Sodium thiosulfate (E539). Benefit and harm, indications

Sodium thiosulfate Is a chemical compound, the dosage of which ensures the purification of the blood from toxic substances.

The main benefit of the component lies in its detoxifying properties and a positive effect on the processes of restoring the functions of the digestive system after severe poisoning.

Sodium thiosulfate does not belong to the category of chemicals that can harm the human body. Violation of the prescribed dosage regimen can lead to the appearance of signs of local and more extensive allergies, which are accompanied by various symptoms.

What is sodium thiosulfate?

Sodium thiosulfate is a complexing chemical also known under the designation E539. This component acts as an antidote for poisoning with the most dangerous toxins of natural and synthetic origin.

Sodium thiosulfate is included in the World List of Essential Medicines, since the timely use of this substance allows restore the functions of internal organs, which were disturbed by the poisonous action of cyanides, salts of heavy metals and other harmful connections.

The therapeutic benefits of E539 have been confirmed by laboratory studies of its pharmacological and pharmacodynamic properties.

Based on the chemical compound sodium thiosulfate, preparations are made that are intended for intramuscular injection and external use on certain areas of the skin with signs of dermatological diseases.

Achieving a therapeutic effect from the use of this substance is possible if in the process treatment, its dosage form is used, which has undergone industrial processing and sterilization of the components components.

Sodium thiosulfate is characterized by a very high biological activity, as well as the ability to chemically interact with other organic and inorganic compounds. In this regard, the dosed intake of this component should be carried out only under the supervision of the attending physician.

How does it affect the human body

Sodium thiosulfate (the benefits and harms of this substance are based on its biochemical properties) has a positive effect on the human body who has survived chemical poisoning or biological poisons. At the same time, E539 itself does not show toxic signs even in the conditions of its prolonged use.

Benefit

Laboratory tests and clinical studies of sodium thiosulfate have shown that this complexing substance has the following beneficial properties for the human body.

Namely:

• forms completely non-toxic or slightly toxic compounds after contact with heavy metal salts, halogen-containing components, as well as cyanides of natural and synthetic origin;
• acts as a safe antidote against carcinogenic benzene, toxic compounds based on mercury, lead, copper, aniline and phenol;
• breaks down chemicals containing mercuric chloride, arsenic, mercury to the state of sulfites, which do not have a toxic effect on the human body;
• has an antipruritic effect on patients whose skin is infected with an itch mite (this effect is achieved due to the destructive effect on the larvae of parasites);
  
• accelerates the regeneration process of epithelial tissues that have been damaged by a dermatological disease in the form of scabies;
• enters into an active biochemical reaction with hydrocyanic acid, decomposing its simpler compounds, which are low-toxic, unable to disrupt the work of internal organs and life support systems (in this case, the substance of thiocinate ion is formed, the further metabolism of which occurs in the liver tissues, and its excretion occurs together with urine);
• under conditions of external use, under the influence of ambient oxygen, sodium thiosulfate undergoes oxidation processes, which leads to the release of sulfurous anhydrite (this component has a detrimental effect on the eggs of the scabies mite, which parasitizes in the upper layers of the skin person);
• accelerates the process of detoxification of the tissues of the liver, blood and internal organs of the human body, which have suffered from prolonged exposure to alcoholic beverages;
• does not show any toxic properties, which makes it possible to use it in relation to patients with severely weakened body, chronic diseases of the liver, kidneys and other vital organs;
• it has a very fast half-life, which is in the range of 40-45 minutes. (this useful property of sodium thiosulfate suggests that the components of this substance do not accumulate in the tissues of the human body);
• has a moderate anti-inflammatory effect on the soft tissues of the body and the musculoskeletal system, which have suffered from severe poisoning with chemical compounds or biological poisons.

The main benefit of sodium thiosulfate is that this substance, as well as drugs, created on its basis, can be used for detoxification therapy of patients with severe forms poisoning.

The chemical compound E539 can be used as an independent agent, or it is included in the complex treatment with other medicines.

Sodium thiosulfate not only cleanses the body of toxic components, but also accelerates the restoration of internal organs after severe poisoning with synthetic and biological poisons.

The greatest benefit of this antidote is manifested in the fact that, provided its timely administration, it is possible to save a person who has been poisoned by the strongest cyanide-based toxins.

Harm

Sodium thiosulfate (the benefits and harms of the substance are confirmed by laboratory) has practically no negative pharmaco-therapeutic characteristics.

The disadvantages of this complexing component are that it can have the following effect on the human body:

• cause a mild diuretic effect, without which it is almost impossible to quickly eliminate toxic compounds;
• provoke hypovolemia, which is characterized by a reduction in the circulating blood volume, a decrease in blood pressure and a decrease in the rate of cardiac output;
• become a causative local or more extensive allergic reaction, the appearance of which indicates an individual intolerance to this substance.

Dosed use of sodium thiosulfate is completely harmless, and the above reactions of the human body are side effects of this chemical component.

In order to prevent the onset of symptoms of hypovolemia, it is enough to observe the regime of abundant drinking, preventing dehydration of the body. Compliance with this rule is especially important, since in most cases sodium thiosulfate is used in case of body poisoning.

Indications

Sodium thiosulfate (the benefits and harms of this component are proven by chemical studies) is indicated for use by children, adult men and women who have suffered poisoning with substances.

Namely:

• arsenic;
• iodine and bromine salts, regardless of the severity of the overdose;
• mercury and vapors of this metal;

  

• lead in any chemical form.

Sodium thiosulfate can be used as part of the combined treatment of chronic alcohol intoxication. For example, during the treatment of patients with signs of alcoholic delirium.

Sodium thiosulfate is used during the treatment of patients with signs of an allergic reaction, arthritis and other inflammatory diseases of the joints, neuralgia.

Contraindications

The complexing agent E539 is characterized by the presence of a minimum number of restrictions on its use. Sodium thiosulfate is contraindicated for use in children and patients of the adult age group, whose body exhibits an individual intolerance to this component.

A negative reaction to the antidote E539 can be expressed in the form of the following symptoms:

• the appearance of a red rash on the skin;
• itching of epithelial tissues;
• redness of the mucous membrane of the eyes;
• bronchial spasm when administered intravenously;
• redness of certain areas of the skin;
• the formation of edema.

The presence of the above signs of hypersensitivity to the complexing substance in the form of sodium thiosulfate is the basis for canceling detoxification therapy with this component.

Release form

The dosage form of sodium thiosulfate is a transparent and almost colorless solution that intended for intravenous administration, as well as external use during dermatological therapy diseases.

The antidote E539 is packed in glass ampoules made of neutral glass, with a capacity of 5 or 10 ml.

As part of a medicinal solution of sodium thiosulfate, chemicals perform an auxiliary function bicarbonate in the amount of 20 mg and sterile water for injection, which serves as a safe solvent.

1 ml of the finished solution contains at least 300 mg of sodium thiosulfate. Packaging of the finished medicinal product is carried out in cell blisters and cardboard boxes.

Application of sodium thiosulfate

Sodium thiosulfate (the benefits and harms of the chemical compound E539 are determined by pharmacists) is prescribed for intravenous administration or use this substance as an external agent to combat scabies mites, as well as other dermatological diseases.

In case of poisoning

Patients with signs of heavy metal or hydrocyanic acid poisoning are prescribed sodium thiosulfate in an amount of 5-10 ml of the finished solution. In case of severe intoxication of the body with chemical compounds based on cyanides, the dosage with this substance is 50 ml of a solution of 30% concentration.

In this case, sodium thiosulfate can be part of an intravenous infusion in combination with other medicines that do not interact with the antidote E539.

For example, during a complex detoxification therapy with the simultaneous restoration of the water-salt balance in the body.

Patients who have symptoms of body intoxication caused by cyanide poisoning should receive treatment with sodium thiosulfate as soon as possible. Otherwise, a rapid onset of death is possible.

Patients of this category are in the hospital of the toxicology department under the special supervision of medical personnel. Within 1-2 days from the moment of hospitalization of a patient who has been poisoned with cyanide, a re-emergence of pathological symptoms is possible.

In this case, it is necessary to perform repeated intravenous administration of sodium thiosulfate. The final dosage regimen, the timing of therapy with a complexing agent are determined by the doctor, depending on the severity of the patient's intoxication.

To cleanse the body according to the method of Kondakova

According to the system of purification of the body, which was developed by V. Kondakov, the substance sodium thiosulfate should be taken orally. In this case, the contents of the ampoules are dissolved in water, observing a ratio of 1 to 2. The concentration of the active substance in the ready-made solution is 2-3 g.

The prepared product is drunk before bedtime. In this case, the last meal should take place no later than 2 hours ago. After the sodium thiosulfate solution enters the digestive tract, it begins to irritate the mucous membrane and cells of the intestinal ciliated epithelium.

A person who takes this remedy internally begins diarrhea, which ultimately leads to the cleansing of the digestive tract of feces.

Practitioners have a negative attitude to this method of cleansing the body, focusing on the fact that sodium thiosulfate is not intended for oral administration.

For allergies

At the discretion of the attending allergist, sodium thiosulfate may be included in the course of general drug therapy aimed at combating the manifestation of skin allergies. In this case, the antidote E539 is administered intravenously in doses of 5-10 ml of solution.

The main therapeutic effect of the chemical is directed to the areas of the epidermis that are covered with a red rash, have signs of hives, swelling, and itch a lot.

In patients whose body is hypersensitive to sodium thiosulfate, an aggravation of allergic reactions may be observed. Therefore, before using this substance, it is necessary to apply a few drops of the solution to the inner side of the wrist.

Further use of sodium thiosulfate is possible in the absence of signs of redness or itching.

For the treatment of female diseases

Sodium thiosulfate solution can be used to treat the following gynecological diseases:

• menstrual irregularities, which are accompanied by unstable ovulation;
• cystic and polycystic ovary disease;
• damage to the organs of the reproductive system with a tuberculosis bacillus;
• endometriosis of the uterus.

Treatment of the above gynecological diseases with sodium thiosulfate solution should be performed simultaneously the use of other drugs, the action of which is aimed at restoring the functions of the female reproductive systems.

In this case, sodium thiosulfate is indicated for intravenous administration. The dosage and duration of therapy is determined by the gynecologist.

With psoriasis

Sodium thiosulfate has anti-inflammatory effects. Patients suffering from psoriasis can apply this substance to the surface of the skin, which shows signs of damage from this autoimmune disease.

The course of treatment, as well as the frequency of treatments for psoriatic plaques, must be agreed individually with the attending dermatologist.

The therapeutic effect of the use of sodium thiosulfate is enhanced if the initial prerequisite for the development of psoriasis was dermatological diseases of an infectious or parasitic nature.

With scabies

People whose skin is infected with scabies mites can use sodium thiosulfate topically.

The table below provides a step-by-step treatment for this parasitic disease:

Step-by-step therapy for scabies	Organization of the treatment process
Leather processing	In this case, a solution of the complexing substance E539 with a concentration of 60% is rubbed into the epithelial tissues of the trunk, upper and lower extremities. Particular attention is paid to the abdomen, forearms, inner thighs.
Application of sulfuric acid solution	After drying of sodium thiosulfate, sulfuric acid of 6% concentration is applied to the affected areas of the body. This substance enhances the antiparasitic properties of the antidote, and the minimum amount of the main substance does not cause chemical burns, and is also completely safe for humans organism.

After treatment of the skin surface, mass death of sexually mature individuals of the itch mite and already laid larvae occurs.

Slimming

The substance sodium thiosulfate is not formulated for weight loss. The purpose of this chemical compound is to neutralize the toxic properties of mercury, heavy metal salts, cyanides and other harmful components.

For quick weight loss, sodium thiosulfate is used in everyday life to reduce weight, but at the same time not devote much time to sports activities. For this purpose, 1 ampoule of antidote E539 solution is added to 250 ml of water at room temperature, and then drunk in the morning on an empty stomach.

After that, you need to eat a slice of lemon. A slimming course with sodium thiosulfate lasts from 7 to 10 days. At the same time, the attitude of doctors to this method of getting rid of excess weight is negative, because this substance is created for intravenous and external use.

Sodium thiosulfate and alcohol

Sodium thiosulfate reduces the toxic effect of alcohol, maintains stable liver and kidney function.

People who simultaneously take the antidote E539 and drink alcohol do not face symptoms of alcohol intoxication, hangover syndrome, or their manifestations are insignificant.

Sodium thiosulfate is used by physicians to restore the functions of internal organs and the central nervous system in patients who were admitted to the hospital of a medical institution with signs of severe poisoning with ethyl alcohol.

The positive effect of blood detoxification and restoration of liver function occurs within 1-2 hours, depending on the severity of the clinical case.

Side effects and overdose

Violation of the prescribed dosage regimen with a complexing agent sodium thiosulfate can lead to the appearance of allergic reactions in the form.

Namely:

• hyperemia of the skin;
• hives;
  
• itching of the treated areas of the epidermis;
• bronchial spasm;
• anaphylactic shock.

Side effects from the use of the antidote E539 are manifested by similar symptoms. Local and extensive allergic reactions are what can happen to a person in case of an overdose or hypersensitivity of his body to sodium thiosulfate.

Interaction of sodium thiosulfate with other medicines

Sodium thiosulfate can be used in combination with buffer solutions or sorbent preparations.

The simultaneous use of this substance with medicines that contain hyposulfite or sodium nitrite, enhances the therapeutic effect of the antidote E539 in neutralizing the toxic properties of cyanides.

Analogs

The main analogue of the complexing agent E539 is the preparation Sodium sulfate.

Most of the pharmaceutical companies in the Russian Federation and neighboring countries are engaged in the release.

Prices

The average cost of an injection solution of sodium thiosulfate with 30% concentration in 10 ml ampoules is from 69 to 79 rubles. per packing. Sodium thiosulfate is a chemical that has a high biological activity towards compounds of arsenic, mercury, heavy metal salts and halogens.

The tool is found under the code designation E539. Sodium thiosulfate is used to quickly detoxify the body of people who have suffered cyanide poisoning.

During the biochemical reaction of the antidote E539 with compounds of hydrocyanic acid, the latter is split into less toxic components that are excreted from the patient's body by the kidneys. Sodium thiosulfate is indicated for intravenous and external use.

Treatment of the skin with a substance allows you to get rid of the parasitic activity of the itch mite. Sodium thiosulfate is completely harmless, the main benefit of which is to create a detoxifying effect.

Video about sodium thiosulfate (E539)

Cleansing the body with sodium thiosulfate: