Pentaxim and Prevenar at the same time. Is it possible to do, as transferred, temperature, reviews

Childhood vaccination is of key importance in the prevention of common infectious diseases. It forms a stable immunity against pathogenic pathogens. Pentaxim and Prevenar are complex vaccines that are used simultaneously to protect the body from streptococci and other pathogenic bacteria.

Composition and active substance of Pentaxim and Prevenar vaccines

Immunological preparations contain strains of biologically inactive pathogenic pathogens. Intramuscular administration of a prophylactic suspension allows the formation of a stable defense mechanism against bacterial cultures, which are included in the chemical formula of vaccines.

Pentaxim is a combined immunological medication containing pathogenic agents of 5 dangerous diseases:

• Diphtheria.
• Tetanus.
• Whooping cough.
• Poliomyelitis;
• Hemophilic bacillus.

The vaccine contributes to the development of long-term immunity to the corresponding diseases. The preparation contains laboratory inactivated toxoids of infectious pathogens.

The antidiphtheria effect of Pentaxim is due to the content of the neutralized bacteria of the genus Corynebacterium. Toxins released by microorganisms are the main factor of pathogenicity.

They trigger immune responses as they are recognized by competent cells as foreign substances (antigens). Protection against pertussis is provided by the appropriate component of the vaccine.

This infectious disease is especially dangerous for young children - from birth to 6 months. Pentaxime contains a tetanus component, which contributes to the development of specific immunity.

This sapronous infectious disease is transmitted by contact and affects the nervous system. It provokes tonic tension of skeletal muscles and gives rise to generalized convulsions.

Pentaxim and Prevenar are simultaneously used for comprehensive protection of the child's body from a wide range of dangerous infectious pathologies. The vaccines are considered compatible. Pentaxim contains a laboratory-inactivated polio pathogen.

This highly contagious disease, called infantile spinal palsy, provokes a poliovirus that invades the central nervous system and quickly replicates in motor neurons. Pathology is practically not amenable to treatment.

Prevenar is an immunomodulatory vaccine containing conjugated pneumococci of 13 serotypes as the main component.

Composition of the preparation:

Immunological component	Volume, mg
Pneumococcal polysaccharide serotype 4	0,002
High molecular weight carbohydrate 6B	0,004
Polysaccharide 9V	0,002
Pneumococcus serotype 14	0,002
Oligosaccharide 18C	0,002
Polysaccharide 19F	0,002
Pneumococcus serotype 23F	0,002

Vaccination promotes the synthesis of antibodies to these pathogenic pathogens. The auxiliary components of the vaccine are sodium chloride and aluminum phosphate.

Manufacturer

Until 2016, Pentaxim was produced only by the French pharmaceutical concern Sanofi Pasteur. It is the most famous and largest manufacturer of immunological medicines intended for vaccination.

In 2016, the French company located its factory facilities in the Kirov region. There, 5-valent Pentaxim is produced at the biotechnological site of the pharmacological developer Nanolek.

Technological equipment and manufactured product fully meet the requirements of the global GMP standard. Prevenar is produced by the American concern Pfizer and its numerous subsidiaries around the world. The company produces a huge amount of medicines.

Many of them are leading in world sales rankings. Prevenar is a vaccine that was sold in 2015 for a total amount of US $ 6.245 billion. dollars. Every year, the sales of the drug only increase.

What are Pentaxim and Prevenar protecting from?

A pathogenic microorganism of the genus Haemophilus influenzae provokes the development of severe inflammatory processes. This culture in small doses and inactivated form is included in Pentaxim.

Such an infection has a record resistance to antibiotics used in clinical practice, and therefore is extremely difficult to treat. Vaccination is a quick, cheap and easy way to protect the body from this pathogen.

The disease is especially difficult in early childhood, when the immune system is still unstable and not fully formed. Vaccination against Haemophilus influenzae is standardly included in the vaccination calendar of many developed countries of the world.

Pentaxim protects the child's body from:

• Hib type B infections;
• purulent meningitis;
• pneumonia;
• arthritis.

Children with hereditary immunodeficiency, oncological hyperplasia and hematological disorders are especially in need of such vaccination. They are most vulnerable to this pathogenic bacterial culture. The formation of one's own immune system and its stabilization ends in 5-6 years.

Pentaxim and Prevenar are administered simultaneously to provide the comprehensive protective support that the child's body desperately needs. According to the WHO, in countries with mass vaccination, the incidence of tetanus is 100 times less than in those where it is not practiced.

Prevenar is a drug that forms a specific immune response to infection with streptococcal bacteria. This common disease-causing culture lives in large numbers in the environment.

It is also contained in the human body, where it has a conditionally pathogenic character. With healthy immunity, streptococci do not pose a significant threat. However, with the weakening of the defense mechanism, the situation changes dramatically.

Viral infections and various diseases create favorable conditions for the rapid multiplication of pathogenic microflora. Streptococcus is a facultative anaerobic bacterium.

Such microbes are actively developing with an increased content of carbon dioxide compounds in the environment. The environmental situation is becoming an important factor in the pathogenesis of streptococcal pneumonia and other concomitant diseases.

Vaccination with Prevenar provides the child's body with reliable protection against them. The immunomodulatory drug has a wide range of effects.

Vaccination significantly reduces the risk of getting sick:

• pneumonia;
• inflammation of the bronchi and upper respiratory tract;
• otitis media, tonsillitis, pharyngitis and other bacterial lesions of the ENT organs;
• meningitis;
• endocarditis;
• glomerulonephritis;
• dermatological pathologies provoked by the target pathogen.

Children are hard to tolerate such infectious diseases. Often they are accompanied by a variety of complications. Vaccination medication Prevenar significantly enhances the immune defense of the child's body.

Benefits of vaccines

Both immunological solutions potentiate the synthesis of antibodies to pathogenic pathogens introduced into the body. Vaccination is a common and safe method of protecting against disease-causing bacteria.

Its clinical effectiveness has been scientifically proven by numerous studies and practice in different countries. Each of the drugs has its own set of undeniable benefits.

Pentaxim is characterized by:

• reliable protection against 5 common and socially significant microbial pathogens;
• the minimum required number of injections;
• proven efficacy and safety of each component of the immunological composition;
• full compliance with the requirements of the world health organization;
• good tolerance for babies.

Pentaxim contains laboratory-inactivated strains of poliomyelitis, tetanus and other dangerous diseases, which eliminates the risk of developing vaccine-associated complications. It can be administered simultaneously with Prevenar, which has an equally high safety profile.

Streptococcal immunomodulator has a more narrowly targeted protective effect, but no less clinical efficacy than Pentaxim.

The undoubted advantages of the vaccine include:

• absence of side effects and complications after immunization;
• a small number of contraindications to the appointment of a prophylactic injection;
• the possibility of use in relation to newborns;
• simplicity and painlessness of using the suspension;
• affordable cost of the drug.

Clinical studies have confirmed the high specific effectiveness of Prevenar in the prevention of invasive pathologies of pneumococcal genesis.

Contraindications and side effects

Vaccines are not used in case of revealed increased sensitivity to their constituents.

Pentaxim is not vaccinated in children who are hypersensitive to:

• glutaraldehyde - a lipid derivative of glutaric acid;
• streptomycin - aminoglycoside antibiotic with a wide range of antimicrobial effects;
• neomycin - an antibacterial chemical compound produced by microorganisms of the genus Streptomyces fradiae;
• polymyxin class B - a biochemically aggressive substance that destroys the cytoplasmic membranes of gram-positive pathogens.

For diseases in which vaccination with Pentaxim is not performed, progressive encephalopathy is considered. Children who are prone to hyperthermia, convulsive states of febrile or non-febrile type are not vaccinated with immunological medication.

Further vaccination is prohibited if the child develops a hypotonic-hyperreactive syndrome for 2 days after administration of the solution. This side effect can occur in response to the whooping cough component.

The immunological agent is not used for severe allergy to tetanus vaccines. Injection prophylaxis is not performed during the period of bacterial infections and ARVI.

Pentaxim is capable of causing some systemic and local negative effects. Hyperemia and compaction may occur at the puncture sites of the skin.

Fixed systemic side effects of Pentaxim:

• sleep disturbance;
• decreased appetite;
• dyspepsia;
• nausea and vomiting;
• hives;
• swelling of the extremities in response to the Hib component;
• a sharp increase in body temperature.

Negative phenomena disappear within 48 hours. and do not require medical intervention. Rarely, vaccinated children have Guillain-Barré syndrome, an acute inflammatory polyradiculoneuropathy that occurs in response to tetanus toxoid.

Pentaxim and Prevenar are simultaneously administered to form a full-fledged immune circuit of the child's body. This comprehensive approach has many advantages and does not increase the risk of developing systemic side effects.

Prevenar has its own set of absolute clinical contraindications and temporary situational restrictions.

Vaccination is not done when:

• hereditary autoimmune pathologies;
• severe neurological disorders;
• congenital heart disease;
• renal failure.

Vaccination with Prevenar is not performed at elevated body temperature, allergies, active bacterial infections. Possible side effects include fever, apnea, episodic arterial hypertension. Prevenar is not prescribed for disorders of the central nervous system and the rheological properties of blood.

Can Pentaxim be used simultaneously with Prevenar?

Vaccination drugs are compatible both with each other and with any other vaccines, with the exception of the anti-tuberculosis vaccine. Pediatricians often prescribe injections of Pentaxim and Prevenar on the same day.

