Cefazolin injections. Price, instructions for use, how to breed, what it treats, reviews

Cefazolin - it is a medicine for the setting of injections used in the treatment of infectious lesions of the respiratory system. The drug has a low cost, but a high therapeutic effect.

Forms of release and composition of the drug

This drug is manufactured in India as a powder for the preparation of an injection solution for intravenous or intramuscular administration. The main component of the product is cefazolin (in the form of sodium salt).

The medication is poured into bottles and packed in cardboard containers. Each package is accompanied by a detailed guide for the use of the medication.

Pharmacological properties

This medicine belongs to the category of antibacterial drugs that have a wide spectrum of action.

The main substance is a 1st generation antibiotic. It has a bactericidal effect aimed at destroying the cell walls of infectious agents. The development of resistance of pathogenic microflora depends on the area and scope of the drug. In view of this, it is necessary to clarify the area and region of application of antimicrobial treatment before using it.

The drug is effective against gram-positive and gram-negative pathogens - staphylococcus, Proteus, Escherichia coli.

The drug is not effective against the following pathogenic microflora:

• enterobacteria;
• citrobacter;
• proteas of the genus mirabilis;
• morganella;
• Proteus of the genus Vulgaris;
• pseudomonad;
• indole-positive proteas;
• mycobacteria;
• klebsiella;
• anaerobic pathogens;
• resistant to the action of methicillin - Staphylococcus aureus, Providence.

Beta-hemolytic streptococcus species (including the pneumonia form), hemophilus influenzae, and staphylococcus epidermidis can develop resistance to the action of the drug.

Pharmacodynamics and pharmacokinetics

Cefazolin - injections (the price of injections is affordable for most patients) that exhibit specific pharmacokinetic and pharmacodynamic properties. With the introduction of 1 liter of solution, the maximum concentration of the active substance in the blood is reached after 60 minutes. The maximum concentration level depends on the period after the application of the drug, it fluctuates in the region of 64-180 μg / l.

The active ingredient is able to penetrate the placental barrier, into the renal system, organs breathing, abdominal cavity, joints, skin, cardiovascular system, as well as in the area middle ear. In this case, the substance in small quantities penetrates into breast milk.

The level of accumulation of the active ingredient is much higher in the biliary system than in the blood. However, with obstructive disorders in the gallbladder region, the level of the active substance in the blood is much higher.

The drug interacts with proteins. At the same time, the level of interaction is 85%. The half-life of the components of the agent for intramuscular administration is about 100 minutes, for intravenous administration - 120 minutes.

With functional disorders of the renal system, the half-life increases significantly and ranges from 20 to 40 hours. In the presence of cirrhosis of the liver, the half-life of the active substance can be significantly reduced.

The components of the drug are excreted mainly with the help of the kidneys in an unchanged form. During the first 6-9 hours, the body leaves about 60-90% of the substances. At the end of the day, these indicators are from 70 to 95%.

Indications for use

The solution is used in the treatment of various infectious processes occurring in the internal organs.

Indications:

• infectious-inflammatory and bacterial lesions of the respiratory tract, urinary system, biliary tract;
• infections of the pelvic organs;
• infectious lesion of the skin and bone and articular system;
• endocarditis;
• septic lesion;
• peritonitis;
• the presence of osteomyelitis;
• otitis media of the middle ear;
• mastitis;
• gonorrhea;
• syphilis;
• infection of wound or burn surfaces;
• pre- and postoperative period.

Before using the product, it is necessary to undergo additional studies to determine the sensitivity of pathogens to the active substance of the drug.

Contraindications

Cefazolin - injections (the price of the product may vary slightly in different pharmacies), which have some restrictions in use due to the action of the main substance.

Contraindications:

• intolerance to the composition;
• anaphylactic reactions;
• newborns and premature babies.

With extreme caution, the solution can be used in patients with kidney failure, as well as in the presence of intestinal diseases, including colitis.

At what age can the drug be used?

The drug is approved for use in children from the 1st month of life. In this case, the solution is used only under the guidance of the attending specialist.

What is the drug diluted with?

Before giving injections, the solution must be diluted. For this, injection water is used. Dilute 1 g of the drug in liquid and use as an intravenous infusion - from 30 to 60 drops of the drug per minute.

To prepare an intravenous drip solution, it is necessary to dilute 50-100 ml of the product with the following drugs:

• dextrose solution;
• sodium chloride;
• Ringer's solution;
• sodium hydrogen carbonate.

When administered intramuscularly, the main medication should be diluted with 0.25% novocaine solution.

Instructions for use, dosage

The medicine is intended for intramuscular or intravenous administration. Adults are prescribed 1 g of the drug from 2 to 4 times a day.

Before the start of the intervention, 1 g of the medication is prescribed half an hour before the start of the action. During the period of operations, 0.5-1 g of solution is injected. During the rehabilitation period, 0.5-1 g of the drug is prescribed every 6-8 hours throughout the next day. Moreover, the maximum daily dosage should not exceed 6 g.

In childhood, 20-40 mg of the drug is prescribed per 1 kg of the child's body weight. In severe disease, the dosage may be increased to 100 mg. The duration of treatment is 1 to 1.5 weeks.

Side effects

Cefazolin is well tolerated in most cases. However, these injections can provoke various undesirable manifestations. At the same time, the frequency and risks of these reactions do not depend on the cost of the drug.

Side effects:

• Allergic manifestations: rashes, urticaria, itching (including in the genital area), overheating, an increase in the number of eosinophils, bronchospasm, the development of arthralgia. There is also the occurrence of necrolysis on the skin, Quincke's edema, anaphylactic reactions, erythema lesions.
• Common signs: increased fatigue and malaise of the body, pain in the chest area.
• Malfunctions of the central nervous system: development of dizziness, convulsive state.
• Respiratory system disorders: the development of cough, shortness of breath, difficulty breathing, pleurisy.
• Urinary organs: patients with impaired renal function may develop nephropathy, the formation of protein in the urine, nephritis (interstitial form).
• Disorders in the work of the digestive system: the occurrence of vomiting and nausea, pain in the epigastric region, diarrhea, the development of pseudomembranous enterocolitis. In rare cases, taking the medication leads to the development of jaundice, anorexia, and hepatitis.
• Disorders of wasps of the side of hematopoietic functions: thrombocytopenia, anemic conditions, an increase in the number of leukocytes, platelets and monocytes; a decrease in the level of lymphocytes, leukocytes and neutrophils. There is also an inhibition of blood clotting functions, the formation of bleeding, a decrease in hemoglobin and blood cells.

Among the reactions of a local nature, pain often occurs at the injection sites.

Overdose

When the established doses are exceeded, negative reactions develop, including conditions hazardous to health.

Overdose signs:

• dizziness;
• headaches;
• convulsive conditions;
• increased arousal;
• soreness at the injection sites;
• development of paresthesias;
• uncontrolled muscle contraction.

With the development of these symptoms, it is necessary to stop using the solution and contact a medical institution for medical help.

In severe cases, hemodialysis is prescribed. The drug does not have a specific antidote.

special instructions

Great care should be taken when prescribing the drug, since the active substance can cause hypersensitivity reactions, up to and including death. The solution is used with extreme caution in patients with allergic diseases.

When carrying out drug therapy, it is necessary to carry out constant monitoring using Coombus tests. Urine sugar should also be monitored.

With the development of pseudomembranous enterocolitis against the background of the use of the medication, it is necessary to cancel further intake of the solution and consult a specialist for medical help.

When using the medication in patients with functional disorders of the kidneys, systematic studies of renal function are required. If necessary, the dosage of the solution can be reduced.

With prolonged use of the solution, the development of resistance in microorganisms to the active substance is possible, as well as the development of superinfection.

In case of violations of the hematopoietic function, anticoagulants, vitamin K can be additionally prescribed. Patients who follow a dietary diet that excludes sodium should be extremely careful to use the drug, since the solution contains sodium in its composition.

