Clarithromycin tablets 500 mg. Price, instructions for use, analogues, reviews

Clarithromycin - effective antibacterial tablets, which are often prescribed to patients with inflammatory pathologies. The dosage for patients can be 250 or 500 mg, depending on the condition. The price of the drug is affordable, which allows patients to take the full course or repeat it if necessary.

Forms of release and composition of the drug

The pharmacological agent is available for patients in the form of tablets for oral administration. They are small in size, yellow in color, oval and oblong in shape.

When dividing the tablet, there are no foreign inclusions on the cut. The tablets do not have an unpleasant odor. The drug contains the active ingredient clarithromycin, which has the main therapeutic effect.

The tablets also contain additional substances:

• Microcrystalline cellulose.
• Magnesium stearate.
• Silica.
• Starch.
• Gelatin.

Excipients have no therapeutic effect. The drug is also available in the form of oral capsules.

The dosage of the active ingredient in capsules is 250 mg, the tablets contain 500 mg of the active ingredient. Capsules and tablets are packaged in plastic blisters of 7 pieces. An individual cardboard box contains detailed instructions and 2 plates.

Pharmacological properties

Clarithromycin - 500 mg tablets (the price of the product may differ in different regions), which have pronounced antibacterial properties. The product helps to destroy pathogenic microbes and prevents re-damage to tissues and organs.

The drug has anti-inflammatory properties, helps to eliminate tissue edema in the affected area by destroying microbes and cleansing tissues from their waste products.

The medicine also prevents the development of complications as a result of the spread of microorganisms to healthy tissues, damage to organs that perform the most important functions in the body.

Pharmacodynamics and pharmacokinetics

After taking the drug inside, it dissolves in the digestive tract and the ingredients are absorbed through the walls of the small intestine. Clarithromycin spreads throughout the body and destroys bacteria that provoke inflammation in tissues.

The substance belongs to the macrolide group. Possesses a wide spectrum of antimicrobial activity. Under the influence of the ingredient, protein synthesis in pathogenic bacteria is disrupted, which leads to their gradual destruction. As a result, the patient's condition improves significantly already in the first few days after the start of treatment.

Experts note the ability of clarithromycin to act not only on extracellular pathogens of inflammation, but also on microbes localized inside cells. Thanks to this, the agent quickly destroys pathogenic microbes.

The ingredient successfully destroys various microorganisms:

• Gram-positive bacteria streptococci and staphylococci. The activity of the drug against Staphylococcus aureus, which provokes the most severe diseases of internal organs, is noted.
• Gram-negative organisms such as Legionella and Helicobacter pylori. Due to the ability to influence these microorganisms, the agent can be used for damage to various organs.
• Anaerobic microbes such as clostridia. Few medicines can target these bacteria.
• Microorganisms that invade the cell and gradually destroy it. The tool helps to destroy mycoplasma, chlamydia, ureaplasma.
• Experts draw the attention of patients to the ability of the active ingredient to destroy the causative agents of toxoplasmosis.
• The ability of the active substance to destroy some strains of microbes that provoke the development of pneumonia is especially appreciated.

A wide range of antimicrobial activity makes the drug effective for various pathologies and varying degrees of neglect. The tool helps not only to destroy microbes, but also helps to restore damaged tissues, which shortens the recovery period.

When you take a tablet, its dissolution occurs quite quickly. Eating this process slows down somewhat, which does not affect the therapeutic effect. The ingredient binds well to plasma proteins, and its bioavailability reaches 90%, which is considered a high indicator.

Thanks to this, a pronounced effect is carried out. The maximum concentration of the drug in the blood is reached 2 hours after taking a single dosage, there is an accumulation of the drug in the lungs, skin and other soft tissues.

The processing of the active substance is carried out in the liver, where it breaks down into metabolites with medicinal properties. The withdrawal period of the drug takes up to 12 hours. The main amount of clarithromycin is evacuated by the kidneys, a small amount is excreted in the feces.

With damage to the organs of the digestive tract and urinary system, a slowdown in the processing and elimination of metabolites from the body is observed. Pharmacokinetic features may differ in each case.

Indications for use

Clarithromycin 500 mg is prescribed for microbial damage to various organs and tissues.

