Xyzal drops for children. Instructions, reviews

Xizal is an Italian medicine, which is used to eliminate the cause and symptoms of allergies. The medication is produced in the form of tablets and drops for oral administration. The advantages of the drug include the speed and duration of action, as well as the possibility of its use for children.

Composition and form of release

Ksizal drops have the appearance of a transparent and colorless solution, which is odorless and practically tasteless (their taste is not felt in the liquid). The drug is placed in brown glass bottles in a volume of 10 or 20 ml. The bottle is sealed with a dropper and a protective cap. In this case, to open the bottle, you must first press the cap, and then turn it counterclockwise (arrow is indicated on the cap). The bottle is packed in a cardboard box along with instructions.

The antihistamine effect of Ksizal drops is provided by the following components:

List of substances	Characterization of substances
The main component
Levocetirizine dihydrochloride	The element blocks receptors sensitive to allergens, lowers vascular permeability, prevents the production of substances responsible for the development of inflammation. In addition, it reduces the severity of allergic symptoms (reduces swelling, itching). In this case, the component does not cause severe drowsiness.
Additional components
Sodium acetate	The substance acts as a preservative and stabilizer, and also enhances the effect of the main component.
Sodium saccharinate	The element is used as a sweetener, its disadvantage is the presence of a metallic taste.
Propylene glycol	The component is used as a solvent that has analgesic and anti-inflammatory effects.
Glycerol 85%	The substance has a laxative effect, and also has a protective effect on the mucous membranes of the digestive tract.
Methyl parahydroxybenzoate	The element is used as a preservative.
Propyl parahydroxybenzoate	The component is a preservative with a disinfecting effect.
Acetic acid	The substance is necessary to dissolve the components used.
Purified water	The ingredient gives the drops the desired concentration and texture.

1 ml of drops contains 5 mg of the main component.

Terms of sale, storage, prices

Ksizal drops for children cannot be purchased without a prescription from a doctor. At home, the drug should be placed in a dark place, and the ambient temperature should be in the range of 6 to 27 degrees. The duration of storage of the drug in a closed form is 3 years. After the bottle is opened, the contents must be used within 3 months.

Ksizal drops, when taken in large doses, can cause the development of severe poisoning, so they should be kept away from children.

The price of a bottle of Ksizal drops depends on the volume of the bottle and the region of sale:

Vial volume	Minimum price	Maximum price
10 ml	RUB 430	RUB 570
20 ml	670 rbl	RUB 760

Even when ordering a medication on the Internet, a prescription is required when purchasing it. It should be presented to the courier.

Pharmacological properties

Ksizal drops belongs to a group of medicines used to eliminate or prevent the development of allergy symptoms.

Pharmacodynamics and pharmacokinetics

Ksizal drops for children after oral administration show the following therapeutic activity:

• block receptors susceptible to allergens, while the blocking effect is much stronger than that of Cetirizine (a popular antihistamine);
• eliminate or mitigate the severity of an allergic reaction;
• have a laxative effect, contributing to a faster removal of allergens from the body;
• prevent the production of exudate (fluid formed during inflammation);
• reduce itching;
• reduce vascular permeability, as a result, the allergen is less spread throughout the body;
• reduce the activity of eosinophils (leukocytes involved in the destruction of multicellular parasites);
• have a mild analgesic effect;
• prevent the development of inflammation.

At the same time, the use of the drug does not affect the cells of the nervous system, which are responsible for drowsiness and brain activity.

After swallowing drops, the elimination of allergy symptoms is noted within 60 minutes and can last up to a day. It should be borne in mind that food intake does not affect the quality and rate of absorption of the medication. The components of the drops are excreted from the body by the kidneys (about 13%) and with feces (about 85%).

Indications for use

Ksizal drops are used in pediatrics with the following allergy symptoms:

• itching of varying severity;
• sneezing;
• nasal congestion, with or without rhinitis;
• severe tearing or redness of the eyes;
• inflammation of the mucous membranes of the nose or eyes;
• hives. The symptom is manifested by severe itching and the appearance of blisters on the skin (the symptomatology is similar to skin irritation after contact with nettle);
• strong current from the nose;
• allergic symptoms caused by an insect bite;
• various skin rashes, from small spots to purulent papules;
• Quincke's edema (allergy is expressed by swelling of the skin, mucous membranes and tissues, compression of the trachea with subsequent suffocation is more often noted).

To prevent the development of seasonal allergies.

Contraindications

Ksizal drops can be prescribed by a pediatrician only after the patient has excluded all contraindications, which are the same for both adults and children:

• increased sensitivity or allergy to the composition of the drops;
• severe renal failure (if the pathology is mild or moderate, then the agent is used under the supervision of a physician);
• the presence of neoplasms in the prostate gland;
• violation of the outflow of urine from the body (the active substance provokes urinary retention in the body);
• the presence of damage to the tissues of the spinal cord.

Until the child reaches 2 years of age, drops are not used, since their safety for this age has not been proven.