It is recommended to be very careful when driving or carrying out work requiring high psychomotor functions.

Drug interactions

It is not recommended to combine the solution with diuretic drugs. The simultaneous use of the drug and ethanol can lead to the formation of disulfiram-like reactions. The combination of the drug with probenecid can lead to impaired elimination of the residual components of the first agent.

Analogs

Cefazolin - injections (the price of the drug, according to doctors, is comparable to its effectiveness), which, with the development of intolerance reactions, can be replaced by another similar drug.

Analogs:

• Lexin. This medicinal product is available in the form of oral capsules or ready-made solution. Their active component is cephalexin, a substance belonging to the category of cephalosporins. The drug has a wide spectrum of activity and has an antibacterial effect. Indications for the use of pills: infectious diseases of the urinary system, infectious skin lesions integuments and soft tissues, otolaryngological infectious processes, as well as bacterial damage to the respiratory systems. The drug also exhibits a high therapeutic effect against osteomyelitis. The dosage and frequency of daily use depend on the dispensed dosage form of the drug and the patient's age. All the features of the treatment are determined by the infectious disease doctor. Contraindications: intolerance to the components, functional disorders of the kidneys and liver. Dispensing conditions from pharmacies - by prescription. The prices for the medicine vary between 340-390 rubles.
• Ospeksin. This medical product is made on the basis of cephalexin, a substance belonging to the cephalosporin group. The medication is dispensed in the form of capsules or tablets for oral administration, as well as in the form of granules for the preparation of an oral suspension. The product exhibits high antibacterial and bactericidal properties and has a wide spectrum of action. Indications for taking oral forms: infectious lesions of the respiratory and genitourinary system, infection of soft tissues and skin, ENT infection. Adults are prescribed 1 g of the drug 3-4 times a day. The recommended dosage for children is 0.5 g each. The duration of therapy is 1-1.5 weeks. Restrictions on taking capsules / tablets are hypersensitivity reactions. Terms of sale of the medication - by prescription. The cost of the medicine ranges from 98 to 440 rubles.
• Cephalexin. This medication is available as a solution for intravenous or intramuscular administration. Its active ingredient is the component of the same name. The medicine belongs to the category of cephalosporins and exhibits antibacterial and bactericidal properties. It is used in the development of various infectious diseases. Indications: infection of the respiratory tract, genitourinary system, ENT organs, skin and soft tissues, bone and articular system. Contraindications: intolerance to the cephalosporin group of drugs, newborns up to six months, pseudomembranous colitis, kidney failure. The dosage and duration of therapy are set individually by the treating infectious disease specialist. Terms of sale of the drug - by prescription. The cost of the solution in public and private pharmacies starts from 67 rubles. per packing.

Cefazolin - injections (the price of similar drugs can be much higher than the drug), which should be replaced with similar drugs only with the permission of the attending specialist.

Terms, conditions of sale and storage

• It is necessary to store injections in a clean and dark place at temperatures up to 25⁰C.
• The shelf life of the medication is 3 years from the date of manufacture.
• It is forbidden to use the product after the expiration date marked on the package.
• The product is dispensed with a prescription.

Price

The cost of this drug depends on the region and region of its sale. Its price is also influenced by the retail pharmacy chain.

The solution can be purchased at any private or public pharmacy:

Region / region	Form / dosage	Price
Moscow, Moscow region	Powder, 0.5 g	RUB 33-48
St. Petersburg	Powder, 1 g	18-1900 rub.
Saint Petersburg (suburbs)	Powder, 500 mg	35-53 rub.
Leningrad region	Powder, 1 g	RUB 30-42
Novgorod region	Powder, 0.5 g	RUB 37-42

Before using the injection solution, you must consult with a specialist and carefully study the instructions for use of Cefazolin.

Additionally, it is recommended to read the reviews of patients who used injections as the main method of treating an infectious lesion of the body. You can find out the exact cost of the medication at any pharmacy located in the patient's place of residence.

Video about the drug Cefazolin

Review of the doctor about the drug Cefazolin: