Content
- Characteristics of the drug
- Basic instructions
- Analogs
- Heparetta
- Heptral
- Samelix
- Heptor
- Silimar
- Silibinin
- Glutargin
- Price of funds
- Video about drugs with ademetionine
Ademetionine (400-500 mg) belongs to the category hepatoprotective medicines. The drug has a number of analogs, cheaper but no less effective. Generic and original medicines may only be taken as directed by a physician.
Characteristics of the drug
Ademetionine 400-500 mg (analogues, the price of which is presented in the range, is available in sufficient quantities) is a drug that has a hepatoprotective effect. Dosage form - tablets and lyophilisate. The drug is characterized by an antidepressant, antioxidant, neuroprotective, hepatoprotective, detoxifying effect. In the composition of dosage forms there is a substance of the same name, which acts as an active agent.
Ademetionine of synthetic origin helps to restore the concentration of the coenzyme. Under the influence of the component, the processes of the production of this substance are accelerated. The drug is characterized by a slight anti-cholestatic effect. With systematic use, there is a restoration of the rate of outflow of bile.
Ademetionine increases mobility and the level of membrane polarization. The substance is responsible for accelerating the processes of cleansing the gastrointestinal tract. The drug can be taken with endogenous recurrent and neurotic depression due to the ability of ademetionine to have an antidepressant effect.
The instructions for use prescribe the following indications:
- withdrawal symptoms;
- intracranial cholestasis;
- encephalopathy;
- cholangitis;
- cirrhosis of the liver;
- cholecystitis;
- toxic and chronic hepatitis, provoked by prolonged use of certain medications and alcoholic beverages;
- fatty degeneration of the liver.
Ademetionine is strictly forbidden to be taken by people suffering from hyperhomocysteinemia and homocystinuria. Also, children's age, the period of bearing a child and breastfeeding are considered absolute contraindications to the appointment. Do not take the drug in hypersensitive patients.
Basic instructions
The appearance of side effects can provoke non-compliance with the dosage regimen.
Most often, patients complain of the following ailments:
- hyperthermia;
- weakness;
- chills;
- swelling;
- Quincke's edema;
- anaphylactic shock;
- dryness;
- itching;
- excessive sweating;
- arthralgia;
- convulsions;
- paresthesia;
- headache;
- dizziness;
- flatulence;
- esophagitis;
- diarrhea;
- heartburn;
- bouts of nausea.
On sale you can also find Ademetionine in the form of a lyophilisate. The tablets must be taken whole, without dissolving in water or chewing. The therapeutic norm is no more than 160 mg. It is advisable to divide it into several doses. The powder must be dissolved in advance in a lysine solution. The drug must be injected into a vein slowly, mainly in a jet. Intramuscular administration is also acceptable.
Analogs
Ademetionine 400-500 mg (analogs, the price of which is lower, can be purchased at the pharmacy) - a drug that is characterized by a neuroprotective effect.
The original medicine has a number of generics:
- Heparetta;
- Heptral;
- Samelix;
- Heptor;
- Silimar;
- Silibinin;
- Glutargin.
Analogues of Ademetionine may differ from the original in composition, indications for use and contraindications.
Heparetta
The medication is marketed in the form of a lyophilisate, on the basis of which a solution is prepared for intramuscular and intravenous administration. The active ingredient, like the original drug, is ademetionine. The auxiliary elements vary slightly.
The solvent is included with the lyophilisate. Ademetionine belongs to the group of hepatoprotectors. Both drugs have a mild antidepressant effect. The medication is marketed in the form of a lyophilisate, on the basis of which a solution is prepared for intramuscular and intravenous administration. The active ingredient, like the original drug, is ademetionine. The auxiliary elements vary slightly.
The solvent is included with the lyophilisate. Ademetionine belongs to the group of hepatoprotectors. For both drugs, the original and the analogue, a mild antidepressant effect is characteristic. Medicines have neuroprotective, anti-fibrosing, antioxidant, regenerating, detoxifying properties.
Ademetionine, as an active ingredient in both drugs, takes part in metabolic processes at the cellular level. The substance restores the concentration of taurine, cysteine and glutamine, while reducing the level of methionine.
The lyophilisate is administered parenterally. Both drugs are characterized by high bioavailability. They bind to blood proteins by 5-10%. Ademetionine is able to cross the blood-brain barrier.
The active ingredient of the original drug and its analogue is metabolized by the liver. Metabolites leave the body along with urine in an almost unchanged form. Ademetionine and Heparetta have the same indications for use.
Medicines are prescribed for the following pathologies:
- alcoholic encephalopathy;
- cirrhosis;
- cholangitis;
- cholecystitis is stoneless;
- liver damage of a toxic type (drugs, viruses, alcohol);
- chronic hepatitis;
- fatty degeneration.
Unlike the original medication, the analogue has fewer contraindications. The drug is not prescribed for children under 18 years of age and hypersensitive patients. Careful admission is required for elderly patients, people with renal insufficiency, pregnant and lactating women.
The lyophilisate must be placed in a solvent. The finished solution is injected in a stream, intravenously, slowly. Therapeutic dose is not more than 12 mg / kg. The ready-made solution of Ademetionine and Heparetta cannot be stored.
Heptral
Ademetionine 400-500 mg (analogs, the prices of which are presented below in the text, have a therapeutic effect similar to the original) is a medication with a mild antidepressant effect. Heptral is considered a structural substitute for the drug. The medication is marketed in the form of tablets, each of which is coated with an enteric coating. The composition of the original medicine and its analogue is the same. Ademetionine acts as an active ingredient.
Heptral belongs to the category of hepatoprotectors. The drug helps to restore metabolic processes in the organs of the gastrointestinal tract. Heptral, like the original drug, has a neuroprotective, antifibrosing, antioxidant, regenerating, detoxifying, anticholytic and antidepressant effect. Under the influence of the substance, the processes of production of L-methionine, taurine, cysteine and glutamine are activated.
Unlike the original drug, Heptral binds to blood proteins by 40-45%. The bioavailability of the analogue is average. Antidepressant activity does not appear immediately - usually the result is noticeable after 6 days of regular use. It is advisable to take the tablets on an empty stomach. The dosage form is swallowed whole, without chewing or first dissolving in water. The original and its counterpart have approximately the same indications for use.
The instructions indicate the following pathologies:
- liver failure;
- encephalopathy;
- cirrhosis;
- cholangitis;
- cholecystitis;
- violations of the functional activity of the biliary organ caused by prolonged use of antidepressants, antiviral drugs, antibiotics;
- chronic acute hepatitis;
- fatty degeneration.
Also, the reason for prescribing drugs can be increased fatigue, provoked by a prolonged stay in a stressful situation. Heptral, like Ademetionine, should not be taken by people with bipolar disorder and hypersensitivity. Children's age is considered an absolute contraindication to the appointment of the original medication and its analogue.
Heptral and Ademetionine tablets must be taken daily. The daily rate should not exceed 25 mg / kg. Both drugs are well tolerated by patients.
Possible side effects are spelled out in the instructions:
- diarrhea;
- nausea;
- headache;
- insomnia;
- confusion of consciousness;
- dizziness;
- spikes in blood pressure.
If the dosage regimen is not followed, patients may complain of nausea, heaviness and pain in the stomach.
Samelix
Samelix can be considered a structural analogue of Ademetionine. It goes on sale in the form of a lyophilisate. The kit includes a solvent. The active element is ademetionine (no more than 400 mg).
Synthetic hepatoprotector with pronounced neuroprotective, antioxidant, antidepressant activity. The component takes part in the metabolic processes of transamination, transsulfitation and transmethylation. The bioavailability of drugs varies between 92-93%. They bind to blood proteins to an insignificant extent. Samelix, like the original medication, can cross the blood-brain barrier.
