Allopurinol (Allopurinol) 100-300 mg. Price, instructions for use, reviews

Allopurinol is an anti-gout agent (reduces the rate of formation of uric acid), which is produced by pharmaceutical companies in Russia, Ukraine and China. The drug is convenient in dosage and use, thanks to the tablet form of release with different dosages (100 and 300 mg). At the same time, the medication has negative sides (a large list of side effects) and positive (high efficiency and affordable price).

Composition and form of release

Allopurinol tablets are made in a classic flat round shape. The smell is practically absent. The product has a white color, the edges are chamfered, and on one plane there is a risk (used to divide the tablet into 2 parts), on the other there is an engraving E351. The drug is packaged in 10 pcs. in blisters, which are in a cardboard box in the amount of 3 pcs. Also, the medication can be bought in jars in the amount of 50 pcs.

The constituent elements of Allopurinol are:

List of substances	Characterization of substances
Main components
Allopurinol	Reduces the production of uric acid, reduces the amount of salts in the blood and prevents their deposition in tissues.
Secondary components
Lactose monohydrate	A filler that gives the tablets a sweet taste.
Potato starch	The substance protects the mucous membranes of the digestive tract from the aggressive effects of the active ingredient, and also allows the tablet to quickly dissolve in the stomach.
Povidone K-25	Combines and removes harmful substances from the body, in addition, it is an artificial substitute for joint fluid.
Talc	Facilitates the swallowing of tablets, prolongs their shelf life, has anti-inflammatory and antibacterial properties. In addition, the element contributes to the rapid dissolution of the tablets.
Magnesium stearate	A filler to facilitate dissolution of the tablet in the digestive tract.
Sodium carboxymethyl starch (type A)	Thickener, gives the tablets the desired appearance and does not affect its disintegration and absorption of the active substance.

The active ingredient in tablets can be at a concentration of 100 and 300 mg.

Terms of sale, storage, prices

Allopurinol 100-300 mg, the price of which depends on the dosage and the manufacturer's company, belongs to the group of prescription drugs. After purchasing, the drug must be placed in a dark place with a temperature not exceeding 30 degrees. The storage period of the medication is 36 months.

Taking the drug is often accompanied by the development of side effects, and its use in large doses threatens with serious poisoning, so it must be stored away from children.

Estimated price range for Allopurinol tablets:

Tablet dosage	Number of tablets	Minimum price	Maximum price
100 mg	50 pcs.	108 RUB	167 r
300 mg	30 pcs.	RUB 95	RUB 160

The lowest cost of Allopurinol tablets is recorded in online pharmacies. At the same time, when buying online, it should be borne in mind that a decrease in cost is often associated with the approaching end of the expiration date of the medication.

Pharmacological properties

Allopurinol belongs to the group of anti-gout drugs.

Pharmacodynamics and pharmacokinetics

Allopurinol 100-300 mg, the price of which is budgetary, lowers the concentration of uric acid in the body by reducing its production and dissolving the existing deposits of urate deposits. The drug acts both in liquid media and in body tissues.

After taking the active substance of the tablet, it begins to act within 1 hour (it dissolves in the upper parts of the digestive tract). The action of the drug lasts approximately 3-5 hours.

Indications for use

Doctors prescribe Allopurinol when diagnosing the following diseases in a patient:

• an increased amount of uric acid or its salts in the blood and tissues (hyperuricemia);
• identification of sand or stones (small size) in the kidneys;
• treatment and prevention of the development of gout. Pathology is expressed by the deposition of uric acid salts in the joints and in the periarticular tissues;
• deposition of uric acid salts in soft tissues;
• psoriasis. An autoimmune dermatological disease affecting the top layer of the skin. It is manifested by the formation of dry red plaques on the epidermis;
• undergoing radiation therapy or taking cytostatics for oncological pathologies. The listed methods of treatment provoke the accumulation of uric acid in the tissues;
• violation of the condition or functioning of bone marrow tissues;
• long-term use (or in large doses) of glucocorticosteroids;
• increased production of uric acid;
• renal failure, provoked by obstruction of the renal tubules (provided that the dysfunction of tissues is caused by damage to their uric acid salts);
• violation of purine metabolism. When purines are destroyed, uric acid is formed.

To prescribe a medication, only the symptoms of the listed diseases are not enough; diagnostic confirmation of the disease is required.

Contraindications

Allopurinol attracts the attention of patients with its low cost and proven efficacy, but the drug cannot be used (regardless of the concentration of the main element in the tablet, 100 or 300 mg), if the patient has the following pathologies:

• the presence of allergies to the constituents of the drug;
• chronic renal failure, accompanied by an increased nitrogen content in the tissues of the organ;
• period of bearing the child;
• breastfeeding the baby;
• gout in the acute stage;
• an increased content of iron in tissues and organs, caused by a violation of the metabolism of this element;
• liver failure during an exacerbation (the main element is metabolized in this organ);
• asymptomatic course of hyperuricemia, that is, with an increased value of uric acid, salts are not deposited in tissues and fluids, but are excreted from the body without delay;
• the patient's age is less than 3 years.

With diabetes mellitus, high blood pressure, the presence of kidney disease, as well as in old age, Allopurinol is used with extreme caution and under the supervision of a treating specialist.

Method of administration and dosage

Allopurinol tablets should be used after eating (food reduces the irritating effect of the active substance on the mucous membranes of the digestive tract). When treating, it should be borne in mind that the drug with a dosage of 300 mg cannot be taken once (the tablet is divided into at least 2 parts according to the dividing risk).

Features of taking Allopurinol, taking into account the type and severity of the disease, the patient's age, as well as the presence of conditional prohibitions:

List of diseases	Restrictions on admission	Dosing rules
Hyperuricemia	From 3 to 10 years old.	The dosage is 5 mg per 1 kg of patient weight. The daily dose is allowed to be divided.
From 10 to 15 years old.	Take 100-150 mg every 24 hours. The daily dose should be divided into 2-3 doses.
Over 15 years old.	Take 100-200 mg per day. It is desirable to divide the dose into 2 doses.
After 65 years.	Assign 100 mg per day. Divide the indicated dose into 2 doses.
With diabetes, high blood pressure, kidney or liver pathologies.	The initial daily dose is 100 mg, which is preferably divided into 2-3 doses. Increase the dosage with your doctor.
Sand or kidney stones	From 3 to 10 years old.	Use 5-10 mg of Allopurinol per day per 1 kg of body weight. If necessary, divide the dose into 2 doses.
From 10 to 15 years old.	The daily dose is 100-300 mg. The frequency of use of the drug is established by the doctor.
Over 15 years old.	Take 200-300 mg per day. This dose is divided into 2-3 doses. If necessary, the doctor may increase the dosage.
After 65 years.	Consume 100-200 mg per day, the dose is divided into morning and evening intake.
With diabetes, high blood pressure, kidney or liver pathologies.	The initial daily dose is 100-150 mg. Depending on the patient's condition, the doctor may increase the dosage.
Gout (treatment)	From 3 to 10 years old.	The daily dose is 5-10 mg of Allopurinol per 1 kg of the patient's weight. The dose is divided into 2-3 doses.
From 10 to 15 years old.	The daily dosage is 100-300 mg. You need to use the product in the morning and in the evening. An increase in the dose is allowed (determined by the doctor).
Over 15 years old.	In a mild form, 200-300 mg of the drug is used in 24 hours, and if the disease is severe, then the dose can be increased by 2-3 times (but not more than 900 mg per day). In this case, the frequency of admission is at least 2 times a day.
After 65 years.	The daily dose is 200 mg, which is divided by 2 times. An increase in dosage is possible gradually.
With diabetes, high blood pressure, kidney or liver pathologies.	The starting dose per day is 200 mg. It needs to be divided by 3 times. The dose should be divided by 3 times.
Gout (prevention)	From 3 to 10 years old.	5 mg of Allopurinol is used per day per 1 kg of body weight. Take the medication in the morning and in the evening.
From 10 to 15 years old.	Take 100 mg per day. The dose is divided by 2 times.
Over 15 years old.	Consume 200 mg per day. Divide the used dose by 2 times.
After 65 years.	Assign 100 mg per day. You can take the remedy once.
With diabetes, high blood pressure, kidney or liver pathologies.	Take 100 mg per day, while the dose is divided by 2-3 times. The possibility of increasing the dosage is determined by the physician.
Deposition of uric acid in soft tissues	From 3 to 10 years old.	Use 10 mg of Allopurinol per 1 kg of body weight. The calculated dose is divided by 3 times.
From 10 to 15 years old.	Consume 300 mg every 24 hours. The dose is divided into 3 doses.
Over 15 years old.	The drug is prescribed at a dose of 400-600 mg per day. In this case, the specified amount of medication must be divided by 3-4 times.
After 65 years.	It should be used at 150-200 mg per day. Divide the dosage by 2 times.
With diabetes, high blood pressure, kidney or liver pathologies.	The initial daily dose is 100-150 mg. Depending on the patient's condition, the doctor may increase the dose. The frequency of reception is 2-3 times.
Psoriasis	From 3 to 10 years old.	The daily dose is 5 mg of Allopurinol per 1 kg of body weight. Divide the dose by 2 times.
From 10 to 15 years old.	Use 100-200 mg of the drug per day. Divide the dose by 2 times.
Over 15 years old.	Take 200-300 mg per day. The number of receptions is 2-3 times.
After 65 years.	Take 100 mg per day for 2 doses.
With diabetes, high blood pressure, kidney or liver pathologies.	First, 100 mg of the drug is used per day, then the dose can be increased. The multiplicity of reception is individual.
Radiation therapy, use of cytostatics or glucocorticosteroids	From 3 to 10 years old.	The daily dose is calculated at the rate of 10 mg of Allopurinol per 1 kg of body weight. The doctor determines how many receptions to divide the drug.
From 10 to 15 years old.	The daily intake is 300 mg. The specialist establishes the frequency of reception.
Over 15 years old.	Take 600-800 mg of the medication during the day. The course is designed for three days. The frequency of taking the pills is selected by the doctor.
After 65 years.	Prescribe 200 mg per day. The attending physician sets the frequency of admission.
With diabetes, high blood pressure, kidney or liver pathologies.	Take 200 mg per day, which must be divided by 2 times. Further treatment is adjusted by the doctor.
Bone marrow pathologies	From 3 to 10 years old.	5 mg of Allopurinol is used per day per 1 kg of the patient's weight. Take the medication 2 times.
From 10 to 15 years old.	Take 100-200 mg of the medication per day. Use the product in 2 doses.
Over 15 years old.	The daily dose is 200-300 mg, it must be divided by 2 times.
After 65 years.	Use 100-150 mg of the drug per day. Divide the dose by 2 times.
With diabetes, high blood pressure, kidney or liver pathologies.	Initial daily intake of 100 mg. Gradually, the doctor can increase the dose, and also indicates the frequency of administration.

The data from the table are indicative, the exact dose and course (the duration of therapy is determined by the dynamics of improvements) can only be established by a doctor.

It is recommended to start treatment with a daily dosage of 100-200 mg. Further, if necessary, the dose can be increased by 100 mg every 7 days.

Side effects

Allopurinol 100-300 mg, the price of pills can vary by region, it is dangerous with a large list of adverse reactions, which include the following manifestations:

• decreased vision clarity;
• change or loss of sense of taste;
• clouding of the lens, complete loss of vision is possible;
• inflammation of the mucous membranes of the eye;
• constant sleepiness;
• depressive state;
• muscle weakness;
• inflammation or damage to the nerves;
• headache;
• tingling or creeping sensation on the skin;
• stomach ache;
• loose stools;
• painful digestion;
• nausea, there may also be vomiting;
• increased production of liver enzymes;
• decreased secretion of bile into the duodenum;
• increased production of bilirubin;
• inflammation of the blood vessels of the liver;
• an increase in the size of the liver;
• necrosis of liver tissue;
• inflammation of the arteries and veins;
• a decrease in the frequency of heart contractions;
• increase in pressure value;
• inflammation of the heart tissue;
• muscle pain;
• the development of seizures;
• neuromuscular diseases;
• joint pain;
• swelling of the limbs;
• enlargement of the mammary glands in size;
• the development of infertility and a decrease in potency;
• the presence of blood or protein in the urine;
• an increase in the rate of urea;
• exacerbation of renal failure;
• interstitial nephritis is the development of tissue inflammation in the kidneys, while the disease does not respond to antibiotic therapy;
• a decrease in the level of iron, platelets or leukocytes in the blood;
• the development of nose or internal bleeding;
• dehydration of the body;
• hair loss or discoloration;
• the formation of purulent papules on the body;
• increased body temperature;
• an increase in lymph nodes in size;
• inflammation of the tonsils with the presence of necrosis;
• an increase in the number of fat cells in the blood;
• the development of diabetes mellitus;
• falling of the patient into a coma;
• nocturnal ejaculation in men;
• paralysis of the limbs;
• severe dizziness;
• dysfunction of the bone marrow.

The development of allergies in both mild and severe forms is not excluded.

Overdose

Taking pills in large doses is dangerous by the development of serious poisoning, which in the victim may manifest itself with the following symptoms:

• a sharp decrease in vision or complete blindness;
• lack of sensations of taste;
• severe inflammation of the mucous membranes of the eyes;
• depression or aggression;
• severe weakness, accompanied by drowsiness;
• inflammation and nerve damage, accompanied by pain;
• severe abdominal pain and headache;
• vomiting and severe diarrhea;
• yellowing of the skin and pain in the right side caused by a violation of the liver;
• swelling of tissues due to deterioration of kidney function;
• disruption of the heart;
• a sharp increase in blood sugar levels;
• falling of the patient into a coma;
• rapid increase in pressure;
• the appearance of seizures;
• muscle or joint pain;
• blood and protein appear in the urine;
• a sharp change in the composition of the blood in the form of a decrease in the values ​​of iron, leukocytes and platelets;
• a sharp rise in temperature.

If the patient is prone to allergies, poisoning can cause the development of anaphylactic shock.

In case of an overdose with Allopurinol, blood purification apparatus is recommended. At home, the victim should drink more water and take diuretic medications.

special instructions

Allopurinol 100-300 mg, the price of which depends on the supplier in pharmacies, doctors recommend taking under the following conditions:

• it is forbidden to use the drug if the increase in uric acid is not accompanied by the deposition of salts;
• if the patient has large kidney stones, then Allopurinol can provoke their dissolution and movement along the urinary tract. The process may be accompanied by severe back pain;
• in the absence of indications or the presence of any of the contraindications, the drug is not used;
• in the presence of restrictions in use, as well as after 65 years, Allopurinol begins to be taken with a minimum dosage. Further, at the discretion of the doctor, it is possible to increase the dose;
• for the period of using the medication, you need to drink at least 2 liters of liquid per day (preferably pure water);
• at the beginning of the course, the symptoms of pathology may increase. In this regard, in the first 2 weeks, doctors recommend taking Allopurinol in combination with anti-inflammatory drugs;
• pills can provoke the development of severe allergies, therefore, before taking them, it is required to exclude it;
• with prolonged treatment, or in the case of taking pills in an increased dose, it is necessary to monitor the condition and work of vital organs, as well as check the composition of the blood;
• in pediatrics, the drug is recommended to be used only for the period of treatment of oncological pathologies;
• Allopurinol must not be combined with alcoholic beverages, as they increase the toxic effects of the medication.

The medication affects vision, can cause severe dizziness and muscle weakness, in this regard, driving vehicles and performing life-threatening actions is prohibited during the period of taking the pills.

Drug interactions

Allopurinol is allowed to be taken in combination with other medicines, but only if the medicines are agreed with the doctor.

The following are drugs with which it is better not to combine tablets:

• anticoagulants increase the likelihood of internal bleeding;
• immunosuppressants Azathioprine, Cyclosporine and Mercaptopurine increase the toxicity of the tablets;
• the antiviral agent Vidarabine increases the toxicity of Allopurinol;
• salicylic acid-based medicines reduce the therapeutic properties of tablets;
• the diabetic agent Chlorpropamide increases the likelihood of developing a diabetic coma;
• tablets improve the absorption of the bronchial drug Theophylline;
• antibiotics increase the likelihood of developing allergies;
• cytostatics (anticancer drugs) provoke disruption of the bone marrow;
• Allopurinol increases the toxicity of the drug used for HIV infection (Didanosine);
• diuretic medications increase the risk of developing impaired renal function;
• drugs that interfere with the absorption of uric acid increase the likelihood of side effects.

A complete list of medicines that cannot be used in conjunction with Allopurinol or can be used, but when the dosage is changed, can be checked with your doctor.

Analogs

In the event that Allopurinol did not have the desired result, or the medication is not on sale, then the doctor can replace the drug with the following drugs:

• Allohexal. German drug based on a similar active substance in identical quantities, with a smaller list of side effects and contraindications. Prescription medication. The average cost is 150 rubles;
• Milurite. Hungarian prescription based on the same main substance with identical dosage. The remedy for contraindications and negative reaction is similar to Allopurinol. Estimated price 150 rubles;
• Purinol. Russian prescription drug based on allopurinol. The drug is similar to the original in terms of characteristics. The approximate cost is 120 rubles.

  

• Allozyme. Japanese prescription medication based on allopurinol. The analogue is close to the original in terms of characteristics. Estimated price 100 rubles;
• Zilorik. German prescription analogue with allopurinol in the composition. The substitute has similar characteristics. The approximate price is 1100 rubles.

Allopurinol is one of the most effective medicines that are used in case of an increased level of uric acid and its salts in the body. Due to the different dosage of tablets (100 and 300 mg), the agent is convenient to dose. When choosing a drug, it must be borne in mind that its use can cause the development of dangerous side effects. Therefore, doctors can advise analogues of the remedy, the reception of which is safer, but the price may be higher.

Author: Kotlyachkova Svetlana

Video about the drug Allopurinol

Instructions for the use of Allopurinol: