Contents of the page
- 1 Mexidol - action of the preparation
- 2 Composition and form of the release
- 3 When Mexidol is prescribed - indications
- 4 Instructions for use( tablets, solution for injections)
- 5 Analogues
- 6Price
- 7 See video: Mexidol: Brain Update
- 8 Reviews on the application of
Mexidol is a popular drug that was developed in 1996 by Russian scientists. Refers to antioxidants of a new generation, is used to improve cerebral circulation. It is part of a group of nootropic drugs, whose action is aimed at normalizing metabolic processes in the brain cells and protecting them from free radicals. This makes it possible to widely use Mexidol in neurological practice.
Its use is not limited to one area of medicine, the drug is used to treat various pathologies in psychiatry, surgery and narcology. Unique properties of the antioxidant allow not only to restore memory, speech and skills lost as a result of a stroke or ischemic brain damage, but also increase the body's resistance to various intoxications and stressful situations. In addition, Mexidol as part of complex therapy helps to cut acute purulent inflammatory processes in the abdominal cavity. Let us dwell in more detail on the therapeutic effect of this medication, the methods of its use, and we will tell what it helps.
Mexidol - the action of the drug
Mexidol is an antioxidant that possesses nootropic, antihypoxic, anticonvulsant and anti-stress action. The main active ingredient is ethylmethylhydroxypyridine succinate. The main goal of the drug is to increase the body's resistance to the action of various damaging factors( hypoxia, cerebral circulation, ischemia, intoxication).
Mexidol helps to improve blood microcirculation, better blood supply to the brain and restore metabolism in nerve cells. Under its action, the structure of the cell membranes stabilizes, the aggregation of platelets decreases, and the content of cholesterol in the blood decreases.
Nootropic effect of the drug is expressed in the activation of mental activity, increasing the ability to learn and assimilate information, improve memory. As an antioxidant, the drug protects body cells from excessive oxidation, reduces the harmful effects of free radicals, slows down aging and increases the resistance of organs and tissues to oxygen starvation.
The use of Mexidol helps to restore the disturbed cycle of sleep and wakefulness and to reduce the rate of development of degenerative processes. With the use of the drug, the production of the "joy hormone" - dopamine - increases, which makes Mexidol an excellent remedy for the treatment of depressive conditions.
This hormone helps relieve anxiety, suppresses anxiety and fear, helps with sleep disorders, neurological and vegetative disorders. The drug has anti-stress, anticonvulsant and antihypoxic effect, contributing to the saturation of blood with oxygen.
The drug allows you to weaken the toxic effects of alcohol, it stops acute abstinence syndrome, restores behavioral disorders, has an anticonvulsant effect. The combined use of Mexidol with tranquilizers, antidepressants, hypnotics, antipsychotics, enhances their effect, which allows to reduce the doses of these drugs and to reduce the adverse reactions.
When ingestion Mexidol is rapidly absorbed and distributed in organs and tissues. The drug is excreted from the body with urine in the form of metabolites, a small amount of the drug is excreted unchanged. The greatest intensity of excretion is observed within 4 hours after taking the dose of the drug.
Composition and form of release
Mexidol is produced in two dosage forms:
- Medication Mexidol in the form of oral tablets
- Mexidol in ampoules for intravenous and intramuscular administration
Mexidol tablets biconvex, coated with white or slightly creamy color. In the cross-section, two layers are visible: a gray core and a white outer shell. One tablet contains 125 mg of active ingredient. The preparation is packaged in contour squeeze blisters for 10 pills in each( 3 to 5 blisters per pack) or plastic jars containing 90 pieces. For hospitals, the drug is sold in plastic containers containing 450 or 900 tablets each.
Solution of the drug is released in ampoules of colorless or dark glass, with a white break point, which are packed in 5 or 10 pieces into contour squares. One or two blisters are inserted into the carton with the preparation. Ampoules Mexidol have a volume of 2 and 5 ml. This form of the drug is a clear, colorless or slightly yellowish solution, intended for infusion or intramuscular injection.1 ml of the solution contains 50 mg of the active ingredient.
Mexidol is stored in a dry, dark place. Storage temperature should not exceed 25 ° C, all forms of the drug are usable for 3 years.
When Mexidol is prescribed - indications
In medical practice, the list of diseases in which Mexidol is applied is quite extensive. First of all, it is used in neurology for the treatment of the following conditions:
- Prevention and treatment of strokes in acute and recovery period
- Manifestations of vegetative vascular dystonia
- Progressing cerebral circulation insufficiency( encephalopathy)
- Light craniocerebral trauma and its consequences
- Cognitive disorders arisingas a result of atherosclerosis( impairment of intelligence, memory, speech)
- Ischemic disease
- Asthenic syndrome
In psychiatry :
- Prevention of somatic neuroses
- Neurotic disorders: anxiety, sleep disturbances
- With symptoms of neurodegenerative poisoning
- With extreme stress factors
In addiction :
- Abstinence syndrome relief
- Withdrawal of alcohol withdrawal manifested in vegetative-vascular and neurotic symptoms
In surgery:
- In the complex therapeutic treatment of acute purulent inflammatory pathologies of the peritoneum( peritonitis, nekrotic pancreatitis).
Specialists consider the most expedient use of Mexidol in sclerosis, encephalopathy of various etiology, vegetative-vascular dystonia, convulsive states, epilepsy, neuroses, phobias and craniocerebral trauma.
Instruction for use( tablets, solution for injections)
According to the instructions for the use of Mexidol, the drug for ingestion appoint 1-2 tablets three times a day. At the beginning of treatment, the recommended dose is taken once or twice a day, then the frequency of reception is increased, achieving the desired effect. The maximum daily dose should not be more than 800 mg( 6 tablets).Duration of treatment is from 2 to 6 weeks, for withdrawal of withdrawal symptoms it is enough to take the drug for 7 days.
Treatment can not be interrupted abruptly, the dose should be gradually reduced for 3 days before the drug is completely discontinued. The optimal scheme of treatment is selected by the doctor, taking into account the individual characteristics of the patient, the general condition and severity of the symptoms. With ischemic disease, the course of treatment is more prolonged - up to 8 weeks, if necessary, the doctor may after a break appoint a second course of therapy. The most optimal period for a second course of treatment is spring and autumn.
Methidol solution can be administered intravenously and intramuscularly. Before the infusion with the help of a dropper, the drug should be diluted in an isotonic solution of sodium chloride. The speed of drip infusion should not exceed 40-60 drops per minute. The recommended volume of the drug is 100-150 ml. The jetting must be done very slowly, for 5-6 minutes.
For treatment of acute disorders of cerebral circulation the drug should be poured according to a certain scheme. In the first 10-14 days, the amount of 200-500 mg is dripped intravenously by a drop method from 2 to 4 times a day. In the next 2 weeks, intramuscular injections are performed, injecting 200-250 mg of the drug 2-3 times a day.
To eliminate the consequences of craniocerebral trauma, the drug is administered by a drip method in a volume of 200-500 mg from 2 to 4 times a day, depending on the patient's condition. The course of therapy is 10-15 days.
With slowly progressing circulatory failure, the dose is selected individually by the attending physician. The drug is administered intravenously or struino once a day for 2 weeks. Further treatment is performed by intramuscular injection.
For anxiety disorders and cognitive disorders in the elderly, the drug is administered intramuscularly in a daily dose of 100 to 300 mg. Treatment is carried out within 2-4 weeks.
To eliminate alcohol withdrawal, the medication is injected intramuscularly or with the aid of a dropper. In a day 2-3 procedures are performed, injecting the drug in a volume of 200 to 500 mg.
In purulent abscesses of the abdominal cavity, Mexidol can be administered iv or intramuscularly a day before surgery, or on the first day after surgery. The dose is selected individually, it depends on the severity of the disease, the degree of damage and the general condition of the patient.