Antigrippin (Antigrippin) powder pharmacy. Composition

Antigrippin is a Polish drug, which is prescribed to eliminate the symptoms of the common cold. It can be purchased as a powder or effervescent tablet for suspension. In this case, the therapeutic effect of the drug, as well as the pharmaceutical composition of the main components, are the same for all forms of release.

Composition and form of release

Antigrippin powder is a small white granule.

Depending on the flavoring agent used, the preparation may have different shades and aromas:

• light yellow tint and lemon scent;
• pink tint (with varying degrees of color saturation) and raspberry aroma;
• light pink shade and smell of black currant;
• gray-beige and honey-lemon aroma;
• grayish-beige shade and dry chamomile smell.

The granules can crumble into small lumps that can be easily crumbled with finger pressure. Placed granules in sachets of 5 g. The carton can contain 1-16, as well as 20 or 30 sachets and instructions.

The constituent components of Antigrippin powder are:

List of components	Component Description
Main elements
Paracetamol	The component has a pronounced analgesic, antipyretic effect and a weak anti-inflammatory property. At high doses, paracetamol can cause serious damage to the kidneys, circulatory system and liver.
Chlorphenamine maleate	The substance eliminates spasms in the bronchi and intestines, removes tissue inflammation, reduces irritation in the nasopharynx. It also improves the clearance of mucus from the respiratory tract, suppresses the cough reflex and reduces allergy symptoms.
Vitamin C	The component protects cells from the harmful effects of toxins, helps to strengthen the immune system, has antioxidant properties, and also has anti-inflammatory and antihistamine effects.
Secondary elements
Sodium bicarbonate	The component liquefies phlegm in the bronchi, facilitates and accelerates its removal. It also restores the alkaline balance of the blood.
Lemon acid	The element normalizes metabolic processes, strengthens blood vessels, cleanses the blood of harmful substances, in addition, strengthens the immune system, has anti-inflammatory and bactericidal effects.
Sorbitol	The substance gives the powder sweetness without increasing the level of glucose in the blood, and also has a detoxification, choleretic and laxative effect.
Povidone	The component binds toxins and activates their excretion with feces.
Sucrose	The component is a preservative and gives sweetness to the finished suspension.
Sodium cyclamate	The element gives sweetness to the drug (ten times sweeter than sugar), and does not cause an increase in blood sugar.
Aspartame	The substance is used as a sweetener, which does not provoke a jump in glucose in the body.
Acesulfame potassium	The ingredient is a sweetener that does not affect blood sugar levels.
Dokuzat sodium	The component has a laxative effect, accelerating the removal of toxins from the body with feces.
Flavors (lemon, raspberry, black currant) or chamomile extract	The color of the powder, as well as its taste and aroma, depends on the selected flavoring agent.
Honey flavor	The substance gives the powder a honey aroma, and also has a laxative effect.
Caramel color	The component gives the powder a sweet aroma and gives the powder the desired shade.

The concentration of active elements in the powder is as follows: paracetamol - 500 mg; chlorphenamine maleate - 10 mg; ascorbic acid - 200 mg.

Terms of sale, storage, prices

Antigrippin powder, the pharmaceutical composition of which is presented above, is freely available. After purchase, the drug should be placed in a dark place, where the temperature should be in the range of 10 to 28 degrees above zero. The storage period of the medication, under these conditions, is 3 years.

The drug should be away from children, as its accidental use in large doses can cause the development of serious poisoning.

The cost of Antigrippin in powder form (10 sachets per package) is in the range of 330-420 rubles.

Pharmacological properties

Antigrippin (typical for all dosage forms) has three main actions - eliminates fever, pain and fights allergies.

Pharmacodynamics and pharmacokinetics

Antigrippin powder (the pharmaceutical composition can be specified on the package) after oral administration has the following effect on the body:

• eliminates pain symptom (joint, head and other pains provoked by a cold);
• prevents the development of allergies, and also reduces the severity of its symptoms, if the pathology has already manifested itself;
• eliminates heat;
• fights the development of inflammation;
• makes breathing easier by reducing swelling of the tissues in the nose;
• eliminates spasms in the bronchi, making breathing easier;
• removes irritation in the throat and sneezing provoked by a cold;
• accelerates the removal of harmful substances from tissues, and also protects cells from the effects of toxins;
• promotes loosening of the stool, as a result, the process of removing harmful substances from the body is accelerated;
• liquefies mucus and phlegm and facilitates its removal from the respiratory tract;
• strengthens the protective functions of the body;
• has a light disinfecting effect;
• helps to restore the alkaline balance and blood composition;
• prevents redness of the eyes and profuse lacrimation, which are caused by a cold;
• accelerates the process of repairing damaged tissues;
• has a strengthening effect on blood vessels;
• regulates metabolic processes in tissues;
• reduces the cough reflex, eliminating cough.

