Vertran. Indications for use, instructions, tablet analogs, price, reviews

Vertrand - this drug, affecting the functions of the labyrinth of the inner ear, which belongs to the pharmaco-therapeutic group of drugs based on histamine. This medication is actively used to treat patients with various diseases of the vestibular apparatus.

Vertran is indicated for use during a continuous therapeutic course, and can also be used in combination with other medicines that restore normal coordination of movements, improve cerebral circulation and eliminate dizziness.

Forms of release and composition of the drug

Vertran is a drug, the main form of release of which is round gray or white tablets. A distinctive feature of this medication is the presence of dividing risks and beveled edges. The packaging of the therapeutic agent is carried out in bubbles made of brown organic glass.

Each bottle of this drug contains 30 or 60 tablets. depending on the individual needs of each patient. The main packaging of the medication is a cardboard box, complete with detailed instructions manufacturer, which contains information on indications for the use of tablets, side effects and regimen dosing.

Vertran is an effective drug that has a simple biochemical composition. The table below describes the main and auxiliary substances of this medication.

The composition of the drug Vertran	Pharmacological purpose of components
Betahistine dihydrochloride	This is the active substance of the drug Vertran, the concentration of which is 8 mg.
Microcrystalline cellulose	This is an auxiliary component, the main purpose of which is to maintain a stable structure of the drug.
Talc	It is an excipient of the drug Vertran, which is an anti-caking agent. Talc makes the structure of the tablets more durable.
Citric acid concentrate	It is an additional component of the drug that acts as a safe preservative.
Silica	This auxiliary substance, which stabilizes the structure of the tablets, prevents changes in their density under conditions of prolonged storage.
Mannitol	It is an auxiliary component, which is an osmotic diuretic. Mannitol has a pronounced anti-edema effect.

All the constituent substances of Vertran tablets do not have toxic properties, do not contain carcinogenic compounds in their formula, and are also well tolerated by patients of all age groups.

Pharmacological properties

Vertran (indications for the use of this medication are determined by the attending physician based on the results of a diagnostic examination) is a medicinal a drug that has the following therapeutic properties:

• improves blood microcirculation inside the labyrinth of the middle ear;
• stabilizes indicators of intracranial pressure;
• reduces the incidence of unpleasant symptoms in the form of dizziness, which manifests itself in patients with pathological conditions of the vestibular apparatus;
• stimulates the functional activity of the middle ear, which provides an improvement in hearing in patients with symptoms of its rapid decline;
• tones up the smooth muscles of the digestive tract, as well as the respiratory system;
• has a positive effect on cerebral circulation, providing better nutrition for the tissues of this organ;
• eliminates the feeling of tinnitus, the appearance of which is associated with unstable intracranial pressure.

Clinical trials of the pharmacological properties of Vertran tablets have shown that this drug is able to stimulate more active secretion of the glands responsible for the production of gastric juice. In this regard, patients taking this medication may experience a persistent and prolonged feeling of hunger.

Pharmacodynamics and pharmacokinetics

Vertran (indications for the use of the drug are detailed in the manufacturer's instructions) is a drug whose active ingredient is a synthetic substitute for histamine. After oral administration, the tablets quickly dissolve in the gastrointestinal tract, saturate the blood composition, and spread throughout the body.

The active substance of this medication in the form of betahistine dihydrochloride acts directly on the histamine H1 receptors. Pharmacodynamics Vertran is characterized by a rapid expansion of the precapillaries, which automatically leads to an improvement in blood circulation in the labyrinth.

Patients with pathological conditions of the vestibular apparatus, suffering from intracranial pressure, cerebrovascular accident, experience significant relief. Signs of significant improvement are observed in patients who previously experienced severe attacks of dizziness, constantly heard tinnitus, and experienced gradual hearing loss.

The pharmacodynamic feature of Vertran tablets is their indirect property in the form of the ability to increase the tone of the muscles of the bronchial tree, as well as of the gastrointestinal tract. This aspect must be taken into account in patients with concomitant diseases of the lungs, stomach, intestines, pancreas.

Pharmacokinetics of the drug Vertran is distinguished by the high biochemical activity of its main component. After taking the tablets inside, betahistine dihydrochloride is very quickly absorbed into the intestinal walls, enters the bloodstream, but at the same time is characterized by a low ability to bind to proteins plasma.

The metabolism of this substance occurs in the liver tissues, which creates an additional load on the functional activity of this organ. The decay period with further excretion of betahistine dihydrochloride outside the body is 24 hours. Utilization of this component occurs through the kidneys as part of urine.

Indications for use

Vertran (indications for the use of this medication should be established based on the results of the patient's examination) is an effective drug that is used for children, adult men and women, as well as elderly patients age.

