Promedol (Promedol) in ampoules. Price, instructions for use, dosage, where to buy

Promedol in ampoules is a drug that is used for symptomatic therapy aimed at suppressing attacks of acute pain. The drug belongs to the clinical and pharmacological category opioid receptor agonists with pronounced analgesic properties.

Promedol is used as part of a general drug course to alleviate pathological symptoms in patients of different age groups. The price of the medicinal product depends on the concentration of the active substance in the composition of the injection solution.

Forms of release and composition

Promedol is a potent drug, the main form of release of which is a completely transparent solution without a specific odor, dyes and signs of sediment.

The filling of the medication is carried out in glass ampoules with a capacity of 1 ml. Promedol injection solution is produced with 1% and 2% concentration of the active substance, depending on the individual needs of the body of each patient.

The packaging of this medicinal product is carried out in contour packages made of plastic, which are placed in cardboard boxes. Each box of Promedol medication contains 5 ampoules with a solution, as well as detailed instructions for its use. The price of this drug is fully consistent with its quality characteristics.

The active component of the drug Promedol is the synthetic substance trimeperidine. An auxiliary function is performed by sterile water for injection, which undergoes thorough chemical cleaning from the presence of foreign mineral impurities and other chemical compounds.

For patients who need long-term therapy with potent pain relievers with pronounced analgesic effect, Promedol is produced in cardboard packages with a complete set of 10, 100, 150, 200, 250, as well as 500 ampoules of 5 ml each. In this case, the injection solution of trimeperidine is also presented in the form of 1% and 2% concentration.

Pharmacological properties

Promedol in ampoules (the price of the drug is affordable for most citizens with a steady income) is a drug for symptomatic therapy, which has the following pharmacological properties:

• disrupts the transmission of pain impulses between areas of the central and peripheral nervous system;
• promotes more rapid disclosure of the cervix during the onset of the active phase of labor;
• changes the emotional component of pain sensations, making them less pronounced, or completely invisible;
• has a direct effect on the higher parts of the cerebral cortex, which are responsible for the perception of pain with the further development of a state of shock;
• significantly increases the threshold of pain sensitivity;
• inhibits most of the conditioned reflexes, which automatically has a relaxing effect on the muscle and connective tissue of the musculoskeletal system;
• has a mild hypnotic effect (this property of the drug is realized in the first 10-15 minutes. after its injection into the patient's body);
• stimulates the contractility of the uterine myometrium, and also increases the tone of the smooth muscles of this organ of the female reproductive system;
• acts as a safe antispasmodic by dilating blood vessels, and suppressing an attack of pain, which is caused by a sharp contraction of muscles, cramps, spasms of various etiology.

In terms of its therapeutic properties, Promedol injection solution, regardless of its therapeutic concentration, is very close to morphine-based medicines. Moreover, this drug has fewer side effects and is more easily tolerated by the human body.

Unlike morphine-containing drugs, Promedol is much less likely to cause indigestion, nausea, loss of appetite, vomiting, depression of the respiratory and cardiovascular systems.

Pharmacodynamics and pharmacokinetics

Promedol in ampoules (the price of the drug is fully consistent with its excellent therapeutic properties) is a narcotic drug that acts directly on the opioid receptors of the central nervous system. After this drug enters the bloodstream, its active substance rapidly spreads through all the tissues of the internal organs.

A distinctive feature of the pharmacodynamic properties of Promedol is that the constituents of the solution easily overcome the blood-brain barrier, which leads to disruption of the interneuronal transport of pain impulses. A person experiencing acute pain does not feel it due to the fact that Promedol actually blocks the functional activity of nerve endings.

The pharmacodynamic properties of this drug apply simultaneously to the central and peripheral nervous systems. Together with a pronounced analgesic effect, the antispasmodic and relaxing properties of Promedol are realized.

Patients receiving injections of this medication on an ongoing basis experience significant dulling of conditioned reflexes.

The appearance of some inhibition of psychoemotional reactions is possible. At the same moment, the absolutely opposite effect is on the tone of the smooth muscles of the uterus. In women who are in a state of pregnancy, injection of Promedol accelerates the process physiological opening of the neck of the genital organ with a faster onset of the active phase of labor activities.

The pharmacokinetics of Promedol injection solution with 1% and 2% concentration has been well studied at the stage of many clinical trials of this medication. The active substance of the drug in the form of trimeperidine has a pronounced analgesic effect after 10-20 minutes. after its injection.

The maximum concentration of the drug in the patient's bloodstream is reached after 40 minutes.

The average duration of the analgesic effect lasts for the next 2-4 hours, depending on the individual characteristics of each patient. The main component of Promedol is characterized by low binding to plasma proteins, which is within 40%.

The metabolism of trimeperidine is carried out by a process of hydrolysis with the further formation of normeperidine and meperidine acids, which are subsequently subjected to conjugation in the liver tissues. The half-life of the active component of the Promedol solution lasts for all 4 hours from the moment of its injection.

Products of chemical etiology, which are formed during the metabolism of this drug, are disposed of in urine and feces. At the same time, the kidneys have a minimal load. In this regard, Promedol in moderate doses is used in relation to patients who have concomitant disease in the form of chronic renal failure.

Indications for use

Promedol in ampoules (the price of this drug is relatively low) is indicated for use in children and adults who suffer from severe and moderate pain attacks, caused by the following types of diseases:

• acute myocardial infarction;
• thrombosis of the arterial vessels of the kidneys;
• pericarditis;
• inflammation of the tissues of the pancreas with a chronic form of the course;
• prostatitis of a bacterial or non-infectious nature of origin, which is in the acute phase of its development;
• radiculitis of the lumbosacral spine (in this case, an injection solution in is mandatory used in combination with anti-inflammatory drugs spectrum of action);
• paranephritis of the kidneys;
• acute infarction of lung tissue;
• foreign bodies present in the cavity of the bladder, excretory canal, kidneys, rectum;
• an attack of acute neuritis with severe pain syndrome;
• pneumothorax of the lung, arising spontaneously, which has an unspecified etiology;
• stomach ulcer, as well as damage to the mucous membrane of the walls of the duodenum;
• thromboembolism of the arteries of the upper or lower extremities, as well as impaired blood supply to the lung tissues;
• perforation of the walls of the esophagus, which has arisen due to their traumatic injury, or is caused by complications of surgical intervention;
• terminal stage of cancer, when the patient is inoperable, but at the same time constantly needs to be removed acute pain syndrome (in this case, Promedol injections are indicated for use to improve the quality of the last days of life patient);
• progressive aortic aneurysm with signs of dissection of its walls;
• various kinds of injuries and pathological conditions of the spine, as well as other elements of the musculoskeletal system;
• shock state of a cardiogenic nature;
• acute failure of the left ventricle of the heart;
• colic localized in the kidneys, liver or intestines;
• pulmonary edema, regardless of its nature of origin;
• pain relief, as well as stimulation of active labor;
• the period of postoperative recovery of patients who need analgesic therapy.

Depending on the type of surgery, Promedol injections can be used at the stage of preparing the patient for surgery. In combination with drugs that belong to the pharmacological group of neuroleptics, this medication is used to perform neuroleptanalgesia.

Contraindications

Promedol in ampoules (the price of this drug is not higher than that of drugs with similar properties) is categorically contraindicated for use in the following cases:

• individual intolerance to trimeperidine, which is expressed in the form of various kinds of allergic reactions;
• concomitant therapy with drugs belonging to the pharmacological group of MAO inhibitors, as well as within 21 days after the termination of their regular intake;
• states of the body, expressed in acute suppression of the functional activity of the respiratory system.

Promedol in the form of an injection solution has limited use and is used with extreme caution in relation to patients who suffer from the following diseases:

• cardiac, renal, hepatic, adrenal, respiratory failure;
• stricture of the walls of the urethra;
• benign prostatic hyperplasia;
• rehabilitation period after severe traumatic brain injury;
• oppression of the functions of the central nervous system;
• asthma (there is a high probability of an exacerbation of this disease with the occurrence of an attack of suffocation);
• high intracranial pressure;
• obstructive pulmonary tissue disease;
• chronic alcoholism;
• mental and neurological disorders, accompanied by the manifestation of suicidal behavior;
• dependence on regular use of drugs;
• inflammatory diseases of the intestinal walls, capturing large areas of its mucous membrane;
• cachexia;
• arrhythmia and other disturbances in the rhythmic activity of the heart muscle;
• hypotension.

The drug Promedol is used only under the supervision of a doctor or junior medical personnel in relation to elderly patients, women, in a state of pregnancy, lactating a newborn baby with a breast, severely weakened patients with signs of exhaustion organism.

At what age can the drug be used?

Promedol injection solution can be used to treat children who are already 2 years old, or they are older.

Instructions for use, dosage

The drug Promedol is intended for subcutaneous, intravenous or intramuscular administration. For patients of the adult age group, the standard therapeutic dosage with this medication, which is used to suppress acute or moderate pain is 1 to 2 ml of injectable solution.

Depending on the severity of the patient's condition, a drug of 1% or 2% concentration can be used. For children from 2 years old, this drug is prescribed in doses from 0.003 to 0.01 g per day, depending on the age of the child, the type of disease, the intensity of the pain syndrome and its total body weight.

For the purpose of pain relief during childbirth, Promedol is used at a dosage of 0.02-0.04 g, but provided that the throat is open by 3 cm, and the condition of the fetus is satisfactory.

Side effects

Promedol is a potent narcotic drug that can affect the functional activity of the central nervous system and internal organs.

In this regard, taking this medication may be accompanied by the manifestation of the following side effects:

• constipation;
• discharge of vomit;
• nausea;
• loss of appetite;
• yellowness of the skin;
• spasm of the walls of the biliary tract;
• increased dryness of the mucous membranes of the oral cavity;
• intestinal obstruction;
• a state of euphoria;
• slowing down of psychomotor reactions;
• cramps of the lower extremities;
• Strong headache;
• impaired vision;
• tremor of the upper limbs;
• visual hallucinations;
• nightmares;
• increased agitation and nervousness;
• feeling anxious;
• choking and feeling short of breath;
• arrhythmia;
• delay in urination;
• decrease in the total volume of excreted urine;
• drop in blood pressure indicators;
• swelling of facial tissues;
• the appearance of skin rashes accompanied by itching;
• bronchial spasm;
• a burning sensation in the area of ​​the injection solution;
• angioedema;
• heart palpitations;
• profuse sweating;
• addiction to the active component of the drug with the development of stable drug dependence.

The appearance of the above signs of an allergic reaction is the basis for the immediate termination of further therapy with this medication. With a deterioration in the general condition, severe dysfunctions of internal organs, the patient is hospitalized in the inpatient department of the hospital, where he receives appropriate therapy.

Overdose

Violation of the dosage regimen with Promedol can provoke an overdose, which is manifested by the following symptoms:

• the onset of a coma;
• oppression of the psychoemotional state;
• miosis;
• nausea;
• vomit;
• dysfunction of the cardiovascular, respiratory, nervous system;
• allergic reactions.

In patients with an overdose of Promedol, there is an exacerbation of side effects, which are described in the section above. Patients in this category should be immediately hospitalized in the toxicology department.

The main treatment for an overdose of Promedol is the timely implementation of artificial ventilation, intravenous administration of a solution of Naloxone, which is an opioid antagonist, allows you to quickly restore the impaired lung function. In the absence of a therapeutic effect after 2-3 minutes. re-introduction of this drug is carried out.

special instructions

Throughout the course of treatment with Promedol injection solution, you must refrain from driving vehicles, as well as performing work requiring special attention and active thinking process. Simultaneous therapy with this medication, as well as the accompanying use of alcoholic beverages, is not allowed. Otherwise, negative reactions may occur that disrupt the work of the central nervous system.

Drug interactions

It is not recommended to jointly take Promedol with medications of the following pharmaco-therapeutic groups:

• barbiturates;
• ganglion blockers;
• anxiolytics;
• muscle relaxants;
• antipsychotics;
• analgesics;
• antipsychotic and narcotic drugs;
• diuretics;
• anticholinergic drugs;
• antidiarrheal agents.

Simultaneous therapy with the above medicines can lead to dysfunctions of the central nervous system, respiratory, excretory, and cardiovascular systems.

Analogs

Promedol injection solution has a unique chemical composition. The table below lists the main medicines that belong to the pharmacological group of opioid analgesics and have similar properties.

Name of medicines	Price
Tramadol	RUB 87
Fentanyl	141 r
Dipidolor	RUB 540
Prosidol	RUB 630
Butorphanol	RUB 670

The above drugs are characterized by pronounced analgesic and antispasmodic properties, and their intake should be carried out only as prescribed by the doctor.

Terms, conditions of sale and storage

The injection agent Promedol is dispensed exclusively with a doctor's prescription. It is necessary to store the drug at a temperature not higher than +20 degrees Celsius away from sunlight and children of all age groups. The shelf life of this medication is 5 years, after which its further use is prohibited.

Price

The average cost of 10 ampoules of the drug Promedol 2% concentration is 650 rubles. Promedol is an injection solution that belongs to the pharmacological group of drugs with a pronounced analgesic effect.

This medication is available in glass ampoules of 5 ml each, and its main package is a cardboard box. Promedol is used only for symptomatic therapy of seriously ill patients who require urgent elimination of pain attacks of moderate or severe intensity.

The use of this medication is possible only in an inpatient department of a hospital under the supervision of medical personnel. Violation of the dosing rules and prolonged use of Promedol injections can lead to the development of drug addiction. The price of this drug is fully consistent with its pharmacological properties.

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