De-Nol (De-Nol) tablets 120-240 mg. How to take for adults, price

De-Nol - antibacterial medication with a specific antimicrobial effect, which helps to improve the condition of patients with pathologies of the gastric mucosa of varying severity. It is recommended to take effective pills for specific indications, which are determined at an appointment with a specialist. The drug has a narrow spectrum of action, but is often used for patients.

Composition and form of release

The medicine is available to patients in the form of medium-sized, round, biconvex tablets. They are film-coated, the color of the tablets is white or almost white. Upon admission, patients may notice a specific aroma and taste.

The tablets are packed in blisters of 8 pieces. The plates are placed in cardboard boxes. Each such package may contain 56 or 112 tablets, as well as a description indicating the features of the treatment, possible contraindications and complications.

The composition of the tablets includes the main ingredient, represented by bismuth tripotassium dicitrate, which has the main therapeutic effect.

The tablet contains auxiliary components:

• Corn starch.
• Povidone.
• Macrogol.
• Magnesium stearate.
• Hypromellose.

These substances do not help to treat diseases, but are necessary for the formation of the tablet and its shell. The amount of the main ingredient per 1 tablet is 120 mg.

Terms of sale, prices

The drug is dispensed in different pharmacies freely, but this is not considered a reason for uncontrolled independent use. The cost of a package depends on the number of tablets in it, the average price ranges from 400-950 rubles.

Pharmacological properties

De-Nol - tablets (it is necessary to take the medicine after examination by a doctor), which have gastroprotective and antibacterial properties. The spectrum of action of the main ingredient is narrow, since bismuth destroys certain bacteria that provoke the inflammatory process.

The medication reduces the likelihood of progression of symptoms, helps to improve the condition in the presence of concomitant abnormalities from other organs of the digestive system. The medicine helps to normalize the stomach, weakens the negative effect of substances on the mucous membrane.

The antiulcer properties of the drug increase its effectiveness, help reduce the likelihood of complications in the form of internal bleeding.

Pharmacodynamics and pharmacokinetics

After penetration of the agent inside, its component has a therapeutic effect rather quickly. The substance has anti-ulcer properties due to its ability to envelop the walls of the stomach, protecting against the aggressive effects of food and drinks.

The medicine acts on Helicobacter pylori. This bacterium leads to damage to the mucous membranes and the development of gastritis. When the drug is taken, its death occurs, the gradual cleansing of tissues from the waste products of bacteria. The drug exhibits bactericidal activity, that is, it quickly destroys microorganisms, and not only stops their development.

Additional properties of the medication:

• The drug not only destroys bacteria, but also affects the acidity of gastric juice, somewhat reduces it, which has a positive effect on the tissues.
• The medication prevents the development of indigestion, which often disturbs patients when diagnosed with gastritis.
• The tool helps to speed up the healing of lesions formed under the influence of bacteria and their waste products. During the course of therapy, the mucous membrane can completely recover if the foci are small. In the presence of extensive foci, they are significantly reduced, partially scarred.
• Gastroprotective properties are more pronounced in the case when the patient has lesions on the mucous membranes for the first time, and there are no complications from the intestine.

When used as a course, the remedy helps to achieve a pronounced result, eliminates symptoms and prevents their recurrence within a short period of time. Ingredients of the composition, when they enter the digestive tract, are almost not absorbed into the bloodstream, which reduces the likelihood of developing severe complications from other organs.

The components of the composition do not accumulate in the body, which reduces the likelihood of complications in the form of an overdose. After providing a therapeutic effect, the ingredient is processed in the liver, and the products of its decay are evacuated with the help of the kidneys. Disruption of the functioning of the digestive tract and kidneys leads to a slowdown in the processing and excretion of the ingredients of the composition.

This usually does not diminish the therapeutic effect unless the disorder is severe.

Indications for use

De-Nol is prescribed for various pathologies of the digestive tract.