A decrease in cold symptoms is noted approximately 30 minutes after taking the drug and may persist for up to 4 hours. Active and auxiliary elements are excreted from the body mostly with urine, less with feces.

Paracetamol passes to the fetus through the placenta and into breast milk.

Indications for use

Doctors recommend using Antigrippin in powder form for colds of an infectious and inflammatory nature, occurring with high fever, cough, runny nose, as well as head and joint pain (for example, acute respiratory infections, flu, rotavirus infection other).

Contraindications

Antigrippin in powder form should be taken after familiarization with the contraindications and the pharmaceutical composition of the product.

The list of prohibitions includes:

• high sensitivity or allergy to the elements of the powder;
• exacerbation of pathologies of the digestive tract;
• liver failure in moderate and severe form;
• increased intraocular pressure;
• disruption of the prostate gland, accompanied by urinary retention in the body;
• severe violation of the composition of the blood (deficiency of iron, platelets, leukocytes);
• high pressure indicator;
• diabetes mellitus, since the powder contains sucrose;
• increased formation of oxalic acid, as well as excess salt content in the body;
• the presence of stones or sand in the kidneys, as well as moderate to severe renal dysfunction;
• the presence of cancers;
• carrying a child (all trimesters);
• increased content of bilirubin in the blood;
• the presence of alcohol dependence (in these patients, there is a pronounced violation of the liver);
• breastfeeding the baby.

Antigrippin in powder form is prohibited to use until the child reaches 15 years of age, since the effect of the drug on a growing body has not been studied. And also you need to take the remedy with caution to patients after 65 years, due to the deterioration of the body.

Method of administration and dosage

Antigrippin in powder form is recommended to be used after a meal, then the irritating effect of the drug on the gastric mucosa will be less pronounced. Before use, the product must be dissolved in 200 ml of water with a temperature of 45-50 degrees. The finished solution must be drunk immediately, the suspension cannot be stored.

Features of dosing powder Antigrippin:

Purpose of admission	Dosage	Course and notes
Mild catarrhal pathologies	Use 1-2 sachets every 24 hours.	Course up to 3 days.
Moderate colds	Take 2-3 packages during the day.	Duration of admission is 3-5 days. Combination therapy may be required.
Severe colds	Consume 3 packets per day.	Duration of treatment is 5 days. A complex intake of drugs is required.

The maximum daily dose is 3 packets, while the interval between the use of the product should not be less than 4 hours. But if the patient has mild renal or hepatic insufficiency, then Antigrippin should be taken no more often than after 8 hours. And also elderly patients should consume no more than 1 sachet per day.

Important. If, on the fourth day from the start of therapy, there is no improvement in well-being, then an adjustment of therapy is necessary. Additionally, it should be borne in mind that the drug cannot be taken for more than 5 days.

Side effects

Antigrippin powder (the pharmaceutical composition of the drug allows you to quickly eliminate the signs of a cold) can cause the development of the following side effects:

• swelling, urinary retention in the body due to impaired renal function;
• yellowing of the skin, pain in the right hypochondrium as a result of deterioration of the liver;
• an allergic reaction with varying degrees of symptoms, from itching to choking;
• a decrease in platelets in the blood, manifested by poor stopping of bleeding;
• anemia, expressed by rapid fatigue and decreased appetite;
• increased drowsiness, especially on the first day of taking the drug;
• a decrease in the pressure indicator;
• oppressive feeling in the chest;
• severe dizziness, especially when changing position;
• dry mouth;
• the development of bleeding in the digestive tract;
• diarrhea, or vice versa, constipation;
• deterioration of vision in the form of impaired focusing of the gaze or double vision in the eyes;
• dilated pupil;
• increased intraocular pressure;
• increased frequency or disturbance of the rhythm of heart contractions;
• urinary incontinence due to deterioration of the nervous system;
• violation of balance and coordination of movement;
• impairment of memory and concentration;
• hallucinations;
• muscle weakness;
• abdominal pain due to irritation of the stomach lining;
• flushed face;
• nausea, in rare cases vomiting was noted;
• increased nervous irritability;
• deterioration in sleep;
• in very rare cases, the appearance of sand in the kidneys;
• a sharp drop in blood glucose;
• confusion of consciousness.

Depending on the severity of the side effects, you may need to stop taking the drug or go to the hospital for medical care.