This practice is common in the countries of the European Union, the United States and Canada. Well-founded fears about an increased risk of developing systemic side effects are refuted by some immunologists, citing research results.

The number of adverse reactions and complications with the joint use of vaccines does not differ much from the indicator for single use. Pathological symptoms quickly and spontaneously disappear within 2 days.

How is vaccine administration on the same day tolerated?

Pentaxim and Prevenar are injected at the same time to develop a strong immune response. Both drugs have proven themselves well in pediatric practice in Germany, Belgium, and other developed European countries.

Rarely, after injections on one day, there is an increase in rectal body temperature, which always exceeds the axillary indicator by 0.6-1.1 ° C. Therefore, this value was assessed in the study.

Most children tolerate joint injection of immunological solutions well. Prevenar considers it a rather painful injection, but it provides reliable and long-term protection of the child's body from serious diseases of bacterial genesis.

At the point of injection, seals may occur, allergic reactions may develop in the form of urticaria or dermatitis. Such undesirable manifestations are eliminated on their own and do not require outside participation. Some children experience lethargy and reluctance to eat after the injection.

This is due to the adaptation of the developing organism to the pathogenic microflora introduced, albeit killed in the laboratory. Complications associated with double vaccination are almost never recorded.

Rapid allergic reactions, muscle and bronchospasm, characteristic of children of the 1st year of life, are extremely rare. Its connection to double vaccination has not been proven. It is theoretically possible to develop temporary generalized lymphadenopathy.

This pathological condition is manifested by an increase in the size of the lymph nodes, which play an important role in the body's immune defense. The diagnosis is temporary. The lymph nodes return to normal after the body gets used to the vaccine.

After how many days is it better to get the next vaccination?

Pediatricians recommend vaccinating a child with both drugs on the same day. This makes it easier to respond to the possible occurrence of unwanted effects and complications. The child will only have to go through the unpleasant moments associated with the injection once.

If the time interval between the intramuscular administration of Pentaxim and Prevenar is more than a day, the next vaccination will have to be postponed for a month. This is due to the increased immune activity of the body in response to the deliberate supply of pathogenic microflora.

It is necessary to wait until the irritation subsides and the defense mechanism returns to its natural state. During this period of time, the introduction of an additional portion of a foreign biomaterial can lead to unpredictable reactions and conditions.

Complications

Within 30 min. after vaccination, the child must be under medical supervision. This is necessary because of the risk of developing immediate anaphylactic reactions and complications.

The latter develop not because of the administration of an immunological drug, but because of the patient's health condition. Before vaccination, the pediatrician conducts an examination and determines the possibility of vaccination.

It is important to follow the rules of antiseptics, transportation and storage of the medication. It is necessary to distinguish the short-term reaction of the body to a foreign biomaterial from pathological complications. They require immediate medical attention and adequate therapy.

An allergic reaction is considered a side effect, and anaphylactic shock is an acute complication. Bronchial spasm, which impedes the implementation of respiratory function, refers to conditions that require immediate medical attention. Vaccination rarely provokes an exacerbation of chronic diseases.

Vaccination schedule

The universal vaccination plan proposed by WHO provides for 3 prophylactic injections of Pentaxim for children 1 year of age. Vaccinations are given at 12 weeks, 4.5 and 9 months. The immunological effect is fixed by revaccination at 1.5 years. The next vaccination is given at 6-7 years of age.

The first 2 injections are most difficult for children. Young age and physiological instability of the body cause side effects. The minimum interval between these vaccinations is recommended for pediatricians to be 1-1.5 months.

For children under one year old, the drug is administered intramuscularly to the lateral part of the thigh. At an older age, injection of Pentaxim into the deltoid muscle is allowed. The recommended single dosage of the immunomodulating solution is 0.5 ml.

For the next 3 days, medical supervision of children under the age of 5 months is required. If pathological manifestations occur, measures should be taken to eliminate them immediately.

The vaccination schedule with Prevenar is somewhat different. It is developed individually, depending on the age and history of the child. Children 2-24 weeks of age are prescribed 3 single doses at intervals of a month.

If the 1st injection is given at 2 months, revaccination (4th injection of Prevenar) is performed after a year. The most favorable moment for her is the interval between the 12th and 15th months of life.

If the first injection is made at the age of six months, then the prophylactic solution is given 3 times - the first 2 times with an interval of 30 days, and the last one at the 2nd year of life. For children from 2 years old, Prevenar is prescribed in exceptional cases, with excessive susceptibility to bacterial infections. Children over 5 years of age and adults are not vaccinated with the medication.

Price

The immunological drug Pentaxim in Moscow costs about 1,438 rubles. When vaccinating at the same time as Prevenar, the price of vaccination in the capital's medical institutions will be lower. An injection of pneumococcal medication will cost 1,873 rubles.

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