The active ingredient is found in saliva and cerebrospinal fluid. Ademetionine present in Samelix and the original medication is metabolized by the liver. The half-life varies between 5-7 hours. The structural analogue has the same indications for use as Ademetionine.
It is advisable to use the medication when:
- encephalopathy;
- cirrhosis;
- cholecystitis;
- cholangitis;
- lesions of the biliary organs caused by the toxic effects of drugs, alcoholic beverages and viruses;
- fatty degeneration.
Contraindications for both drugs are also the same. It is not recommended to take medications for children, pregnant and breastfeeding women. Also, the use of the drug should be abandoned for hypersensitive patients.
Heptor
Ademetionine 400-500 mg (analogs, prices for which may be lower, must be taken according to the instructions) is a synthetic anticholestatic. Generic from a domestic manufacturer contains ademetionine in its composition. Mannitol, magnesium stearic acid, crosspovidone and microcrystalline cellulose act as auxiliary elements.
Release form:
- enteric-coated tablets;
- lyophilisate for solution preparation.
Generic belongs to the group of hepatoprotectors. The analogue is characterized by a moderate hepatoprotective, antifibrosing, detoxifying, antioxidant, restorative, stimulating and antidepressant effect. With the participation of ademetionine, a number of biochemical processes occur that contribute to the regeneration of liver cells.
Like the original drug, the analogue is rapidly absorbed and enters the systemic circulation, evenly distributed over the tissues of the kidneys, liver, and adrenal glands. Its bioavailability is moderate. The active component binds to blood proteins to an insignificant extent. Ademetionine is found in breast milk and cerebrospinal fluid.
Indications for the use of Heptor and the original medication are slightly different.
An analogue is prescribed for:
- depression;
- withdrawal symptoms;
- encephalopathy;
- viral hepatitis;
- toxic hepatitis;
- cirrhosis of the liver;
- intrahepatic cholestasis.
Unlike the original, Heptor has practically no absolute contraindications (with the exception of individual intolerance). Elderly people, pregnant women and children over 14 years of age may need to adjust the dosage regimen.
Side effects are extremely rare. Patients may complain of epigastric pain and local allergic reactions. Heptor and Ademetionine are taken according to the standard scheme: the drug form is swallowed whole, without chewing or dissolving in water.
Powder for preparation of injections is placed in a solvent, the container with the solution is shaken thoroughly, drawn into a syringe and injected intramuscularly / intravenously. The treatment regimen, course of administration and therapeutic doses are selected by the doctor on an individual basis.
Silimar
Ademetionine and Silimar have different compositions. Milk thistle extract acts as an active ingredient. The auxiliary elements also vary. Silymar contains magnesium stearic acid, povidone and lactose. The original drug and the generic drug have the same release form - both drugs are marketed as tablets.
The herbal preparation has an antiseptic, anti-inflammatory, antispasmodic and hepatoprotective effect. The extract stimulates the synthesis of proteins and enzymes in liver cells. Thanks to the active substance, toxins, poisons and free radicals are removed from the body faster. Indications for the use of Ademetionine and Silymar are also different.
The herbal preparation is prescribed for:
- systematic alcohol abuse or long-term use of certain medications (antibiotics, antineoplastic, antiviral medicines).
- intoxications;
- cirrhosis of the liver;
- hepatitis (acute, chronic);
- violations of the functional activity of the liver caused by toxic lesions.
Silimar, unlike the original, has practically no contraindications (with the exception of hypersensitivity). Side effects are also rare. The instructions for use describe only local allergic reactions, manifested in the form of urticaria, rash, itching and burning.
Silymar tablets are taken according to the standard scheme, orally, with a large amount of liquid in the dosage form. The daily rate is no more than 6 tablets. The course of treatment is 24-30 days.
Silibinin
Ademetionine 400-500 mg, like Silibinin (analogue is cheaper), has a prolonged effect. The herbal preparation contains milk thistle extract. It goes on sale in the form of flat cylindrical tablets. Chamfer and risk are present. Magnesium salt of stearic acid, vegetable starch and milk sugar are used as auxiliary elements.
Like most analogs of Ademetionine, Silibinin is able to have an antiseptic, hepatoprotective effect. The extract of the medicinal plant has a beneficial effect on the work of the biliary organ. He participates in metabolic processes at the cellular level. The active ingredient strengthens the walls of hepatocytes, preventing the penetration of toxins into them.
The drug can be included in the complex drug therapy when diagnosing the following pathologies in a patient:
- intoxication caused by long-term medication;
- hepatitis of various etiologies;
- cirrhosis of the liver;
- violations of the functional activity of the biliary organ, provoked by intoxication.
Like Ademetionine, Silibinin is not prescribed for children under 12 years of age. Also, the reception is contraindicated in hypersensitive patients. The period of gestation and breastfeeding is considered to be relative restrictions on use.
No serious ailments were identified during clinical trials. Minor local allergic reactions occurred in 3% of patients.
Glutargin
Glutargin is a drug that has a similar therapeutic effect with adenomethinine. The composition contains arginine in the form of glutamate. The drug goes on sale in the form of a solution, a lyophilisate and tablets.
Glutargin is characterized by a hepatoprotective effect. Like Ademetionine, the generic drug exhibits energy-supplying activity. Under the action of the component, hepatocyte membranes are stabilized, which minimizes the risk of penetration into liver cells from toxins and free radicals.
Taking Glutargin is indicated for people who systematically abuse alcohol. The component accelerates the breakdown of alcohol molecules in the biliary organ.
The instructions contain the following indications for use:
- post-intoxication disorder;
- alcohol intoxication;
- encephalopathy;
- alcoholic coma or precoma caused by intoxication with poisons of medicinal plants or mushrooms;
- cirrhosis of the liver;
- chronic and acute hepatitis.
The drug is often included in the complex of complex drug therapy in the treatment of alcoholism. Ademetionine and Glutargin have different contraindications.
The latter is not prescribed for:
- disorders of the psycho-emotional background;
- psychosis;
- violations of the functional activity of the kidneys;
- fever.
The period of childbearing and breastfeeding, as well as children's age, can be attributed to absolute restrictions. Glutargin is a broad-spectrum drug. It is well tolerated by patients. In rare cases, nausea, heaviness, intestinal cramps may occur. Most often, the ailments disappear on their own after a few days of regular use.
Instructions for use of Ademetionine and Glutargin are slightly different. The tablets must be drunk within 14 days, the therapeutic norm is no more than 750 mg. The solution is administered intravenously twice a day (speed - no more than 70 drops per minute). With drip injection, the concentrate is diluted in a sodium chloride solution.
Price of funds
The approximate cost of Ademetionine and its structural analogs:
| Name | Price |
| Heparetta | RUB 1100-1315 |
| Heptral | RUB 1350-1500 |
| Samelix | RUB 1150-1210 |
| Heptor | RUB 880-960 |
| Silimar | RUB 190-320 |
| Silibinin | RUB 110-170 |
| Glutargin | 420-480 rub. |
| Ademetionine | RUB 1480-1680 |
The products can be purchased over the counter without a prescription. It is strictly forbidden to independently select a treatment regimen without knowing the exact cause of the development of the disease.
Ademetionine 400-500 mg is a medication that has a beneficial effect on the work of the biliary organ. Analogues with a similar therapeutic effect, which have lower prices, should be selected by the attending physician if there are contraindications to the use of the original drug. If necessary, the specialist will prescribe an examination to identify the exact reason for the restrictions.
Video about drugs with ademetionine
Doctor about Heptral:
