Lorinden S ointment is a drug local spectrum of action, which is indicated for use in adults and children suffering from dermatological diseases. This drug belongs to the pharmacological group of glucocorticosteroids, which have anti-inflammatory and antiseptic properties.
Lorinden C ointment is used exclusively for external application with strict adherence to the dosages specified in the manufacturer's instructions. The medication is prescribed as an independent means of therapy, or in combination with other drugs to achieve a faster therapeutic effect.
Record content:
- 1 Forms of release and composition of the drug
- 2 Pharmacological properties
- 3 Pharmacodynamics and pharmacokinetics
- 4 Indications for use
- 5 Contraindications
- 6 At what age can the drug be used?
- 7 Instructions for use, dosage
- 8 Side effects
- 9 Overdose
- 10 special instructions
- 11 Drug interactions
- 12 Cheap counterparts
- 13 Terms, conditions of sale and storage
- 14 Price
- 15 Video about the drug
Forms of release and composition of the drug
Lorinden S is produced in the form of an ointment for application to the diseased area of the skin. Externally, the drug looks like a thick, oily and homogeneous mass of white with a slight yellowish tinge. The manufacturer of this medication allows the presence of a small amount of crystal-like particles. Lorinden C does not have a pronounced chemical odor.
After application to the surface of the body, it quickly conceals and acquires a less dense consistency. The drug is packaged in aluminum tubes with a lacquered inner surface, the total volume of which is 15 ml.
The main packaging of Lorinden S ointment is a cardboard box, inside which contains detailed instructions with indications for the use of this drug.
The table below shows the constituent components of Lorinden C ointment, and also displays their concentration in 1 g of the drug.
| Compound | Dosage and characteristics of biochemical substances |
| Flumethasone pivalate | Flumethasone pivalate is the active component of Lorinden C ointment, which is a synthetic glucocorticoid with a local spectrum of action. The concentration of this basic substance is 0.2 mg. |
| Clioquinol | Clioquinol is the active component of this drug, the presence of which provides the antimicrobial effect of Lorinden S. The mass fraction of the substance is 30 mg. |
The Lorinden C glucocorticosteroid ointment contains auxiliary components in the form of natural beeswax and petroleum jelly. These biochemicals create a fatty and oily base for flumethasone pivalate and clioquinol. Subject to all the rules of the instructions, the constituent components of Lorinden S ointment are completely safe for the body of adults and children.
Pharmacological properties
Lorinden C ointment, indications for the use of which are described in the manufacturer's instructions, has a combined effect.
This drug has the following pharmacological properties:
- narrows the walls of the smallest blood vessels located in the epithelial tissues at the site of application of the drug;
- has an anti-inflammatory effect, which is realized in the first 1-2 hours after treatment of the diseased part of the body;
- relieves swelling of epithelial tissues and restores their normal trophism, blood supply;
- reduces the severity of exudative reactions in those areas of the skin that are affected by an acute inflammatory process of an infectious nature of origin;
- eliminates the feeling of itching and other allergic reactions, which are manifested by the pathological state of the epidermis;
- has pronounced antibacterial properties, exhibiting antiseptic activity against gram-positive and gram-negative bacteria;
- accelerates the regeneration processes of the skin, which was destroyed as a result of chronic or acute inflammation provoked by pathogens;
- suppresses the pathogenic activity of fungal infections (this property of Lorinden C ointment is less pronounced, therefore, for treatment of mycoses, this drug is recommended to be used in combination with other potent antifungal means).
The active implementation of the pharmacological properties of Lorinden C ointment is carried out in the first 1-2 days from the start of drug therapy. A stable positive effect becomes noticeable upon completion of the general course of treatment.
In combination with other dermatological preparations of antiseptic and anti-inflammatory spectrum of action, the pharmacological properties of Lorinden C become more pronounced.
Pharmacodynamics and pharmacokinetics
Lorinden C ointment (indications for the use of the medication are determined by the attending dermatologist) is a drug with a combined chemical composition. After the therapeutic dose of this drug is applied to the diseased skin area, its main components are rapidly absorbed.
The pharmacodynamics of flumethasone pivalate is characterized by suppression of acute and chronic inflammation, elimination of signs of itching, redness and edema of epithelial tissues.
It is a synthetic glucocorticoid that prevents the appearance of exudative reactions in the presence of wound lesions of the skin. Flumethasone pivalate promotes more active healing of ulcers and stimulates the regeneration of epithelial cells.
The pharmacodynamics of clioquinol is distinguished by the pronounced antibacterial activity of this component. This chemical is effective against a large number of infectious microorganisms, but practically does not show activity against viruses. Clioquinol inhibits the progression of mycotic infection, prevents the further formation of fungal colonies.
At the same time, this substance is not able to independently withstand severe dermatological diseases associated with the destruction of the skin by fungi. Clioquinol in combination with the synthetic glucocorticoid flumethasone pivalate provides a quick relief of the inflammatory process with antiseptic sanitation of infected body tissues.
The pharmacokinetics of flumethasone and clioquinol is characterized by the rapid absorption of these substances into the stratum corneum of the epidermis and an insignificant degree of penetration into the general bloodstream. More active absorption of a glucocorticoid and an antibacterial agent is observed in the case if Lorinden S ointment is applied to thin areas of the skin, neck, face, epithelial folds fabrics.
Under the conditions of using occlusive dressings, the degree of absorption of flumethasone pivalate and clioquinol is more pronounced. Especially if the ointment is used to treat large areas of the body.
The absorption of glucocorticosteroid and antimicrobial agents is more active in pediatric patients. In this regard, the risk of developing side effects increases. The metabolism of absorbed flumethasone and clioquinol is carried out in the liver tissues, and its excretion occurs along with the urine.
Indications for use
The drug Lorinden C is used to treat inflammatory skin diseases, which are characterized by the absence of the release of serous exudate. This drug is indicated for use in children, adult men and women, as well as the elderly, who have been diagnosed with the following dermatological diseases:
- atopic dermatitis;
- psoriasis (therapy of this disease is more effective if ointment is applied using occlusive dressings and applications);
- seborrheic dermatitis;
- various kinds of allergic reactions, which are manifested by a pathological state of the skin of the body, or their development is complicated by the addition of a secondary bacterial infection;
- exudative erythema multiforme type;
- infectious eczema;
- lichen planus, or a chronic form of this disease without signs of redness of the skin;
- limited neurodermatitis of infectious etiology;
- allergic contact dermatitis.
In the process of treating the above diseases of the skin of the body, Lorinden C ointment allows you to achieve therapeutic effect in the form of elimination of signs of inflammation, relief of itching, edema, suppression of pathogenic infections. The appointment of this medication should be carried out by a dermatologist after a preliminary examination of the patient and testing.
Contraindications
Lorinden C ointment (indications for the use of this drug must be observed at all stages of treatment) is a drug that has a minimum number of restrictions on its use.
This medication is contraindicated in patients suffering from the following diseases and pathological conditions of the skin:
- diaper dermatitis in children of the younger age group;
- varicose veins, the complication of which is the appearance of trophic ulcers and thrombophlebitis;
- thermal, chemical and electrical burns of the body;
- perioral dermatitis;
- malignant neoplasms of the skin (including those tumors that, according to the results of a diagnostic examination, are recognized as precancerous);
- damage to epithelial tissues caused by tuberculosis or syphilitic infection;
- acne vulgaris and rosacea, which are quite common in adolescents and adults with unstable hormonal levels;
- severe bacterial, fungal and viral skin infections, the treatment of which requires the use of potent antimicrobial agents in tablets and injections;
- post-vaccination period of the body's recovery (within 3 days from the moment of receiving the vaccination, it is not recommended to treat the body with Lorinden C ointment).
The drug Lorinden S is contraindicated for use in women who are in the 1st trimester of pregnancy, as well as breastfeeding a newborn baby. At a later stage of fetal development, this medication can be used, but only when absolutely necessary and under the supervision of the attending physician.
It is recommended to apply the drug with extreme caution in case of extensive tissue damage, when the ointment large areas of skin are processed, as well as the area of the armpits, groin, folds, the circumference of the eyes. Particular attention should be paid to the process of treating elderly patients who have signs of atrophic changes in the subcutaneous tissue.
At what age can the drug be used?
Lorinden S ointment is approved for use in children who are 2 years old. For a younger child, this drug is contraindicated, since there are no clinically confirmed data on its safety and sufficient efficacy.
Instructions for use, dosage
Lorinden C ointment, indications for the use of which were compiled according to the results of laboratory studies of the drug, is used only for external treatment of diseased areas of the body. It is necessary to apply the drug in the thinnest possible layer, and then rub in with massage movements for better absorption.
If signs of hyperkeratosis appear, an occlusive dressing should be used, which should be changed every 24 hours. Patients of the adult age group perform the treatment of the diseased skin area 1-2 times a day, depending on the type of dermatological disease and the general condition of the epithelial tissues.
For children over 2 years of age, Lorinden C ointment is applied to small areas of the body no more often than once a day. In this case, the child must be under constant supervision of a pediatric dermatologist.
It is strictly forbidden to use this medication for treating the skin surface of the face, since there is a high likelihood of side effects and allergic reactions.
The course of continuous therapy for adults and children should not exceed more than 2 weeks. For a child, these terms of treatment can be reduced by 2 times. Adults who are undergoing facial skin therapy should use Lorinden C ointment for no longer than 7 days. Within 1 week, it is allowed to use no more than 1 tube of this drug (15 g).
Side effects
Negative reactions of the body caused by the use of Lorinden C ointment occur extremely rarely, and most of them are completely reversible.
Despite this, the development of the following side effects is not excluded:
- post-steroid rash;
- increased dryness of the skin;
- depigmentation of epithelial tissues;
- complete or partial alopecia;
- skin atrophy;
- hypertrichosis;
- short-term decrease in visual acuity;
- exacerbation of existing ophthalmic diseases in the form of glaucoma or cataracts;
- decrease in general immunity (this negative reaction appears in patients who use Lorinden C ointment for more than 2 weeks);
- increased blood pressure;
- growth retardation and physical development in patients of the pediatric age group;
- decreased functional activity of the adrenal cortex;
- inflammatory processes in the structure of hair follicles that have been treated with this drug;
- hives;
- allergic reactions in the form of itching, redness of the skin, dermatitis, desquamation of epithelial tissues;
- accession of a secondary bacterial infection;
- exacerbation of existing dermatological diseases.
Long-term therapy with Lorinden C ointment, as well as the use of an occlusive dressing with the closure of large areas skin can provoke symptoms of neurotoxicity, which are caused by an antimicrobial component clioquinol.
In this case, the patient may experience headache attacks, impaired coordination of movements, nausea, and dizziness. Such symptoms are extremely rare.
Overdose
The occurrence of an overdose with Lorinden C ointment is unlikely, since the drug does not have a pronounced absorption. The application of this medication to large areas of the skin under conditions of prolonged therapy with occlusive dressings can provoke symptoms of hypercortisolism, namely:
- rapid set of adipose tissue;
- depletion of the upper layer of the skin, which becomes less dense and more vulnerable to inflammatory and infectious diseases;
- violation of the menstrual cycle in women, accompanied by increased body hair;
- loss of muscle mass;
- general physical weakness;
- osteoporosis;
- increased blood glucose levels;
- arterial hypertension;
- a change in the cellular composition of the blood towards an increase in platelets;
- panic attacks and unstable psycho-emotional state;
- insomnia, as well as a violation of the process of falling asleep;
- thrombosis of the great vessels.
Due to the low percentage of absorption of the constituent components of Lorinden C ointment, the appearance of signs of acute intoxication of the body is almost impossible. The above symptoms indicate systemic blood saturation with an excess amount of flumethasone pivalate.
After an overdose with this drug is detected, further administration of the ointment should be discontinued, since there is a high probability of developing adrenal insufficiency.
special instructions
During therapy with Lorinden C, it is necessary to ensure that the drug does not enter the oral cavity, as well as the mucous membrane of the eyes.
If, after using the medication, signs of an allergic reaction appear on the epithelial tissues, the symptoms of the already existing dermatological disease, it is recommended to contact your doctor, and until you receive current advice, temporarily stop using of this drug.
Patients who use Lorinden C ointment with short therapeutic courses, but over a long period of time, should donate venous blood for analysis of cortisol levels.
The development of a secondary bacterial or fungal infection requires the inclusion in the treatment course of a drug that is effective against pathogenic microorganisms of a particular type. It is necessary to use this medication with the utmost care in the eyelid area, as well as the eye circumference, since there is a high risk of cataract or glaucoma.
Patients who already have these diseases in the anamnesis may face an exacerbation of these ophthalmic diseases. The constituent components of the drug Lorinden C do not affect the reaction rate and concentration of attention, therefore they can used by drivers when driving vehicles, as well as by employees performing work with increased danger.
Drug interactions
Lorinden C ointment is contraindicated for use with drugs of the following pharmacological groups:
- estrogens;
- nitrates;
- tricyclic antidepressants;
- antihistamines;
- diuretics;
- oral contraceptives;
- cardiac glycosides;
- anabolic steroid;
- antipsychotic drugs.
In conditions of simultaneous therapy with the above medicines, the likelihood of the development of negative reactions of the body caused by Lorinden S. ointment increases.
Cheap counterparts
The table below lists medicines that have similar properties, but at a lower cost.
| Name of the medication | Price |
| Dermalex cream | 320 RUB |
| Sudokrem | RUB 295 |
| Belosalik cream | 260 RUB |
| Trimistin ointment | 225 RUB |
| Lorinden A ointment | 330 RUB |
Cheaper drugs analogs of Lorinden C ointment may differ in less pronounced anti-inflammatory and antiseptic properties. These medications are prescribed by a dermatologist.
Terms, conditions of sale and storage
Lorinden S ointment is dispensed in retail pharmacy chains on the basis of a prescription from a doctor in charge. The air temperature in the room where the medication is stored should be + 20-25 degrees. The shelf life of this medicinal product is 3 years.
Price
The average cost of Lorinden C ointment is in the range of 350-380 rubles. Lorinden C ointment is an effective medication that is indicated for use by children aged 2 years and older, adults men and women, as well as elderly patients who have no signs of subcutaneous tissue atrophy.
This drug has a pronounced anti-inflammatory and antiseptic effect, relieves itching, redness, swelling of epithelial tissues, accelerates the restoration of the epidermis. The implementation of the pharmacological properties of the ointment is provided by its constituent substances in the form of the glucocorticoid flumethasone pivalate and the antimicrobial agent clioquinol.
Video about the drug
Lorinden C ointment:
