Cetrine. Indications for use, instructions, cheap analogs, side effects, price, reviews

Cetrin - antihistamine medicationwith pronounced therapeutic properties. Indications for its use are allergic manifestations in adults and children of different ages. To get only benefits from therapy, you should carefully study the instructions and visit a doctor who will determine the most optimal dosage.

Release form and composition of the drug

The drug can be found on drugstore shelves in the form of tablets for oral administration, as well as syrup for ingestion. The tablets are small and white in color, do not have an unpleasant odor, but have a rather bitter taste.

They are packaged in blisters of 10 pieces. In an individual cardboard box, you can find 2 or 3 plates, as well as instructions for the correct use of the medicine.

The syrup has a thick consistency and a pleasant fruity smell. It can be colorless, sometimes has a yellowish tint. The syrup is packaged in bottles of 30 or 60 ml, which fit into cardboard boxes, where you can also find instructions.

The component cetirizine acts as the main active substance in the composition of the product in any form. 1 tablet contains 10 mg, 1 ml of a solution of 1 mg of the ingredient.

The tablets contain auxiliary ingredients:

• Magnesium stearate.
• Lactose.
• Corn starch.
• Povidone.
• Sorbic acid.
• Titanium dioxide.
• Macrogol.
• Dimethicone.

The syrup also contains auxiliary ingredients in the form of flavoring, sucrose, glycerin. Water, sodium citrate and benzoic acid are present in the syrup. Auxiliary ingredients in the composition of the drug do not have therapeutic properties. The product is manufactured by a pharmaceutical company in India.

Pharmacological properties

Tsetrin, the indications for the use of which it is better to discuss with a specialist, has pronounced antiallergic properties. The therapeutic effect is carried out by selectively blocking histamine receptors.

In this case, there is a weakening of the negative effects of histamine on the central and peripheral vessels. This avoids swelling and redness of the skin in the area of ​​contact with the allergen. Thanks to this effect, there is a weakening of external manifestations and a relief of the patient's condition.

In addition, the drug has a mild sedative effect, despite the fact that it belongs to the next generation of drugs. However, when taken in the prescribed dose, no pronounced hypnotic effect is observed, only a slight weakening of concentration is noted.

Another property of the drug is the ability to prevent the re-development of negative reactions from the nose, eyelids and skin throughout the day.

Pharmacodynamics and pharmacokinetics

After penetration of the drug into the digestive tract, it is actively absorbed, the main ingredient enters the bloodstream and has a therapeutic effect. Cetirizine blocks the production of some histamine receptors, which leads to a decrease in the negative effect of histamine on the vascular walls.

Histamine is produced in every patient's body when the body comes into contact with allergens. The reaction can be triggered by animal hair, plant pollen, medicines and other substances. As a result, pronounced systemic and external manifestations of the skin appear.

Cetirizine prevents the development of skin edema and redness in the affected area. At the same time, there is a significant decrease in itching if the allergy is accompanied by a similar manifestation. As a result, the patient's condition improves, complications in the form of acute urticaria and other pathologies that may arise in the absence of treatment at the initial stages are prevented.

After taking the pill, the active ingredient spreads through the systemic circulation and has a therapeutic effect. Its maximum concentration in the blood is detected 60 minutes after ingestion. The bioavailability of the drug is quite high, which is explained by its good binding to blood plasma proteins. It is noted that in children, the bioavailability index is slightly higher than in adults.

The metabolism of the active component is carried out in the liver, where the substance is excreted by metabolic products. About 50% of cetirizine is excreted unchanged by the kidneys. A small part is evacuated with feces. Ingestion of food or liquids does not impair the absorption of the active ingredient and does not impair the effectiveness of the drug. In this case, the rule applies to any form of drug release.

However, the consumption of food somewhat slows down the evacuation of components from the body, which on average lasts about 12-18 hours. In each individual case, this indicator may vary. This is especially noticeable in patients who suffer from one or another pathology of the kidneys, liver.

Indications for use

In most cases, Cetrin is used to relieve the symptoms of various allergic reactions.

The main indications for its use are as follows:

• Allergic dermatitis of varying severity.
• Psoriasis and eczema in the acute stage. In this case, the medicine is used as part of a complex treatment.
• Allergic conjunctivitis with severe clinical manifestations.
• Seasonal allergic rhinitis. The tool can be used not only for exacerbation of allergies, but also with the constant presence of symptoms.
• Angioedema.
• Pollinosis in patients of different ages.
• Urticaria in acute and chronic form.
• Itching, swelling and redness of the skin of unspecified origin.
• Bronchial asthma of allergic origin. The drug is indicated as an auxiliary method of therapy.
• Quincke's edema is also considered one of the indications. The remedy will not help completely eliminate the symptoms, but it will significantly alleviate the patient's condition.
• Atopic dermatitis.
• Neurodermatitis of varying severity.

In addition, the medicine is often prescribed to children in courses of 3-5 days after routine vaccination. Taking the medication helps to avoid negative reactions to the vaccine.

Contraindications

The medicine is not used in the treatment of patients who suffer from cetirizine intolerance. If the patient is allergic to drugs that contain this active ingredient in the composition, Cetrin is not prescribed.

Contraindications include the period of breastfeeding and bearing a child, since the active substance can adversely affect the patient and the fetus. It is forbidden to take any form of the drug in case of diagnosis of chronic renal failure. It is not recommended to use the medicine for liver cirrhosis, hepatitis, or progression of liver failure.

Elderly patients suffering from heart failure, ischemic disease, the drug is prescribed with caution. Contraindications include internal bleeding, recovery period after myocardial infarction or ischemic stroke.

There are also individual contraindications for which the drug is not used. They are determined in each case by a doctor after examining a specific patient.

At what age can the drug be used?

Tsetrin (indications for use are determined after a preliminary examination) in pediatric practice is used only for the treatment of children from 2 years of age. But such patients can only take syrup.

Tablets are allowed for use by patients from 6 years old, only as prescribed by a doctor and in the dosage indicated by him.

Instructions for use, dosage

Tablets and syrup are prescribed for adults and children according to a specific scheme. The dosage and duration of the course largely depends on the disease, as well as complications.

Form of funds	Admission scheme for children	Dosage and features of use for adults
Pills	Tablet medication is prescribed for children from 6 years old. The maximum daily allowance for a child is 10 mg, that is, 1 tablet. However, do not give it to your child right away. It is better to divide the tablet into 2 parts, take it in the morning and in the evening. The duration of use ranges from 3-14 days, depending on the degree of neglect of the disease and the body's response to the drug.	For adults, the drug is most often prescribed in the form of tablets. The daily dosage should not exceed 2 pieces, but usually it is enough to take 1 tablet to achieve a therapeutic result. The duration of the course is 5-10 days. It is worth noting that taking the pill again must be approved by a doctor, constant use of increased dosage leads to a decrease in the body's sensitivity to cetirizine and a weakening of the therapeutic effect.
Syrup	It is recommended to give syrup to children under 6 years old, which is associated with better absorption, as well as ease of dosing. The daily rate is 2.5 ml. If the effect of the intake is not observed or it is insufficient, the doctor prescribes the intake of 2.5 ml 2 times a day. Children from 6 years of age are prescribed no more than 10 ml of medication per day, while the rate can be divided several times in order to achieve a constant antihistamine effect. Duration of use is from 3 to 10 days.	Syrup is rarely prescribed for adults. The daily dosage is 10 ml. But in case of impaired renal and liver function, the doctor adjusts the dosage taking into account these pathologies. Typically, an adult takes 5 ml of syrup per day. Elderly patients who do not suffer from liver or kidney disease do not need dose adjustment. The duration of the therapeutic course is 5-10 days.

In each individual case, the dosage and duration of use may vary.

Side effects

If the instructions are violated, negative reactions may develop during treatment with the agent. But doctors draw the attention of patients to the fact that if all the rules are observed, the risk of complications cannot be completely excluded.

The most common side effects:

• On the part of the nervous system, headache, weakness and dizziness are noted. Some patients report drowsiness, decreased performance, and poor coordination. In patients with a tendency to neurological diseases, the development of migraine is noted, the symptoms of which are not relieved by conventional analgesics.
• Nausea when taking medication is common. In addition, patients report pain in the intestines, increased gas production and bloating.
• Dry mouth and intense thirst are considered common complications with long-term therapy. In most cases, symptoms do not require specific treatment.

Quite often, complications manifest themselves in the form of allergies, if the patient has an intolerance to the main component, which is detected for the first time after its use. Allergy is accompanied by a rash, itching and peeling of the skin. The patient is worried about irritation, the rash gradually spreads to large areas of the skin.

If negative reactions appear, you should refuse to take the drug. This is usually enough to eliminate manifestations. If this does not happen, it is recommended to see a doctor for symptomatic treatment.

Overdose

Tsetrin (indications for use are considered individually) quite often provokes an overdose, especially with uncontrolled independent use. The main part of the symptoms is associated with the effect of the active substance on the patient's central nervous system.

The patient speaks of severe drowsiness, apathy and headache. His appetite worsens, his thirst increases, and perhaps even clouding of consciousness. In some cases, short-term fainting is observed. In addition, in some patients, apathy is replaced by strong anxiety, motor activity, and excessive excitability. The condition is accompanied by twitching of the eyeball.

Patients who suffer from any heart disease have arrhythmias, tachycardia and fluctuations in blood pressure. Quite rarely, an overdose is accompanied by acute urticaria or Quincke's edema.

At the same time, the spread of large red spots of various sizes is noted, as well as swelling of the mucous membrane of the throat. Symptoms are rapidly aggravated in the absence of treatment, and threaten the patient's life.

The specific antidote to the drug is currently unknown, therefore, when signs of an overdose appear, doctors prescribe symptomatic therapy to alleviate the patient's condition.

special instructions

Doctors strongly recommend not to combine the drug with the intake of alcoholic beverages in any dosage, which is associated with an increase in the depressing effect on the central nervous system. Patients with a severe course of epilepsy are rarely prescribed medication, since there is a risk of more frequent seizures.

It is worth noting that when using the drug in the recommended dosages, there is no significant slowdown in the reaction when driving vehicles or mechanisms.

However, in many patients, even taking a small dose provokes drowsiness. If the patient independently exceeds the permissible daily rate, the risk of developing negative reactions from the nervous system increases.

Drug interactions

Cetrin (indications for use include all types of allergies) should not be combined with products that contain the same active ingredient. In addition, you should not use antihistamine medication at the same time as sedatives, antidepressants and tranquilizers. This can lead to depression of the central nervous system and the development of complications.

It is allowed to use the medicine simultaneously with antibiotics, anti-inflammatory and vascular drugs. They do not interfere with the absorption of Cetrin and its effect on the body. There are no negative reactions when the drug is combined with antihypertensive, analgesic and antiviral drugs.

In each case, the doctor individually decides on the combination of a particular medication with Cetrin.

Analogs

If it is impossible to use the original medication, a substitute with similar therapeutic properties is prescribed.

The most effective analogues:

• Cetirizine - the most popular and affordable analogue, produced in the form of tablets for oral administration. It contains the active ingredient of the same name, has pronounced medicinal properties and eliminates allergy symptoms of various origins. It is prescribed in most cases for adults, but it is allowed for admission to children from 6 years old.
• Zyrtec - tablets and drops for oral administration, which have a therapeutic effect due to the content of cetirizine. Tablets are prescribed for adults, drops are indicated for the therapy of adults and children from 6 months. The drug is considered very effective, the dosage is determined individually.
• Zodak - a popular medication that also contains cetirizine as the main active ingredient. The tool is convenient to use, since it is available in the form of tablets, as well as syrup and drops. Drops are prescribed to patients from 1 year old, syrup - from 2 years old. In most cases, tablets are prescribed for adults, but they are also not contraindicated for children from 6 years old. The tool is effective, it is applied once or in courses.

Analogues of drugs are considered very effective, but they should be used only after consulting a doctor, especially when treating children.

Cetrin is a popular and effective medication, indications for the use of which involve the use of any allergic reactions. The medicine helps to eliminate the manifestations of pathology, improve the patient's condition and prevent complications. When used correctly, the drug provokes complications in exceptional cases.

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