Neurobion tablets. Price, instructions for use, analogs, where to buy, composition, patient reviews

Neurobion is a vitamin-like agent intended for the treatment of various neuralgic diseases. Tablets can also be used as part of complex therapy with a lack of vitamin B1, B6 or B12. The price of a medicine often fluctuates depending on the financial policies of the pharmacies.

Forms of issue

The drug is currently available in the form of tablets and ampoules for intramuscular injection. The tablet form of the drug is a white or cream-colored biconvex capsule coated with a shell.

The package contains 2 blisters, each containing 10 tablets. The number of ampoules for injection is from 3 to 10 pieces per pack. Among the excipients that form the composition of the drug in liquid form, it is worth mentioning sodium hydroxide solution (72 mg), potassium cyanide (0.1 mg) and distilled water (up to 3.5 ml).

Composition of the preparation

Neurobion is a pill, the price of which is quite affordable for most people. They refer to drugs that have a complex of active ingredients in their composition. The concentration of active ingredients may vary slightly.

It is more convenient to present the composition of the tablet form in the form of a table:

Active ingredients	Excipients	Shell composition
Thiamine disulfide (100-200 mg)	Magnesium stearate (2.12 mg)	Calcium carbonate (8.63 mg)
Pyridoxine hydrochloride (200-250 mg)	Talc (50 mg)	Glycolium wax (280 mcg)
Cyanocobalamin (200 mcg)	Cornstarch (17 mg)	Colloidal silicon dioxide (8.7 mg)
—	Lactose monohydrate (41 mg)	Titanium dioxide (26mg)
—	Gelatin (23.89 mg)	Glycerol 85% (4.33 mg)
—	Methylcellulose (up to 3.8 mg)	—

The manufacturer indicates that the concentration of cyanocobalamin in the drug may exceed 200 μg (but not higher than 240 μg). Also, polyvinylpyrrolidone (4.35 mg) is present in the composition as an excipient.

Pharmacological properties

The drug is deficient in B vitamins due to the action of active substances (thiamine - vitamin B1, pyridoxine - vitamin B6 and cyanocobalamin - vitamin B12). The combination of neotropic components has a restorative effect in case of disorders of intermediate metabolism, and also strengthens the peripheral and central nervous system.

Other actions of the medication include:

• Providing the body with essential trace elements, stimulating the synthesis of these substances.
• Stabilization of the amount of coenzymes (especially in the absence of their regular intake with food).
• Increase in the therapeutic efficacy of B vitamins (thanks not to one active substance, but to a complex of several components that mutually affect each other).

To these points it is worth adding a slight analgesic effect. The use of thiamine disulfide is justified in the treatment of pathologies of the central nervous system; in these cases, the substance compensates for the existing deficiency in useful trace elements, as well as the natural regeneration processes of the body.

Features of pharmacokinetics

Thiamine disulfide, getting into the body, begins to be actively absorbed into the blood plasma (indicators - up to 2.1 μmol / l). The phospholation of the substance occurs in the liver. The half-life from the body is 4 hours.

In the average person, the amount of natural (produced by the body) thiamine is no more than 30 mg; under normal metabolic processes, the component is completely excreted from the body after 4-6 days (in some cases - up to 10 days).

Pyridoxine hydrochloride has a very high absorption rate. Absorption occurs in the upper intestine. When it enters the liver, pyridoxine binds to plasma proteins (up to 75% of the initial concentration). Excretion from the body is carried out with the help of the kidneys (1.6 - 3.6 mg per day).

The absorption of cyanocobalamin occurs in the gastrointestinal tract under the action of hydrochloric acid, which is part of the gastric juice, as well as through passive diffusion.

The substance is excreted from the body along with bile; during the intestinal-hepatic circulation of bile acids, cyanocobalamin undergoes reabsorption. In the absence of metabolic abnormalities, the body excretes about 2.6 μg of this substance per day.

Indications for use

Neurobion - tablets, the price of which depends on the concentration of active substances. They are recommended to be used only as an aid in complex therapy.

To the most typical indications include the following diseases:

• Diseases of the spine with pronounced pain syndrome - plexopathy (plexitis), lumboischialgia, radiculopathy, degenerative changes in the bone structure of the vertebrae.
• Intercostal neuralgia, thoracalgia.
• Bell's palsy, prosoplegia and other inflammatory lesions of the facial nerves.
• Sciatica.
• Herpes zoster.

The drug is also prescribed for trigeminal neuralgia (for diseases of the trigeminal nerve). Among other things, the medicine can be used to compensate for the deficiency of B vitamins or in preventive therapy.

The main contraindications

The medicine is forbidden to be taken by people who have an individual intolerance to any of the active ingredients, as well as excipients. The high content of active ingredients makes the drug contraindicated for use in children under 18 years of age.

Undesirable factors are the presence of certain hereditary diseases:

• Isomaltase-sucrase deficiency.
• Intolerance to fructose, galactose.
• Lactase deficiency.

You should also know that vitamin B1 is contraindicated in case of a tendency to allergic reactions (especially in patients with a rich allergic history), vitamin B6 is not It is recommended for use in case of gastrointestinal ulcers (due to increased acidity of the stomach), and vitamin B12 is prohibited if the patient has erythrocytosis, thromboembolism, and erythremia.

Pregnancy and lactation

Neurobion - pills, the price of which can be significantly cheaper in comparison with other neuralgic drugs. They are not recommended for use during pregnancy or during breastfeeding.

The drug is high in B vitamins, which can penetrate into breast milk, and can also suppress its production (in cases where the dosage exceeds 600 mcg per day).

According to clinical studies, the active components are excreted along with breast milk; in this case, cases of overdose in newborns have not been established. Despite this, the medication should be taken only when the intended benefit outweighs the potential harm to the health of the mother and child.

Instructions for use

Neurobion must be taken orally without chewing the pill and washing it down with lukewarm boiled water.

The medication must be taken either with meals, or 10-15 minutes before that. It is not recommended to drink the medicine with strong tea, coffee or citrus juices, as this can reduce the therapeutic efficacy of the drug (regardless of the concentration of the substance, price and other parameters).

The dosage is determined by the attending physician. The standard dose is 3 tablets per day. The duration of the course is from 4 to 6 weeks. For long periods of therapy, a dose adjustment downward is necessary (up to 2 or up to 1 tablet per day).

Side effects

The negative effect of the drug may be associated with a violation of the dosage regimen, as well as in the case when the patient's disease belongs to one of the points of contraindications.

The negative reactions of the body can affect the following body systems:

• Central nervous system disorders. Headaches, dizziness, nausea, nervous excitement, sometimes - peripheral sensory neuropathy.
• Skin. The occurrence of sweating, acne, edema. In exceptional cases - anaphylactic shock, urticaria.
• Vascular and cardiac disorders. Tachycardia.
• The gastrointestinal tract. Pain syndrome, constipation or bouts of diarrhea. Sometimes - increased acidity of the stomach, exacerbation of ulcers (if any).

It should be noted that side effects were recorded extremely rarely and were practically not observed with strict adherence to medical advice. If you observe any of the unpleasant symptoms in yourself, you should immediately stop taking the drug and consult a doctor to look for safe analogues.

Overdose

Overdose symptoms are similar in their manifestations to oversaturation of the body with vitamins B1, B6 and B12. Excess thiamine reduces the conduction of nerve impulses and causes a curariform effect (relaxation of skeletal muscles).

Pyridoxine is capable of producing neurotoxic effects; with significant overdoses, ataxia and cerebral seizures may occur. In exceptional cases, seborrheic dermatitis was recorded.

High doses of cyanocobalamin can lead to eczematous changes in the skin. You may also feel pain in the heart, heart rhythm disturbances. Very rarely - disturbances in the activity of hepatic enzymes and a decrease in their activity.

The standard therapeutic measure used is gastrointestinal lavage. path, taking absorbent agents (activated carbon), as well as the appointment of symptomatic therapy.

special instructions

If the patient has funicular myelosis or megaloblastic anemia, laboratory values ​​should be checked regularly when taking any medications containing B vitamins.

Other features of Neurobion include the following points:

• Drinking alcoholic beverages, tea and coffee reduces the rate of absorption of thiamine into the blood plasma.
• For patients with a history of liver or kidney pathology, a reduced dosage is recommended (due to the presence of vitamin B6 in the drug).
• You should refrain from products containing sulfites, including as preservatives (E220), as sulfur dioxide contributes to the degradation of thiamine.
• The use of the drug in the presence of an acute form of decompensated heart failure should be carried out only under medical supervision.

Neurobion does not affect the reaction rate, and its use does not interfere with the management of vehicles and other mechanisms. The exception is cases in which the patient is prone to side effects from the central nervous system (dizziness).

Drug interactions

Neurobion - tablets, the price of which varies significantly depending on the number of blisters in the package. They are not recommended to be taken simultaneously with levodopa and other antiparkinsonian drugs in order to avoid a decrease in their effectiveness. Antacids such as magnesium trisilicate or vicalin slow down the absorption of thiamine into the blood plasma.

The simultaneous use of neuralgic drugs and diuretics (furosemide) is prohibited, since the blockage of the tubular resorption can enhance the excretion of thiamine and, as a consequence, there is a significant decrease in its concentration in blood.

Fluorouracil inactivates vitamin B1, significantly reducing the therapeutic effect of taking Neurobion. Combined therapy with penicillamine, cycloserine, isoniazid and other pyridoxine antagonists adversely affect its absorption rates, and also reduce its concentration.

Analogs and generics

Today, there are many similar drugs that have both similar active ingredients and other active ingredients. In order to avoid the occurrence of side effects and other negative reactions, all analogues of original medicines should be prescribed only by the attending physician.

Combilipen Tubs

The drug is almost an exact copy of Neurobion in terms of active ingredients and pharmacological action. The auxiliary formulation includes, but is not limited to, lidocaine hydrochloride, potassium hexacyanoferrate, and sodium tripolyphosphate.

Indications for use include:

• Neuralgic diseases.
• Polyneuropathy of various origins.
• Chronic fatigue, acute stress.

Kombilipen Tabs is also used as an aid in the transition from an injection to a tablet form of treatment. Dosage - 3 tablets per day, course duration - 1 month. The drug is intended only for adults (children under 18 are prohibited from taking it). The number of tablets in a package is 30 pieces. The cost of the product is 310-360 rubles.

Neuromultivitis

Vitamin complex containing thiamine, pyridoxine and cyanocobalamin. In comparison with the original drug, Neuromultivit has a more gentle effect; the drug has a minimum of contraindications. The dosage ranges from 1 to 3 tablets per day.

In exceptional cases, the drug can be used for children (danger for this the age group has not been clinically established, however, such an appointment can only be made by a medical specialist).

The package can contain from 2 to 6 blisters, each containing 10 tablets. The cost varies from 240 to 410 rubles.

Neurovitan

The active ingredients of the drug are riboflavin (vitamin B2), octothiamine, as well as pyridoxine and cyanocobalamin. Riboflavin helps to normalize protein and fat metabolism; this component is indispensable in the synthesis of hemoglobin.

The indications for the use of Neurovitan, in addition to neuralgic pathologies, include the following points:

• Diseases of the central nervous system, including as an auxiliary vitamin therapy.
• Diabetic neuropathies.
• Paresthesias of various origins.
• Liver diseases (including cirrhosis and hepatitis).
• Gynecological pathologies.
• Gestosis and other complications during pregnancy.
• Avitaminosis (including during pregnancy and lactation).

In some cases, Neurovitan is indicated for admission in the presence of vascular pathologies, in radiation sickness and in the occurrence of regular immunodeficiency states.

The product can be used as a vitamin therapy for an unhealthy lifestyle.

This drug can be used in children - the dosage in this case will be 1 tablet per day; for adults, a single dose is 1 to 4 tablets per day. The package contains 20 or 30 tablets. The price per pack is 390–500 rubles.

Neurobeks

Despite the same composition as Neurobion, the drug has significant differences. The concentration of active substances is almost 2 times higher - thiamine (100-300 mg), pyridoxine (200-400 mg) and cyanocobalamin (300-500 mg). The composition contains ascorbic acid (170 mg), nicotinamide (100 mg), folic acid (0.5 mg) and calcium pantothenate (27 mg).

The drug is indicated not only for neuropathies, but also for asthenia, insomnia, encephalopathy, spastic diseases, as well as for saturating the body with microelements in hypovitaminosis.

There are several varieties of the drug - Neurobeks, Neurobeks-Forte (with the highest concentration) and Neurobeks-Neo. The drug can be used for children from 3 years old. The average dosage is determined by the physician; for adjuvant therapy, the dose is set at 1 tablet per day. The package contains 30 or 60 tablets. The cost varies from 340 to 550 rubles.

Vitaxon

It is one of the most affordable analogues of Neurobion in terms of price. The active ingredients are pyridoxine hydrochloride (100-150 mg) and benfotiamine (100-125 mg). Vitaxon is prescribed as an adjuvant for diabetic or alcoholic neuropathy, for myalgia, as well as for the relief of radicular syndrome.

Contraindications and side effects are exactly the same as those of Neurobion. The daily dosage is no more than 3 tablets per day. Price per pack with 20 tablets - 290 rubles.

Milgamma

The active ingredients of the drug are pyridoxine hydrochloride and benfotiamine; the concentration of these components in 1 tablet is 100 mg. Excipients include long chain partial glycerides, calcium croscarmellose and microcrystalline cellulose.

Milgamma is prescribed not only for neuralgic ailments, but also for providing an analgesic effect., to improve blood circulation and to improve the overall functioning of the nervous system.

The drug is not recommended for use in children, however, for pregnant patients, the use of the drug is possible, subject to a special dosage of 25 mg per day (1/4 tablet).

Side effects are similar to those of similar neuralgic drugs. The recommended daily dose is 1-3 tablets, the course of treatment is 1 month. Milgamma is sold both in the form of a cardboard package with 4 blisters of 15 tablets each, and individually in blisters. Packing price - 1600 rubles, 1 blister costs 460-500 rubles.

Cocarnit

A product based on cocarboxylase, nicotinamide, cyanocobalamin and disodium trihydrate. The drug can be prescribed for radiculitis, lumbago and neuropathies of various origins.

Also, the list of indications includes the following pathologies:

• Bursitis.
• Tendinitis.
• Myocarditis.
• Ischemic heart disease, pre-infarction state.

Contraindications include arterial hypertension, lung diseases with inflammatory genesis, psoriasis, as well as types of heart failure (this also includes a recent transfer of a heart attack myocardium). The drug should not be taken by children and pregnant women. The average price for Cocarnit is from 600 to 750 rubles.

Storage conditions and price

The drug in tablet form is dispensed without a prescription (as opposed to ampoules for injection). It must be stored in a dark place protected from UV rays at room temperature. The shelf life is 3 years from the date of manufacture. The cost of a cardboard package with 2 blisters (10 tablets each) is 300-350 rubles.

Neurobion (despite the fact that these pills are most often used only as an auxiliary therapy) must be used with caution, following the dosage indicated by the doctor. The price for exceeding the permissible norm may be undermined health or, at best, the lack of a therapeutic effect from the drug.

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