Calcium gluconate (Calcii gluconas) tablets. Price, instructions for use, what they are prescribed for, reviews

Medicine Calcium gluconate is popular due to its affordable price, versatility, and minimal side effects. The drug is produced in tablets and in the form of an ampoule solution for injection.

Indications for use

Calcium gluconate improves the rheological properties of blood, normalizing its clotting. The drug is intended to restore phosphorus-calcium and tissue metabolism.

The action of the drug is aimed at replenishing the Ca2 + deficiency, which leads to:

• deterioration in the transmission of nerve impulses;
• violation of smooth muscle contractions;
• fragility of the skeletal structure;
• disorder of the myocardium;

Calcium gluconate - tablets, the price of which is available to the widest range of potential consumers.

The drug is often prescribed to children with an increased need for Ca2 +, due to the intensive growth of the body, as well as with:

• hypoparathyroidism;
• hidden tetany;
• osteoporosis;
• hypocalcemia;
• abnormal permeability of cell membranes;
• acute vitamin D deficiency;

The drug is effective for spasmophilia and osteomalacia - congenital pathologies characterized by insufficient mineralization of bone tissues of skeletal structures.

An important property of calcium gluconate is the ability to eliminate the effects of intoxication with heavy magnesium salts, in particular Mg2 +. The medicine neutralizes fluoric and oxalic acid compounds.

The medication is prescribed to patients with chronic renal failure, in which hyperphosphatemia develops, a pathological condition caused by an excessive concentration of phosphates in the blood.

Compound

Calcium gluconate is a monopreparation of mineral origin. The basis of the chemical formula is the active substance of the same name. Glutamic calcium acid at a concentration of 9% serves as a structural component of cell membranes.

They are intensively consumed in the phase of the formation of the organism, its active growth, become thinner in some congenital or acquired pathologies. Bone fibers and teeth are saturated with calcium glutamic acid, which this biochemical mineral gives strength to.

Auxiliary components of the medicinal product:

• starch - natural polysaccharide with enveloping and softening properties;
• colloidal form of anhydrous silicon dioxide - enterosorbent, which suppresses the vital activity of pathogenic pathogens and removes toxins from the body;
• calcium stearate - surfactant compound, effective plasticizer, gelling agent.

Silicon dioxide regulates the composition of the intestinal microflora, breaks down cholesterol and radionuclides. Calcium stearate has an emulsifying and heat stabilizing function.

Forms of issue

The drug is produced in the form of tablets, powder for injection, ready-made solution in ampoules for intramuscular and intravenous administration. The chemical formula of all 3 variants is identical.

Distilled water is additionally present in the finished injection solution. This drug is a colorless liquid in ampoules with a capacity of 5 and 10 ml. The cost varies between 100-150 rubles. per pack in the amount of 10 pcs.

Calcium gluconate - tablets (the lowest price among all forms of release) of flat-cylindrical section of white color. They are delivered to pharmacies in cardboard boxes, each of which contains 1, 2 or 3 non-cell contour packs of 10 units. drug.

1 tablet contains 250 or 500 mg of a pharmacologically active component. The approximate price in Russian pharmacies is 30-50 rubles. Powdered preparation requires dilution with medical distilled water. This form of release is used mainly in hospitals. The price of powdered calcium gluconate is 60-90 rubles.

Pharmacodynamics

Some pathological conditions are associated with a sharp decrease in the concentration of calcium ions in the blood, which promotes the formation and development of latent tetany - involuntary painful muscle contractions of spasmodic character.

Calcium gluconate eliminates hypocalcemia and normalizes skeletal muscle function. Its active substance restores the permeability of the walls of the blood arteries, suppresses inflammatory processes, and reduces the release of pathological exudate.

The drug has anti-anaphylactic and hemostatic effects. It replenishes the supply of calcium ions, which serve as structural elements of bone fibers, activators of enzymatic processes and conductors of nerve impulses. They regulate the rate of permeability of cell membranes.

The drug demonstrates good effectiveness in allergic reactions and colds, the cause of which is hypocalcemia. In the treatment of such pathological conditions, the drug is included in the complex therapy along with antihistamine drugs.

Pharmacokinetics

With oral administration of calcium gluconate tablets, the active ingredient and auxiliary components are partially absorbed into the lumen of the small intestinal cavity, stomach and bloodstream. The maximum concentration in the body of a pharmacologically active mineral compound is reached after 1.2-1.3 hours.

The half-life of Ca ions is 6.8-7.2 hours. from the moment of oral administration. It is evacuated from the body with urine and feces. Calcium gluconate is metabolized in the kidneys.

The value of drug absorption ranges from 20-35% and largely depends on:

• blood levels of cholecalciferol,
• pH value;
• characteristics of the patient's diet;
• biochemical characteristics of the pathological condition.

Calcium ions are absorbed more intensively if the food intake is not saturated with them, and the body is experiencing an obvious deficiency. With intravenous administration of an ampoule preparation, there is an increased excitability of the sympathetic nervous system and an increase in the secretion of adrenaline by the adrenal cortex.