The tablets are affordable and can be used in the following cases:

• Pathologies of the inner and middle ear, accompanied by severe symptoms of inflammation against the background of bacterial lesions.
• Diseases of the upper and lower respiratory tract. With sinusitis, sore throat, laryngitis, tonsillitis, the remedy helps to significantly improve the condition and prevent complications. The drug is also used to eliminate the symptoms of pneumonia, bronchitis of various forms and severity.
• Mycobacterial infections of various forms. The tool is considered effective at the initial and advanced stage of the pathological condition.
• Infectious diseases of the skin and soft tissues. With the formation of abscesses, large boils and some other diseases, the remedy, in combination with other medicines, helps to eliminate manifestations and accelerate recovery.
• Increased activity of the bacteria Helicobacter pylori in the patient's digestive tract. In patients with gastritis and gastric ulcer, this microorganism is often present on the mucous membranes, which provokes a deterioration in the condition. The tool helps to suppress the activity of bacteria, which significantly reduces the risk of complications.
• The defeat of the bacterium Helicobacter pylori of the intestinal mucous membranes. In this case, the development of colitis and enteritis is possible.

The tool can be used as part of the complex treatment of certain heart pathologies of inflammatory origin.

Contraindications

The drug is contraindicated in patients in the 1st trimester of pregnancy. In the 2nd and 3rd trimester, the drug is not contraindicated, but it is used with extreme caution, only as directed and in the presence of acute indications.

There are other contraindications for drug therapy:

• Breastfeeding period. If the use of medication is required, feeding should be temporarily abandoned in order to prevent complications in the child. This is due to the ability of the active ingredient to penetrate into breast milk in large quantities.
• Intolerance to the components of the composition or a tendency to similar manifestations in the patient's history.
• Acute or chronic hepatic failure of a neglected form. The tool is also not used in diagnosing liver cirrhosis, fatty hepatosis or hepatitis of viral origin.
• Renal failure with severe dysfunction of the organ. With such violations, the drug will not be able to be excreted from the body normally, which can lead to excessive accumulation of the active substance in the body and the development of complications.
• Internal bleeding, accompanied by the loss of a large amount of blood against the background of damage to the abdominal organs.
• Acute period after suffering an ischemic stroke.
• Allergic reaction to drugs with a similar composition in the patient's history.
• Acute mental disorders. If it becomes necessary to use the medication, it is worth strictly monitoring the intake and not allowing self-use.

The medication is not used if the patient has a tendency to internal bleeding against the background of pronounced damage to the mucous membranes of the digestive tract. In each case, the decision on the application is made by the doctor.

At what age can the drug be used?

Clarithromycin - 500 mg tablets (the price of the drug is available for most patients), prescribed for patients over 12 years old.

At an earlier age, clarithromycin-based drugs are allowed, but not in tablet form or in capsule form. Suspensions for oral administration are indicated for such patients.

Instructions for use, dosage

Tablets and capsules are taken only orally in the prescribed dosage and after a preliminary examination. The standard dose for an adult is 500 mg 2 times a day, that is, patients take 1 tablet in the morning and in the evening at approximately equal intervals.

Treatment lasts 3 to 7 days, depending on the condition. In only some cases, therapy can last up to 2 weeks, but this is usually not required. Children from 12 to 18 years old usually take 250 mg per day for 5-7 days. It is allowed to divide the tablet into 2 parts or take 2 capsules of 250 mg during the day.

The remedy is taken before meals or 2 hours after it, with plenty of water. If necessary, for adults, the dosage is increased to 3-4 capsules per day if the condition is severe and a quick effect on bacteria is required.

If the patient suffers from chronic renal failure, the drug is usually not prescribed to him, but if if necessary, the daily dosage is 250-500 mg, depending on the degree of neglect of the pathology kidneys.

Treatment lasts no more than 7 days, and the patient's condition is constantly monitored by a doctor. With the help of laboratory tests, a specialist assesses the functioning of the kidneys during the period of antibiotic treatment.

Side effects

Clarithromycin - 500 mg tablets (the price of the medicine may differ depending on the number of tablets in the package), which can provoke complications, especially if used incorrectly. Adverse reactions affect internal organs and systems.

Organs and systems	Most common complications
Nervous system	When taking pills for a long period of time, you may experience a headache, weakness, dizziness. The condition worsens, weakness and fatigue appear, performance decreases, concentration of attention is impaired. Patients can be overly irritable, restless, sleep disorder, apathy are observed. If you stop using the medicine, the condition may improve, sometimes special treatment is required.
Heart, blood vessels, hematopoietic system	Quite rarely, thrombocytopenia develops in patients when taking the drug. Some talk about tachycardia and arrhythmias, pain in the heart, fluctuations in blood pressure. If the patient suffers from chronic heart pathologies, the condition requires treatment.
Digestive tract	The most pronounced disorders during treatment appear from the digestive tract. Patients experience heartburn, severe nausea and even vomiting, stool disorder, manifested in the form of diarrhea. Patients may notice severe pain in the intestinal area, spasms that worsen after eating. The condition worsens with the continuation of the course of therapy.
Sense organs	Deterioration in the quality of vision and hearing is observed when using the product quite rarely. More often, patients talk about the appearance of tinnitus, disorders of the taste buds. Usually, the condition returns to normal within a few days after discontinuation of therapy.
Skin	An allergic reaction to a medication is manifested by pronounced symptoms in the form of a rash, irritation, itching of the skin. continuation of treatment provokes an aggravation of the condition, which threatens the patient's life.

In different patients, the severity of negative reactions differs, which depends on the individual characteristics and duration of drug use.

Overdose

When using the medicine, an overdose may develop. It does not always manifest itself with acute symptoms, but it often significantly worsens the condition. In case of an overdose, severe weakness, lack of appetite and thirst, accompanied by dryness of the mucous membranes of the oral cavity, are possible.

Many patients note the development of intestinal colic, severe pain in the intestinal region. Over the course of several days, the condition may worsen, repeated vomiting and frequent loose stools join.

With prolonged persistence of symptoms, the development of dehydration associated with a violation of assimilation of water in the digestive tract and the rapid elimination of foods, liquids without normal digestion.

Overdose may be accompanied by a severe allergic reaction, turning into angioedema. The condition is characterized by a rash on the body, severe itching and burning of the skin. Symptoms are aggravated by swelling of the mucous membranes in the throat. This leads to difficulty breathing, up to and including suffocation. The condition is dangerous not only for health, but also for the patient's life.

If you develop negative reactions or signs of overdose, you should consult a doctor. In a hospital setting, the patient is assisted, the stomach is washed if necessary, symptomatic therapy is prescribed depending on the manifestations. The agent has no specific antidote.

special instructions

Clarithromycin - 500 mg tablets (the price of the drug allows many patients to undergo a full course of treatment), used in combination with drugs to normalize the bowel function. These funds must necessarily contain bifidobacteria, which help prevent the development of dysbiosis.

Most often, the funds are prescribed immediately after the end of the course, but with prolonged use, bifidobacteria are used simultaneously with antibiotics. Linex and its analogues are most often taken. The scheme of use is determined by a specialist individually.

You should not independently prolong the course or increase the daily dosage. If you have a history of chronic digestive tract pathologies, it is worth taking the medicine only after eating, which helps to reduce the risk of developing negative reactions.

Drug interactions

Do not prescribe the drug in combination with other antibiotics from the macrolide group. With simultaneous use with anticoagulants, cardiac glycosides and some cyclosporins, an increase in the concentration of these substances in the body is noted, which can provoke complications.

Taking Clarithromycin in combination with Omeprazole increases the amount of funds in the blood, which also increases the risk of adverse reactions. You should not use the antibiotic at the same time as Fluoxetine, as the toxic effect of the latter increases. If it is necessary to use any medication, you must first consult with a specialist.

Analogs

The tool has several analogues, which are allowed to be used in consultation with the doctor.

Most popular substitutes:

• Ecozitrin - a clarithromycin-based drug produced in the form of tablets for oral administration. Differs in high efficiency and helps to treat pathologies of the respiratory system, soft tissues, digestive tract. The drug is taken orally in the prescribed dosage, the duration of the course depends on the severity of the course of the disease and is usually at least 7 days.
• Klacid - means in the form of tablets and suspensions for children, which contains clarithromycin as the main active ingredient. The medication is highly effective, helps to cope with mild and advanced forms of the pathological condition. The duration of use and the dosage of the drug in each case is determined individually.

Substitutes for the product are considered effective, but use is not allowed without a preliminary examination by a doctor.

Terms, conditions of sale and storage

You can get the medicine at the pharmacy with a prescription from your doctor. Store it in a dark, cool and dry place. It is important to restrict access to children.

The maximum storage time is 2 years. After that, it is forbidden to use the medicine. The production date is indicated on the packaging.

Price

The cost of the medication depends on the pharmacy, the region of distribution and the number of tablets in the package. The average price is 200-300 rubles.

Clarithromycin is an effective antibiotic pill that has a dosage of 500 mg and is often used to relieve symptoms of inflammatory pathologies of internal organs. The price of the product is affordable, so each patient can undergo a full-fledged therapeutic course if such a need arises.

Video about the drug

Doctor about Claritomycin: