Tramadol (Tramadol) in ampoules. Price, instructions for use, where to buy, reviews

The most popular ampoule, Tramadol, used to relieve severe painarising against the background of various pathologies of internal organs and systems. The price of the product is quite high, but the effectiveness fully justifies it. The medicine alleviates the course of many conditions, it is considered one of the most effective remedies among the analgesics existing today.

Terms of dispensing from pharmacies, drug price

The medicine is dispensed in pharmacies only with a prescription from a doctor. In this case, the specialist, when writing out a prescription, uses a form intended for potent medicines.

The cost of 1 ampoule of the drug starts from 65 rubles. This price is considered high, so not every patient can afford to use the solution.

Composition, release form

Tramadol in ampoules (the price of the drug exceeds the cost of many other analgesics) contains hydrochloride as the main active ingredient in tramadol. In 1 ml of the product, the amount of the basic substance reaches 100 mg. The medication is available in the form of a clear, colorless solution, packaged in 1 ml clear glass ampoules.

The solution does not have a specific odor or sediment at the bottom of the ampoule. Excipients in the composition of the product are represented by water for injection and sodium acetate. Ampoules are packaged in plastic contour cells in 5 pieces. An individual cardboard box can contain 10 ampoules, they are accompanied by detailed instructions for correct use.

Various manufacturers also produce capsules and tablets for oral use. They usually have a standard size and shape, the color depends on the specific manufacturer. In most cases, the product is packaged in blisters of 10 pieces. There can be 2 plates in an individual cardboard box.

Tramadol hydrochloride is also present in tablets and capsules as the main active ingredient. There are auxiliary ingredients in the composition, the content and set of which may differ depending on the pharmaceutical company that manufactures the medicine.

Principle of operation and efficiency

The drug belongs to the group of opioid analgesics, but is the only non-narcotic drug from this group. The main component has pronounced analgesic properties, which helps to eliminate severe pain in various pathologies of internal organs and systems.

The principle of action of the drug is based on the ability of the main substance to bind to the opiate receptors of the nervous tissue, which helps to significantly reduce pain and prevent its reappearance in the event of an exacerbation symptoms.

The drug has stabilizing properties against the central nervous system. This increases the patient's endurance to various types of pain in case of somatic disorders, injuries and after surgery.

The medicine helps to improve the conduction of nerve impulses to tissues, but blocks substances that provoke the appearance of discomfort and severe pain. The ingredient in the drug also helps open calcium and potassium channels, which improves the functioning of the heart and prevents the development of complications against the background of severe pain that is difficult to stop medicines.

Against the background of the use of the drug, a weakening of discomfort of varying intensity is noted due to the inhibition of the activity of centers in the cerebral cortex.

Experts note that the medication also affects the respiratory center and the cough center in the brain, which can lead to a decrease in heart rate and suppression of severe cough in patients who suffer from respiratory pathologies without signs inflammation.

The drug also affects the smooth muscles of the digestive tract, can provoke their spasm and the development of complications. The effect of the drug on the oculomotor nerve is noted, which can be seen when examining the patient after using the medication.

The analgesic effect appears rather quickly after the application of the solution. When capsules or tablets are taken, the therapeutic effect develops later. The duration of anesthesia when using the drug is 6 hours. In some patients, this period may last longer, depending on the individual characteristics of the organism.

When the solution is injected, the active substance spreads rather quickly through the systemic circulation, penetrates into the nerve tissues and has a pronounced therapeutic effect. When the drug is taken orally, the bioavailability of the active substance is approximately 90%. However, with parenteral administration, this figure reaches 100%.

With intramuscular injection, the maximum concentration of the ingredient in the blood is reached after 40-50 minutes, which depends on the characteristics of the patient's body. The processing of the active substance is carried out in the liver, after which the products of its metabolism are evacuated with the help of the kidneys. Only one of the metabolites is active and capable of exerting a therapeutic effect.

The withdrawal period of the ingredient is quite long and can take up to 4 days, depending on the condition of the patient's liver and kidneys. Sometimes the time for the evacuation of metabolites is increased to 5 days.

With severe lesions of the urinary system, there is a slowdown in the period of cleansing the body from the decay products of active ingredients. If the disease proceeds in an advanced form, the effectiveness of the analgesic is somewhat reduced.

If the pathology is mild, the action of the agent is almost not weakened. In elderly patients, an increase in the level of the active substance in the blood is noted. Pharmacokinetic features may differ depending on the condition of a particular patient.

Indications for use

Tramadol in ampoules (the price of the product depends on the specific manufacturer) is prescribed for various pathological conditions.

The main indications for the use of the drug:

• Pain syndrome after injuries of extremities, internal organs, spinal column. In this case, the agent is used as part of complex therapy in combination with other medicines.
• Neurological pathologies accompanied by severe pain. The tool helps to eliminate discomfort with neuritis, neuralgia, shingles. The latter disease often provokes severe pain, worsening the general condition and disturbing the patient's sleep.
• Oncological diseases. The tool helps to eliminate discomfort during the formation of a benign tumor, but more often it is used to relieve pain that occurs against the background of malignant neoplasms.
• Discomfort in the region of the heart, accompanying an attack of angina pectoris, as well as the development of myocardial infarction. With such disorders, the medication is not used so often, but if urgently needed, its appointment is allowed.
• Carrying out medical and diagnostic procedures that can provoke pain of varying intensity.
• Migraines of various origins. With frequent exacerbation of symptoms, the drug is not prescribed, but in the event of severe pain and lack of effect from the use of conventional analgesics, it can bring a good result.

The drug can be used as the only method of therapy, but is often part of a complex treatment. Only in this case, the doctor preliminarily studies the interaction of the drug with other drugs.

Contraindications and adverse reactions

Tramadol is not prescribed to patients who suffer from intolerance to the components of the composition. The medication in ampoules is also contraindicated in patients under 18 years of age. The high price of the product is also considered an obstacle to its frequent use.

There are other contraindications:

• A tendency to allergic manifestations or the development of similar reactions when using drug analogues. In this case, therapy can provoke severe complications.
• Launched liver disease, in which there is a critical dysfunction of the organ. The processing of the basic substance in such disorders often slows down, which can provoke its accumulation in tissues and blood, the development of an overdose.
• Internal bleeding against the background of damage to the mucous membranes of the digestive tract or perforation of the wall of the stomach, intestines.
• Kidney pathologies in the terminal stage, accompanied by a significant deterioration in the work of the organ and the development of failure.
• Acute intoxication of the body with drugs from the group of CNS inhibitors. These medicines include tranquilizers, sedatives and hypnotics, psychotropic drugs.
• Poisoning of the body with alcoholic beverages, accompanied by severe disorders of the central nervous system.
• Drug addiction, suicidal tendencies, abuse of psychotropic drugs on an ongoing basis.
• First trimester of pregnancy. The agent in the 2nd and 3rd trimester is also used extremely rarely and only when an urgent need arises, when the potential benefit from its use outweighs the possible harm.
• The patient's age is up to 1 year. The official instruction suggests that the drug is used parenterally for patients over 1 year of age. Despite this, the solution is rarely administered to young children, since negative reactions often suppress the benefits obtained.

The medicine is prescribed with extreme caution to elderly patients suffering from diseases of the heart, blood vessels and the nervous system.

Tramadol in ampoules (the price of the drug justifies its high effectiveness) very often provokes negative reactions that affect internal organs and systems. Despite the non-narcotic origin of the analgesic, it can be fatal if the instructions are not followed. Compliance with the rules does not guarantee the prevention of complications.

Most common reactions:

• On the part of the nervous system, headache, dizziness and impaired consciousness are noted. Patients may be disturbed by unreasonable anxiety, there is a deterioration in the general condition, a decrease in concentration and memory impairment. Additionally, patients may talk about increased drowsiness, apathy, and even the development of a depressive state. In some cases, the drug provokes the development of euphoria, hallucinations and some other disorders.
• From the side of the digestive tract, complications occur more often when using oral dosage forms. However, when using the solution, they can also occur. Many patients experience nausea, bouts of vomiting, dry mouth, and lack of appetite. Disorders can affect bowel function, manifesting as flatulence and bloating, diarrhea, or persistent constipation.
• In women, with prolonged or frequent use of the solution, complications from the reproductive system may develop. They resemble the course of menopause, there is discomfort in the vagina, menstrual irregularities, dry mucous membranes. In addition, general disorders appear in the form of weakness, tachycardia and changes in blood pressure indicators.
• Respiratory disorders occur due to the effect of the active component on the respiratory center in the brain. They can be accompanied by shortness of breath during exertion and at rest, feeling short of breath, and respiratory failure. The condition threatens not only the health, but also the patient's life, which is associated with an increased risk of suffocation.
• Convulsive activity develops in patients quite rarely, but it can significantly worsen the condition and lead to severe complications.
• Disorders from the blood system are extremely rare, almost always accompanied by a violation of the formation of the most important cells.
• On the part of the musculoskeletal system, there is pain in the muscles and joints, increased muscle activity, in which tissue damage often occurs.

Prolonged use of the solution can provoke difficulty in swallowing. In this case, a similar symptom is present when eating and drinking. The condition is aggravated by a slow decrease in body weight, up to the development of depletion of the body. The drug can provoke an overdose on condition of prolonged use in higher doses.

The condition is accompanied by severe convulsions, respiratory depression, changes in the size of the pupils, impaired consciousness. The condition can provoke the development of a coma, which can be fatal. It is worth noting that the medicine often provokes allergic reactions quite often.

In this case, patients note the appearance of a rash on the skin of the body and limbs, severe itching. Scratching the skin aggravates the condition and can lead to infection. If symptoms of an overdose appear, it is important to immediately stop using the medication and seek medical attention. Ignoring the manifestations can be fatal.

The patient is assisted in a hospital setting. In severe disorders, the patient is administered Naloxone as an antidote. The treatment regimen also includes drugs that act to combat the most severe disorders. If a person has seizures, Diazepam may be used.

How to use the medicine correctly

Tramadol in ampoules (the price of the product makes it impossible to use it for some patients) is used only in a hospital setting and after a thorough examination of the patient, identifying the degree of neglect states. Depending on the patient's age, the dosage is selected individually.

Patient age	Scheme of application and dosage
Children from 1 to 14 years old	The dosage is prescribed depending on the body weight. The daily rate is 1-2 mg of funds per 1 kg of body weight. This means that for every 10 kg, there is 0.1 or 0.2 ml of solution. The maximum daily dose can be increased to 8 ml per 1 kg of body weight. However, the decision to exceed the dosage is made by the doctor based on the examination data. Therapy is carried out only under the supervision of a physician. It should be noted that in the absence of severe pain and other disorders, the medicine is not used, that is, a single injection or repetition of the procedure is possible within 3-7 days if signs appear again.
Children over 14 and adults	A single dose of the drug is 1 ml, but the maximum amount of solution per day can reach 4 ml. There are no definite rules regarding the duration of the therapeutic course, since the drug is used symptomatically.
Patients over 75 years old	Assign no more than 3 ml of solution per day. It is not recommended to enter the entire daily rate at once, it is divided into 3 times, administered at intervals of 6-7 hours.

The drug is administered intramuscularly, subcutaneously or intravenously. Experts prefer the first 2 methods, since intravenous infusions can provoke severe complications. With subcutaneous and intramuscular administration, an additional solvent for the drug is not required.

If necessary, intravenous infusion of 1 ml of the solution is added to 200 ml of sodium chloride, after which it is slowly poured using a dropper. Usually, intravenous infusions are required for patients who suffer from severe pain after undergoing surgery on the internal organs. For children, the drug is administered intravenously in exceptional cases.

special instructions

With intramuscular injection in the area of ​​injection, a small painful seal may form, as well as the formation of a hematoma. If untreated and continued administration of the solution into this area, the risk of abscess formation increases.

In this case, surgery may be required to prevent blood poisoning. When using oral dosage forms, you should first consult with your doctor in case of chronic diseases of the digestive tract.

Experts draw the attention of patients to the fact that the analgesic properties of the drug cannot be compared with the effect of Morphine, Fentanyl. Despite this, the drug has a pronounced effect and can significantly facilitate the course of cancer pathologies of a malignant nature.

Patients with malignant diseases note that the action of Tramadol differs from the actions of the usual analgesics and non-steroidal anti-inflammatory drugs, which are often used to relieve pain. Sometimes medicines are used simultaneously with the aim of enhancing the action and obtaining a more pronounced therapeutic result.

It is strictly contraindicated to mix the solution in one syringe with other drugs. This can lead to the development of severe complications at the injection site and unexpected general reactions.

Interaction with other drugs

It is forbidden to prescribe the drug in combination with drugs that contain similar active ingredients. The development of negative reactions is noted when Tramadol is combined with drugs that affect the central nervous system, that is, sedatives, hypnotics, tranquilizers.

The use in combination with psychotic drugs is strictly contraindicated, since the risk of developing a convulsive seizure significantly increases.

Storage conditions and periods

When storing the product, you should avoid exposure to the solution of sunlight. Usually, the medication is stored in a hospital in a special safe.

The maximum storage time is 5 years.

The drug Tramadol is one of the most effective non-narcotic analgesics in ampoules, which has pronounced therapeutic properties. The price of the product is quite high, but experts and patients note that it is fully justified by its effectiveness, provided it is used correctly.

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