Overdose

When taking the drug for more than 14 days or with a single use of more than 10 sachets, the patient may develop the following symptoms of poisoning:

• pallor of the skin;
• severe abdominal pain;
• severe tremor of the limbs;
• constant desire to sleep;
• an increase in the number of heart contractions;
• arrhythmia (violation of the rhythm of the heart);
• yellowness of the skin due to an increase in bilirubin in the blood;
• deterioration of metabolism;
• severe swelling of the limbs;
• profuse vomiting, blood impurities are possible;
• diarrhea, blood may also be present in the feces;
• loss of consciousness, the development of a coma is possible;
• a sharp decrease in pressure;
• severe chest pain;
• severe impairment of the quality of vision;
• hallucinations;
• severe muscle weakness;
• temporary memory loss;
• insomnia;
• capillary necrosis;
• sharp weight loss;
• liver failure;
• disruption of the pancreas or gallbladder;
• the development of ulcerative formations in the digestive tract;
• bleeding in the eyes as a result of a strong increase in intraocular pressure;
• allergy in the form of anaphylactic shock.

To normalize the condition in case of a single poisoning, gastric lavage and subsequent symptomatic therapy are performed. If the poisoning has developed gradually, or the symptoms are pronounced, then a visit to the hospital is required.

special instructions

When choosing Antigrippin to eliminate cold symptoms, the following features of the drug should be considered:

• to eliminate the heat, the agent must be used no more than 3 days;
• in the fight against headache and joint pain, the duration of taking the powder is no longer than 5 days;
• Antigrippin is most effective when used from the first days of infection;
• for severe forms of disease, the drug is taken in complex therapy;

  

• you can not combine the remedy with alcohol intake, as it enhances the negative effect on the liver;
• prolonged use of the powder can cause serious disruption of the kidneys and liver;
• with prolonged therapy, it is necessary to examine the blood in order to determine the amount of iron, platelets and leukocytes in the blood;
• if the patient has diabetes, it should be borne in mind that the powder contains sucrose;
• control the indicator of bilirubin, uric acid and glucose in the body during a long course;
• Antigrippin affects the quality of vision and concentration of attention, therefore, when taking it, it is required to drive vehicles with caution and perform hazardous work.

Taking Antigrippin can cause an exacerbation of the symptoms of oncological pathologies.

Drug interactions

Antigrippin powder (pharmacy composition includes the same active substances for all forms of drug production) should not be used concomitantly with the following medicines:

• alcohol-containing solutions increase the likelihood of liver dysfunction;
• medicines to normalize the functioning of the digestive tract can reduce the effectiveness of the powder;
• drugs that affect the activity of the nervous system, increase the likelihood of side effects and accelerate the removal of ascorbic acid from the body;
• drugs that put a heavy load on the liver also increase the side effects of Antigrippin;
• oral hormonal agents and freshly squeezed juices impair the absorption of ascorbic acid, which is the active component of the powder;
• anti-diarrhea drugs impair the absorption of paracetamol;
• the powder enhances the effect of blood thinners, as a result, the likelihood of internal bleeding increases;
• Antigrippin increases the concentration of antibiotics in the blood;
• powder improves the absorption of iron-containing drugs;
• hormonal medications provoke an increase in intraocular pressure and increase the likelihood of sand formation in the kidneys.

Antigrippin powder should not be used in combination with non-steroidal anti-inflammatory drugs, since the likelihood of exacerbation of side effects increases (more often capillary necrosis and renal failure and liver).

Analogs

If Antigrippin powder did not fit in composition, caused the development of side effects or is not on sale, then it can be replaced with the following drugs:

• Phenacetin. Dosage form: powder and tablets, which include the active substance phenacetin. The medication has antipyretic, pain relieving and anti-inflammatory effects. Estimated cost 350 rubles;
• Combigripp. A multicomponent drug in the form of tablets with antipyretic and analgesic effects. The approximate price is 1450 rubles;
• Coldflu. Multi-component tablets with anti-allergic, anti-inflammatory, analgesic and antipyretic effects. The approximate cost of 100 rubles;
• Fervex. The dosage form is a powder containing 3 active substances. The medication has antihistamine, antipyretic and analgesic effects. Estimated price 400 rubles;
• Panadol. Paracetamol-based tablets, which have antipyretic and analgesic effects. The approximate cost is 100 rubles.

Antigrippin in powder form allows you to quickly eliminate the symptoms of colds and allergic reactions. The tool is convenient to use, dosing, and also stands out with a short therapeutic course. In addition, the types of powder considered in terms of pharmaceutical composition differ only in flavoring additives.

Author: Kotlyachkova Svetlana

Video about the drug Antigrippin

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