Tablets are usually recommended to be taken when the following diseases are diagnosed:

• Gastritis against the background of reproduction of Helicobacter pylori.
• Inflammation of the gastric mucosa as a result of prolonged use of non-steroidal anti-inflammatory drugs. The drug can be prescribed in combination with other drugs to improve the effectiveness of treatment.
• Stomach ulcer at various stages, damage to the duodenum. Usually tablets are included in the course of the main treatment to accelerate tissue healing.
• Gastroduodenitis at different stages.
• Dyspeptic disorders that are not associated with functional disorders of the digestive system. The medicine is used in combination with antiemetic and some other remedies to quickly eliminate symptoms.
• Irritable bowel syndrome, in which patients usually have other abnormalities in the digestive system.

The drug can be prescribed for acute and chronic pathological conditions, as it helps to shorten the recovery period. Sometimes it is used as part of the complex treatment of acute pancreatitis, but only according to indications.

Contraindications

The drug has contraindications, which are important to consider before using it. The main obstacle to treatment is considered intolerance to the components of the composition or a tendency to such reactions in the patient's history.

Other contraindications for patients:

• The patient's age is up to 4 years. Experts note that children rarely need medication, but if necessary, it can be prescribed in an individual dosage.
• Acute gastrointestinal bleeding, accompanied by a decrease in blood pressure and other symptoms.
• Decompensated renal failure.
• Infectious kidney disease in the acute stage.
• Myocardial infarction, ischemic and hemorrhagic stroke. It is allowed to prescribe pills after relief of acute symptoms.
• Hepatitis of viral origin, liver failure.
• A state of shock, manifested by fluctuations in blood pressure indicators and impaired consciousness.

The period of pregnancy and breastfeeding refers to contraindications for treatment, since experts have not carried out enough studies confirming the safety of the main substance for such patients.

In each case, the doctor can identify individual contraindications for the patient that are absent in the official instructions.

Method of administration and dosage

De-Nol - pills that should be taken after establishing the cause of the symptoms, prescribed short and long courses, depending on the manifestations of the disease and the presence of concomitant complications. Additionally, doctors take into account the patient's age.

Patient age	Features of the use of tablets
Patients from 4 to 8 years old	For patients of this age, the dosage of the drug is selected depending on the weight. 1 kg of body weight accounts for 8 mg of the drug. The daily rate is usually divided into 2 doses during the day, which allows you to maintain the optimal level of the component in the blood. Reception continues from 2 to 4 weeks, depending on the disease.
Children from 8 to 12 years old	Patients at this age take 1 tablet of the drug in the morning and in the evening. This is considered the optimal dosage to achieve a therapeutic effect. The duration of use depends on the specific disease. On average, the course lasts from 2 to 6 weeks.
Adolescents over 12 and adults	For adolescents and adults, the dosage per day is 4 tablets. The duration of therapeutic use can be up to 8 weeks, if the doctor considers it appropriate.

It is necessary to take tablets 30 minutes before a meal. Adolescents and adults alike can take different daily allowances. Some people prefer to divide it in 2 times, taking 2 tablets in the morning and in the evening. Others use 1 piece 4 times a day with approximately equal time intervals.

The therapeutic effect does not depend on the dosage regimen, if the number of tablets per day does not change. When taking it, it is important to drink the medicine with a sufficient amount of water to speed up the process of dissolution of the film shell.

Side effects

De-Nol - tablets (it is better to take a medication in courses to achieve a stable therapeutic effect), provoking negative reactions from the digestive tract and other systems. This usually happens when the instructions are violated, but complications may develop even if all recommendations are followed.

Common complications:

• On the part of the digestive system, nausea and bouts of vomiting are observed, as well as stool disorders. Some patients develop persistent constipation, but sometimes patients report frequent loose stools. The condition is accompanied by bloating and flatulence, pain in the stomach and intestines. Doctors draw the attention of patients to the fact that a change in the color of feces is not considered a negative reaction requiring discontinuation of the use of tablets. This is a natural reaction of the body to a component of the composition.
• From the side of the nervous system, complications often manifest themselves in the form of headaches, impaired coordination of movements, impairment of memory and concentration. With prolonged use of the drug in high doses, patients may develop encephalopathy, but such disorders do not always occur.
• The heart and blood vessels usually do not suffer during treatment with medication, but sometimes patients note tachycardia and an irregular heart rhythm. Such disorders more often occur in patients with chronic diseases of the cardiovascular system.
• Allergy to the drug manifests itself in the form of classic symptoms, that is, rash, itching. Skin irritation. Symptoms may appear in the first few days after starting therapy, but sometimes appear after 1-3 weeks of treatment. In the second case, symptoms are less likely to appear in an acute form.

The emergence of complications is most often considered a reason for refusing treatment. The patient is advised to visit a doctor who will assess the condition, cancel treatment if necessary, adjust the dose or prescribe medications to normalize the condition.

Overdose

Despite the absence of a pronounced cumulative effect, the drug can lead to the development of an overdose when using a large number of tablets at a time. In this case, the most acute symptoms affect the kidneys, manifested in the form of pain, organ dysfunction, renal failure.

Allergic symptoms are also aggravated if they occur in the patient. Patients are more likely to develop complications from the mucous membranes of the throat. When symptoms of an overdose appear, treatment is canceled.

Patients can undergo a gastric lavage procedure to cleanse the remains of the tablets and prevent further absorption of the component into the blood. Be sure to prescribe enterosorbents, as well as medicines from other groups, depending on the symptomatology. Some patients require laxatives, others may need drugs to control loose stools.

special instructions

De-Nol - tablets (taking medication for long courses is allowed only for the intended purpose), which can be used in combination with other drugs that increase the effectiveness of treatment. The main ingredient is one of the few substances that can destroy Helicobacter pylori, which is why the drug is considered so effective.

After the start of admission, patients may notice a deterioration in appetite. After a few days, it usually returns to normal, but sometimes the symptom persists throughout the entire therapeutic course. This does not affect the effectiveness of treatment, but it can negatively affect the condition of patients with underweight.

Drug interactions

The tablets can be administered concurrently with antibacterial drugs. This combination is often needed to speed up the process of tissue repair and prevent the spread of infection.

Antacid drugs reduce the effectiveness of the tablets, therefore, if necessary, prescribing them, it is necessary to take a break between taking at least 2 hours. The effectiveness of tetracycline antibiotics is somewhat reduced when combined with tablets.

If you need to combine several medications, you should first visit a doctor. He will determine the appropriateness of the simultaneous use of several medicines.

Analogs

The tool has analogues with similar properties. More often, substitutes contain the same active ingredient.

Popular analogues:

• Vis-Nol is considered the most popular analogue based on the same active ingredient. The medicine is available in the form of capsules, which are taken orally for the purpose of treating pathologies of the stomach and duodenum. The medication has gastroprotective properties, relieves symptoms, helps to stop the progression of the disease.
• Gastrocepin in the form of tablets and solution for parenteral administration has gastroprotective properties, but does not affect the development and growth of bacteria in the digestive tract. The drug has a different composition, but it helps to restore the mucous membranes of the stomach in the presence of lesions on them.
• Novobismol in tablet form contains bismuth, which has the main therapeutic effect on tissues. The mechanism of action of the drug does not differ, as well as the scheme of application. Sometimes patients need the appointment of an analogue when an allergy to excipients in the original develops. The substitute may have other optional components.

The choice of an analogue is made by the doctor after a preliminary examination of the patient, clarification of the symptoms, concomitant manifestations from other organs.

Storage conditions and periods

The duration of storage of the drug is 4 years. During this period, it is necessary to store the drug in a dark and cool place.

The tablets should be protected from children and direct sunlight. It is forbidden to use them after the expiration date.

De-Nol - effective tablets for oral use, which are used for peptic ulcer and gastritis of bacterial origin. It is recommended to take the medication for long courses, which allows you to achieve a pronounced result, consolidate it and prevent the development of complications.

Video about the drug De-Nol

Instructions for the use of De-Nol tablets: