Etamsylate (Etamsylate) in ampoules. Instructions for use, where to buy, price, reviews

Etamsilate is a hemostatic medication, which has pronounced properties and helps to stop bleeding of various origins.

The tool in ampoules is considered more versatile, since the instructions for its use allow be used even when for some reason it is impossible to take others orally dosage forms. When used correctly, the risk of complications is reduced.

Terms of dispensing from pharmacies, drug price

Today, pharmacies dispense drugs by prescription from a specialist, which significantly reduces the risk of complications as a result of independent use.

The cost of the medication is quite affordable, it is about 80-100 rubles. per pack of 10 ampoules. That is why each patient, if necessary, can undergo a therapeutic course.

Composition, release form

The medicine is available to patients in the form of a clear, colorless solution for intramuscular or intravenous administration, packaged in 2 ml ampoules. Ampoules can be in cardboard boxes or plastic cells, which are also placed in cardboard boxes.

Each box contains 10 ampoules, as well as detailed instructions describing all the features of using the medicine, indications and contraindications. The composition of the medication contains the main component etamsylate, which has the main therapeutic effect.

Among the auxiliary components are the following:

• Water for injections.
• Edetate disodium.
• Sodium disulfite.
• Anhydrous sodium sulfite.

Additional substances do not have a therapeutic effect, they are necessary to preserve the chemical formula.

Etamsylate in ampoules (instructions for use are attached to the medication) is not the only dosage form of the drug. The drug is also available in tablet form, but this form is less often prescribed due to the slower onset of the therapeutic effect.

Principle of operation and efficiency

The principle of action of the drug is based on its ability to exhibit hemostatic activity, which leads to stopping bleeding and improves the state of blood vessels. After entering the blood, the medicine normalizes the process of its coagulation and accelerates the formation of a blood clot in the area of ​​the affected vessel.

Experts note the ability of the drug to strengthen the vascular wall and improve microcirculation not only in the affected area. Against the background of normalization of blood circulation, a significant improvement in the general condition occurs, the development of complications is prevented.

Etamsylate in ampoules (instructions for use assumes a preliminary examination of the patient) is effective for different types and stages of bleeding, especially in combination with other drugs.

It has other properties as well:

• Helps to stop bleeding when used promptly, but does not provoke the rapid formation of many large blood clots.
• It does not affect the prothrombin index, which is considered an advantage, since it does not lead to the development of severe complications in patients who suffer from peripheral vascular pathologies.
• Strengthens the vascular wall and prevents its destruction.
• Normalizes microcirculation even in small vessels.
• Prevents profuse blood loss, as well as complications that develop against the background of this condition.
• It acts quite quickly, which allows it to be used in emergency situations when it is necessary to immediately get an effect.

The product is well absorbed in the body. When administered parenterally, it spreads through the systemic circulation, which provides a rapid onset of the therapeutic effect. The maximum concentration in the blood is observed 20 minutes after the administration of a single dose.

After that, the level of etamsylate in the blood gradually decreases. The ingredient is processed in the liver, where it is broken down into metabolites. The elimination period takes 8-15 hours, depending on the patient's body.

The main amount of the substance is evacuated with the help of the kidneys, a small part is excreted with feces. When using tablets, the absorption and excretion of the ingredients from the body is carried out more slowly, which somewhat slows down the onset of the therapeutic effect. Pharmacokinetic characteristics may differ from patient to patient.

In acute disorders, a parenteral dosage form is used, in the subacute course of the disease, the use of tablets is sufficient.

Indications for use

Etamsilate in ampoules and other dosage forms is prescribed for various disorders.

Instructions for use assumes use in the following cases:

• Bleeding from injuries of limbs, skin. The drug is prescribed in an acute and advanced form of a disorder.
• Uterine bleeding against the background of pathologies of the inner layer of the uterus, as well as the formation of benign tumors.
• Bleeding during surgery on internal organs, dental procedures.
• Carrying out gynecological or urological procedures, accompanied by bleeding.
• Internal bleeding against the background of lesions of the mucous membranes of the digestive tract. For example, with an exacerbation of peptic ulcer and perforation of the organ wall, the agent helps to significantly improve the condition and prevent profuse blood loss.
• Profuse capillary bleeding.
• Menses with excess blood flow. At the same time, there is a risk of developing anemia if profuse blood loss occurs every month.
• Diabetic angiopathy, accompanied by violations of the vessels of the lower extremities.
• Hemorrhagic diathesis of various forms and degrees of neglect.

The drug is often included in the course of therapy for pathologies of internal organs, accompanied by blood loss. In each case, the doctor decides on the prescription of the medication.

Contraindications and side effects

The drug is not used when identifying intolerance to the components of the composition or a tendency to similar manifestations. It is contraindicated if the patient develops allergies when using similar medications earlier.

There are other contraindications:

• Tendency to thrombosis.
• Peripheral arterial thrombosis.
• Acute thrombophlebitis, accompanied by varicose veins.
• The development of bleeding against the background of the use of drugs to thin the blood. In this case, the use of the medicine is ineffective, but it can provoke complications.
• Acute renal failure. With such a violation, the performance of the paired organ may deteriorate.
• Severe liver failure. The condition is not considered an absolute contraindication, but it is possible to aggravate the course of the underlying disease.
• Acute cerebrovascular accident.
• Myocardial infarction in the acute period. After the disappearance of the expressed symptoms, it is allowed to use the remedy in the absence of other contraindications.
• The first trimester of pregnancy is considered a relative contraindication, since the remedy is used quite rarely and with extreme caution.

The drug is not used when patients have an increase in the level of platelets in the blood against the background of any diseases. The agent is used with caution in many heart diseases, since they are often accompanied by thickening of the blood.

Etamsylate in ampoules (the instructions for use of the medication suggest the selection of the dosage in each case individually) can provoke adverse reactions if used improperly. Compliance with all recommendations does not guarantee the absence of complications. Negative symptoms affect the work of internal organs and systems.

Organs and systems	The most common complications
Nervous system	From the side of the nervous system, complications are rare. Sometimes patients talk about headache, dizziness, sleep disturbance. Some people report increased irritability, weakness, and decreased performance. Only in some cases is there a disturbance of consciousness, seizures and some other neurological disorders.
Digestive tract	On the part of the digestive system, complications often occur when using tablets, but in the case of administration of a solution, they are also not excluded. The most common symptoms are nausea, epigastric pain, and indigestion. Some people note a stool disorder, but the nature of the disorder depends on the individual characteristics of the organism. Some develop frequent loose stools, while others report persistent constipation.
Respiratory system	Shortness of breath and difficulty breathing are observed during therapy quite often, but in the case of improper use. In this case, there is an aggravation of symptoms from the nervous system. Usually, the manifestations disappear after stopping the use of the medication. If the patient has a history of bronchial asthma or chronic obstructive pathologies of the lungs and bronchi, the symptoms disappear after the use of special medications.
Heart and blood vessels	On the part of the cardiovascular system, complications manifest themselves in the form of tachycardia, heart rhythm disturbances and fluctuations in blood pressure indicators. Disorders can significantly aggravate the condition of patients, especially in the case when they suffer from diseases of the heart or blood vessels of a chronic form. If there is a history of thrombophlebitis, it is possible to aggravate its symptoms, increase pain in the area of ​​the affected vessels.
Blood system	An increase in the level of platelets in the blood is often observed when the solution is used, despite the absence of a significant effect of the drug on blood parameters. The violation can be accompanied by the formation of blood clots, which aggravates the condition and often provokes a violation of blood circulation.

An allergic reaction to a drug manifests itself with standard symptoms in the form of a skin rash, severe itching, peeling and irritation. Sometimes the symptoms are aggravated, there is swelling of the mucous membranes of the eyes, as well as the development of allergic rhinitis, which complicates nasal breathing and provokes other complications.

Experts have not recorded cases of drug overdose, but such a possibility cannot be ruled out. Usually, an overdose develops with prolonged use of the drug in high doses without a doctor's prescription. At the same time, all negative reactions are aggravated, there is a significant deterioration in the condition and the development of other disorders.

If negative reactions or symptoms of an overdose appear, you should stop using the medication and visit a doctor. The patient receives help in a hospital, within a few days his condition is normalized. The drug does not have a specific antidote, therefore, in the event of such violations, the therapy regimen is selected individually, depending on the symptomatology.

Instructions for use

The medicine can be administered intramuscularly or intravenously. The first method is used more often. The daily dosage of the solution for mild bleeding is 2 ml. 1 ml of the product contains 125 mg of the active ingredient, that is, in 1 ampoule the dosage reaches 250 mg.

The maximum daily dosage is 6 ml, but it is divided into 3 times during the day at regular intervals. The duration of treatment is also determined individually, depending on the neglect of bleeding and the presence of concomitant deviations. Usually the drug is administered intramuscularly. This does not require the addition of sodium chloride.

If the agent is administered intravenously, 10 ml of sodium chloride 0.9% is required for 2 ml of solution. The drug can also be given intravenously using a dropper. In this case, the daily dosage is also no more than 6 ml, but the solution is added to 200 ml of sodium chloride. The introduction is carried out at a speed of 60-70 drops per minute. The course of therapy with droppers lasts 5-20 days, depending on the severity of the symptoms.

If necessary, several courses are carried out when patients bleed again. In each case, a preliminary blood test is required to assess the condition and note changes in indicators.

With uterine bleeding

Etamsylate in ampoules (instructions for use assumes the appointment strictly according to indications) is often used for uterine bleeding of varying degrees of neglect. In this case, the duration of the therapeutic course is 5-7 days. This is usually sufficient to obtain a therapeutic result.

The agent can be administered intramuscularly 2 ml 3 times a day or intravenously using a dropper, adding a daily rate of 200 ml of sodium chloride. The introduction is carried out at a speed of 60 drops per minute. If necessary, the patient's blood pressure indicators are measured, and after completing the course, the blood is examined to identify the main indicators.

With heavy periods

With heavy menstruation in women, the remedy is used to prevent the development of anemia as a result of regular and heavy blood loss. Use is started 3 days before the onset of menstruation, 2-4 ml of solution is injected per day. The application continues for another 2-3 days after the end of menstruation.

Usually, pills are used for such violations, but not every patient can use them. The appointment of the remedy must be done by a doctor. In case of complications, it is worth stopping the application immediately and visiting a specialist. It is not recommended to use the solution on your own to prevent heavy menstruation.

With hematuria

When an impurity of blood appears in the urine, the solution is used in order to prevent such a violation, but after a preliminary examination, which makes it possible to identify the cause of the pathology.

The drug is administered intramuscularly, 2 ml 2 times a day for 5-7 days. If necessary, the treatment is extended, but only after consulting a doctor.

During pregnancy

During pregnancy, the remedy in most cases is used to stop bleeding and prevent premature birth or spontaneous miscarriage. The therapy is carried out in a hospital under the supervision of a physician. The daily dosage depends on the degree of bleeding. Usually, the introduction of 2-4 ml of the drug per day is sufficient, but sometimes an increase in the daily dosage to 6 ml is required.

The agent is injected intramuscularly, only in some cases it is injected intravenously by jet or by means of a dropper. The duration of treatment is different for different patients. For some, 10 days is enough, others receive injections for 2-3 weeks. Often, the drug is combined with other drugs that enhance the effectiveness of therapy.

Interaction with other drugs

The drug is not prescribed simultaneously with other hemostatic agents based on the same active ingredient, as this can provoke the formation of blood clots. In one syringe, the solution is not mixed with other liquid dosage forms. The exception is sodium chloride and water for injection.

Do not use the solution in combination with anticoagulants, as well as angioprotectors. If necessary, the course is stopped and other means are used. The drug has no effect on the action of systemic medicines if a parenteral dosage form is used. In the case of using tablets, you should not combine the reception with antacids, enterosorbents and gastroprotectors.

In each case, before starting to use any medications, you should first consult with a specialist.

Storage conditions and periods

It is allowed to store the medication for 3 years. The production date is indicated on the packaging. During storage, it is important to prevent direct sunlight from entering the solution.

It is forbidden to use the medicine after the expiration date.

Analogs

In the absence of a medication in pharmacies or the impossibility of using it, it is allowed to use substitutes with similar therapeutic properties.

Analogues have the same effect on the body, but may contain other active ingredients:

• Dicinon - a drug based on etamsylate, which is available in the form of a solution and tablets for oral use. The drug is highly effective, helps to stop bleeding and significantly improves the condition, even with severe blood loss. The remedy is prescribed in short and long courses, depending on the disease and the presence of concomitant deviations. Tablets are taken orally, 2-4 pieces per day, the solution is administered intravenously or intramuscularly, 2-6 ml per day, depending on the state of neglect.

  

• Tranexam - a drug based on tranexamic acid, which is considered more effective in stopping bleeding. The medication is also available in the form of tablets and parenteral solution. Application is allowed with heavy menstruation, uterine bleeding and other conditions accompanied by heavy blood loss. The remedy acts quite quickly, is effective, which usually helps to shorten the period of therapy. The solution is in most cases administered intravenously, 5 ml per day. It should also be diluted with sodium chloride, which will weaken the negative effects of the drug on the body.

Substitutes for the remedy are indicated when the patient cannot, for any reason, use the original medication. However, the appointment is made by the doctor; it is forbidden to replace the medication on his own.

Etamsilate in ampoules is considered a fairly effective remedy for stopping bleeding, instructions for the use of which involves the appointment after a preliminary examination and identification of the cause diseases. Correct use of the medication helps to significantly shorten the recovery period and prevent complications associated with blood loss.

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