This medication is used for the complex treatment of the following diseases and pathological conditions of the body:

• Meniere's disease;
• dropsy, localized in the labyrinth of the middle ear;
• progressive hearing loss of unknown etiology;
• vertebrobasilar insufficiency;
• pathology of the blood vessels of the brain, including atherosclerosis;
• neuritis of the vestibular type;
• acute or chronic labyrinthitis;
• painful conditions of the vestibular apparatus in the form of nausea, dizziness, sensation of noise and bouts of pain in the ears, discharge of vomit, partial hearing loss;
• the period of rehabilitation after a previous neurosurgical intervention;
• benign dizziness of the positional type;
• encephalopathy that occurs after traumatic brain injury.

Treatment of atherosclerosis of the blood vessels of the brain should be carried out using complex therapy. In this case, not only Vertran tablets are used, but also other potent drugs, the pharmacological properties of which are aimed at normalizing the process of blood supply to the brain tissues.

Contraindications

Vertran (indications for the use of this drug are the same for all patients with pathological conditions of the vestibular apparatus, as well as the labyrinth of the middle ear) - This is a medication that has the following contraindications for its use for therapeutic purposes:

• hypersensitivity to the constituent components of the drug, and especially to its synthetic compound in the form of betahistine dihydrochloride;
• ulcerative lesion of the mucous membrane of the duodenum or the walls of the stomach;
• bronchial asthma (taking this medication can provoke an exacerbation of the disease and another attack of suffocation);
• pheochromocytoma;
• I trimester of pregnancy (at this stage of the intrauterine development of the child, taking Vertran tablets is under a categorical ban, since the active component of the drug can negatively affect health fetus).

The drug Vertran is used with extreme caution in relation to pediatric patients, women, who are in the II and III trimester of pregnancy, as well as those who are lactating a newborn baby by a maternal milk.

For patients in this category, this drug is used only in extreme cases, when it is impossible to do without the use of drug therapy.

At what age can the drug be used?

The drug Vertran is not recommended for use in children. Taking this medication can be prescribed to a child only in special cases and under the personal responsibility of the doctor. Restrictions on the use of Vertran tablets in the treatment of children are associated with the lack of clinically confirmed data on the safety of this drug for the body of underage patients.

Instructions for use, dosage

A single dose of the drug Vertran is 1-2 tablets, which is equal to 8-16 mg of the active substance. This medication is taken up to 3 times a day, regardless of the meal schedule. It is desirable that this drug enters the patient's body at the same time of day.

This approach to the organization of treatment will allow maintaining a stable concentration of betahistine dihydrochloride in the patient's blood. The duration of the therapeutic course is determined individually by the attending physician who examined the patient.

The duration of treatment is also influenced by the type of pathology of the vestibular apparatus or the labyrinth of the inner ear, which was established in a particular patient.

Side effects

The drug Vertran is well tolerated by most patients of all age groups. Despite this, clinical trials of the drug have shown that in rare cases, taking it can cause the following side effects, which appear within 1-2 hours after a single use of a therapeutic dose:

• a feeling of heaviness and discomfort in the central part of the abdominal cavity, which indicates irritation of the mucous membrane of the stomach or intestines;
• itching of the skin surface;
• hives;
• swelling of the mucous membranes, as well as epithelial tissues;
• the appearance of a red rash that can form on the surface of the abdomen, back, forearms, neck, cheeks;
• bronchial spasm (this side effect of the drug most often occurs in patients who are initially prone to allergic reactions, or suffer from bronchial asthma);
• nausea and vomiting;
• loss of appetite;
• angioedema, which is a manifestation of an acute allergic reaction that can lead to death;
• diarrhea.

The occurrence of the above side effects is the basis for discontinuing further therapy with the use of Vertran tablets.

A patient faced with this symptomatology should contact the attending physician who prescribed this medication in order to get additional advice. The progression of an allergic reaction requires hospitalization in the hospital of the therapeutic department for a course of treatment with antihistamines.

Overdose

Clinical trials of the drug Vertran have shown that the appearance of signs of an overdose with this medication is possible after a single dose of 640 mg of the active substance.

In this case, the patient has symptoms of general intoxication of the body, which are accompanied by the following conditions:

• nausea and vomiting;
• cramping pain in the area of ​​the stomach and intestines;
• feeling of heaviness in the abdomen;
• drowsiness and loss of physical strength;
• decreased performance, rapid fatigue after minor loads;
• cramps of the lower extremities;
• heart palpitations and other heart rhythm disturbances;
• a drop in blood pressure, which is especially pronounced in patients prone to hypotension;
• headache;
• various kinds of allergic reactions in the form of urticaria, itching of the skin surface, red rash, angioedema, bronchial spasm;
• dizziness;
• feeling short of breath.

The above symptoms of an overdose of betahistine dihydrochloride are especially pronounced if this active substance is taken in combination with other potent drugs. Patients with the indicated signs of intoxication of the body should be examined by a general practitioner, or by another specialist who prescribed the administration of this medication.

Patients with an overdose of Vertran tablets should receive first aid in the form of gastric lavage, taking medications sorbents, restoring water-salt balance using a buffer solution, which is introduced by setting intravenous droppers.

special instructions

The drug Vertran is used with extreme caution in patients who have chronic diseases of the gastrointestinal tract. This is especially true for patients who previously had ulcerative lesions of their mucous membranes.

Throughout the entire period of treatment, it must be remembered that a stable therapeutic effect is achieved only if you take the drug Vertran for a long course, which can last several months.

Patients with signs of dyspeptic disorders should take this medication directly during or immediately after completing a meal. This will reduce the negative impact on the mucous membrane of the gastrointestinal tract.

Vehicle drivers, operators of high-tech equipment, mechanisms, as well as persons performing work with increased danger, it is necessary to temporarily stop practicing the usual types activities. Sudden dizziness, drowsiness, physical weakness, can lead to negative consequences.

Drug interactions

The simultaneous administration of medications belonging to the pharmacological group of antihistamines leads to a decrease in the therapeutic efficacy of the main substance of Vertran tablets. Clinical trials of this medication have not confirmed its drug interactions with medications of other categories.

Analogs

The modern pharmaceutical market offers a wide range of medicines, containing the active substance betahistine dihydrochloride, which are analogs tablets Vertran.

Betaserc

Betaserc is a betahistine-based drug manufactured by the American pharmaceutical company Abbott. This drug allows you to get rid of attacks of vestibular dizziness, headache, nausea, tinnitus.

The dosage of the active substance contained in 1 tablet is 16 mg. The average cost of this medication is 662 rubles. per pack of 30 tablets. The dispensing of the medicinal product is carried out on the basis of a prescription from the attending physician.

Tagista

Tagista is a tablet preparation, the active ingredient of which is the chemical betahistine dihydrochloride. This medication is produced by the domestic pharmaceutical company Hemofarm, which has a positive effect on the cost of the drug. 1 tablet of the drug Tagista contains 16 mg of the main substance.

The drug is not recommended for use in women who breastfeed a newborn baby. The retail price of this medication is 96 rubles, for 30 tablets, and to purchase them you will need to present a prescription from your doctor.

Vestibo

Vestibo is a histamine-like drug with a vasodilating effect. The active component of this drug in the form of betahistine dihydrochloride is an antagonist of H1 and H3 receptors. Regular use of this medication improves cochlear blood flow, as well as the physiological functions of the vestibular apparatus.

At the same time, Vestibo is contraindicated in patients suffering from individual intolerance to betahistine dihydrochloride. The drug is prescribed with extreme caution to women who are in a state of pregnancy, as well as to children of all age groups.

This medication is produced by the German pharmaceutical company "Katalen Schorndorf". The average cost of Vestibo tablets is 265 rubles. per pack of 30 tablets, the dosage of which is 16 mg.

Betaver

Betaver is a drug for improving the functions of the central part of the vestibular apparatus, increasing blood flow in basilar artery, suppression of painful symptoms in the form of tinnitus, headache, nausea, dizziness, decrease hearing. The release of this medication is carried out by the domestic pharmaceutical company "Veropharm".

Mass fraction of active substance in 1 tablet is 16 mg. A synthetic substitute for histamine, which is the active component of this drug, acts directly on the H1 receptors, promoting the expansion of the precapillary walls.

Also, Betaver tablets have the therapeutic property of regulating endolymphatic pressure inside the cochlea and the labyrinth of the inner ear. The average cost of this drug is 217 rubles. per pack of 30 tablets. Dispensing of the medication is carried out after the presentation of the prescription.

Terms, conditions of sale and storage

The sale of Vertran tablets is carried out on the basis of a prescription from the attending physician. Storage of this medication is possible in a dark and cool room, where the air temperature does not exceed +25 degrees Celsius.

The drug must be out of reach of children of all age groups. The shelf life of Vertran tablets is 3 years, after which the further use of the medication is strictly prohibited.

Price

The average cost of the drug Vertran is 325 rubles. per pack containing 60 tablets.

Vertran is a tablet drug that is indicated for use in adult men and women suffering from seizures. dizziness, unstable intracranial pressure, disorders of cerebral circulation, as well as pathological conditions of the inner ear and vestibular apparatus.

This medication is taken over a continuous course that lasts several months.

The use of this histamine can improve the quality of life of patients with vertebrobasilar insufficiency. The main signs of individual drug intolerance are manifestations of various kinds of allergic reactions.

Video about the active substance of the drug

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