Vinpocetine tablets 5 mg. Price, instructions for use, analogues, what is needed for, reviews

The drug Vinpocetine in a dosage of 5 mg is recommended for patients who have suffered a stroke or suffer from cerebral vascular pathologies. The tablets improve blood flow and metabolism in the central nervous system. But before starting therapy, you need to familiarize yourself with the rules for taking the medicine, as well as find out the price for it.

Terms of dispensing from pharmacies, drug price

Vinpocetine (5 mg tablets, the price of which depends to a greater extent on the manufacturer, is included in the list of prescription drugs) in the cities of Russia has the following value in rubles:

City	OJSC Renovation PKF	Pharmproject JSC	Ozone LLC	Izvarino Pharma LLC
Moscow	114	62	120	169
St. Petersburg	103	65	119	176
Kazan	109	59	115	172
Saratov	112	55	123	171
Ufa	108	54	114	175
Nizhny Novgorod	128	59	112	168
Yoshkar-Ola	109	54	110	167

Composition, release form

One of the forms of release of the medication is tablets. They contain vinpocetine as an active ingredient. The drug is produced by several companies, so the composition of its auxiliary components may differ significantly.

The following inactive components may be included in the tablets:

• milk sugar;
• MCC;
• E-572;
• povidone-K25;
• maize or potato starch;
• E-553b;
• sodium carboxymethyl starch;
• copovidone;
• aerosil.

Principle of operation and efficiency

Vinpocetine belongs to psychostimulating and nootropic medicines. It improves the blood supply to the brain, as well as the metabolism in it, and has a positive effect on the rheological properties of blood.

Vinpocetine protects brain cells from damage, that is, it has a neuroprotective effect.

It reduces the harmful effects of excitatory amino acids, inhibits sodium and calcium channels, NMDA and AMPA receptors, selectively blocks calcium-calmodulin-dependent-cGMP-phosphodiesterase. While taking the drug, the exchange of serotonin and norepinephrine in the central nervous system increases. The drug has an antioxidant effect.

Vinpocetine, as a result of reducing the excessive viscosity of the blood mass, increases the blood supply to the brain. Suppresses the reuptake of adenosine, it weakens the affinity of oxygen for red blood cells, as a result, it better passes into cells.

Vinpocetine selectively improves the blood supply to the brain, since it reduces the resistance of the vessels of the central nervous system, while blood pressure, cardiac output, heart rate, and systemic vascular resistance do not change. While taking the medication, there is no “stealing” effect.

According to the manufacturer, the nootropic drug improves cognitive function in patients with chronic cerebral vascular pathologies.

After oral administration, the medication is rapidly absorbed. Its highest content in the blood is noted after 1 hour, and in the tissues 2-4 hours after ingestion.

Absorption of the drug occurs mainly in the proximal intestine.

Up to 66% of the dose taken binds to blood plasma proteins, the bioavailability of the drug is approximately 7%. Passing through the liver, the medication is metabolized. The nootropic agent does not accumulate in the body, therefore, patients with liver and kidney dysfunction can drink the medicine as usual.

Up to 60% of the dose taken from the body is excreted in the urine, the rest in the bile. Vinpocetine is obtained from vincamine, which is an alkaloid of the evergreen perennial plant Periwinkle Minor and is also used for vascular pathologies.

He was the first to distinguish it in 1975. Hungarian chemist Csaba Santay. And 3 years later, the Hungarian pharmaceutical company Gedeon Richter began the production of a synthetic medication based on vinpocetine.

Currently, the nootropic is registered as a drug in Eastern Europe, while in the United States of America it is sold only as a dietary supplement.

It was also banned from selling in Australia, New Zealand, Canada, as it is considered a drug with unproven efficacy and can cause a number of adverse reactions. And in Russia, it is included in the list of vital and necessary medicines.

In experimental studies, it was found that the drug stops the inflammatory process, dilates blood vessels, protects tissues from the aggressive effects of antioxidants, has a neuroprotective and antiepileptic effect action. The medicine prevents platelet adhesion and oxygen starvation of tissues, improves cerebral circulation, and reduces blood viscosity.

But there have also been a number of meta-analyzes that have not confirmed that the drug improves the survival of patients with acute stroke.

In 2006 g. a study was conducted that proved that the drug protects the endothelium in people suffering from chronic cerebral ischemia. In such patients, endothelium-dependent vasodilation is restored, which is important in arterial hypertension, discirculatory encephalopathy.

A number of studies have shown that the drug can redistribute blood flow in ischemic areas of the brain and improve glucose delivery to it in people who have had a stroke.

In 2003 g. 3 clinical studies were conducted in which patients of the older age group with memory problems took part, but the final results were not convincing enough.

A clinical study was also conducted in Russia, in which 6065 people took part, complaining of dizziness. They took a nootropic drug in a daily dosage of 30 mg for 2 months.

In the course of these trials, a decrease in the number of dizziness, a decrease in the number of headaches and ringing in the ears, a decrease in anxiety was noted in patients, and their gait became more stable.

Indications for use

Vinpocetine (5 mg tablets, the price of which is not very high) is recommended for the following pathologies:

• tinnitus;
• Meniere's disease (this is a pathology of the ear of an unclear nature, which is characterized by the absence of pus, an increase in the amount of endolymph and intra-labyrinth pressure, the appearance of attacks of hearing loss (usually one-sided), dizziness, ringing in the ears, disturbances balance);

  

• sensorineural hearing loss;
• chronic eye pathologies of vascular origin.

They can be taken to relieve complications that have arisen after the following diseases:

• ischemic stroke, in which, due to a violation of cerebral circulation, brain dysfunction is observed;
• dementia of vascular origin;
• cerebral atherosclerosis;
• encephalopathy due to trauma or hypertension;
• vascular vertebrobasilar insufficiency, in which there is dysfunction of the brain due to a weakening of blood flow in the basilar and vertebral arteries.

Contraindications and side effects

The price and therapeutic effect of vinpocetine in 5 mg tablets are not grounds for uncontrolled administration of the drug. It has a number of contraindications and side effects.

It is forbidden to take the remedy for the following health problems:

• hemorrhagic stroke in the acute stage;
• strong phenomena of arrhythmias;
• IHD in complicated forms;
• allergy to medication.

If milk sugar is included in the fillers, then the tablets should not be drunk with lactose intolerance.

Vinpocetine should not be given to children, since there is not enough data on how the medication affects a growing body. The drug is contraindicated in women in position, since it crosses the placenta and can provoke placental bleeding and miscarriage.

The medication penetrates into breast milk, therefore, during therapy, it is necessary to transfer the baby to artificial feeding.

It should be taken with caution in case of angina pectoris, small arrhythmias.

Vinpocetine can cause the following adverse reactions:

• gluing of erythrocytes, lowering hemoglobin, reducing the number of leukocytes and platelets;
• lack of appetite;
• diabetes mellitus, increased blood cholesterol levels;
• deterioration in sleep, anxiety, depression, euphoria, drowsiness;
• allergy;
• headaches, memory loss, trembling of certain parts of the body, taste perversion, spasms, stupor, one-sided paralysis;
• redness of the conjunctiva, swelling of the nipple of the optic nerve;
• attacks of dizziness, ringing in the ears, hyper- or hypoacusia;
• increased or decreased heart rate, atrial fibrillation, heart rhythm disturbances, angina pectoris, coronary artery disease, heart attack, increased or decreased blood pressure, thrombophlebitis, hot flashes;
• unpleasant and painful sensations in the abdomen, dryness in the oral cavity, impaired swallowing, stomatitis, loose stools, lack of defecation;
• increased sweating;
• dermatitis;
• discomfort in the chest;
• impotence;
• lowering the temperature;
• weight gain;
• decrease or increase in the number of eosinophils;
• decrease in thrombin time.

Dosing regimen and overdose

Vinpocetine (5 mg tablets, the price of which depends on the specific manufacturer, should be prescribed by the attending physician) is taken individually, depending on the severity of the clinical picture.

To start the drug, you need to take 5 mg three times a day. With good tolerance and insufficient therapeutic effect, a single dose can be increased to 10 mg three times a day. The highest daily dose should be 30 mg.

The course of admission can vary from 1 to 3 months.

So far, there have been no cases of overdose with Vinpocetine tablets. But if this happened, then the antidote is unknown, therefore symptomatic therapy is recommended to the victim. It is necessary to induce vomiting, for which drink 2 liters of water, place the index and middle fingers in the mouth and press on the root of the tongue. Also, in case of poisoning, it is recommended to take an enterosorbent, for example, Enterosgel.

Instructions for use

According to the instructions for use, the tablets should be drunk after meals. The therapeutic effect of them begins to be felt after about 7 days from the start of therapy.

special instructions

If a person has a syndrome of lengthening the QT interval or he receives medications against the background of treatment with Vinpocetine, which lead to this, then an electrocardiogram should be periodically done.

The medicine can cause undesirable reactions from the central nervous system and cardiovascular system, such as amnesia, falling blood pressure, so care must be taken when driving and when working on potentially hazardous production.

Interaction with other drugs

If methyldopa is taken in combination with Vinpocetine, then blood pressure decreases more strongly.

Although there is no information on how anticoagulants and antiarrhythmics affect, if they are used in combination with a nootropic agent, care must be taken when they are prescribed together.

Storage conditions and periods

Vinpocetine tablets 5 mg, the price of which is regulated by the manufacturer, have different storage conditions and shelf life (they must be specified in the annotation). The drug produced by Ozone LLC is allowed to be stored at temperatures up to 25 degrees, while the medicine Gedeon Richter LLC does not lose its medicinal properties if kept at a temperature of 15 to 30 degrees.

The shelf life of the tablets manufactured by KFK LLC is 24 months, while the drugs of Ozone LLC are 36 months.

Analogs

There are complete analogues of Vinpocetine on sale, the price level of which can be either higher or lower.

These are medications such as:

• Cavinton. This is a Hungarian drug produced by Gedeon Richter OJSC. One of the dosage forms of the drug are 5 mg tablets. They are round, flat, beveled and odorless. The color of the tablets is white or almost white. They have the inscription "CAVINTON" on one side. In addition to vinpocetine, the tablets include such inactive components as aerosil, maize starch concentrate, milk sugar, E-553b, E-572. They need to be stored in a non-humid place, the temperature should be in the range from 15 to 30 degrees. The shelf life is determined by the manufacturer at 5 years from the date of issue. The price of 50 Cavinton tablets of 5 mg is about 110 rubles.
• Korsavin. This is a domestic medicine that contains vinpocetine as an active ingredient. In addition to it, the following inactive ingredients are included in the tablets: MCC, E-553b, medical gelatin, E-572, potato starch powder, milk sugar. It should be stored in a light-protected, non-damp storage facility at temperatures up to 25 degrees. within 36 months from the date of issue.
• Telektol. This is a Russian drug containing vinpocetine as its main component. It is produced in blue tablets, which have a round convex shape on 2 sides. As inactive components, they contain starch, milk sugar, MCC, E-572, E-171, E-1201, blue dye, E-553b, E-551, E-464, copolyvidone. It must be stored in a dark, dry place at temperatures up to 25 degrees within 24 months from the date of production.

In addition, Vinpocetine substitutes for the therapeutic group are on sale, such as:

• Omaron. This is a domestic drug that is available in tablets. The therapeutic effect of it is explained by cinnarizine and piracetam. The first substance is a selective slow calcium channel blocker. It reduces the tone of smooth muscle fibers of the arterioles, dilates the vessels of the brain while not significantly lowering blood pressure. Cinnarizine reduces blood viscosity, prevents oxygen starvation of tissues, weakens the excitability of the vestibular apparatus and the effect of the sympathetic nervous system. Piracetam improves the blood supply to ischemic areas, improves the metabolism of substances in the brain, as well as the absorption of glucose by them, and prevents oxygen starvation of tissues.
• Lucetam. This nootropic comes in several dosage forms, including oral tablets. The medicine contains piracetam as the main component.
• Stugeron. This is a Hungarian drug that is produced in tablets. They contain cinnarizine as the main ingredient.
• Aminalon. This is a domestic nootropic medication, which is available in tablets. The therapeutic effect of it is explained by gamma-aminobutyric acid. It normalizes the metabolism in the brain, improves the absorption of glucose by its tissues, and helps to eliminate toxins from them. Against the background of its intake, memory improves, sleep is normalized, dizziness is weakened in patients with hypertension.

The tablets in question can only be purchased with a prescription, at a set price. They should be prescribed by a doctor, taking into account the indications, contraindications and tolerability of the nootropic agent. In addition, only a doctor can determine in what dosage Vinpocetine 5 mg should be taken.

Video about Vinpocetine

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