, the application is carried out in the morning 1 time per day. The product is applied pointwise with a cotton pad, the layer should be thin. After 6 hours, the product is removed from the skin using running water. The application continues for 2 weeks, after which the specialists evaluate the result of therapy, prolong the therapy or cancel the medication.
Pigmented spots spreading to the face and other areas	With such violations, the agent is prescribed in short courses of 10-14 days. The drug is applied to the entire lesion area with a thin layer and left for 6 hours, after which it is removed. You should adhere to the recommendations and not prolong the course if not needed.
Other skin diseases	Various dermatological pathologies are treated within 2-3 weeks, but sometimes with a chronic course of the disease, it takes 3 months to normalize the condition. The product is always applied in a thin layer, it is left on for 6 hours and removed. Depending on the nature of the lesion, the scheme may differ, but in most cases the standard method is used.

When using, it is always necessary to adhere to the doctor's recommendations, which will significantly reduce the risk of complications. The dosage does not depend on the age of the patient.

Side effects

Tretinoin - cream (reviews on the action of the drug may be negative, which is most often associated with intolerance to the components of the composition), which often provokes negative reactions, even if all the rules. When applied externally, complications in most cases affect the skin, but the penetration of the component into the blood can lead to systemic disorders.

The most common adverse reactions are:

• On the part of the nervous system, complications manifest themselves in the form of drowsiness and weakness, a significant decrease in working capacity. Patients can talk about depression, apathy, irritability. Sometimes patients have increased intracranial pressure, the condition is accompanied by headache and dizziness.
• On the part of the digestive tract, nausea and bouts of vomiting, flatulence and upset stools are noted. Such violations are not so common, sometimes accompanied by a lack of appetite and intense thirst.
• Respiratory complications are also rare. In this case, patients are worried about shortness of breath and an unreasonable cough. Usually, the manifestations disappear after discontinuation of therapy, but may persist.
• Cardiac disorders are rare, usually occurring in middle-aged patients who already suffer from pathologies of the cardiovascular system. Tachycardia, arrhythmia and pain in the heart area significantly aggravate the condition, almost always the patient needs special treatment.
• The most pronounced disorders appear on the part of the skin. If the patient develops an allergy, a rash appears on the skin, itching and burning, peeling is observed. Symptoms are aggravated by the development of cheilitis, in which the mucous membranes of the lips are affected. Usually, such disorders are characteristic when applied to the therapy of the skin of the face.
• Sometimes complications manifest themselves in the form of aggravation of the symptoms of the disease, which the patient treated with a cream. In this case, the therapy should be discontinued.

If complications occur, it is important to discontinue use immediately. Symptoms usually resolve on their own within a few days. If the manifestations are aggravated, a visit to a doctor is required, who will prescribe special treatment.

Overdose

When applied externally, the likelihood of an overdose is quite low. Only sometimes such disorders are observed if the patient applies the medicine in high doses for a long period of time and more often than necessary.

Overdose is accompanied by headache, weakness and bouts of vomiting. The condition worsens with the development of motor disorders. Among the external manifestations, a deterioration in the condition of the skin, nails and hair can be noted.

If signs of overdose appear, it is important to stop using the product immediately and visit a doctor. Help is provided to the patient in a hospital setting and under supervision. The drug does not have a specific antidote, but Dexamethasone is administered for 3 days to eliminate the symptoms. Usually this time is enough to eliminate manifestations.

special instructions

Tretinoin is a cream (drug reviews characterize its high effectiveness), prescribed only by a doctor if indicated. You can not use a remedy for prophylaxis, as this can lead to complications.

It is necessary to apply the product only in a thin layer. Increasing the dosage does not improve the therapeutic effect, but it can provoke complications. If the patient has dry skin, as well as an insufficient amount of melanin, provoking pallor, the cream is applied for no longer than 30 minutes for the first few days. Then it is removed under running water.

If there are no negative reactions for several days of such use, it is allowed to apply the medicine for a longer time. When applying the cream, it is important not to be in open sunlight for a long time, and also to be exposed to low temperatures or strong winds.

Drug interactions

Do not prescribe a remedy in combination with drugs that have a similar composition and therapeutic properties. Do not apply the cream at the same time as anti-inflammatory and hormonal topical medications.

The effectiveness of contraceptive drugs when using the cream is somewhat reduced, which must be taken into account when prescribing. The agent has no effect on the action of vascular, analgesic, antihypertensive drugs. Before using any drug, prior consultation with a doctor is required.

Analogs

The drug has several analogs that have pronounced properties. They are used most often, since the original product is not available on the territory of Russia and Ukraine.

The most common substitutes are:

• Retin-A - a popular tretinoin-based cream that has a pronounced anti-inflammatory and regenerating effect. It is prescribed for various skin lesions, helps to eliminate symptoms and prevent the progression of the condition.
• Retasol - a solution for external use, which contains isotretinoin as the main active substance. It has anti-seborrheic, anti-inflammatory and regenerating properties. The tool is considered effective and is often used when dermatological problems appear.
• Retinoic ointment - isotretinoin-based remedy, which is considered the most popular analogue. It has pronounced properties and is used for skin lesions of various shapes and severity. The drug belongs to the most affordable drugs, therefore it is used most often.

Substitutes can be used in the absence of contraindications and after consulting a doctor. Independent uncontrolled use often leads to the development of negative reactions.

Terms, conditions of sale and storage

The cream is sold over the counter without a doctor's prescription. Its storage period is 3 years. During storage, it is important to protect the drug from children and direct sunlight.

The date of manufacture of the product is indicated on the package, use after the expiration date is prohibited.

Price

The cost of Tretinoin is unknown, since the drug is not sold in pharmacies in Ukraine and Russia. But its substitutes can be purchased for 200-1500 rubles. This difference in cost is attributed to different manufacturers. Domestic drugs are cheaper than their foreign counterparts.

Tretinoin is an effective and popular cream with pronounced regenerating and anti-inflammatory properties. It is used for various dermatological pathologies, if you study patient reviews, it helps to eliminate acute manifestations. Application without preliminary examination is categorically contraindicated.

Video about the drug

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