Method of administration and dosage for children

Drops of Ksizal should be diluted in water before taking (a tablespoon or teaspoon is enough), the solution is not prepared in advance. For children, water can be replaced with tea, compote or juice.

The dosage of the medication depends on the age of the patient, the presence of renal failure and the severity of the manifestation of the symptoms of pathology:

Indications	Age	Dosing rules	Course and notes
Chronic allergies of mild to moderate severity	From 2 to 6 years old	1.25-2.5 mg or 5-10 drops per day.	Ksizal is used no more than 4 times every 7 days. The course can last up to 1 month. If necessary, the doctor can make adjustments to therapy.
6 to 12 years old	2.5-5 mg or 10-20 drops over 24 hours.
Chronic allergy in severe form	From 2 to 6 years old	2.5 mg or 10 drops throughout the day.	The remedy is taken every other day. The duration of the course can be up to 6 months. It is possible to take the medication more often with the permission of the doctor.
6 to 12 years old	5 mg or 20 drops in 24 hours
Prevention of seasonal allergies	From 2 to 6 years old	Take 1.25 mg or 5 drops 1-2 times a day.	It is recommended to start using drops one day before the onset of the alleged seasonal allergy. At the same time, the duration of treatment for each patient is individual.
6 to 12 years old	Use 2.5 mg or 10 drops 1-2 times every 24 hours.
Quincke's edema	From 2 to 6 years old	2.5 mg or 10 drops one time. The multiplicity of the prima is selected individually.	On the first day after the onset of signs of allergy, the indicated dosage is used. Further, provided that the victim's well-being improves, the dose may be reduced by 2 times. The duration of therapy can only be determined by a doctor, according to the dynamics of stabilization of the patient's condition.
6 to 12 years old	5 mg or 20 drops one time. The frequency of admission is set to improve well-being.
A sudden, mild to moderate allergic reaction	From 2 to 6 years old	1.25-2.5 mg or 5-10 drops in 24 hours.	In case of a sudden allergy (insect bite, ingestion or inhalation of an allergen), the earlier the drops are taken, the less likely the signs of an allergic reaction will worsen.
6 to 12 years old	2.5-5 mg or 10-20 drops throughout the day.

If the allergy manifests itself in an extremely severe form (the victim has lost consciousness or cannot swallow the medication due to laryngeal edema) drops are not suitable for use.

If a child has renal failure, the dosage is calculated individually according to the patient's weight and the level of keratin in the blood using the following formula:

KK = Mx (140-B) / 72xKS,

Where:

CC - blood clearance, it is used to determine the permissible daily dosage;

M is the weight of the child, indicated in kg;

B is the patient's age (in years);

CS - serum creatinine (the patient should know the CS value from the last blood test, since tests for kidney pathology are taken regularly).

When calculating the dosage value for female children, the result should be multiplied by 0.85.

For children over 6 years old, the dosage value of drops can be used from the table:

The severity of kidney damage	QC for boys	QC for girls	Dosage
The body is working normally	The value is more than 80 ml / min.	The number is less than 68 ml / min.	5 mg or 20 drops once a day.
Mild kidney damage	50 to 80 ml / min.	42 to 68 ml / min.	5 mg or 20 drops one time or divided into 2 doses.
Moderate severity	30 to 50 ml / min.	25 to 42 ml / min.	Use 5 mg or 20 drops once every 48 hours.
Severe renal impairment	Less than 30 ml / min.	Less than 25 ml / min.	Take 5 mg or 20 drops once every 72 hours.
Hemodialysis (blood purification using an artificial kidney)	Less than 10 ml / min.	Less than 8 ml / min.	Drops are not used, since their use can lead to organ failure.

In case of liver dysfunction, an individual dosage calculation is not required. The average course duration can be from 7 to 42 days. In extremely rare cases, it is allowed to extend the course of therapy up to 1.5 years.

Side effects

Ksizal drops for children can cause the development of a negative reaction, which is manifested by the following symptoms:

• drowsiness, weakness or fatigue, deviations occur if an increased dosage of drops is used;
• headache;
• a feeling of the taste of metal in the mouth;
• dry mouth;
• abdominal discomfort or pain;
• neuropsychic weakness;
• deterioration of vision;
• increased frequency and thinning of the stool;
• nausea or lack of appetite;
• the appearance of cramps in the limbs;
• hallucinations;
• exacerbation of allergy symptoms if the child is allergic to the components of Ksizal drops;
• an increase in the number of heart contractions;
• shortness of breath or difficulty breathing;
• muscle pain;
• temporary cessation of breathing;
• deterioration of the outflow of urine or, on the contrary, urinary incontinence;
• disruption of the kidneys, especially in the presence of pathologies in this organ;
• aggression or increased arousal;
• the development of a depressive state or the appearance of suicidal thoughts;
• muscle weakness;
• violation of blood circulation in the tissues of the brain (very rare);
• fainting;
• the development of thrombosis;
• inflammation of the liver tissue.

With long-term treatment, an increase, but more often a decrease, in body weight is possible.

Overdose

It is required to take drops of Ksizal strictly in the dosage selected by the doctor, since in the case of using the drug in large quantities it is possible the development of poisoning, accompanied by the following symptoms:

• a pronounced desire to sleep, accompanied by severe weakness;
• migraine or severe muscle pain;
• frequent vomiting;
• respiratory failure up to respiratory arrest;
• abdominal pain with varying intensity of manifestation;
• severe irritability, excitability, or anxiety;
• double vision or blurred images;
• diarrhea;
• lack of appetite;
• the development of seizures;
• falling out of reality;
• severe dry mouth;
• lack of urine or urinary incontinence;
• pronounced disruption of the kidneys or their refusal to work;
• loss of consciousness;
• deterioration of the condition and work of the liver;
• anaphylactic shock if the child is allergic to the components of Ksizal drops.

In the case when the poisoning occurred with a single dose and after the moment of taking the medication no more than 40 minutes have passed, then gastric lavage will be effective. Further, the patient must take sorbents, and after about 2 hours, symptomatic therapy is used. If more than 1 hour has passed after the poisoning, or a large number of drops were taken during the day, then the victim is immediately given sorbents, and then symptomatic therapy is selected.

There is no antidote against Ksizal drops. Also, if a child is poisoned with a drug (even if the dosage was slightly exceeded), it is necessary to go to the hospital to check the kidney function.

special instructions

Before you start taking Ksizal drops, you need to study special recommendations for their use:

• a solution of drops should be prepared immediately before using them, while it is better to dilute the product in warm drinking water;
• an overdose of medication is dangerous with a strong disruption of the kidneys, therefore, it is strictly forbidden to exceed it on your own;
• the first drops should be taken in the morning so that you can track the reaction of the child's body;
• if the allergy manifests itself in a severe form (severe suffocation), then Ksizal drops may be ineffective, since they do not begin to act immediately, but within 1 hour;
• if necessary, long-term use of the medication is required every 2-3 weeks to donate blood and monitor the condition of the kidneys and liver;

Ksizal drops can cause an imbalance in psychological balance and concentration of attention, this nuance must be taken into account when preparing for a test or exams in children.

Drug interactions

Ksizal drops for children should be used with caution with the following medicines:

• medicines containing ethanol increase the toxic effect of drops on the liver;
• sorbents should be taken about 2.5-3 hours before or after using Ksizal;
• Theophylline (the drug normalizes the activity of the lungs) contributes to the delay of the main component of the drops in the body;
• Ksizal enhances the effect of medications that affect the activity of the nervous system.

Diuretics taken with Ksizal increase the likelihood of kidney damage.

Analogs

Ksizal analogs (in the form of drops) are:

List of analogues, their prices and terms of sale	The active substance and action of the medication	Features of reception
Zyrtec drops with a volume of 10 ml cost about 110 rubles. Sale is free.	Cetirizine is the main element. The drug blocks histamine receptors, reduces the severity of allergy symptoms, and eliminates muscle spasms. The effect of the drops occurs within 20 minutes and can last up to 3 days (after the end of the course).	The analog can be used from 6 months. The main characteristics of the drug are identical to Ksizal drops.
Cetirizine drops with a volume of 20 ml cost 160 rubles. Prescription.	The main substance is cetirizine. The drug reduces the sensitivity of histamine receptors, and also reduces the severity of allergic symptoms. The therapeutic effect occurs (after taking the medication) within an hour and lasts about a day.	Cetirizine is prescribed from 6 months (up to a year taken under strict control). The main characteristics of the substitute are close to the original.
Zodak drops with a volume of 10 ml cost about 180 rubles. Sale is free.	The active ingredient is cetirizine. The drug prevents the effects on histamine receptors and reduces the severity of allergy symptoms. The action of the drops occurs within 1 hour and lasts up to 24 hours.	Zodak can be used from 6 months. Other characteristics of the drug are identical to Ksizal.
Cetrin. Drops with a volume of 10 ml cost approximately 240 rubles. Vacation is free.	The active ingredient is cetirizine. The drug blocks the sensitivity of histamine receptors. Also, the medication reduces the severity of allergy symptoms and eliminates spasms in the lungs. The therapeutic effect occurs within 20 minutes and lasts up to 72 hours.	Tsetrin is approved for use from 6 months. Before using the product, you need to familiarize yourself with its main characteristics.
Alerzin drops with a volume of 20 ml cost about 350 rubles. sale is free.	Levocetirizine dihydrochloride is the main substance. The tool reduces the sensitivity of histamine receptors. The effect of the drug occurs within 12 minutes and can last up to 48 hours.	Alerzin can be taken from 6 months. The drug has a large list of side effects.

Ksizal drops are allowed to be replaced with an analogue (especially for children) only in conjunction with a doctor. A specialist will select a more suitable remedy, taking into account the indications and the presence of prohibitions.

Ksizal won the trust of patients due to the rapid elimination of allergy symptoms, as well as the long-term preservation of the achieved effect. Subject to compliance with the selected dosage of drops, the likelihood of side effects is small. The disadvantage of the drug is the possibility of its use only for children over 2 years old.

Author: Kotlyachkova Svetlana

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