Problems at work, quarrels with close people and personal experiences can lead to the development of a depressed state, which can drag on for quite a long time.
As a rule, with conventional depressive disorder, you can cope with improvised means( occupation of your favorite hobby, favorite business, etc.), but with a long depression it's hard to fight and that's why there are such drugs as antidepressants with an invigorating and soothing effect that are capable ofreturn the stimulus to life and cheer up.
One of the effective means to combat depression is Mirtazapine.
Contents
- General information about
- Composition and preparation
- Pharmacological properties
- Pharmacokinetics of drug
- Scope and contraindications
- Instruction for use
- Overdose and adverse reactions
- Additional guidance
- Practice and once again practice
- Advantages and disadvantages of practical application
- Buying medicines and analogs
General information about the preparation
Mirtazapine is a tetracyclic antidepressant of a new generationWhich was developed by the famous pharmaceutical company Organon International and is used not only to relieve symptoms of depression, but also as a weakly acting sedative and hypnotic( in small doses).
Due to the fact that Mirtazapine is a new generation antidepressant, it has the following advantages from its less modern analogs:
- natural composition without the addition of synthetic additives, which does not harm the body when taken;
- is not addictive;
- fast effect, lasting all day;
- drug activates the production of the hormone of happiness and awakens the patient's positive emotions, which allow you to deal with the state of deep depression.
Composition and preparation
Composition: 
- Active ingredient - mirtazapine;
- is an active biological supplement;
- cornstarch;
- natural supplements to ensure that the drug is better absorbed by the body;
- vitamins.
Produced in the form of tablets, coated with a shell for faster passage through the body.
Pharmacological properties
The drug has an antidepressant effect due to the blocking of central presynaptic and postsynaptic alpha 2-adrenergic inhibitory receptors.
The effect of the active substance of the drug on peripheral alpha-adreno and m-cholino receptors has the property of reducing the systolic and diastolic blood pressure, as well as reducing the ability of brain cells to transmit neural signals.
The medication has the best effect in the presence of the following symptoms:
- is a prolonged depressive condition that is characterized by loss of interest in any kind of activity, lack of mood and lack of emotion;
- feelings of anxiety and insecurity;
- constant jumps in body weight( abrupt weight loss or, conversely, a set of excess fat mass);
- anxiety, experiences, persecution mania.
Medication blocking the irritability of nerve receptors by soothing effects on the nervous system.
The drug is absorbed quickly enough inside the stomach, and recent food intake does not affect the ability of the body to absorb the drug. Within a few hours, Mirtazapine is fully bioavailable( approximately 50%), and after a few hours the drug is completely absorbed by the body, achieving maximum effect. Super-family of isoenzymes of cytochromes P-450 are responsible for the formation of:
- 8-hydroxy metabolite mirtazapine, for this process the substrates CYP1A2 and CYP2D6 are responsible;
- N-oxidized and N-demethylated metabolic products, in the synthesis of which the enzyme CYP3A4 is involved.
Some of these compounds have pharmacological activity, however, their blood levels are very low.
The active substance is excreted from the human body with feces - urine( about 80%) and feces( 20%).
Negative stereoisomer is released twice as slowly as positive, the half-life of the drug is:
- in men - about 27 hours;
- in women - 36 h.
The index of the blood plasma cleavage factor from Mirtazapine decreases when the patient develops a functional impairment of the liver or kidneys.
Pharmacokinetics of the drug
The main component of the drug is an active antagonist of presynaptic nature and central effect, which exerts a tonic effect, improves the performance of the entire nervous system.
Once taken, the antidepressant is rapidly absorbed by the body, and the maximum effect is achieved a few hours after ingestion.
Most of the medication( about 85%) interacts with blood and proteins, causing a slight addiction of the patient, which occurs a few days after the completion of the course of admission.
Once the drug has got inside, it begins to be actively absorbed by the body and after a few hours it has a positive effect on the body.
Scope and contraindications
Indications for use Mirtazapine:
- depressive state;
- chronic irritability;
- chronic fatigue;
- inhibition, which was developed at the psychomotor level;
- chronic insomnia;
- unexplained loss or weight gain( most likely, caused by similar metamorphosis were experiences or nervous breakdown);
- mood change( several times a day);
- Anxiety Disorders;
- affective disorders;
- obsessive-compulsive disorder;
- thoughts of suicide and deprivation of interest in life.
Contraindications:
- no psychological abnormalities;
- intolerance to the components of this drug, since they can cause allergies.
Instruction for use
It is necessary to take the drug before or after eating( eating does not affect the absorption of tablets).Take one capsule at a time( 2 times a day).
As a rule, the course of treatment takes up to six months, and the completion of therapy is gradual, in several stages, as the medication tends to be addictive.
Dosage:
- for men and women under 60 years old - 15 to 35 milligrams per day( the maximum dose is 45 milligrams).
- men and women after 60 years of age - the dosage does not change, but patients with age should be more careful, and they should always be under the care of the attending physician-psychotherapist.
Overdose and Adverse Reactions
In overdose, the patient is experiencing excessive drowsiness, memory problems, loss of orientation in space, faster heart rate 
.In this case, it is necessary to withdraw the medication from the body with the help of activated carbon and abundant drinking.
Side effect:
- drowsiness;
- hallucinogenic effects;
- decreased potency in men;
- metabolic disorder.
Additional information
Mirtazapine should be taken with caution when:
- problems with urination;
- diabetes mellitus.
The drug is not compatible with alcohol, as this can cause nausea.
In case of impaired renal and hepatic function, the patient is not recommended to take this antidepressant, since its active substance adversely affects these organs.
As a rule, antidepressants are not used in complex treatment.
Practice and once again practice of
Review of the doctor and reviews of patients taking or taking Mirtazapine.
Mirtazapine is a pretty good, and most importantly proven antidepressant, which can pull the patient out even because of the deepest depression( even if other methods of treatment do not help).The only drawback of the drug is a little addictive.
Nikolay Antonovich, doctor-psychotherapist
After the death of her husband, there was a protracted dispersion( lack of desire to live, constant tears and weight loss by almost 10 kilograms).Realizing that I can cope with depression alone can not, I turned for help. The doctor advised me Mirtazapin, who pulled me out for several months from this condition.
Anna Nimirova, 32,
The problems at work and in the family caused me a deep depressive state, which I could not cope with. Having addressed to the doctor to me have appointed or nominated Mirtazapin who on responses reduced potency at men. But, in practice it turned out that the male libido and potency do not suffer.
Alexey Morov, 35 years
Advantages and disadvantages of the practical application of
Pros:
- natural composition;
- quick and lasting effect.
Cons:
- individual intolerance of the drug components;
- is an addictive;
- a feeling of drowsiness
Buying medicines and analogs
Mirtazapine is produced in tablets, and their price is 1500 rubles.
Store the medicine in a dry place protected from the sun. The permissible storage temperature is from +2 to +30 degrees Celsius. Also, you need to keep this medicine away from children's eyes and hands.
The drug is dispensed in a pharmacy exclusively on prescription.
There is no analogue for the active substance with this drug, as Mirtazapin has a unique unique composition. However, in their overall effect there are similar means:
- Alventa - suppression of depressive state;
- Velaxin - treatment of prolonged episodes of depression;
- Venlaxor - prevention of depression and its manifestations;
- and numerous other antidepressants ( full list of the best).