Application

Calcium gluconate - tablets, the price of which makes them the first choice for people with Ca2 + deficiency. The regimen is prescribed by the doctor individually for each patient. The standard course of treatment lasts 7-14 days.

In severe pathologies, intravenous injections are performed. The ampoule drug quickly suppresses allergic symptoms and eliminates the spasmodic state of muscle fibers.

Calcium gluconate is often used in combination therapy:

• bleeding of various etiologies;
• hematological disorders;
• serum disease - a systemic pathology arising from sensitization (hypersensitivity) to foreign protein elements;
• urticaria - an allergic rash on the skin, accompanied by severe itching;
• febrile syndrome;
• dermatoses of anaphylactic genesis;
• angioedema - an acutely developing dermatological disorder of the mucous membrane and subcutaneous tissue due to contact with allergenic agents.

Calcium gluconate in tablets or injections is often included in the complex treatment of bronchial asthma, tuberculosis, parenchymal hepatitis. The low price and versatility of the drug allow it to be used widely enough.

For children under 18

In the minimum dosage, the medicine is prescribed even to infants. For children under 1 year old, tablets are given in a thoroughly crushed state. The resulting powder should preferably be washed down with plenty of water or fruit juice. It is important to observe the established age-related dosages, which are given in the table:

Child's age	Active ingredient rate
Up to 1 year	0.5 g per day
2 to 5 years old	1 g, maximum daily dose - 3 g
5-7	1-1.5 g, maximum 4.5 g / day.
7-10	2 g, per day - up to 6 g
10-13	2-2.5 g, maximum per day - up to 8 g
13-18	3 g per dose, no more than 9 g / day.

Injectable calcium gluconate is not prescribed for infants because of the risk of soft tissue necrosis. The child is given a powdered tablet before meals or after 1-1.5 hours. after eating.

In acute allergic conditions, children are prescribed a medication together with an antihistamine drug to enhance the clinical effect. Patients aged 10 years and older are prescribed "hot" injections of calcium gluconate using a solution warmed up to body temperature.

For adults

It is not recommended to use the medicine for severe renal organ dysfunctions. For other pathologies, a special dose adjustment and frequency of administration is not required. A typical regimen for adult patients is 3 times a day, 1 tablet.

This method of administration is used for osteoporosis, hypocalcemia, and other pathologies. The solution for injection is injected slowly over 1-2 minutes. Adults are served one-time 5-10 ml of 10% of the drug. It can be administered intramuscularly, intravenously in a jet, or infusion using a drip system.

For pregnant

When restoring the calcium-phosphorus balance in patients in such a physiological state, doctors often give preference to calcium gluconate tablets. Assign 2-3 units of medication daily for 7-14 days.

The standard daily dose is 1-1.5 g. In acute conditions, when it is required to quickly restore the mineral balance in the body, pregnant women are prescribed injections of calcium gluconate with preliminary heating of the solution to body temperature.

The drug has probiotic and antioxidant functions. Calcium gluconate is involved in the formation of the skeletal structure and nervous system of the embryo. The drug in a concentration of 9% of the active substance is especially necessary in the 2nd semester of bearing a child, when the active growth of bone and muscle tissues of the fetus begins.

For the elderly

In old age, the likelihood of developing osteoporosis increases significantly. Calcium gluconate is prescribed to restore the mineral balance. In elderly women, hypocalcemia is often associated with hormonal changes in the body during menopause.

This category of patients is prescribed a drug as part of complex therapy for:

• depressed state;
• apathy;
• cardiovascular insufficiency;
• increased fragility of bones;
• loss and loosening of teeth;
• age-related disorders of calcium-phosphorus metabolism;
• hyperphosphatemia;
• after prolonged treatment with medications that provoke intensive excretion of Ca2 + from the body - corticosteroids, antiepileptic and diuretic drugs.

Elderly patients do not need to adjust the dose and frequency of calcium gluconate intake by age. The drug is effective for liver damage with salts of heavy metals, oxalic acid, and other types of intoxication.

Contraindications

Calcium gluconate - tablets, the price of which is low. It looks attractive in the eyes of potential patients and is successfully combined with a minimum number of medical bans on taking the drug. This is one of the factors in its popularity.

The drug is not considered a potent one, therefore it has a small number of absolute contraindications.

The main ones are:

• intolerance to the 1st or several components of the chemical formula of the drug;
• hypercalceuria;
• hereditary predisposition to thrombosis;
• calcium-type nephrourolithiasis;
• sarcoidosis is a multisystem disease of unknown etiology, which is characterized by the formation of epithelioid cell granulomas and noncaseated character;
• high density of blood fluid and other hematological disorders;

Calcium gluconate is not prescribed during the period of taking cardiac glycosides and in severe kidney pathologies.

Particular care must be taken when taking medication against the background of:

• dehydration (dehydration) of the body;
• electrolyte disorders;
• dysfunctions of the digestive system;
• hypercoagulability.

The drug is not used with high blood cholesterol levels, as it strengthens plaques and further reduces venous lumen.

Overdose

If the maximum daily norm is regularly exceeded, typical signs of drug intoxication are not are detected, but there is a risk of developing hypercalcemia with deposition of salts in the joints and muscle tissues Ca.

This likelihood increases with cross-treatment with loading doses of drugs containing vitamin D and its derivatives.

This undesirable effect is manifested:

• anorexia;
• the formation of muscular dystrophy;
• violation of the stool;
• nausea and vomiting;
• increased irritability, which is associated with hyperactivity of the central nervous system;
• polyuria - intense urination;
• pain syndrome of an abdominal nature;
• polydipsia - unnaturally intense thirst;
• surges in blood pressure;
• arthralgia - pain in the joints in the absence of pathological signs of destructive changes in them;
• nephrocalcinosis - diffuse (penetrating) accumulation of calcium salts in the kidneys, which is accompanied by an inflammatory-sclerotic process.

With a significant overdose of the drug, symptoms of cardiac arrhythmia may occur. To eliminate such manifestations, the course of treatment is interrupted. In some cases, your doctor will prescribe an intravenous jet injection of calcitotin, a protein hormone in the thyroid gland produced by C cells.

Side effects

Course intake of calcium gluconate in tablets can lead to complications of the process of defecation and irritation of the mucous membrane of the gastrointestinal tract.

When using an injectable drug, in rare cases, the following are observed:

• nausea and vomiting;
• bradycardia;
• burning sensation in the mouth;
• a sharp decrease in AT;
• arrhythmia;
• tissue necrosis in the injection zone.

With increased intolerance to the components of the chemical formula of calcium gluconate, allergic reactions and fainting are possible. In some cases, pain is observed in the epigastric region and in the region of the umbilical ring.

Violation of cardiac muscle contractions is associated with the ability of the drug to conduct and increase the activity of cardiomyocytes - functional cells of the organ. The drug rarely causes manifestations of hypertension.

Possible swelling of the lower extremities and the skin of the periorbital zone in people with kidney pathologies. After the cancellation of the course of treatment, all alarming symptoms quickly disappear.

Drug interactions

Calcium gluconate does not enter into chemical reactions with components of other medicines. However, it is able to slow down the action of etidronate, stramustine, and other bisphosphonates.

Calcium gluconate weakens the pharmacological effect of taking tetracycline antibiotics and anti-inflammatory drugs of the quinolone category. When taken simultaneously with medicines saturated with fluoride and iron, a time interval between their use of more than 3 hours should be maintained.

Calcium gluconate has the property of reducing the bioavailability of antiepileptic and anticonvulsants of the phenytoin series.

The tablets increase the cardiac toxicity rate of glycoside-based pharmacological pacemakers. With the parallel administration of calcium gluconate and calcitonin medicines, the clinical effect of the latter is slightly reduced.

In combination with quinidine, the injectable drug slows down intraventricular conduction, which causes impaired myocardial contractions. It is undesirable to combine calcium gluconate with thiazide category diuretics.

This significantly increases the likelihood of oversaturation of the body with Ca2 +. Do not prescribe the simultaneous intake of calcium gluconate with carbonate, sulfate, salicylic drugs.

Storage conditions and periods

An injectable preparation is suitable for use within 2 years from the date of manufacture, tablets - 5 years. Opened ampoules are not subject to long-term storage. The optimum temperature for any form of calcium gluconate is set at + 10... + 25 ° С.

Conditions of dispensing from pharmacies

The pill is an over-the-counter drug. They can be freely purchased at any pharmacy. To purchase calcium gluconate in ampoules, you need a prescription form certified in accordance with all the rules and signed by a doctor.

Analogs

A large group of medications has an identical mechanism of pharmacological action.

Rating of the most popular of them in terms of ratio. cost / efficiency / safety:

1. Calviv. Combined drug that compensates for the deficiency of Ca2 + and ascorbic acid. The active ingredients are calcium carbonate and lactogluconate. Available in large effervescent, water-soluble tablets. Used for osteoporosis, climacteric syndrome, latent tetany. The standard daily dose is 1-5 tablets.
2. Calcemin. The drug stabilizes the calcium-phosphorus balance in the body. Release form - tablets in a gelatinous shell. The active substance is colecalciferol. Contains copper, manganese, zinc, boron. Prescribed for osteoporosis of any genesis, micronutrient deficiency in adolescents, pregnant women, nursing mothers. Take 1 tablet daily.
3. LecT. Enzymatic digestive medication with a broad spectrum of action. Available in biconvex enteric tablets. The active ingredients are pancreatin and lactogluconate. The main indications for use are a violation of the digestive function, exocrine pancreatic insufficiency, dyspepsia. Take 1-3 tablets with an interval of 8 hours.

Any of the analogs, as well as calcium gluconate itself, should be consumed only after consultation with the attending physician. Tablets and injectables for this purpose have contraindications and clinical limitations. The price of all medicines for restoring calcium-phosphorus balance does not differ much.

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